Theory of Hematopoiesis Control PDF
Preview Theory of Hematopoiesis Control
SPRINGER BRIEFS IN CELL BIOLOGY A.M. Dygai V.V. Zhdanov Theory of Hematopoiesis Control 123 SpringerBriefs in Cell Biology A.M. Dygai (cid:129) V.V. Zhdanov Theory of Hematopoiesis Control A.M. Dygai V.V. Zhdanov Institute of Pharmacology Institute of Pharmacology Russian Academy of Medical Sciences Russian Academy of Medical Sciences Tomsk Tomsk Russia Russia ISBN 978-3-319-08583-8 ISBN 978-3-319-08584-5 (eBook) DOI 10.1007/978-3-319-08584-5 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014948745 © Springer International Publishing Switzerland 2014 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Introduc tion The accumulated data on the work of blood systems in norm and pathology showed that during balanced hematopoiesis, the neuroendocrine substances produce no direct action on proliferation and differentiation of hemopoietic cells. Under these conditions, the blood system demonstrates autonomic behavior controlled mostly by local mechanisms. In contrast, the leading role in upregulating hematopoiesis under extreme (stressful) conditions counterbalanced by the development of com- pensatory processes within the blood system is given to neuroendocrine regulatory structures. At present, numerous regularities in the work of hemopoietic tissue as an integral system adequately reacting to varying conditions of external and internal environ- ments are not evident. In the study of this problem during more than 30 years, we employed various experimental models of pathological processes (immobilization stress, acute and chronic blood loss, infectious infl ammation, cytostatic and radia- tion myelosuppressions, encephalopathies of diverse genesis, experimental neuro- ses, spontaneous leucosis, e tc .) T he results of these and other studies carried out by numerous workers had been described in a number of monographs published in our and other countries. They focused on specifi c problems relating to the control of hemopoiesis in norm and during the development of diverse pathologies. With deeper insight into this fi eld and establishing new data widely discussed in literature (fi rst of all, data on the hematopoietic stem cells and the regulatory molecules), we revisited the studies with previously employed models of pathological processes under a reliable meth- odology implying the study of the reactions of all major compartments of hemato- poietic tissue to the action of a pathogenic factor with simultaneous testing of the functional activity of diverse regulatory systems. Without such a systemic approach, it is little probable to develop the theory of hematopoiesis control, whose numerous aspects we discussed many a time in previously published research papers and monographs. The authors are well aware of the fact that they cannot put the ”fi nal touch” to the problem of hematopoiesis since the study of any biological process seems to have no winning post. v vi Introduction H owever, a huge amount of accumulated data needs generalization and analysis to formulate the cornerstones of the theory of hematopoiesis control describing the regularities in the work of major subdivisions of hematopoietic tissue under normal and pathological conditions with due attention to interlacing activity of local and long-ranged regulatory systems. T he authors are grateful to the colleagues in State Research Institute of Pharmacology of Siberian Department of Russian Academy of Medical Sciences and in other agencies for courteously provided data. Contents 1 Mechanisms of Hematopoiesis Control . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 Alterations in Blood System Induced By Extreme Conditions Provoking No Myelosuppression. . . . . . . . . . . . . . . . . . . . . . 15 3 Disturbances in Hemopoietic Control During Neurotic Disorders. . . . 27 4 Alterations in the Blood System During Myelosuppression Induced by Cytostatic and Radiation Treatment . . . . . . . . . . . . . . . . . . 33 5 Disturbances in Hematopoietic Control During Experimental Leucosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 6 Disturbances in the Control of Blood System During Posthypoxic Period. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Conclusions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 vii Abbreviations ANS Autonomic nervous system BFU-E Burst-forming unit-erythroid CFU-E Colony forming unit-erythrocyte CFU-F Colony forming unit-fi broblast CFU-G Colony-forming unit–granulocyte CFU-GEMM Colony forming unit-granulocyte-erythrocyte-macrophage- megakaryocyte CFU-GM Colony forming unit-granulocyte macrophage CFU-MM Colony forming unit-monocyte macrophage CFU-S Colony-forming unit–spleen CNS Central nervous system CSA Colony-stimulating activity EP Erythropoietin EPA Erythropoietic activity F lt3(Flk-2)-ligand A member of cytokine moiety still not comprehensively characterized GAGs Glycosaminoglycans G-CSF Granulocyte colony-stimulating factor GM-CSF Granulocyte-macrophage colony-stimulating factor HI Hematopoietic islet HIM Hemopoiesis-inducing microenvironment HSC Hematopoietic stem cell IFN-γ Interferon γ LPS Lipopolysaccharide MAF Macrophage activating factor M-CSF Macrophage colony-stimulating factor MPS Mononuclear phagocyte system MTD Maximum tolerated dose PHSC Pluripotent hematopoietic stem cell SCF Stem cell factor (Steel factor) SDF-1 Stromal cell-derived (chemotactic) factor ix
The list of books you might like
