Khantzian EDWARD J. KHANTZIAN, M.D., is clinical profes- Edward J. Khantzian, M.D., and Mark J. Albanese, M.D. Addictive behaviors beg for an informed ex- and sor of psychiatry at Harvard Medical School, PSYCHOLOGY • ADDICTION planation to guide patients, families, stu- a senior member of the department of psy- Albanese dents, and clinicians through the maddening chiatry at Cambridge Health Alliance, and “Doctors Khantzian and Albanese wrote this book directly from their experi- and often incomprehensible nature of the associate chief of psychiatry at Tewksbury ence with patients, as well as their close involvement with vast research. This Understanding addictions. Too often addiction is perceived U Hospital, Tewksbury, MA. blessedly brief and clear volume is an original, useful, and wise tour de force. to be merely a moral weakness or purely a These two doctors, who have given their professional lives to understanding n brain disease, ignoring the deep personal MARK J. ALBANESE, M.D., is director of Addictions and helping those who are affected by addictions, now give to the world a con- d pain that can permeate the lives of the ad- Treatment Services at Cambridge Health Al- summate gift: what they know. Combining knowledge with love, the authors e AAddddiiccttiioonn dicted. Taking an honest look at the under- liance and assistant clinical professor of psy- have moved the dialogue on addictions to an entirely new level.” r lying emotional or mental issues can more s chiatry at Harvard Medical School. —EDWARD HALLOWELL, M.D., author of Driven to Distraction t clearly illuminate not only the causes of the a addiction, but also the cure. Doctors Edward “Understanding Addiction as Self Medication provides a clear explanation of the n J. Khantzian and Mark J. Albanese, leading reasons behind many addictions, emphasizing the pain experienced by many d researchers in the fi eld of addiction, see ad- addicted people. This is an important and readable book that provides useful i dictions primarily as a kind of self medica- n as Self Medication insights to professionals, families, and friends, as well as individuals suffering tion—a self medication that can temporarily g with addictions.” —KATHLEEN T. BRADY, M.D., Ph.D., professor of psychiatry, soothe anxiety or pain, but that ultimately Medical University of South Carolina A wreaks havoc on the lives and health of both the addicted and their loved ones. d “This book is an admirably clear exposition of how a universal human need to d manage distress and control emotions can take extreme forms in addicted indi- i With practical advice, compelling case stud- viduals, leading to perilous solutions and chemical careers. Doctors Khantzian c ies, and nuanced theory drawn from their t Finding and Albanese creatively use the self-medication hypothesis to explain multiple i years in clinical practice, Doctors Khantzian pathways into addiction and describe various exit routes, signifying hope, help, o and Albanese look at the core reasons behind n and resolution.” many addictions and provide a pathway to —MARTIN WEEGMAN, consultant clinical psychologist and group analyst, a Hope hope. Understanding Addiction as Self Medi- Gatehouse Drug Service, London, England s cation looks at a range of addictions, includ- ing alcohol and drugs, and clearly explains S “Understanding Addiction as Self Medication is rich in information about the ad- Behind how to understand other addictive behaviors e diction process, the physical and psychological effects of various types of drugs, through the lens of the self-medication hy- l and the lives of the addicted. With an engaging and personal style, Doctors Ff pothesis. This book provides a much-needed in Khantzian and Albanese gently correct misconceptions about addicts and ad- dM guide to both understanding addictions and dictive disorders and share new truths. The authors have struck just the right in the Pain working toward healing. g e balance in presenting theory and practical tools that can help the addict, family, H d friends and caregivers change the course of an addiction.” o pi —MARYANN AMODEO, Ph.D., MSW, Boston University School of Social Work e c Ba e Rowman & Littlefi eld Publishers, Inc. ht A wholly owned subsidiary of ini do The Rowman & Littlefi eld Publishing Group, Inc. 4501 Forbes Boulevard, Suite 200 ISBN-13: 978-0-7425-6137-3 thn ISBN-10: 0-7425-6137-2 e Lanham, Maryland 20706 90000 P www.rowmanlittlefi eld.com a in 9 780742 561373 Cover design by Neil D. Cotterill LR ittlefi eowma ldn & UUnnddeerrAAddddiiccttiioonnDDJJ..iinndddd 11 88//44//0088 44::1188::0033 PPMM Understanding Addiction as Self Medication Understanding Addiction as Self Medication Finding Hope Behind the Pain Edward J. Khantzian, M.D., and Mark J. Albanese, M.D. ROWMAN & LITTLEFIELD PUBLISHERS, INC. Lanham•Boulder•New York•Toronto•Plymouth,UK ROWMAN & LITTLEFIELD PUBLISHERS,INC. Published in the United States of America by Rowman & Littlefield Publishers,Inc. A wholly owned subsidiary of The Rowman & Littlefield Publishing Group,Inc. 4501 Forbes Boulevard,Suite 200,Lanham,Maryland 20706 www.rowmanlittlefield.com Estover Road Plymouth PL6 7PY United Kingdom Copyright © 2008 by Rowman & Littlefield Publishers,Inc. All rights reserved.No part of this publication may be reproduced,stored in a retrieval system,or transmitted in any form or by any means,electronic,mechanical, photocopying,recording,or otherwise,without the prior permission of the publisher. British Library Cataloguing in Publication Information Available Library of Congress Cataloging-in-Publication Data: Khantzian,Edward J. Understanding addiction as self medication :finding hope behind the pain/ Edward J.Khantzian and Mark J.Albanese. p.;cm. Includes bibliographical references and index. ISBN-13:978-0-7425-6137-3 (cloth :alk.paper) ISBN-10:0-7425-6137-2 (cloth :alk.paper) eISBN-13:978-0-7425-6551-7 eISBN-10:0-7425-6551-3 1. Substance abuse.2. Self medication.3. Compulsive behavior. I.Albanese,Mark J., 1961- II.Title. [DNLM:1. Substance-Related Disorders—psychology.2. Behavior,Addictive— psychology.3. Self Medication—psychology. WM 270 K45u 2008] RC564.K536 2008 616.86—dc22 2008015248 Printed in the United States of America (cid:2)™ The paper used in this publication meets the minimum requirements of American National Standard for Information Sciences—Permanence of Paper for Printed Library Materials,ANSI/NISO Z39.48-1992. For CarolAnn, Nancy Jo, Susan, Jane, and John E. J. K. For Jeni, Ariana, Elena, Chiara, Marcus, Ian, and Maya M. J. A. Perhaps it took a little time,but it seemed to happen instantly. He could feel his body relaxing,a stiffness going out ofhis shoul- ders as he sensed the warm glow seeping through him in all the distant forgotten corners ofhis being ... It was a miracle.There was no other word.A miracle that was affecting him mentally,physically,and,as he would soon learn,spiritually. Bill W.’s first experience with alcohol as reported to his biographer,Robert Thomsen Contents Foreword ix Timothy E.Wilens Acknowledgments xiii Introduction xv 1 Why the Self-Medication Hypothesis? 1 2 Addiction:Disease or Disorder 7 3 The SMH and Addiction as a Problem in Self-Regulation 13 4 Self-Medication Hypothesis Research:Study of Affect Regulation and Drug Preference 21 Jesse J.Suh,Psy.D. 5 Contexts and Models for Understanding Addiction— A Brief Overview 31 6 Suffering and Self-Medication 39 7 Self-Medication,Psychiatric Disorders,and Emotional Pain 49 8 Trauma and the Self-Medication Hypothesis 61 9 Addiction and the Perpetuation of Suffering 69 10 Nicotine,Marijuana,and the SMH 81 11 Behavioral Addictions:Does the SMH Apply? 87 12 The Neurobiology of Addiction and the SMH 97 13 How the SMH Can Guide Treatment and Recovery 105 14 Conclusion 117 vii viii Contents Afterword:The SelfMedication Hypothesis 121 A.Thomas McLellan Notes 127 Selected References 149 Index 151 About the Authors 157 Foreword A ddiction is one of the most compelling disorders because it is devas- tating not only to individuals, but to their entire networks of family and friends.While much is heralded about the etiologies of substance use dis- orders (SUDs),it has become increasingly evident that there are multiple intersecting pathways by which an individual seemingly develops an ad- diction.Moreover,once somebody is addicted,an entirely separate set of events or stressors may perpetuate the addiction. Not surprisingly, the ability to predict who will recover relatively easily and who will struggle with the perils of an addiction their entire life—perhaps suffering severe morbidity or even death—continues to remain elusive. One of the most compelling theories to explain the initiation, per- sistence, and successful remission from SUD is the self-medication hy- pothesis (SMH) of addictive disorders.As Drs.Khantzian and Albanese clearly describe throughout this book,when addicted individuals resort to addictive drugs, more than anything, they are self-medicating their dis- tress.This approach is helpful both conceptually and practically,in terms of better understanding the addicted person and the role the addiction may play in his or her life.The SMH integrates developmentally inherent vulnerabilities, psychological distress, and life events. Having been ex- posed to the self-medication notion during my professional development, I often examine the role that substances may be playing in an individual’s life—be it to relieve disturbing symptoms or, more covertly, to diminish underlying unbearable feelings. As a psychiatrist for both children and adults,and as both a clinician and researcher, I am always examining what factors contribute to the ix
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