Signaling Mechanisms and Gene Expression in the Ovary PDF
Preview Signaling Mechanisms and Gene Expression in the Ovary
Serono Symposia, USA Norwell, Massachusetts FERTIliZATION IN MAMMALS Edited by Barry D. Bavister, Jim Cummins, and Eduardo R.S. Roldan GAMETE PHYSIOLOGY Edited by Ricardo H. Asch, Jose P. Balmaceda, and Ian Johnston GLYCOPROTEIN HORMONES: Structure, Synthesis, and Biologic Function Edited by William W. Chin and Irving Boime GROWI'H FACTORS IN REPRODUCTION Edited by David W. Schomberg THE MENOPAUSE: Biological and Clinical Consequences of Ovarian Failure: Evaluation and Management Edited by Stanley G. Korenman NEUROENDOCRINE REGULATION OF REPRODUCTION Edited by Samuel S.C. Yen and Wylie W. Vale SIGNAliNG MECHANISMS AND GENE EXPRESSION IN THE OVARY Edited by Geula Gibori UTERINE CONTRACTIliTY: Mechanisms of Control Edited by Robert E. Garfield Serono Symposia, USA Norwell, Massachusetts Geula Gibori Editor Signaling Mechanisms and Gene Expression in the Ovary With 207 Figures Springer-Verlag New York Berlin Heidelberg London Paris Tokyo Hong Kong Barcelona Geula GiOOri, Ph.D. Department of Physiology and Biophysics College of Medicine University of lllinois Chicago, IL 60680 USA Proceedings of the Eighth Ovarian Workshop on Regulatory Processes and Gene Expression in the Ovary, sponsored by Serono Symposia, USA, held July 12 to 14, 1990, in Maryville, Tennessee. For information on previous volumes, please contact Serono Symposia, USA. Printed on acid-free paper. © 1991 Springer-Verlag New York, Inc. Softcover reprint oft he hardcover 1s t edition 1991 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer-Verlag New York, Inc., 175 Fifth Avenue, New York, NY 10010, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use of general descriptive names, trade names, trademarks, etc., in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors, nor the editors, nor the publisher, nor Serono Symposia, USA, nor Serono Laboratories, Inc., can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, expressed or implied, with respect to the material contained herein. Permission to photocopy for internal or personal use, or the internal or personal use of specific clients, is granted by Springer-Verlag New York, Inc., for libraries registered with the Copyright Clearance Center (CCC), provided that the base fee of $0.00 per copy, plus $0.20 per page is paid directly to CCC, 21 Congress Street, Salem, MA 01970, USA. Special requests should be addressed directly to Springer-Verlag New York, Inc., 175 Fifth Avenue, New York, NY 10010, USA. Production and typesetting services by Technical Texts, Scituate, Massachusetts. 9 8 7 6 5 4 3 2 1 lSBN-13: 978-1-4612-7830-6 e-lSBN-13: 978-1-4612-3200-1 DOl: 10.1007/978-1-4612-3200-1 PROCEEDINGS OF THE EIGHTH OVARIAN WORKSHOP ON REGULATORY PROCESSES AND GENE EXPRESSION IN THE OVARY Ovarian Workshop Board Geula Gibori, Ph.D., Chainnan, Eighth Ovarian Workshop Chicago, lllinois Eli Y. Adashi, M.D. Baltimore, Maryland JoAnne Fortune, Ph.D. Ithaca, New York Anne Hirshfield, Ph.D. Baltimore, Maryland Aaron Hsueh, Ph.D. La Jolla, California Julia Lobotsky, Ph.D. Bethesda, Maryland Gordon Niswender, Ph.D. Fort Collins, Colorado David W. Schomberg, Ph.D. Durham, North Carolina Richard Stouffer, Ph.D. Beaverton, Oregon Jerome Strauss, III, M.D., Ph.D. Philadelphia, Pennsylvania Organizing Secretary L. Lisa Kern, Ph.D. Serono Symposia, USA 100 Longwater Circle Norwell, Massachusetts Preface Since its inception in 1976, the overall goal of the Ovarian Workshop has been to bring together biologists from various disciplines so that they may collectively achieve a better understanding of the latest developments and define important problems in ovarian physiology. The Ovarian Workshop, which was pioneered by Dr. A. Rees Midgley, has developed into a major biennial meeting for investigators in the ovarian field. Largely as a consequence of advances in technology, especially in mo lecular biology, progress in the area of gene expression and signal transduc tion has been rapid. The Eighth Ovarian Workshop focused on two major topics: (1) the expression of hormonally and nonhormonally controlled genes involved in the functional and morphological differentiation of the cells forming the ovary and (2) the signaling mechanisms by which endogenous and exogenous hormones and cytokines affect ovarian differentiation and steroidogenesis. The Eighth Ovarian Workshop, held on the campus of Maryville College in Maryville, Tennessee, July 12 to 14, 1990, was again generously funded and coordinated by Serono Symposia, USA. I would especially like to thank Dr. Lisa Kern of Serono for her expert help in organizing this meeting. The board of directors of the Eighth Ovarian Workshop consisted of Drs. Eli Adashi, JoAnne Fortune, Anne Hirshfield, Aaron Hsueh, Julia Lobotsky, Gordon Niswender, David W. Schomberg, Richard Stouffer, and Jerry Strauss. Their valuable advice and the important roles they played in the planning of the scientific program are gratefully acknowledged. GEULAGmORI vii Contents Preface.................................................................................................... vii Contributors ........................................................................................... xvii Part I. Gonadotropin Receptors and Transfactors 1. The Gonadotropin Receptors: Structural Insights Learned from the Cloning of Their cDNAs ........................................................ 3 DEBORAH L. SEGALOFF 2. Hormonal Regulation of Gonadotropin Gene Expression ........... 11 J. LARRY JAMESON, THOMAS W.H. KAY, DEBRA S. DRUST, LAIRD D. MADISON, AND CHRIS ALBANESE Part ll. Signaling Pathways in the Ovary 3. Inositol Lipid Metabolism and Calcium Signaling in Rat Ovarian Cells .............................................. .............. ..................... 25 MARIE R. RODWAY AND PETER C.K. LEUNG 4. Interactions Among the cAMP and IP:JI)AG Intracellular Signaling Systems in Bovine Luteal Cells .... .......... ..................... 39 JOHN S. DAVIS 5. Variant Diacylglycerol-Dependent Protein Phosphotransferase Activity in Ovarian Tissues ............................................ .............. 54 EVELYN T. MAIZELS, VICTORIA JACKIW, JOSEPHINE B. MILLER, RICHARD E. CurLER, JR., ELLEN M. CARNEY, AND MARY HUNZICKER-DUNN ix x Contents 6. Endocrine, Paracrine, and Autocrine Regulators of the Macaque Corpus Luteum .............................................................. 68 RICHARD L. STOUFFER 7. Steroid Signaling in the Follicular Paracrine System .................. 84 S.G. HILLIER AND I.M. TuRNER Part III. Hormonal Control and Gene Expression in the Ovary 8. Regulation of Inhibin and Activin Genes in the Rat Ovary ........ 99 JOANNA C. DYKEMA, JASON O. RAHAL, AND KELLY E. MAYO 9. mos Proto-Oncogene Product and Cytostatic Factor ................... 112 NICHOLAS SCHULZ AND GEORGE F. VANDE WOUDE 10. Regulation of Genes Encoding Steroidogenic Enzymes in the Ovary .................................................................................. 129 MARKUS LAUBER, MICHELLE DEMETER, DAVID STIRLING, RAYMOND RODGERS, MICHAEL R. WATERMAN, AND EVAN R. SIMPSON 11. Oxysterols: Regulation of Biosynthesis and Role in Controlling Cellular Cholesterol Homeostasis in Ovarian Cells ............ ........ 137 JEROME F. STRAUSS, III, HANNAH RENNERT, RITSU YAMAMOTO, LEE-CHUAN KAO, AND JUAN G. ALVAREZ Part IV. Relevance of Resident Ovarian White Blood Cells 12. Leukocyte Chemo-Attraction and Periovulatory Follicular Processes ....................................................................................... 153 W.I. MURDOCH AND R.I. MCCORMICK 13. The Role of IL-l in the Ovary ...................................................... 163 MARY LAKE POLAN, JILL A. LoUKIDES, AND PAMELA NELSON 14. Effects of Bacterial Endotoxin (Lipopolysaccharide) on FSH-Induced Granulosa Cell Activities ....................................... 170 PAUL E. GOTTSCHALL AND AKIRA ARIMURA 15. TNF a: Altering Thecal and Granulosal Cell Steroidogenesis .... 178 P.F. TERRANOVA, K.F. ROBY, M. SANCHO-TELLO, J. WEED, AND R. LYLES Contents xi 16. TNF IX Modulation of Ovarian Steroidogenesis in the Rat ......... 190 DONNA W. PAYNE, ARYE HURWITZ, JEFFREY N. PACKMAN, CRISTIANA L. ANDREANI, CAROL E. RESNICK, AND ELI Y. ADASHI 17. Inflammatory Cells in the Rabbit Corpus Luteum: Relationship to Luteal Involution .... ........ ..... ... ........ ........ ........ ........ .................. 200 R.c. P. BAGAVANDOSS, WIGGINS, S.L. KUNKEL, D.G. REMICK, AND P.L. KEYES Part V. Submitted Manuscripts 18. Two Populations of Steroidogenic Cells in the Theca Layer of Chicken Ovarian Follicles .... ... ..... ........................ ........ ........ ........ 207 HIROAKI NITTA, YOSHIO OSAWA, AND JANICE M. BAHR 19. Localization of mRN As That Encode Steroidogenic Enzymes in Bovine Ovaries ......................................................................... 213 R.I. RODGERS AND H.F. RODGERS 20. Fetal Calf Serum: Eliciting Phosphorylation of Ca++j Calmodulin-Dependent Protein Kinase II in Cultured Rat Granulosa Cells .... ........ ..... ....... ...... ...... ........ .... .... ................ ......... 218 TAKASHI OHBA, YASUTAKA OHTA, KOHn MIYAZAKI, HITOSHI OKAMURA, AND EISHICHI MIYAMOTO 21. Differential Regulation of Cytosolic-Free Calcium in Ovine Small and Large Luteal Cells: Effects on Secretion of Progesterone .... ........ ........ ......... ............... ........ ..... ........... ........ ...... 225 P.B. HOYER AND J.A. WEGNER 22. Presence of an Endogenous Inhibitor of Protein Kinase C Throughout Pseudopregnancy in the Rat Ovary .... ........ ........ ...... 234 KATHLEEN M. EYSTER 23. Effects of Gonadotropins and PGE on Ovarian Adenylate 2 Cyclase in Cellular Membrane from Mature Cyclic Cows. ... ...... 240 SERGE-ALAIN WANDJI, M.A. FORTIER, AND M.-A. SIRARD 24. Sphingosine Derivatives, Calmodulin Inhibitors, and TMB-8: Inhibitors of Adenylate Cyclase Activity in Rat Luteal Membranes .................................................................................... 248 M. LAHAv, D. BARZILAI, AND O. TOPAZ xii Contents 25. Cadherins and Ovarian Follicular Development .......................... 254 RIAz FAROOKHI AND OREST W. BLASCHUK 26. Differential Regulation of 3P-HSD and 17P-HSD Expression in Granulosa Cells ........................................................................ 261 Y. TREMBLAY, B. MARCOTTE, AND J.F. STRAUSS, III 27. Pituitary Hormone Regulation of Ovarian 3 P-HSD Gene Expression and Activity in the Rat.................... ........................... 268 CLAUDE LABRIE, CELINE MARTEL, JACQUES COuEr, CLAUDE TRUDEL, V AN Luu-THE, AND FERNAND LABRIE 28. Molecular Cloning of Rat 3P -HSD: Structure of Two Types of cDNAs and Differential Expression of Corresponding mRNAs in the Ovary .................................................................................. 274 JACQUES SIMARD, HUI FEN ZHAO, CLAUDE LABRIE, CLAUDE TRUDEL, ERIC RHEAUME, ERIC DUPONT, NATHALIE BRETON, V AN Luu-THE, GEORGES PELLETIER, AND FERNAND LABRIE 29. The Signal Transduction System in Luteotrophic Stimulation of Expression of the 3P-HSD Gene in Porcine Granulosa Cells in Culture........................................................................................... 280 P. JORGE CHEDRESE, DANIEL SCHOTT, DAVID ZHANG, AND BRUCE D. MuRPHY 30. Control of 3P-HSD mRNA and Activity During the Estrous Cycle in the Bovine Ovary ................................. ,......................... 285 J. CODET, C. MARTEL, V. Luu-THE, M.-A. SIRARD, H.F. ZHAO, AND F. LABRIE 31. Expression of IGF-I and IGF-I Receptor Gene in the Corpus Luteum .......................................................................................... 291 T.G. PARMER, M. ZILBERSTEIN, I. KHAN, C. ALBARRACIN, ANDG.GmORI 32. Expression of IGF-I and IGF-I Receptor Gene in Transformed Luteal Cells .... ................................................ ................ ........ ....... 297 M. ZILBERSTEIN, T.G. PARMER, S. NELSON, M.P. McLEAN, L. HARLOW, N. GLEICHER, J.Y. CHou, AND G. GmoRI 33. Relationships of Oocyte Quality and IGF-I in Follicular Fluid During the Estrual Period in Cattle and Effects of Pre-Estrual Progestins ............. .......... ...... ........... ................ ...... ....... ......... ........ 304 T. WISE, J .M. GRIZZLE, AND R.R. MAURER
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