Table Of ContentAdvances in Experimental Medicine and Biology 841
Bing Sun Editor
T Helper Cell
Differentiation
and Their
Function
Advances in Experimental Medicine and Biology
Volume 841
Series editors
Irun R. Cohen, Rehovot, Israel
N.S. Abel Lajtha, Orangeburg, USA
Rodolfo Paoletti, Milan, Italy
John D. Lambris, Philadelphia, USA
More information about this series at http://www.springer.com/series/5584
Bing Sun
Editor
T Helper Cell Differentiation
and Their Function
123
Editor
Bing Sun
Instituteof Biochemistryand Cell Biology
ChineseAcademy ofSciences
Shanghai
China
ISSN 0065-2598 ISSN 2214-8019 (electronic)
ISBN 978-94-017-9486-2 ISBN 978-94-017-9487-9 (eBook)
DOI 10.1007/978-94-017-9487-9
LibraryofCongressControlNumber:2014951155
SpringerDordrechtHeidelbergNewYorkLondon
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Preface
ThisbookfocusesonthedifferentiationandregulationofvarioussubsetsofCD4+
T cells. It also covers CD4+ T cell subset plasticity and CD4+ T cell function in
physiological and diseased states. Where the classic T cell model describes that
every subset or subpopulation of T cells develops by producing its own unique
cytokinesandmasterregulators,morerecentresearchhasshownthatthetruthmay
beabitmorecomplicated.WithnewtechnologiessuchasChIP-seq,RNA-seq,and
data-based analysis, potential transcript factors and binding cites have been iden-
tifiedindifferentTcellsubsetsanddifferentiationstages.Theseresultssuggestthat
Tcelldifferentiationisnotalinearprocessfromstarttofinishthatcanbeswitched
“on” and “off,” but is the result of complex molecular signaling cascades, subtly
controlledbyavarietyofmasterregulators.Additionally,epigeneticregulation,the
modificationofDNAorhistones,mighthelptodecideTcellfatebyfacilitatingor
blocking the binding of transcript factors. While correct and moderate stimulation
willleadtopreciseTcellresponses,incorrectsignalscausedysfunctionslikeauto-
immune diseases and allergies. As CD4+ T cells play the key role in our adaptive
immunesystem,examiningchemokinereceptorinterferencebysmallmoleculesor
antibodies represents a new approach to disease treatment. This book provides
researchers, graduate students, and clinic practitioners with a cutting-edge and
comprehensive summary of research on CD4+ T cells and their potential applica-
tions in the clinic. I sincerely thank all the chapter authors for their great contri-
butiontothebook.IalsothankQiaoshiLian,HaiyanZhou,andWenjingXuanfor
their coordination and help.
v
Contents
1 Overview of Orchestration of CD4+ T Cell Subsets
in Immune Responses. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Bing Sun and Yuan Zhang
2 Th1/Th2 Cell Differentiation and Molecular Signals. . . . . . . . . . . 15
Yuan Zhang, Yaguang Zhang, Wangpeng Gu and Bing Sun
3 Th1/Th2 Cell’s Function in Immune System . . . . . . . . . . . . . . . . 45
Yuan Zhang, Yaguang Zhang, Wangpeng Gu, Lan He and Bing Sun
4 Regulatory T-Cell Differentiation and Their Function
in Immune Regulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Miranda Piccioni, Zuojia Chen, Andy Tsun and Bin Li
5 Th17 Differentiation and Their Pro-inflammation Function. . . . . . 99
Xinyang Song, Hanchao Gao and Youcun Qian
6 Tfh Cell Differentiation and Their Function in Promoting
B-Cell Responses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
Hai Qi, Xin Chen, Coco Chu, Dan Liu, Weiwei Ma,
Yifeng Wang, Longyan Wu, Hu Yan and Jiacong Yan
7 Differentiation, Regulation and Function of Th9 Cells . . . . . . . . . 181
Lei Jia and Changyou Wu
8 The Biology and Functions of Th22 Cells. . . . . . . . . . . . . . . . . . . 209
Lei Jia and Changyou Wu
vii
Contributors
Zuojia Chen Key Laboratory of Molecular Virology and Immunology, Unit of
Molecular Immunology, Institute Pasteur of Shanghai, Institutes for Biological
Sciences, Chinese Academy of Sciences, Shanghai, China
XinChen LaboratoryofDynamicImmunobiology,SchoolofMedicine,Schoolof
Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University,
Beijing, People’s Republic of China
Coco Chu Laboratory of Dynamic Immunobiology, School of Medicine, School
of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University,
Beijing, People’s Republic of China
Hanchao Gao The Key Laboratory of Stem Cell Biology, Institute of Health
Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China
Wangpeng Gu State Key Laboratory of Cell Biology, Institute of Biochemistry
andCellBiology,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyof
Sciences, Shanghai, China
Lan He State Key Laboratory of Cell Biology, Institute of Biochemistry and
Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences, Shanghai, China
Lei Jia Key Laboratory of Tropical Disease Control Research of Ministry of
Education, Zhongshan School of Medicine, Institute of Immunology, Sun Yat-Sen
University, Guangzhou, China
Bin Li Key Laboratory of Molecular Virology and Immunology, Unit of
Molecular Immunology, Institute Pasteur of Shanghai, Institutes for Biological
Sciences, Chinese Academy of Sciences, Shanghai, China
ix
x Contributors
DanLiu LaboratoryofDynamicImmunobiology,SchoolofMedicine,Schoolof
Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University,
Beijing, People’s Republic of China
WeiweiMa LaboratoryofDynamicImmunobiology,SchoolofMedicine,School
of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University,
Beijing, People’s Republic of China
Miranda Piccioni Key Laboratory of Molecular Virology and Immunology, Unit
of Molecular Immunology, Institute Pasteur of Shanghai, Institutes for Biological
Sciences, Chinese Academy of Sciences, Shanghai, China
Hai Qi Laboratory of Dynamic Immunobiology, School of Medicine, School of
Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University,
Beijing, People’s Republic of China
Youcun Qian The Key Laboratory of Stem Cell Biology, Institute of Health
Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China
Xinyang Song The Key Laboratory of Stem Cell Biology, Institute of Health
Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China
BingSun StateKeyLaboratoryofCellBiology,InstituteofBiochemistryandCell
Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences, Shanghai, China
Andy Tsun Key Laboratory of Molecular Virology and Immunology, Unit of
Molecular Immunology, Institute Pasteur of Shanghai, Institutes for Biological
Sciences,ChineseAcademyofSciences,Shanghai,China;NewDrugandCellLine
Development, Department of Process Development, Innovent Biologics Inc,
Suzhou, China
Yifeng Wang Laboratory of Dynamic Immunobiology, School of Medicine,
School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua
University, Beijing, People’s Republic of China
ChangyouWu KeyLaboratoryofTropicalDiseaseControlResearchofMinistry
of Education, Zhongshan School of Medicine, Institute of Immunology,
Sun Yat-Sen University, Guangzhou, China
Longyan Wu Laboratory of Dynamic Immunobiology, School of Medicine,
School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua
University, Beijing, People’s Republic of China
Jiacong Yan Laboratory of Dynamic Immunobiology, School of Medicine,
School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua
University, Beijing, People’s Republic of China
Contributors xi
HuYan LaboratoryofDynamicImmunobiology,SchoolofMedicine,Schoolof
Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University,
Beijing, People’s Republic of China
Yaguang Zhang State Key Laboratory of Cell Biology, Instituteof Biochemistry
andCellBiology,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyof
Sciences, Shanghai, China
YuanZhang StateKeyLaboratoryofCellBiology,InstituteofBiochemistryand
Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences, Shanghai, China
