THE BIOMEDICAL ENGINEERING HANDBOOK FOURTH EDITION Biomedical Engineering Fundamentals THE BIOMEDICAL ENGINEERING HANDBOOK FOURTH EDITION Biomedical Engineering Fundamentals Edited by Joseph D. Bronzino Founder and President Biomedical Engineering Alliance and Consortium (BEACON) Hartford, Connecticut, U.S.A. Donald R. Peterson Professor of Engineering Dean of the College of Science, Technology, Engineering, Mathematics, and Nursing Texas A&M University – Texarkana Texarkana, Texas, U.S.A. MATLAB® is a trademark of The MathWorks, Inc. and is used with permission. The MathWorks does not warrant the accuracy of the text or exercises in this book. This book’s use or discussion of MATLAB® software or related products does not constitute endorsement or sponsorship by The MathWorks of a particular pedagogical approach or particular use of the MATLAB® software. 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Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents Prefaceix Editors xv Contributors xvii MATLAB Statement xxv Section i Physiologic Systems Herbert F. Voigt 1 An Outline of Cardiovascular Structure and Function1-1 Daniel J. Schneck 2 Kidney Structure and Physiology 2-1 Joel M. Henderson and Mostafa Belghasem 3 Nervous System 3-1 Evangelia Micheli-Tzanakou 4 Vision System 4-1 Aaron P. Batista and George D. Stetten 5 Auditory System 5-1 Ben M. Clopton and Herbert F. Voigt 6 Gastrointestinal System 6-1 Berj L. Bardakjian 7 Respiratory System 7-1 Arthur T. Johnson, Christopher G. Lausted, and Joseph D. Bronzino Section ii Biomechanics Donald R. Peterson 8 Mechanics of Hard Tissue 8-1 J. Lawrence Katz, Anil Misra, Orestes Marangos, Qiang Ye, and Paulette Spencer 9 Musculoskeletal Soft-Tissue Mechanics 9-1 Richard L. Lieber, Samuel R. Ward, and Thomas J. Burkholder v vi Contents 10 Joint-Articulating Surface Motion 10-1 Kenton R. Kaufman and Kai-Nan An 11 Joint Lubrication 11-1 Michael J. Furey 12 Analysis of Gait 12-1 Roy B. Davis III, Sylvia Õunpuu, and Peter A. DeLuca 13 Mechanics of Head/Neck 13-1 Albert I. King and David C. Viano 14 Biomechanics of Chest and Abdomen Impact 14-1 David C. Viano and Albert I. King 15 Cardiac Biomechanics 15-1 Andrew D. McCulloch and Roy C. P. Kerckhoffs 16 Heart Valve Dynamics 16-1 Choon Hwai Yap, Erin Spinner, Muralidhar Padala, and Ajit P. Yoganathan 17 Arterial Macrocirculatory Hemodynamics 17-1 Baruch B. Lieber 18 Mechanics of Blood Vessels 18-1 Thomas R. Canfield and Philip B. Dobrin 19 The Venous System 19-1 Artin A. Shoukas and Carl F. Rothe 20 The Microcirculation Physiome 20-1 Aleksander S. Popel and Roland N. Pittman 21 Mechanics and Deformability of Hematocytes 21-1 Richard E. Waugh and Robert M. Hochmuth 22 Mechanics of Tissue/Lymphatic Transport 22-1 Geert W. Schmid-Schönbein and Alan R. Hargens 23 Modeling in Cellular Biomechanics 23-1 Alexander A. Spector and Roger Tran-Son-Tay 24 Cochlear Mechanics 24-1 Charles R. Steele and Sunil Puria 25 Inner Ear Hair Cell Bundle Mechanics 25-1 Jong-Hoon Nam and Wally Grant 26 Exercise Physiology 26-1 Cathryn R. Dooly and Arthur T. Johnson 27 Factors Affecting Mechanical Work in Humans 27-1 Ben F. Hurley and Arthur T. Johnson Section iii Biomaterials Joyce Y. Wong 28 Metallic Biomaterials 28-1 Joon B. Park and Young Kon Kim Contents vii 29 Ceramic Biomaterials 29-1 W. G. Billotte 30 Polymeric Biomaterials 30-1 Hai Bang Lee, Gilson Khang, and Jin Ho Lee 31 Composite Biomaterials 31-1 Roderic S. Lakes 32 Biodegradable Polymeric Biomaterials: An Updated Overview 32-1 C. C. Chu 33 Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen) 33-1 Shu-Tung Li 34 Biologic Biomaterials: Silk 34-1 Biman Mandal and David L. Kaplan 35 Biofunctional Hydrogels 35-1 Melissa K. McHale and Jennifer L. West 36 Soft Tissue Replacements 36-1 K. B. Chandran, K. J. L. Burg, and S. W. Shalaby 37 Hard Tissue Replacements 37-1 Sang-Hyun Park, Adolfo Llinás, and Vijay K. Goel Section iV Bioelectric Phenomena Roger C. Barr 38 Basic Electrophysiology 38-1 Roger C. Barr 39 Volume Conductor Theory 39-1 Robert Plonsey 40 Electrical Conductivity of Tissues 40-1 Bradley J. Roth 41 Cardiac Microimpedances 41-1 Andrew E. Pollard 42 Membrane Models 42-1 Anthony Varghese 43 Computational Methods and Software for Bioelectric Field Problems 43-1 Christopher R. Johnson 44 The Potential Fields of Triangular Boundary Elements 44-1 A. van Oosterom 45 Principles of Electrocardiography 45-1 Edward J. Berbari 46 Electrodiagnostic Studies 46-1 Sanjeev D. Nandedkar viii Contents 47 Principles of Electroencephalography 47-1 Joseph D. Bronzino 48 Biomagnetism 48-1 Jaakko Malmivuo 49 Electrical Stimulation of Excitable Tissue 49-1 Dominique M. Durand Section V neuroengineering Daniel J. DiLorenzo 50 History and Overview of Neural Engineering 50-1 Daniel J. DiLorenzo and Robert E. Gross 51 Theory and Physiology of Electrical Stimulation of the Central Nervous System 51-1 Warren M. Grill 52 Transcutaneous FES for Ambulation: The Parastep System 52-1 Daniel Graupe 53 Comparing Electrodes for Use as Cortical Control Signals: Tines, Wires, or Cones on Wires—Which Is Best? 53-1 Philip R. Kennedy 54 Development of a Multifunctional 22-Channel Functional Electrical Stimulator for Paraplegia 54-1 Ross Davis, T. Johnston, B. Smith, R. Betz, T. Houdayer, and A. Barriskill 55 An Implantable Bionic Network of Injectable Neural Prosthetic Devices: The Future Platform for Functional Electrical Stimulation and Sensing to Restore Movement and Sensation 55-1 J. Schulman, P. Mobley, J. Wolfe, Ross Davis, and I. Arcos 56 Visual Prostheses56-1 Robert J. Greenberg 57 Interfering with the Genesis and Propagation of Epileptic Seizures by Neuromodulation57-1 Ana Luisa Velasco, Francisco Velasco, Marcos Velasco, Bernardo Boleaga, Mauricio Kuri, Fiacro Jiménez, and José María Núñez 58 Transcranial Magnetic Stimulation of Deep Brain Regions 58-1 Yiftach Roth and Abraham Zangen