Separation and Purification by Crystallization

311 Pages·1997·23.966 MB·English

by  Gregory D. Botsaris and Ken Toyokura (Eds.)

Separation and Purification
by Crystallization

In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
667
ACS SYMPOSIUM SERIES
Separation and Purification
by Crystallization
Gregory D. Botsaris, EDITOR
Tufts University
Ken Toyokura, EDITOR
Waseda University
Developed from a symposium sponsored by the
International Chemical Congress of Pacific Basin Societies at the
1995 International Chemical Congress of Pacific Basin Societies
American Chemical Society, Washington, DC
In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
Library of Congress Cataloging-in-Publication Data
Separation and purification by crystallization / Gregory D. Botsaris, editor, Ken
Toyokura, editor.
p. cm.—(ACS symposium series, ISSN 0097-6156; 667)
"Developed from a symposium sponsored by the International Chemical
Congress of Pacific Basin Societies at the 1995 International Chemical Congress
of Pacific Basin Societies, Honolulu, Hawaii, December 17-22, 1995."
Includes bibliographical references and indexes.
ISBN 0-8412-3513-9
1. Crystallization—Congresses. 2. Separation (Technology)—Congresses.
3. Chemicals—Purification—Congresses.
I. Botsaris, G. D. II. Toyokura, Ken, 1933- . III. International Chemical
Congress of Pacific Basin Societies (1995: Honolulu, Hawaii) IV. Series.
QD548.S45 1997
660'.2842—dc21 97-11250
CIP
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In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
Advisory Board
ACS Symposium Series
Mary E. Castellion Omkaram Nalamasu
ChemEdit Company AT&T Bell Laboratories
Arthur B. Ellis Kinam Park
University of Wisconsin at Madison Prudue University
Jeffrey S. Gaffney Katherine R. Porter
Argonne National Laboratory Duke University
Gunda I. Georg
Douglas A. Smith
The DAS Group, Inc.
University of Kansas
Lawrence P. Klemann Martin R. Tant
Nabisco Foods Group Eastman Chemical Co.
Richard N. Loeppky
Michael D. Taylor
University of Missouri
Parke-Davis Pharmaceutical
Cynthia A. Maryanoff Research
R. W. Johnson Pharmaceutical
Leroy Β. Townsend
Research Institute
University of Michigan
Roger A. Minear
William C. Walker
University of Illinois
at Urbana-Champaign DuPont Company

In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
Foreword
IHE ACS SYMPOSIUM SERIES was first published in 1974 to provide
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In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
Preface
A MAJORITY OF CHEMICAL INDUSTRIAL PROCESSES involve, at least
at some stage, the separation of a compound by crystallization or its purification
by recrystallization. Considerable research has been done in recent years in the
crystallization field, and important findings have led to a better understanding of
the crystallization phenomenon and to considerable improvements in the
practice. These changes, however, reveal new levels of complexity in the
crystallization process. At the same time, technological advances necessitate the
use of crystallization in new processes, such as biochemical processes, and in the
production of new compounds, such as biomolecules. For these reasons, the
level of interest in crystallization has been continually increasing.
To satisfy this increased interest, international meetings dedicated to
crystallization are organized, such as the one sponsored every three years by the
European Federation of Chemical Engineering. In addition, both the American
Chemical Society and the American Institute of Chemical Engineers include
crystallization symposia in their national and international meetings.
This volume was developed from a crystallization symposium presented at
the 1995 International Chemical Congress of Pacific Basin Societies
(Pacifichem '95) in Honolulu, Hawaii, December 17-22, 1995. The symposium
included 50 contributions, presented in oral and poster sessions, from nine
countries.
This volume contains 23 chapters organized in five sections. More than a
third of the chapters deal with the crystallization of polymorphic compounds that
can crystallize in more than one form and the crystallization of chiral
compounds. This emphasis is a reflection of the current interest in these two
fields. The other four areas are basic studies, studies related to industrial
crystallizers and processes, and two areas involving crystallization of particular
organic and inorganic compounds. A different organization of the book would
have shown that 10 of the papers deal with aspects of crystallization of proteins,
amino acids, and pharmaceuticals, a sign of the increased activity in this area of
crystallization.
Acknowledgments
This volume is the result of the efforts of many individuals. We thank the
symposium participants and contributors, the authors of the chapters, the
xi
In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
members of the organizing committee of Pacifichem '95 for giving us the
opportunity and the help to organize and conduct the symposium, and the staff
of ACS Books for their assistance and patience.
GREGORY D. BOTSARIS
Department of Chemical Engineering
Tufts University
Medford, MA 02155
KEN TOYOKURA
Department of Applied Chemistry
Waseda University
3-4-1 Okubo, Shinjuku-ku
Tokyo 169
Japan
January 22, 1997

xii
In Separation and Purification by Crystallization; Botsaris, G., et al.;
ACS Symposium Series; American Chemical Society: Washington, DC, 1997.
SeparationandPurificationbyCrystallization
Editor(s):GregoryD.Botsaris1,KenToyokura2 ISBN13:9780841235137
Volume667
eISBN:9780841216266
PublicationDate(Print):June01,1997
DOI:10.1021/bk-1997-0667
Copyright©1997AmericanChemicalSociety
1TuftsUniversity
2WasedaUniversity
Contents
SeparationandPurificationbyCrystallization,Copyright,AdvisoryBoard,
Foreword
ppi-vi
DOI:10.1021/bk-1997-0667.fw001
Preface
GREGORYD.BOTSARISandKENTOYOKURA
ppxi-xii
DOI:10.1021/bk-1997-0667.pr001
BASIC STUDIES
CrystalMorphologyPredictiveTechniquesToCharacterizeCrystalHabit:
ApplicationtoAspirin(CHO)
9 8 4
PaulMeenan
Chapter1,pp2-17
DOI:10.1021/bk-1997-0667.ch001
MechanismofCrystalGrowthofProtein:DifferentialScanningCalorimetryof
ThermolysinCrystalSuspension
H.Ooshima,S.Urabe,K.Igarashi,M.Azuma,andJ.Kato
Chapter2,pp18-27
DOI:10.1021/bk-1997-0667.ch002
SourceofNucleiinContactNucleationasRevealedbyCrystallizationof
IsomorphousAlums
ManijehM.ReyhaniandGordonM.Parkinson
Chapter3,pp28-35
DOI:10.1021/bk-1997-0667.ch003
AKineticModelforUnsteady-StateCrystalGrowthinthePresenceofImpurity
N.Kubota,M.Yokota,andL.A.Guzman
Chapter4,pp36-44
DOI:10.1021/bk-1997-0667.ch004
CRYSTALLIZATION OF OPTICAL ISOMERS AND POLYMORPHS
ConcentrationChangeofL-SCMC[S-(Carboxymethyl)-L-cysteine]ina
SupersaturatedSolutionofDL-SCMCwithSuspendedL-SCMCSeedsinaBatch
Operation
KenToyokura,M.Kurotani,andJ.Fujinawa
Chapter5,pp46-58
DOI:10.1021/bk-1997-0667.ch005
PurityDropinOpticalResolutionofRacemicMixtures
M.Matsuoka
Chapter6,pp59-72
DOI:10.1021/bk-1997-0667.ch006