Stem Cell Genetics for Biomedical Research

426 Pages·2018·7.73 MB·English

by  Raul Delgado-Morales

Raul Delgado-Morales E ditor
Stem Cell
Genetics for
Biomedical
Research
Past, Present, and Future
Stem Cell Genetics for Biomedical Research
Raul Delgado-Morales
Editor
Stem Cell Genetics for
Biomedical Research
Past, Present, and Future
Editor
Raul Delgado-Morales
Duran i Reynals Hospital
Bellvitge Biomedical Research Institute (IDIBELL)
Barcelona, Spain
ISBN 978-3-319-90694-2 ISBN 978-3-319-90695-9 (eBook)
https://doi.org/10.1007/978-3-319-90695-9
Library of Congress Control Number: 2018945917
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Contents
Part I S tem Cells for Brain Disorders
1 Human-Induced Pluripotent Stem Cell-D erived Neurons to Model
and Gain Insights into Alzheimer’s Disease Pathogenesis. . . . . . . . . . 3
Jessica E. Young and Raul Delgado-Morales
2 Modeling Schizophrenia with Human Stem Cells . . . . . . . . . . . . . . . . 13
Juliana Minardi Nascimento, Veronica M. Saia-Cereda,
Giuliana S. Zuccoli, Danielle Gouvêa-Junqueira,
and Daniel Martins-de-Souza
3 Rett Syndrome and Stem Cell Research . . . . . . . . . . . . . . . . . . . . . . . . 27
Keita Tsujimura and Kinichi Nakashima
4 Stem Cell Applications in Spinal Cord Injury: A Primer . . . . . . . . . . 43
James Hong, Christopher E. Rodgers, and Michael G. Fehlings
5 Cell-Based Therapy for Retinal Degenerative Disease . . . . . . . . . . . . 73
Marco A. Zarbin
6 Past, Present and Future of Cell-Based Therapy in Progressive
Multiple Sclerosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
Giulio Volpe, Joshua D. Bernstock, Luca Peruzzotti-Jametti,
and Stefano Pluchino
Part II S tem Cells for Cardiovascular Diseases
7 Cardiac Stem Cells: A Plethora of Potential Therapies
for Myocardial Regeneration Within Reach . . . . . . . . . . . . . . . . . . . . 135
Enrique Gallego-Colon and Eduardo Oliver
v
vi Contents
8 Human-Induced Pluripotent Stem Cell-D erived Cardiomyocytes
in the Evaluation of Cardiotoxic Potential of Drugs . . . . . . . . . . . . . . 173
Yee Xiang Chang, and Christine L. Mummery
Part III Stem Cells for General Medicine
9 Regenerative Medicine for Diabetes Treatment:
New β-Cell Sources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Rosa Gasa and Meritxell Rovira
10 Dental Pulp Stem Cells Promote Wound Healing
and Muscle Regeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221
E. Martínez-Sarrà, S. Montori, C. Gil-Recio, R. Núñez-Toldrà,
N. Carrio Bertran, A. Al Madhoun, M. Sampaolesi, and M. Atari
11 From Bench to Bedside of Mesenchymal Stem Cells
Use for Rheumatoid Arthritis Treatment . . . . . . . . . . . . . . . . . . . . . . . 241
R. A. Contreras, N. Luque, F. Djouad, Roberto Elizondo-Vega,
and Patricia Luz-Crawford
12 Stem Cells and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Meredith Davis, Katja Gassner, Ruth Rodriguez-Barrueco,
and David Llobet-Navas
13 The Relevance of Induced Pluripotent Stem Cells for the Study
of Physiological and Premature Aging . . . . . . . . . . . . . . . . . . . . . . . . . 311
Dido Carrero and Carlos López-Otín
Part IV Technical Challenges and Future
14 Pluripotent Stem Cell Banks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337
Begoña Aran, Ángel Raya, and Anna Veiga
15 Engineering of Human-Induced Pluripotent Stem Cells
for Precise Disease Modeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369
P. Lisowski
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 413
Contributors
A. Al Madhoun Research Division, Dasman Diabetes Institute, Dasman, Kuwait
Begoña Aran Center of Regenerative Medicine in Barcelona (CMRB), Barcelona,
Spain
National Stem Cell Bank-Barcelona Node, Biomolecular and Bioinformatics
Resources Platform PRB2, ISCIII, CMRB, Barcelona, Spain
M. Atari Regenerative Medicine Research Institute, Universitat Internacional de
Catalunya, Barcelona, Spain
Joshua D. Bernstock Department of Clinical Neurosciences and NIHR Biomedical
Research Centre, University of Cambridge, Cambridge, UK
Stroke Branch, National Institute of Neurological Disorders and Stroke, National
Institutes of Health (NINDS/NIH), Bethesda, MD, USA
N. Carrio Bertran Regenerative Medicine Research Institute, Universitat Inter-
nacional de Catalunya, Barcelona, Spain
Dido Carrero Departamento de Bioquímica y Biología Molecular, Facultad de
Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo,
Oviedo, Spain
Yee Xiang Chang University of Utrecht, Utrecht, The Netherlands
R. A. Contreras Laboratorio de Inmunología Celular y Molecular, Centro de
Investigación Biomédica, Facultad de Medicina, Universidad de los Andes,
Santiago, Chile
Inserm, U 1183, Montpellier, France
Meredith  Davis Institute of Genetic Medicine, Newcastle University,
Newcastle upon Tyne, UK
vii
viii Contributors
Raul  Delgado-Morales Cancer Epigenetics and Biology Program (PEBC),
Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat,
Barcelona, Catalonia, Spain
Department of Psychiatry & Neuropsychology, School for Mental Health and
Neuroscience (MHeNs), Maastricht University, Maastricht, The Netherlands
F. Djouad Inserm, U 1183, Montpellier, France
Université de Montpellier, Montpellier, France
Roberto Elizondo-Vega Laboratorio de Inmunología Celular y Molecular, Centro
de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes,
Santiago, Chile
Michael G. Fehlings University of Toronto, Toronto, ON, Canada
University Health Network, Toronto, ON, Canada
Enrique  Gallego-Colon Department of Biochemistry, Medical University of
Silesia, School of Medicine in Katowice, Katowice, Poland
Rosa Gasa Centro de Investigación Biomédica en Red de Diabetes y Enfermedades
Metabólicas Asociadas (CIBERDEM), Barcelona, Spain
Diabetes and Obesity Research Laboratory, August Pi i Sunyer Biomedical Research
Institute (IDIBAPS), Barcelona, Spain
Katja  Gassner Institute of Genetic Medicine, Newcastle University,
Newcastle upon Tyne, UK
Bellvitge Biomedical Research Institute (IDIBELL), Gran via de l’Hospitalet,
L’Hospitalet de Llobregat, Spain
C. Gil-Recio Regenerative Medicine Research Institute, Universitat Internacional
de Catalunya, Barcelona, Spain
Danielle  Gouvêa-Junqueira Lab of Neuroproteomics, Department of
Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
(UNICAMP), Campinas, Brazil
James Hong University of Toronto & Krembil Research Institute, Toronto, ON,
Canada
P. Lisowski Department of Molecular Biology, Institute of Genetics and Animal
Breeding, Polish Academy of Sciences, Jastrzebiec, Magdalenka, Poland
Department of Medical Genetics, Centre for Preclinical Research and Technology
(CePT), Warsaw Medical University, Warsaw, Poland
Mitochondria and Cell Fate Reprogramming Group, Department of Proteomics and
Molecular Mechanisms of Neurodegenerative Diseases, Max Delbrück Center for
Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany
Contributors ix
David  Llobet-Navas Institute of Genetic Medicine, Newcastle University,
Newcastle upon Tyne, UK
Bellvitge Biomedical Research Institute (IDIBELL), Gran via de l’Hospitalet,
L’Hospitalet de Llobregat, Spain
Carlos López-Otín Departamento de Bioquímica y Biología Molecular, Facultad
de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo,
Oviedo, Spain
Centro de Investigación en Red de Cáncer, Madrid, Spain
N. Luque Laboratorio de Inmunología Celular y Molecular, Centro de Investigación
Biomédica, Facultad de Medicina, Universidad de los Andes, Santiago, Chile
Patricia Luz-Crawford Laboratorio de Inmunología Celular y Molecular, Centro
de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes,
Santiago, Chile
E.  Martínez-Sarrà Regenerative Medicine Research Institute, Universitat
Internacional de Catalunya, Barcelona, Spain
Translational Cardiomyology Laboratory, Stem Cell Biology and Embryology Unit,
Department of Development and Regeneration, Leuven, Belgium
Daniel  Martins-de-Souza Instituto Nacional de Biomarcadores em
Neuropsiquiatria (INBION) Conselho Nacional de Desenvolvimento Cientifico e
Tecnologico, São Paulo, Brazil
UNICAMP’s Neurobiology Center, Campinas, Brazil
Lab of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute
of Biology, University of Campinas (UNICAMP), Campinas, Brazil
S. Montori Regenerative Medicine Research Institute, Universitat Internacional de
Catalunya, Barcelona, Spain
Christine  L.  Mummery Department of Anatomy and Embryology, Leiden
University Medical Centre, Leiden, The Netherlands
Kinichi Nakashima Department of Stem Cell Biology and Medicine, Graduate
School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Fukuoka,
Japan
Juliana  Minardi  Nascimento Lab of Neuroproteomics, Department of
Biochemistry and Tissue Biology, Institute of Biology, University of Campinas
(UNICAMP), Campinas, Brazil
D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil
R.  Núñez-Toldrà Regenerative Medicine Research Institute, Universitat
Internacional de Catalunya, Barcelona, Spain
x Contributors
Eduardo Oliver Centro Nacional de Investigaciones Cardiovasculares Carlos III
(CNIC), Madrid, Spain
Luca  Peruzzotti-Jametti Department of Clinical Neurosciences and NIHR
Biomedical Research Centre, University of Cambridge, Cambridge, UK
Stefano Pluchino Department of Clinical Neurosciences and NIHR Biomedical
Research Centre, University of Cambridge, Cambridge, UK
Ángel Raya Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona,
Spain
Center of Regenerative Medicine in Barcelona (CMRB), Barcelona, Spain
Center for Networked Biomedical Research on Bioengineering, Biomaterials and
Nanomedicine (CIBER-BBN), Madrid, Spain
Christopher E. Rodgers University of Toronto & Krembil Research Institute,
Toronto, ON, Canada
Ruth Rodriguez-Barrueco Institute of Genetic Medicine, Newcastle University,
Newcastle upon Tyne, UK
Bellvitge Biomedical Research Institute (IDIBELL), Gran via de l’Hospitalet,
L’Hospitalet de Llobregat, Spain
Universitat de Barcelona, Facultat de Medicina i Ciències de la Salut. Departament
d’Anatomia i Terapèutica Experimental. Bellvitge Biomedical Research Institute
(IDIBELL), Gran via de l’Hospitalet, L’Hospitalet de Llobregat, Spain
Meritxell  Rovira Center of Regenerative Medicine in Barcelona (CMRB),
Hospital Duran i Reynals, Barcelona, Spain
Veronica M. Saia-Cereda Lab of Neuroproteomics, Department of Biochemistry
and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP),
Campinas, Brazil
M. Sampaolesi Translational Cardiomyology Laboratory, Stem Cell Biology and
Embryology Unit, Department of Development and Regeneration, Leuven, Belgium
Human Anatomy Unit, Department of Public Health, Experimental and Forensic
Medicine, University of Pavia, Pavia, Italy
Keita Tsujimura Department of Psychiatry, Nagoya University Graduate School
of Medicine, Showa, Nagoya, Aichi, Japan
Institute for Advanced Research, Nagoya University, Chikusa, Nagoya, Aichi, Japan
Department of Stem Cell Biology and Medicine, Graduate School of Medical
Sciences, Kyushu University, Higashi-ku, Fukuoka, Fukuoka, Japan