Stem Cells and Cardiac Regeneration PDF
Preview Stem Cells and Cardiac Regeneration
Stem Cell Biology and Regenerative Medicine Rosalinda Madonna Editor Stem Cells and Cardiac Regeneration Stem Cell Biology and Regenerative Medicine Series Editor Kursad Turksen, Ph.D. [email protected] More information about this series at h ttp://www.springer.com/series/7896 Rosalinda Madonna Editor Stem Cells and Cardiac Regeneration Editor Rosalinda Madonna Institute of Cardiology Department of Neurosciences and Imaging Laboratory of Experimental Cardiology Center of Excellence on Aging—CESI “G. d’Annunzio” University Chieti Scalo , Italy ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-25425-8 ISBN 978-3-319-25427-2 (eBook) DOI 10.1007/978-3-319-25427-2 Library of Congress Control Number: 2015958809 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. T he publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper S pringer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com) To our families and to our coworkers—our extended families Pref ace Ischemic heart disease (IHD) and heart failure (HF) are the major causes of m orbidity and mortality in Europe and worldwide. IHD and HF patients could ben- efi t from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Although treatment for acute myocar- dial infarction has improved over the past decades, there are currently no effective therapies for the associated problem of IHD and HF. Therefore, novel therapeutic strategies are required in order to reduce the extent of myocardial infarction, pre- serve cardiac function, and improve clinical outcomes in patients with IHD. The purpose of this book is to provide an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in IHD and HF. In this book, cardiologist clinicians and scientists will have an opportunity to learn about the potential of multipotent and pluripotent stem cells and all stem cell-based regenerative therapies, aimed at treating these diseases. The fi rst and second parts of the book cover the basic aspects of stem cells, while subse- quent sections will be more dedicated to the clinical application of stem cells for the treatment of IHD and HF. In particular, Chaps. 1 – 4 provide defi nitions, isolation criteria, and characterization of embryonic and adult stem cells, as well as pluripo- tent stem cells and tissue-s pecifi c progenitor and stem cells (including adipose, bone, lung, brain, blood, heart tissues). Chapters 5 – 9 examine the role of critical regulators of stem cell differentiation in myocardial regeneration that include circa- dian rhythms, microRNAs, epigenetics, microvesicles, and exosomes. Chapter 1 0 assesses the infl uence of cell delivery routes and injectable biomaterials on the engraftment and effi cacy of transplanted stem cells. Finally, Chap. 1 1 critically reviews the use of stem/progenitor cells in cardiac regeneration and discusses cur- rent controversies, unresolved issues, challenges, and future directions. vii viii Preface T he book is the result of collaborative efforts from all members of the European Society of Cardiology Working Group on Cellular Biology of the Heart and differ- ent investigators in the stem cell research fi eld around the world. I would like to thank all authors for their contributions. Chieti Scalo, Italy Rosalinda Madonna, M.D., Ph.D. Acknowledgments T his book would not have been possible without the collaborative efforts, a bnegation, and persistence from all members of the European Society of Cardiology (ESC) Working Group (WG) on Cellular Biology of the Heart, on which behalf the book is published. The ESC-WG is deeply grateful to external authors (Silvia Agostini, Valentina Casieri, Neil Davies, Christina F. de Veij Mestdagh, Pieterjan Dierickx, Federica Diofano, Pieter A. Doevendans, Martijn J. H. Doeleman, Bastiaan Du Pré, Dries A.M. Feyen, Thomas Franz, Niels Geijsen, Kyle Goetsch, Vincenzo Lionetti, Marco Matteucci, Francesco Moccia, Malebogo Ngoepe, Gaia Papini, Paola Rebuzzini, Toon van Veen, Estella Zuccolo) for their expert contributions. ix
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