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673 Pages·2018·11.595 MB·English
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Therapeutic and Nutritional Uses of Algae Therapeutic and Nutritional Uses of Algae Leonel Pereira MARE—Marine and Environmental Sciences Centre and IMAR—Institute of Marine Research Department of Life Sciences University of Coimbra Coimbra Portugal p, p, A SCIENCE PUBLISHERS BOOK A SCIENCE PUBLISHERS BOOK CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 22001178 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed on acid-free paper Version Date: 2200117701101191 International Standard Book Number-13: 997788--11--44998877--45759398--82 (Hardback) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, includ- ing photocopying, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http://www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Names: Pereira, Leonel, author. Title: Therapeutic and nutritional uses of algae / Leonel Pereira, MARE, Marine and Environmental Sciences Centre, and IMAR, Institute of Marine Research, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. Description: Boca Raton, FL : CRC Press, 2018. | "A science publishers book." | Includes bibliographical references and index of algae species. Identifiers: LCCN 2017040101 | ISBN 9781498755382 (hardback : alk. paper) Subjects: LCSH: Marine algae as food. | Marine plants--Nutrition. | Marine algae--Therapeutic use. | Plants, Edible. Classification: LCC TX402 .P475 2018 | DDC 641.6--dc23 LC record available athttps://lccn.loc.gov/2017040101 Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Preface Marine algae (seaweeds and marine microalgae) are one of the largest producers of biomass in the marine environment. They produce a wide variety of chemically active metabolites in their surroundings, potentially as an aid to protect themselves against the environmental stress and aggressive organisms. These active metabolites, such as halogenated compounds, alcohols, aldehydes, terpenoids, polysaccharides and fatty acids derivatives, among other compounds, that are produced by several species of seaweeds and microalgae have antibacterial, antifungal, antiviral, vermifuges, neuroprotective, antitumoral, anti-inflammatory, anti-allergic, antithrombotic, hypocholesterolemic, and hypoglycemic properties, which are effective in the prevention of several diseases and have potential uses as therapeutic drugs. Numerous studies have concentrated on the contribution of marine organisms, including seaweeds and marine microorganisms, in the search for new drugs from natural products. One important approach to drug development involves assaying folk remedies for active ingredients, and several seaweed species are used as traditional medicines, foods and health care products in various regions of the world. The use of seaweed species to treat fever, lumps, and swelling is recorded in the Oriental medical textbook Donguibogam, published in 1613. Many seaweed species have also been used as herbal medicines in China over several centuries. The first industrial interest in studying algae started with the aquaculture industry for both microalgae and macroalgae (seaweed). The demand for seaweed as a direct food resource and the demand for fish production needed the application of aquaculture techniques. In the case of seaweed, this was the only choice for sustainable production. The production of microalgae was necessary for the feeding phase of fish larvae to ensure the survival of newly born juveniles and for the feeding of zooplankton. For development of pharmaceutical compounds from a marine source, supply issues will always be a critical problem, and a major obstacle to drug development is the lack of sufficient material. Among marine organisms, seaweed is a promising candidate for drug production because it’s relatively easy to obtain adequate, reliable and, the most important, renewable supplies by aquaculture. Thus, such an abundant species with immense aquaculture potential will have a better chance of being developed on a large scale for commercial food and drug production. Leonel Pereira Acknowledgements and Credits of Images This work had the support of “Fundação para a Ciência e Tecnologia” (FCT), through the strategic project UID/MAR/04292/2013 granted to MARE. The author also thanks Alan Critchley (Phycologist) the revision of some chapters of this book. Credits of Images Images on Public Domain Fig. 2.2: Edgar 2016 Fig. 2.3: Eklof 2012 Fig. 2.5: Tike 2016 Fig. 2.6: Yikrazuul 2009 Fig. 5.1: Häggström 2014 Fig. 10.2: Beards 2014 Fig. 10.3: PubChem 2017 Fig. 10.4: Edgar 2017 Originals Leonel Pereira Figs. 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.1, 2.4, 3.1, 3.2, 3.3, 10.1, 11.1, 12.1, 12.2 Contents Preface v Acknowledgements and Credits of Images vii Abbreviations and Acronyms xi Glossary xxiii 1. Biodiversity and Description of the Main Algae with Bioactive Properties 1 2. Nutritional Composition of the Main Edible Algae 65 3. Therapeutic Uses of Phycocolloids 128 4. The Cardio-protective Activity of Edible Seaweeds and their Extracts 143 5. Antiviral Activity of Seaweeds and their Extracts 175 6. Antitumor Activity of Seaweeds and their Extracts 212 7. Antifungal Activity of Seaweeds and their Extracts 311 8. Antibacterial Activity of Seaweeds and their Extracts 347 9. Antiparasitic, Insecticidal, and Larvicidal Activities of Seaweeds and their Extracts 428 10. Anti-inflammatory, Anti-allergic, Antipyretic, Antinociceptive, Antithrombotic, and 450 Anti-coagulant Activities of Seaweeds and their Extracts 11. Neurological Activities of Seaweeds and their Extracts 485 12. Thalassotherapy and Marine Cosmeceuticals 503 References 523 Index of Algae Species 627

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