“Have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.” SStteevvee JJoobbss To my beloved family, who among so many other things, always support me. v Preliminary Note I hereby declare that the work presented in this dissertation is my own work and that, to the best of my knowledge and belief, it contains original material, i.e. material that was not previously published or written by another person, or material accepted for any other degree or diploma of this university or any other institution of higher learning. Porto, 6th August 2014 _____________________________________ Ana Rita Pereira Azevedo This dissertation has the collaboration of Faculty of Medicine of University of Porto (Faculdade de Medicina da Universidade do Porto), Rheumatology Service of the São João Hospital Center (Serviço de Reumatologia do Centro Hospitalar de São João), Molecular Oncology Group of the Portuguese Institute of Oncology – Porto (Grupo de Oncologia Molecular do Instituto Português de Oncologia – Porto) and Higher Institute of Health Sciences – North (Instituto Superior de Ciências da Saúde – Norte).
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