Thyroid Hormone Disruption and Neurodevelopment PDF
Preview Thyroid Hormone Disruption and Neurodevelopment
Contemporary Clinical Neuroscience Noriyuki Koibuchi Paul M. Yen Editors Thyroid Hormone Disruption and Neurodevelopment 123 Contemporary Clinical Neuroscience More information about this series at h ttp://www.springer.com/series/7678 Noriyuki Koibuchi • Paul M. Yen Editors Thyroid Hormone Disruption and Neurodevelopment Editors Noriyuki Koibuchi Paul M. Yen Department of Integrative Physiology Laboratory of Hormonal Regulation Gunma University Graduate School of Cardiovascular and Metabolic Disorders Medicine Program Maebashi , Gunma , Japan Duke-NUS Graduate Medical School Singapore , Singapore Contemporary Clinical Neuroscience ISBN 978-1-4939-3735-6 ISBN 978-1-4939-3737-0 (eBook) DOI 10.1007/978-1-4939-3737-0 Library of Congress Control Number: 2016940093 © Springer Science+Business Media New York 2016 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A. Contents Part I Disruption of Thyroid Hormone Action at Molecular Level 1 Mechanisms for Thyroid Hormone Action in the CNS ....................... 3 Rohit Anthony Sinha and Paul. M. Yen 2 Deiodinase and Brain Development ...................................................... 23 Masami Murakami 3 Brominated Organohalogens and Neurodevelopment: Different Mechanisms, Same Consequence .......................................... 33 Kingsley Ibhazehiebo , Toshiharu Iwasaki , and Noriyuki Koibuchi 4 Perinatal Infection-Associated Changes in Thyroid Hormone Status, Gut Microbiome, and Thyroid Hormone-Mediated Neurodevelopment ............................................... 51 E. M. Sajdel-Sulkowska , M. Bialy , and R. Zabielski 5 Disruption of Feedback Regulation of Thyroid Hormone Synthesis/Secretion and Brain Development ........................................ 69 Sumiyasu Ishii and Masanobu Yamada Part II Animal Models to Study Thyroid Hormone Disruption on Neurodevelopment 6 Animal Models to Study Thyroid Hormone Action in Neurodevelopment .............................................................................. 85 Noriaki Shimokawa and Noriyuki Koibuchi 7 Thyroid Hormone Receptor Mutation and Neurodevelopment ......... 103 Jens Mittag 8 Using Mouse Genetics to Investigate Thyroid Hormone Signaling in the Developing and Adult Brain ....................................... 119 F. Chatonnet , S. Richard , and F. Flamant v vi Contents 9 Disruption of Auditory Function by Thyroid Hormone Receptor Mutations................................................................................. 133 David S. Sharlin Part III Thyroid Hormone Disruption and Neurodevelopment: Human Studies 10 The Impact of Maternal Thyrotoxicosis and Antithyroid Drug Exposure on Fetal/Neonatal Brain Development ....................... 153 Ines Donangelo and Gregory A. Brent 11 Deficit in Thyroid Hormone Transporters and Brain Development .......................................................................... 169 Takehiro S uzuki and Takaaki Abe 12 Syndromes of Resistance to Thyroid Hormone and Brain Development .......................................................................... 183 Irene Campi and Paolo Beck-Peccoz Index ................................................................................................................. 205 Contributors Takaaki A be Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan Division of Medical Science , Tohoku University Graduate School of Biomedical Engineering , Sendai , Miyagi , Japan D epartment of Clinical Biology and Hormonal Regulation, T ohoku University Graduate School of Medicine , Sendai , Miyagi , Japan Paolo Beck-Peccoz Department of Clinical Sciences and Community Health , University of Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore , Milan , Italy M. Bialy Department of Experimental and Clinical Physiology, Laboratory of Center for Preclinical Research , Medical University of Warsaw , Warsaw , Poland Gregory A. Brent D epartment of Medicine, D avid Geffen School of Medicine at UCLA , Los Angeles , CA , USA Irene Campi D epartment of Clinical Sciences and Community Health, U niversity of Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore , Milan , Italy F. Chatonnet I nstitut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon, INRA, CNRS, Ecole Normale Supérieure de Lyon, L yon, C edex, F rance Ines Donangelo Endocrinology Division , Allegheny General Hospital , Pittsburgh , PA , USA F. Flamant Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon, INRA, CNRS, Ecole Normale Supérieure de Lyon , Lyon , Cedex , France Kingsley Ibhazehiebo Department of Integrative Physiology , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan Sumiyasu Ishii D epartment of Medicine and Molecular Science, G unma University Graduate School of Medicine , Maebashi , Gunma , Japan vii viii Contributors Toshiharu Iwasaki Department of Integrative Physiology , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan Noriyuki Koibuchi Department of Integrative Physiology, Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan Jens Mittag C enter of Brain Behavior and Metabolism, University of Lübeck, Lübeck , Germany Masami Murakami Department of Clinical Laboratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan S. Richard Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon, INRA, CNRS, Ecole Normale Supérieure de Lyon , Lyon , Cedex , France E. M. Sajdel-Sulkowska D epartment of Psychiatry, H arvard Medical School and Brigham and Women’s Hospital , Boston , MA , USA Department of Experimental and Clinical Physiology, Laboratory of Center for Preclinical Research , Medical University of Warsaw , Warsaw , Poland Department of Physiological Sciences , Warsaw University of Life Sciences, Warsaw , Poland David S. Sharlin D epartment of Biological Sciences, M innesota State University, Mankato , MN , USA Noriaki Shimokawa Department of Integrative physiology , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan Rohit Anthony Sinha Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, D uke-NUS Graduate Medical School, S ingapore, Singapore Takehiro Suzuki Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine , Tohoku University Graduate School of Medicine , Sendai , Miyagi , Japan D epartment of Medical Science, T ohoku University Graduate School of Biomedical Engineering , Sendai , Miyagi , Japan Masanobu Yamada Department of Medicine and Molecular Science , Gunma University Graduate School of Medicine , Maebashi , Gunma , Japan Paul M. Yen Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program , Duke-NUS Graduate Medical School , Singapore , Singapore R. Zabielski D epartment of Physiological Sciences, W arsaw University of Life Sciences , Warsaw , Poland Part I Disruption of Thyroid Hormone Action at Molecular Level Chapter 1 Mechanisms for Thyroid Hormone Action in the CNS Rohit Anthony Sinha and Paul M. Yen Abstract T his chapter aims to summarize our recent understanding about the action of thyroid hormone (TH) in the CNS. The topics will include the molecular action of TH at genomic and non-genomic levels and its impact on the physiology of brain. Keywords Thyroid hormone (TH) • Thyroid hormone receptors (TR) • Brain • Neurons • Epigenetic • Deiodinases 1.1 Introduction Thyroid hormones (THs) mediate important physiological processes such as devel- opment, growth, and metabolism in virtually all tissues of the body (Brent 2 012 ; Cheng et al. 2 010 ; Oetting and Yen 2007 ). There are two major THs secreted by the thyroid gland, levothyroxine (T ) and triiodothyronine (T ), with the latter serving 4 3 as the more biologically active form. Their serum concentrations are tightly regu- lated by the hypothalamic/pituitary/thyroid (HPT) axis. THs are transported by spe- cifi c proteins via the circulation to tissues throughout the body and also must pass the blood/brain barrier for delivery to the CNS. Intracellular uptake of TH occurs by specifi c TH transporters, and the intracellular concentration of TH is further regu- lated by intracellular deiodinases that convert T to T to increase the TH activity or 4 3 transform the THs to inert metabolites to reduce it. Intracellular TH then binds to nuclear thyroid hormone receptors (TRs), members of the nuclear receptor super- family, that are ligand-dependent transcription factors to regulate positive or nega- tive transcription of target genes. There are two major isoforms, TRα and TRβ, which each has different tissue distributions. TRs typically form heterodimers with another member of the nuclear receptor superfamily, RXR, and bind to specifi c R. A. Sinha , Ph.D. (*) • P. M. Yen , M.D. Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program , Duke-NUS Graduate Medical School , 8 College Road , Singapore 169857 , Singapore e-mail: [email protected]; [email protected] © Springer Science+Business Media New York 2016 3 N. Koibuchi, P.M. Yen (eds.), Thyroid Hormone Disruption and Neurodevelopment, Contemporary Clinical Neuroscience, DOI 10.1007/978-1-4939-3737-0_1
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