Tissue Engineering (Academic Press Series in Biomedical Engineering)

777 Pages·2008·77.8 MB·English

by  Clemens van Blitterswijk

Tissue Engineering
A volume in the
ACADEMIC PRESS SERIES IN BIOMEDICAL ENGINEERING
JOSEPH BRONZINO, Ph.D., SERIES EDITOR
The Vernon Roosa Professor of Applied Science, Trinity College – Hartford, Connecticut
President of the Biomedical Engineering Alliance and Consortium
Titles in the series
Modelling Methodology for Physiology and Medicine, Carson & Cobelli, ISBN 9780121602451, 2000
Handbook of Medical Imaging, Bankman, ISBN 9780120777907, 2000
Clinical Engineering Handbook, Dyro, ISBN 9780122265709, 2004
Diagnostic Ultrasound Imaging: Inside Out, Szabo, ISBN 9780126801453, 2004
Introduction to Biomedical Engineering, Second Edition, Enderle, Blanchard & Bronzino,
ISBN 9780122386626, 2005
Circuits, Signals, and Systems for Bioengineers, Semmlow, ISBN 9780120884933, 2005
Numerical Methods in Biomedical Engineering, Dunn, Constantinides & Moghe, ISBN 9780121860318,
2005
Hospital Preparation for Bioterror, McIsaac, ISBN 9780120884407, 2006
Introduction to Applied Statistical Signal Analysis, Third Edition, Shiavi, ISBN 9780120885817, 2006
Biomedical Information Technology, Feng, ISBN 9780123735836, 2007
Introduction to Modeling in Physiology and Medicine, Cobelli & Carson, ISBN 9780121602406, 2007
Tissue Engineering, van Blitterswijk et al, ISBN 9780123708694, 2008
Tissue Engineering
Senior Editor: Clemens van Blitterswijk
Editors : Peter Thomsen, Anders Lindahl, Jeffrey Hubbell, David
Williams, Ranieri Cancedda, Joost de Bruijn, Jérôme Sohier
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First edition 2008
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ISBN: 978-0-12-370869-4
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08 09 10 11 12 10 9 8 7 6 5 4 3 2 1
Contents
List of contributors vii
Foreword xi
Tissue engineering – an introduction xiii
1 Stem cells 1
2 Morphogenesis, generation of tissue in the embryo 27
3 Tissue homeostasis 73
4 Cellular signaling 89
5 The extracellular matrix as a biologic scaffold for tissue engineering 121
6 Natural polymers in tissue engineering applications 145
7 Degradable polymers for tissue engineering 193
8 Degradation of bioceramics 223
9 Biocompatibility 255
10 Cell source 279
11 Cell culture: harvest, selection, expansion, and differentiation 307
12 Cell nutrition 327
13 Cryobiology 363
14 Scaffold design and fabrication 403
15 Controlled release strategies in tissue engineering 455
16 Bioreactors for tissue engineering 483
17 Tissue engineering for skin transplantation 507
18 Tissue engineering of cartilage 533
19 Tissue engineering of bone 559
20 Tissue engineering of the nervous system 611
21 Tissue engineering of organ systems 649
22 Ethical issues in tissue engineering 685
Multiple Choice Questions 705

Index 727
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List of contributors
Anthony, Edwin , Queen Mary ’ s University of Cancedda, Ranieri, Universita ’ di Genova & Istituto
London, UK Nazionale per la Ricerca sul Cancro, Genova, Italy
van Apeldoorn, Aart , University of Twente, Claase, Menno , University of Twente, Enschede, The
Enschede, The Netherlands Netherlands
D ’ Amore, Patricia, Schepens Eye Research Institute,
Atala, Anthony , Wake Forest University of Medicine,
Boston, USA
Winston-Salem, USA
Dalton, Paul , University of Southampton, UK
Azevedo, Helena , University of Minho, Guimarães,
Portugal DeRuiter, Marco , Leiden University Medical Centre,
Leiden, The Netherlands
Baaijens, Frank , Eindhoven University of
Technology, Eindhoven, The Netherlands Deschamps, Audrey , University of Twente, Enschede,
The Netherlands
Badylak, Stephen , McGowan Institute for
Dhert, Wouter, Department of Orthopaedics,
Regenerative Medicine, Pittsburgh, USA
G05.228, University Medical Center Utrecht, P.O.
Barrère, Florence, University of Twente, Enschede, Box 85500, 3508 GA Utrecht, The Netherlands
The Netherlands
van Dijkhuizen-Radersma, Riemke , Progentix BV,
van den Beucken, Jeroen, Department of Bilthoven, The Netherlands
Periodontology & Biomaterials, Radboud University
Ducheyne, Paul, Center for Bioactive Materials and
Nijmegen Medical Center, The Netherlands
Tissue Engineering, University of Pennsylvania,
Philadelphia, USA
van Bezooijen, Rutger , Leiden University Medical
Centre, Leiden, The Netherlands Feijen, J an, University of Twente, Enschede, The
Netherlands
Bianco, Paolo, Universita’ la Sapienza, Roma, Italy
Frey, Peter , Centre Hospitalier Universitaire Vaudois,
van Blitterswijk, Clemens Antoni, University of
Switzerland
Twente, Enschede, The Netherlands
van Gaalen, Steven, Department of Orthopaedics,
de Boer, Jan, University of Twente, Enschede, The
G05.228, University Medical Center Utrecht, P.O.
Netherlands
Box 85500, 3508 GA Utrecht, The Netherlands
Both, Sanne, University of Twente, Enschede, The el Ghalbzouri, Abdoelwaheb , Leiden University
Netherlands Medical Centre, Leiden, The Netherlands.
Brittberg, Mats, University of Göteborg, Göteborg, Gibbs, Susan , VU Medical Centre, Amsterdam, The
Sweden Netherlands
viii List of contributors
Gilbert,Thomas, University of Pittsburgh, Levenberg, Shulamit , Israel Institute of Technology,
Pittsburgh, USA Haifa, Israel
Gomes, Manuela , University of Minho, Guimarães, Lewis, Jennifer, University of Illinois at Urbana-
Portugal Champaign, Urbana, Illinois, USA
Grijpma, Dirk , University of Twente, Enschede, The Lindahl, Anders, Sahlgrenska University Hospital,
Netherlands Göteborg, Sweden
de Groot, Klaas, University of Twente, Enschede, The Malafaya, Patrícia , University of Minho, Guimarães,
Netherlands Portugal
Habibovic, Pamela, University of Twente, Enschede, Malda, Jos , Queensland University of Technology,
The Netherlands Australia
Harvey, Alan, The University of Western Australia, Mano, João, University of Minho, Guimarães,
Australia Portugal
Hierck, Beereend , Leiden University Medical Centre, Martin, Ivan, University Hospital Basel, Switzerland
Leiden, the Netherlands
Meijer, Gert, Department of Oral Maxillofacial
Hirschi, Karen, Baylor College of Medicine, Boston, Surgery, University Medical Center Utrecht, The
USA Netherlands
Hodges, Steve , Wake Forest University Health Mikos, Antonios, Department of Bioengineering,
Sciences, Winston-Salem, USA Rice University, Houston (TX) U.S.A.
Hubbell, Jeffrey Alan, Ecole Polytechnique Fédérale Mistry, Amit, Department of Bioengineering, Rice
de Lausanne, Lausanne, Switzerland University, Houston (TX) U.S.A.
Hutmacher, Dietmar Werner, National University of Moroni, Lorenzo , University of Twente, Enschede,
Singapore, Singapore The Netherlands
Jansen, John, Department of Periodontology & Myers, Simon , Institute of Cell and Molecular
Biomaterials, Radboud University Nijmegen Medical Science, Bart ’ s and University of London, London,
Center, The Netherlands UK
Janssen, Frank, University of Twente, Enschede, The Myers-Irvin, J. , University of Pittsburgh, Pittsburgh,
Netherlands USA
Jukes, Jojanneke , University of Twente, Enschede, Navsaria, Harshad, Institute of Cell and Molecular
The Netherlands Science, Bart ’ s and University of London, UK
Karperien, Marcel, University of Twente, Enschede, Ni, Ming, School of Engineering and Applied
The Netherlands Science, University of Pennsylvania, Philadelphia,
USA
Kruyt, Moyo, Department of Orthopaedics,
G05.228, University Medical Center Utrecht, P.O. Oliveira, Joaquim , University of Minho, Guimarães,
Box 85500, 3508 GA Utrecht, The Netherlands Portugal
Kuleshova, Lilia , National University of Singapore, Olivo, Christina, Department of Immunology,
Singapore University Medical Center Utrecht, The Netherlands
List of contributors ix
Oomens, Cees , Eindhoven University of Technology, Sohier, Jérôme, University of Nantes, Nantes,
Eindhoven, The Netherlands France
Oudega, Martin , Johns Hopkins University School Sousa, Rui , University of Minho, Guimarães,
of Medicine, USA Portugal
Pennesi, Giuseppina, Universita’ di Genova, Italy Svalander, Peter , Swedish Biotechnology AB,
Göteborg, Sweden
Plant, Giles , The University of Western Australia,
Australia Tallheden, Tommi , Göteborg University, Göteborg,
Sweden
Poelmann, Rob , Leiden University Medical Centre,
Leiden, The Netherlands Timmins, Nicholas, University Hospital Basel,
Switzerland
Post, Jeanine , University of Twente, Enschede, The
Netherlands Vunjak-Novakovic, Gordana , Columbia University,
New York, NY, USA
Price, Richard , Institute of Cell and Molecular
Science, Bart ’ s and University of London, UK Welin, Stellan , Professor Biotechnology Culture
Society , Department of Health and Society ,
Radisic, Milica , University of Toronto, Toronto,
Linköping University, Sweden
Ontario, Canada
Wendt, David, University Hospital Basel,
Ratcliffe, Anthony, Synthasome Inc, San Diego, CA,
Switzerland
USA
Williams, David , University of Liverpool, Liverpool,
Reis, Rui , University of Minho, Guimarães, Portugal
UK
Robey, Pamela Gehron, National Institutes of
Woodfield, Tim , University of Twente, Enschede
Health, Bethesda, USA
Yaszemski, Michael, Department of Orthopedic
Roelen, Bernard Antonius Johannes , Utrecht
Surgery, Mayo Clinic College of Medicine, Rochester
University, Utrecht, the Netherlands
(MN), USA.
Rouwkema, Jeroen, University of Twente, Bilthoven,
Zhang, Zheng, University of Twente, Enschede, The
The Netherlands
Netherlands
Siddappa, Ramakrishnaiah, University of Twente,
Enschede, The Netherlands
Silva, Gabriela , University of Minho, Guimarães,
Portugal
Silva, Simone , University of Minho, Guimarães,
Portugal