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USMLE Step 1 Lecture Notes (Kaplan) 2018: Pharmacology PDF

633 Pages·2018·4.281 MB·English
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® USMLE STEP 1: PHARMACOLOGY Lecture Notes 2018 Table of Contents USMLE Step 1 Lecture Notes 2017: Pharmacology Cover Title Page Copyright Editors Feedback Page Part I: General Principles Chapter 1: Pharmacokinetics Pharmacokinetics Absorption Distribution Biotransformation Elimination Steady State Pharmacokinetics Calculations Chapter 2: Pharmacodynamics Definitions Graded (Quantitative) Dose-Response (D-R) Curves Quantal (Cumulative) D-R Curves Signaling Mechanisms: Types of Drug-Responsive Signaling Mechanisms Chapter 3: Practice Questions Practice Questions Practice Questions: Answer Key Practice Questions: Answers and Explanations Part II: Autonomic Pharmacology Chapter 1: The Autonomic Nervous System Anatomy of the ANS Blood Pressure Control Mechanisms Pupillary Size and Accommodation Mechanisms Chapter 2: Cholinergic Pharmacology Cholinergic Neuroeffector Junctions Muscarinic Receptor Activators Muscarinic Receptor Antagonists Nicotinic Receptor Antagonists Chapter 3: Adrenergic Pharmacology Adrenergic Neuroeffector Junctions Direct-Acting Adrenoceptor Agonists Indirect-Acting Adrenergic Receptor Agonists Adrenergic Antagonists Chapter 4: Autonomic Drugs: Glaucoma Treatment and ANS Practice Problems Glaucoma Treatment ANS Practice Problems ANS Practice Problems: Answers and Explanations Chapter 5: Autonomic Drug List and Practice Questions Practice Questions Practice Questions: Answers and Explanations Part III: Cardiac and Renal Pharmacology Chapter 1: Diuretics Types of Diuretics Chapter 2: Antihypertensives Drug Strategy Thiazide Diuretics Drugs Altering Sympathetic Activity Direct-Acting Vasodilators Indications for Use of Antihypertensive Drugs in Comorbid Conditions Treatment of Pulmonary Hypertension Chapter 3: Drugs for Heart Failure Primary Treatments for CHF Inotropes Chapter 4: Antiarrhythmic Drugs Cardiac Action Potential Na+ Channels ANS Regulation of Heart Rate Class I: Na+ Channel Blockers Class II: Beta Blockers Class III: K+ Channel Blockers Class IV: Ca2<sup>+</sup> Channel Blockers Unclassified Chapter 5: Antianginal Drugs Rationale for Use Key Antianginal Drugs Chapter 6: Antihyperlipidemics Cardiovascular Risks of Hyperlipidemia Lipid-Lowering Drugs Chapter 7: Cardiac and Renal Drug List and Practice Questions Practice Questions Practice Questions: Answers and Explanations Part IV: CNS Pharmacology Chapter 1: Sedative-Hypnotic-Anxiolytic Drugs Drugs Used for Sedation, Sleep, Anxiety Chapter 2: Alcohols Chapter 3: Drugs Used for Depression, Bipolar Disorders, and Attention Deficit Hyperactivity Disorder (ADHD) Drugs Used in Depression Drugs Used in Bipolar Disorders Drugs Used in ADHD Chapter 4: Drugs Used in Parkinson Disease and Psychosis Dopaminergic Neural Pathways Dopamine Receptors Drugs Used in Parkinson Disease Antipsychotic Drugs Chapter 5: Anticonvulsants Drugs Used in Seizures Chapter 6: Drugs Used in Anesthesia General Anesthetics Local Anesthetics Skeletal Muscle Relaxants Chapter 7: Opioid Analgesics Properties of Opioids Chapter 8: Drugs of Abuse Chapter 9: CNS Drug List and Practice Questions Practice Questions Practice Questions: Answers and Explanations Part V: Antimicrobial Agents Chapter 1: Antibacterial Agents Principles of Antimicrobial Chemotherapy Inhibitors of Cell-Wall Synthesis Inhibitors of Bacterial Protein Synthesis Inhibitors of Nucleic Acid Synthesis Unclassified Antibiotic Antitubercular Drugs Chapter 2: Antifungal Agents Polyenes (Amphotericin B [Amp B], Nystatin) Chapter 3: Antiviral Agents Antiviral Drug Properties Treatment of HIV Other Antivirals Chapter 4: Antiprotozoal Agents Overview Chapter 5: Antimicrobial Drug List and Practice Questions Practice Questions Practice Questions: Answers and Explanations Part VI: Drugs for Inflammatory and Related Disorders Chapter 1: Histamine and Antihistamines Histamine Chapter 2: Drugs Used in Gastrointestinal Dysfunction Drugs Used in Peptic Ulcer Disease (PUD) Antiemetics Chapter 3: Drugs Acting on Serotonergic Systems Drug Actions on 5HT Receptors Drugs Used in Migraine Headaches Chapter 4: Eicosanoid Pharmacology Eicosanoids Nonsteroidal Antiinflammatory Drug (NSAIDs) Other Drugs Chapter 5: Drugs Used for Treatment of Rheumatoid Arthritis Rheumatoid Arthritis Chapter 6: Drugs Used for Treatment of Gout Gout Chapter 7: Glucocorticoids Glucocorticoid Properties Chapter 8: Drugs Used for Treatment of Asthma Asthma Treatments Chapter 9: Inflammatory Disorder Drug List and Practice Questions Practice Questions Practice Questions: Answers and Explanations Part VII: Drugs Used in Blood Disorders Chapter 1: Anticoagulants Anticoagulant Overview Chapter 2: Thrombolytics Thrombolytic Overview Chapter 3: Antiplatelet Drugs Antiplatelet Overview Chapter 4: Blood Disorder Drug List and Practice Questions Practice Questions Practice Questions: Answers and Explanations Part VIII: Endocrine Pharmacology Chapter 1: Drugs Used in Diabetes Diabetes Mellitus Insulins Forms Drugs for Type II Diabetes Chapter 2: Steroid Hormones Adrenal Steroids Estrogens Progestins Oral Contraceptives Androgens Chapter 3: Antithyroid Agents Thyroid Hormones Chapter 4: Drugs Related to Hypothalamic and Pituitary Hormones Chapter 5: Drugs Used for Bone and Mineral Disorders Osteoporosis Treatment Chapter 6: Endocrine Drug List and Practice Questions Practice Questions Practice Questions: Answers and Explanations Part IX: Anticancer Drugs Chapter 1: Anticancer Drugs Principles Drugs and Drug Properties Chapter 2: Anticancer Drug Practice Questions Anticancer Drug Practice Questions Anticancer Drug Practice Questions: Answers and Explanations Part X: Immunopharmacology Chapter 1: Immunopharmacology Immunosuppressants Chapter 2: Immunopharmacology Practice Questions Immunopharmacology Practice Questions Immunopharmacology Practice Questions: Answers and Explanations Part XI: Toxicology Chapter 1: Toxicology Toxicology Chapter 2: Toxicology Practice Questions Toxicology Practice Questions Toxicology Practice Questions: Answers and Explanations USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME), neither of which sponsors or endorses this product. This publication is designed to provide accurate information in regard to the subject matter covered as of its publication date, with the understanding that knowledge and best practice constantly evolve. The publisher is not engaged in rendering medical, legal, accounting, or other professional service. If medical or legal advice or other expert assistance is required, the services of a competent professional should be sought. This publication is not intended for use in clinical practice or the delivery of medical care. To the fullest extent of the law, neither the Publisher nor the Editors assume any liability for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this book. © 2018 by Kaplan, Inc. Published by Kaplan Medical, a division of Kaplan, Inc. 750 Third Avenue New York, NY 10017 All rights reserved under International and Pan-American Copyright Conventions. By payment of the required fees, you have been granted the non-exclusive, non-transferable right to access and read the text of this eBook on screen. No part of this text may be reproduced, transmitted, downloaded, decompiled, reverse engineered, or stored in or introduced into any information storage and retrieval system, in any form or by any means, whether electronic or mechanical, now known or hereinafter invented, without the express written permission of the publisher. ISBN-13: 978-1-5062-2118-2 Kaplan Publishing print books are available at special quantity discounts to use for sales promotions, employee premiums, or educational purposes. For more information or to purchase books, please call the Simon & Schuster special sales department at 866-506-1949.

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