The Adhesion Molecule Factsbook PDF
Preview The Adhesion Molecule Factsbook
THE ADHESION MOLECULE FactsBook Second Edition THE ADHESION MOLECULE FactsBook Second Edition Other books in the FactsBook Series: Robin Callard and Andy Gearing The Cytokine FactsBook Steve Watson and Steve Arkinstall The G-Protein Linked Receptor FactsBook Shirley Ayad, Ray Boot-Handford, Martin J. Humphries, Karl E. Kadler and C. Adrian Shuttleworth The Extracellular Matrix FactsBook, 2nd edn Grahame Hardie and Steven Hanks The Protein Kinase FactsBook The Protein Kinase FactsBook CD-Rom Edward C. Conley The Ion Channel FactsBook h Extracellular Ligand-Gated Channels Edward C. Conley The Ion Channel FactsBook Ih Intracellular Ligand-Gated Channels Edward C. Conley and William J. Brammar The Ion Channel FactsBook IV: Voltage-gated Channels Kris Vaddi, Margaret Keller and Robert Newton The Chemokine FactsBook Marion E. Reid and Christine Lomas-Francis The Blood Group Antigen FactsBook A. Neil Barclay, Marion H. Brown, S.K. Alex Law, Andrew J. McKnight, Michael G. Tomlinson and P. Anton van der Merwe The Leucocyte Antigen FactsBook, 2nd edn Robin Hesketh The Oncogene and Tumour Suppressor Gene FactsBook, 2nd edn Jeffrey K. Griffith and Clare E. Sansom The Transporter FactsBook Tak W. Mak, Josef Penninger, John Rader, Janet Rossant and Mary Saunders The Gene Knockout FactsBook Bernard J. Morley and Mark J. Walport The Complement FactsBook Steven G.E. Marsh, Peter Parham and Linda Barber The HLA FactsBook Hans G. Drexler The Leukemia-Lymphoma Cell Line FactsBook THE A D H E S I O N MOLECULE FactsBook Second Edition Clare M. Isacke Imperial College of Science, Technology and Medicine, London, UK Michael A. Horton University College London, London, UK ACADEMIC PRESS A Harcourt Science and Technology Company San Diego San Francisco New York Boston London Sydney Tokyo This book is printed on acid-free paper. Copyright (cid:14)9 2000 by ACADEMIC PRESS All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Academic Press A Harcourt Science and Technology Company Harcourt Place, 32 Jamestown Road, London NW1 7BY http://www.hbuk.co.uk/ap/ Academic Press 525 B Street, Suite 1900, San Diego, California 92101-4495, USA h ttp://www, apnet, com ISBN 0-12-356505-7 Library of Congress Catalog Card Number: 00-104879 A catalogue for this book is available from the British Library Typeset by Mackreth Media Services, Hemel Hempstead, UK Printed in Great Britain by Redwood Books, Trowbridge, Wiltshire 00 01 02 03 04 05 RB 9 8 7 6 5 4 3 2 1 Preface vii ... Abbreviations Vlll Chapter 1 Introduction 2 Chapter 2 Adhesion Molecule Families 7 Chapter 3 Accessing Information on the World Wide Web 33 Cadherins CD33 ....................................... 97 E-Cadherin ................................. 43 N-Cadherin ................................. 46 P-Cadherin CEACAM family ..................... 103 R-Cadherin ................................. 5 1 Contactin- 1 108 VE-Cadherin .............................. 53 ICAM- 1 .................................... 111 ICAM-2 .................................... 114 .......................... 57 ICAM-3 .................................... 116 OB-Cadherin .............................. 59 ICAM-4 ................... Cadherin- 14 .......... Ksp-Cadherin .............................. 69 .............. 133 Desmocollin 3 ........................... 78 Sialoadhesin .............................. 138 Desmoglein 1 ....... 80 Desmoglein 2 .............................. 83 Desmoglein 3 .............................. 85 Integrins Immunoglobulin superfamily Integrin aL. ................................ 149 ALCAM .................................... 89 Integrin aM .............................. 152 CD22a and p .............................. 9 1 Integrin ax .............................. 155 CD31 ....................................... 94 Integrin a” .............................. 157 Integrin a1. ................................ 159 CD6 .................. 23 7 CD23 ....................................... 239 Integrin a3. ............... CD39 ....................................... 247 Integrin ah. ................................ 173 Integrin a, ................................. 176 Integrin a8. ... CD42c .................................... 254 Integrin ag. ... Integrin a, .............................. 182 CD43 ........... Integrin aIlb. ............................. 184 Integrin av 187 CD57 ....................................... 264 Integrin aE. ................................ 190 Integrin PI ................................. 192 Integrin PI ................................. 195 Claudin-1 ................................. 271 Integrin P3 ................................. 198 Claudin-3 273 Integrin P4. ................................ 20 1 Claudin-4 ................................. 275 Integrin P, ................................. 208 Collagen type XI11 (a1c hain) ......2 80 Integrin Ps 210 Collagen type XVII (a1 chain) Dystroglycan ..................... Selectins E48 .......................................... 288 E-Selectin ...... 21s ESL- 1 290 L-Selectin ................................. 218 Galectin 3 ................................. 292 P-Selectin ................................. 220 GlyCAM-1 .............................. 294 HSA ....................................... 296 Sy ndecans LYVE- 1 298 Syndecan-1 .............................. 225 Occludin ................................. 300 Syndecan-2 .......... 227 PCLPl .................................... 302 Syndecan-3 .............................. 229 PSGL- 1 304 Syndecan-4 23 1 VAP-1 .................................... 307 Other molecules AMOG ..................2 35 Index ....................................... 309 The authors acknowledge all those who have helped in the completion of this book. In particular we would like to thank Chau Chong for excellent secretarial help, our laboratories for their patience while the book was being written and members of the UK Adhesion Group who filled in questionnaires suggesting molecules that should be included. Many colleagues were invaluable in checking entries and providing unpublished information. We would particularly like to thank Ann Ager, Chris Buckley, Paul Crocker, Pat Doherty, Kurt Drickamer, Nancy Hog, Gudrun Ihrke, David Jackson, Sirpa Jalltanen, Clive Landis, Tony Magee, Fiona Watt, Sue Watt and Lisa Williams. Writing this book was greatly helped by the recent publication of The Leucocyte Antigen FactsBook, and we would like to acknowledge Neil Barclay, Marion Brown, Alex Law, Andrew McKnight, Michael Tomlinson and Anton van der Merwe whose hard work made our task much easier. With the published literature on adhesion molecules increasing by several thousand papers per annum and the various mammalian genome projects sequencing apace, a book will inevitably contain omissions and inaccuracies, and the references have a danger of being superseded. For this we apologize. However, with access to electronic databases on the World Wide Web (see Chapter 3),t his is relatively easy to remedy and the reader is asked to bear with us and make their own updates relating to a favourite molecule. AIDS Acquired immunodeficiency syndrome B B lymphocyte BCR B cell antigen receptor CCP Complement control protein CD Cluster of differentiation CNR Cadherin-related neuronal receptor cs Chondroitin sulphate ECM Extracellular matrix EGF Epidermal growth factor ERM Ezrin/radixin/moesin ES Embryonic stem EST Expressed sequence tag FAK Focal adhesion kinase FGF Fibroblast growth factor GAG Gly cosaminoglycan GalNAc N-A cetylgalactosamine GlcNAc N-A cetylglucosamine GPI Gly cosyl-phosphatidylinositol GSK Glycogen synthase kinase HEV High endothelial venule IFN Interferon Ig Immunoglobulin IgSF Immunoglobulin superfamily IL Interleukin ITIM Immunoreceptor tyrosine-based inhibitory motif kb Kilobase pairs kDa Kilodalton LAD Leucocyte adhesion deficiency LPS Lipopoly saccharide LRR Leucine-rich repeat MAPK Mitogen-activated protein kinase MGI Mouse Genome Informatics MHC Major histocompatibility complex NK Natural killer NMR Nuclear magnetic resonance OMIM Online Mendelian Inheritance in Man PI Phosphatidylinositol SDS-PAGE Polyacrylamide gel electrophoresis in sodium dodecyl sulphate SH2 Src homology domain 2 SH3 Src homology domain 3 sLeA Sialyl-Lewis* sLeX Sialyl-LewisX T T lymphocyte TM Transmembrane TM4SF Tetraspan supcrfamily TNF Tumour nccrosis factor WFl Wingless www Wnrld Widc Wch Size Type Size (approximate (approximate amino acids) 8 amino acids) D Cadherin T 10 Lectin C-type 120 repeat h Galccrin or 140 Collagennus Vatisblc Lectin S-type domain length a 0 LRR repeats 24 Complement "r' control protein 60 (CCPF Link 90 p+ Drsrnoglein @ 30 70-90 repeat Scavenger 110 Epidermal p receptor growth 40 factor (EGF) OTHER SYMBOLS USED N-g Iy cory lation si teP h Fihronectin type 111 /FnN Q-linked glymwlation / Glrcmoam inoglvcan -SJ - GPI anchor in lipid hilayer Jrn munoglohulin Site of propeptide cleavage (Ig) C2 set [c.R.i n cad herins! Unknown nr unclear molecular 7 cnnfnrrnation nr membrane attnchrnent/linkajy Figure 1 Icons used for the protein domains and repeats that are present in adhesion molecules.
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