Syphilis - Recognition, Description and Diagnosis PDF
Preview Syphilis - Recognition, Description and Diagnosis
SYPHILIS – RECOGNITION, DESCRIPTION AND DIAGNOSIS Edited by Neuza S. Sato Syphilis – Recognition, Description and Diagnosis Edited by Neuza S. Sato Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Mirna Cvijic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team Image Copyright Apostrophe, 2011. Used under license from Shutterstock.com First published November, 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Syphilis – Recognition, Description and Diagnosis, Edited by Neuza S. Sato p. cm. ISBN 978-953-307-554-9 free online editions of InTech Books and Journals can be found at www.intechopen.com Contents Preface VII Part 1 Treponema pallidum 1 Chapter 1 Recognition of Treponema pallidum and Other Spirochetes by the Innate Immune System 3 Gunthard Stübs and Ralf R. Schumann Chapter 2 Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies-Specific Molecular Diagnostics 19 David Šmajs, Lenka Mikalová, Darina Čejková, Michal Strouhal, Marie Zobaníková, Petra Pospíšilová, Steven J. Norris and George M. Weinstock Part 2 Syphilis Disease 35 Chapter 3 History of Different Therapeutics of Venereal Disease Before the Discovery of Penicillin 37 Judit Forrai Chapter 4 Psychiatric Manifestations of Neurosyphilis 59 Fabian Friedrich and Martin Aigner Chapter 5 Spatial and Temporal Patterns of Primary Syphilis and Secondary Syphilis in Shenzhen, China 71 Tiejian Feng, Yufeng Hu, Xiaobing Wu and Fuchang Hong Part 3 Syphilis – Laboratorial Diagnosis 85 Chapter 6 Laboratorial Diagnosis of Syphilis 87 Neuza Satomi Sato Chapter 7 Serologic Response to Treatment in Syphilis 109 Neuza Satomi Sato Chapter 8 Syphilis and Blood Safety in Developing Countries 123 Claude Tayou Tagny Preface Syphilis, a sexually transmitted disease was first described in 15th century. It is caused by Treponema pallidum subsp. pallidum, it occurs worldwide and it remains an important health problem. This book collects chapters which present novel knowledge about the T. pallidum, some historical aspects of venereal disease and up to date information about syphilis disease. First section includes chapters 1 and 2, which deal with novel knowledge of T. pallidum: The immunologic recognition of the etiologic agent of syphilis (T. pallidum) by the pattern recognition receptors of the innate immune system, and the identification of new targets for molecular diagnosis of T.pallidum by analysis of treponeme whole genome. Second section includes chapters 3, 4 and 5, which present some information about Syphilis Disease: A historical aspects of venereal diseases treatment, a clinical aspects dealing with psychiatric manifestations of neurosyphilis and spatial and temporal patterns of primary syphilis and secondary syphilis described by the spatial and space-time scan statistics. Finally, the last section includes chapters 6, 7 and 8, which mainly deal with laboratorial diagnosis of syphilis. A review of methods commonly used for laboratorial diagnosis, the serological response to treatment of syphilis and safety in blood transfusion. I would like to thank each of the authors of the chapters, who took their great efforts in writing the articles, and sharing their knowledge, expertise and ideas for this book. I wish to express my gratitude to Ms. Mirna Cvijic, InTech Publishing Process Manager, for her constant assistance and support during all phases of preparation of this book. I would also like to thank very much to Ms. Viktorija Zgela, editorial consultant at InTech, who contacted me to take over the editorial task of this project. I am also indebted to InTech and its staff for the accomplishment of this book project. Dr. Neuza Satomi Sato Center of Immunology, Institute Adolfo Lutz São Paulo, SP Brazil Part 1 Treponema pallidum
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