Structural brain abnormalities in autism - DSpace - Universiteit Utrecht

216 Pages·2005·0.78 MB·English

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Structural brain abnormalities in autism
Saskia Palmen
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The studies described in this thesis were performed at the Department of Child
and Adolescent Psychiatry in collaboration with the Department of Psychiatry,
University Medical Center Utrecht, the Netherlands and at the Department of
Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany.
Cover: From neuron to brain
Palmen, Saskia
Structural brain abnormalities in autism
Thesis Utrecht University
ISBN: 90-393-3940-6
Design and Lay-out: cluster Multimedia, UMC Utrecht
Printed by: Ponsen & Looijen BV, Wageningen
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Structural brain abnormalities in autism
Neuroimaging and neuropathology studies
Structurele hersenafwijkingen in autisme
Neuroimaging en neuropathologie studies
(met een samenvatting in het Nederlands)
Proefschrift
Ter verkrijging van de graad van doctor aan de Universiteit Utrecht
op gezag van de Rector Magnificus, Prof. Dr. W.H. Gispen,
ingevolge het besluit van het College voor Promoties
in het openbaar te verdedigen op dinsdag 22 maart 2005
des middags te 14.30 uur
door
Saskia Johanna Maria Christina Palmen
geboren op 2 januari 1974, te Delft
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Promotor:
Prof. Dr. H. van Engeland
Co-promotores:
Dr. H.E. Hulshoff Pol
Dr. C. Schmitz
Financial support for publication of this thesis by the Korczak foundation and
the Prof. Dr. L.N.J. Kamp Stichting is gratefully acknowledged.
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Voor
Papa
Mama
en
Bert
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Table of Content
Part one: Introduction
Chapter 1
Autism 1
Part two: Neuroimaging findings in autism
Chapter 2
Review on structural neuroimaging findings in autism 29
Chapter 3
Increased gray matter volume in medication-naive high-functioning
children with autism spectrum disorder 65
Chapter 4
Larger brains in medication-naive high-functioning adolescents with
Pervasive Developmental Disorder 83
Chapter 5
No evidence for preferential involvement of medial temporal lobe
structures in high-functioning autism 103
Chapter 6
Brain anatomy in non-affected parents of autistic probands:
an MRI study 111
Part three: Neuropathology findings in autism
Chapter 7
Neuropathologic findings in autism 129
Chapter 8
Cortical neurons are more numerous in autism 157
Part four: Stuctural brain abnormalities in autism: discussion
Chapter 9
Structural brain abnormalities in autism: discussion 167
Nederlandse Samenvatting 183
Curriculum Vitae 193
List of Publications 197
Dankwoord 203
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Chapter 1
Autism
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