Vascular Adhesion Molecules and Inflammation

266 Pages·1999·10.96 MB·English

by  Jeremy D. Pearson (auth.)

Series Editor
Prof. Dr. Michael J. Parnham
PLiVA
Research institute
Prilaz baruna Filipovica 25
10000 Zagreb
Croatia
Published titles:
T Cells in Arthritis, P. Miossec, W. van den Berg, G. Firestein (Editors), 1998
Chemokines and Skin, E. Kownatzki, J. Norgauer (Editors), 1998
Medicinal Fatty Acids, J. Kremer (Editor), 1998
Inducible Enzymes in the Inflammatory Response, DA Willoughby, A. Tomlinson (Editors),
1999
Cytokines in Severe Sepsis and Septic Shock, H. Redl, G. Schlag (Editors), 1999
Fatty Acids and Inflammatory Skin Diseases, J.-M. Schroder (Editor), 1999
Immunomodulatory Agents from Plants, H. Wagner (Editor), 1999
Cytokines and Pain, L. Watkins, S. Maier (Editors), 1999
in Vivo Models of Inflammation, D. Morgan, L. Marshall (Editors), 1999
Pain and Neurogenic Inflammation, S.D. Brain, P. Moore (Editors), 1999
Anti-Inflammatory Drugs in Asthma, A.P. Sampson, M.K. Church (Editors), 1999
Apoptosis and Inflammation, J. D. Winkler (Editor), 1999
Novel Inhibitors of Leukotrienes, G. Folco, B. Samuelsson, R.C. Murphy (Editors), 1999
Forthcoming titles:
Metalloproteinases as Targets for Anti-Inflammatory Drugs, K.M.K. Bottomley, D. Brad
shaw, J.S. Nixon (Editors), 1999
Free Radicals and Inflammation, P. Winyard, D. Blake, Ch. Evans (Editors), 1999
Gene Therapy in Inflammatory Diseases, Ch. Evans, P. Robbins (Editors), 1999
Vascular Adhesion Molecules
and Inflammation
Jeremy D. Pearson
Editor
Springer Basel AG
Editor
Dr. Jeremy D. Pearson
Centre for Cardiovascular Biology and Medicine
School of Biomedical Sciences
King's College London
Guy's Campus
London SE1 9RT
UK
A CIP catalogue record for this book is available from the Library of Congress, Washington D.C., USA
Deutsche Bibliothek Cataloging-in-Publication Data
Vascular adhesion molecules and inflammation ! ed. by Jeremy D.
Pearson. -Basel ; Boston; Berlin: Birkhăuser, 1999
(progress in inflammation research)
ISBN 978-3-0348-9753-2 ISBN 978-3-0348-8743-4 (eBook)
DOI 110 .1007/978-3-0348-8743-4
The publisher and editor can give no guarantee for the information on drug dosage and administration contained in
this publication. The respective user must check its accuracy by consulting other sources of reference in each individual
case.
The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that
they are exempt from the relevant protective laws and regulations or free for general use.
This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned,
specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on micro
films or in other ways, and storage in data banks. For any kind of use, permission of the copyright owner must
be obtained.
© 1999 Springer Basel AG
Originally published by Birkhăuser Verlag in 1999
Softcover reprint of the hardcover 1s t edition 1999
Printed on acid-free paper produced from chlorine-free pulp. TCF =
Cover design: Markus Etterich, Basel
Cover iIIustration:
ISBN 978-3-0348-9753-2
987654321
Contents
List of contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . v.ii . . . . . . . . . . . . . . . . . . . .
Jeremy D. Pearson
How early studies of inflammation led to our current views on the roles
of vascular adhesion molecules. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Klaus Ley
Adhesion of leukocytes from flow: The selectins and their ligands............... 11
C. Wayne Smith, Alan R. Burns and Scott I. Simon
Co-operative signaling between leukocytes and endothelium mediating
firm attachment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.9 . . . . . . . . . . . . . . . . . . . . ..
Martha B. Furie
Production and presentation of chemokines by endothelial cells. . . . . . . . . . . . . 65. . . .
Diane E. Lorant, Thomas M. Mcintyre, Stephen M. Prescott
and Guy A. Zimmerman
Platelet-activating factor: A signaling molecule for leukocyte adhesion. . . . . . . .8 .1 .
James M. Staddon and Tetsuaki Hirase
Tight junctions and adherens junctions in endothelial cells:
structure and regulation .......................................................... 109
William A. Muller
The role of PECAM in leukocyte emigration ...................................... 125
Mark A. Jutila
Selective lymphocyte migration into secondary lymphoid organs and
inflamed tissues ................................................................... 141
Contents
Xi-Lin Chen and Russell M. Medford
Oxidation-reduction sensitive regulation of vascular inflammatory
gene expression .............. . ..................... 161
Tanya Y. Huehns and Dorian O. Haskard
Quantification and imaging of vascular adhesion molecule expression
in inflammatory diseases in vivo... . ....................................... 179
Simon C. Robson and David Goodman
Leukocyte adhesion and activation in xenografts ................................ 197
Tak Yee Aw and D. Neil Granger
Control of leukocyte adhesion and activation in ischemia-reperfusion injury .... 221
Judith A. Berliner, Devendra K. Vora and Peggy T Shih
Control of leukocyte adhesion and activation in atherogenesis .................. 239
Index .............................................................................. 257
vi
List of contributors
Tak Yee Aw, Department of Molecular and Cellular Physiology, LSU Medical Cen
ter, PO Box 33932, 1501 Kings Highway, Shreveport, LA 71130-3932, USA
Judith A. Berliner, Departments of Medicine and Pathology, University of Califor
nia, Los Angeles, CA 90095-1732, USA;
e-mail: j [email protected]
Alan R. Burns, Department of Medicine, Baylor College of Medicine, One Baylor
Plaza, 512C, Houston, TX 77030, USA; e-mail: [email protected]
Xi-Lin Chen, Division of Cardiology, Department of Medicine, Emory University
School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
Martha B. Furie, Department of Pathology, School of Medicine, State University of
New York at Stony Brook, Stony Brook, NY 11794-8691, USA;
e-mail: [email protected]
David Goodman, Department of Clinical Immunology & Nephrology, St Vincent's
Hospital Melbourne, Fitzroy, Australia 3065; e-mail: [email protected]
D. Neil Granger, Department of Molecular and Cellular Physiology, LSU Medical
Center, PO Box 33932, 1501 Kings Highway, Shreveport, LA 71130-3932, USA;
e-mail: [email protected]
Dorian O. Haskard, BHF Cardiovascular Medicine Unit, National Heart and Lung
Institute (Hammersmith Hospital), Imperial College School of Medicine, Du Cane
Road, London W12 ONN, UK; e-mail: [email protected]
Tetusaki Hirase, 1st Department of Internal Medicine, School of Medicine, Kobe
University, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe-City 650, Japan;
e-mail: [email protected]
List of contributors
Tanya Y. Huehns, BHF Cardiovascular Medicine Unit, National Heart and Lung
Institute (Hammersmith Hospital), Imperial College School of Medicine, Du Cane
Road, London W12 ONN, UK
Mark A. Jutila, Veterinary Molecular Biology, Montana State University, Bozeman,
MT 59717, USA; e-mail: [email protected]
Klaus Ley, University of Virginia School of Medicine, Department of Biomedical
Engineering, Health Sciences Center, Box 377, Charlottesville, VA 22908, USA;
e-mail: [email protected]
Diane E. Lorant, University of Utah, CVRTI, 95 South 2000 East, Salt Lake City,
UT 84112-5000, USA
Thomas M. McIntyre, University of Utah, CVRTI, 95 South 2000 East, Salt Lake
City, UT 84112-5000, USA .
Russell M. Medford, AtheroGenics, Inc., 8995 Westside Parkway, Alpharetta, GA
30004, USA; e-mail: [email protected]
William A. Muller, Department of Pathology and the Center for Vascular Biology,
Weill Medical College of Cornell University, 1300 York Avenue, New York, NY
10021, USA; e-mail: [email protected]
Jeremy D. Pearson, Centre for Cardiovascular Biology and Medicine, School of Bio
medical Sciences, King's College London, Guy's Campus, London SE1 9RT, UK;
e-mail: [email protected]
Stephen M. Prescott, University of Utah, CVRTI, 95 South 2000 East, Salt Lake
City, UT 84112-5000, USA
Simon C. Robson, Department of Medicine, Beth Israel Deaconess Medical Center,
Research North, Rm 370H, 99 Brookline Avenue, Boston, MA 02215, USA;
e-mail: [email protected]
Peggy T. Shih, Departments of Medicine and Pathology, University of California,
Los Angeles, CA 90095-1732, USA
Scott I. Simons, Children's Nutrition Research Center, 1100 Bates, Room 6014,
Houston, TX 77030-2600, USA
viii
List of contributors
C. Wayne Smith, Children's Nutrition Research Center, 1100 Bates, Room 6014,
Houston, TX 77030-2600, USA; e-mail: [email protected]
James M. Staddon, Eisai London Research Laboratories Ltd., Bernard Katz Build
ing, University College London, Gower Street, London WC1E 6BT, UK;
e-mail: [email protected]
Devendra K. Vora, Departments of Medicine and Pathology, University of Califor
nia, Los Angeles, CA 90095-1732, USA
Guy A. Zimmerman, University of Utah, CVRTI, 95 South 2000 East, Salt Lake
City, UT 84112-5000, USA; e-mail: [email protected]
ix
How early studies of inflammation led to our current views on
the roles of vascular adhesion molecules
Jeremy D. Pearson
Centre for Cardiovascular Biology and Medicine, School of Biomedical Sciences, King's
College London, Guy's Campus, London SE1 9RT, UK
Dutrochet [1] is generally credited with the first observation, in 1824, that leuko
cytes could be seen to emigrate across the walls of small blood vessels, and the
experimental induction of leukocyte diapedesis in response to tissue injury was first
reported by Addison in 1843 [2]." The most elegant early experimental studies were
carried out by Arnold in Heidelberg in the 1870s, examining leukocyte adhesion to,
and demonstrating emigration between, endothelial cells in small blood vessels of
the frog [3, 4]. He used silver staining to outline endothelial cell boundaries, and
injection of cinnabar to detect sites of leakage. The resulting drawings (e.g. Fig. 1)
accurately demonstrate the early stages of the acute inflammatory process in as
much detail as many contemporary textbooks. He was also perspicacious enough to
attribute emigration to a molecular process, writing:
"It is possible that chemical agents seep into interendothelial junctions and
thereby attract pavemented leukocytes, but there is, as yet, no evidence for
this concept".
Arnold did not use the word "chemotaxis", probably only coined in the 1880s, and
first unequivocally described for leukocytes, attracted into glass capillary tubes con
taining various chemicals placed in the cornea, by Leber in 1888 [5]. It was Metch
nikoff in the 1890s who firmly established the importance of chemotaxis, together
with phagocytosis, in leukocyte behaviour [6].
However, it is to Cohnheim [7] that we owe the first formulation of the impor
tance of changes in the properties of the endothelium in initiating adhesion of leuko
cytes in the acute inflammatory process. In 1882 (published in translation in 1889)
he stated:
" ... we hold fast the conviction which was forced on us by our experiments and
reflection that inflammation is the expression and consequence of a molecular
alteration in the vessel walls. By it, adhesion between the vessel wall and the
blood ... is increased. "
Vascular Adhesion Molecules and Inflammation, edited by J. D. Pearson
© 1999 Birkhauser Verlag Basel/Switzerland