What tests do we use to diagnose Acid-Base Disorders? PDF
Preview What tests do we use to diagnose Acid-Base Disorders?
ميحرلا نمحرلا الله مسب Mohamed Alaa Thabet, Professor of Pediatrics Pediatric Nephrology Unit University of Alexandria اعفنا املع كلأسأ نىا مهللا Introduction Introduction Acid-base homeostasis critically affects ◼ tissue and organ performance Both acidosis and alkalosis can have ◼ severe and life threatening consequences Introduction Small changes in pH can produce major disturbances: Enzymes ◼ Electrolytes ◼ Hormones ◼ 6 You get acidotic every day ! Food ◼ Drinks ◼ Metabolism ◼ Acids-base Homeostasis While living, eating and drinking….there is.. ◼ Production of 1 mmol of fixed acid/kg/day ◼ The body produces more acids than bases Cellular metabolism produces CO . ◼ 2 Metabolism of lipids and proteins produces acids. ◼ CO 2 H CO CO + H O Volatile acid 2 3 2 2 CO CO 2 2 H SO 2 4 H PO Fixed acid 3 4 Uric acid Lactic acid Ketone body The Body and pH Homeostasis of pH is tightly controlled ◼ Extracellular fluid = 7.4 ◼ Blood = 7.35 – 7.45 ◼ < 7.35: Acidosis (acidemia) ◼ > 7.45: Alkalosis (alkalemia) ◼ < 6.8 or > 8.0: death occurs ◼ 10
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