Self-Organized Biological Dynamics and Nonlinear Control: Toward Understanding Complexity, Chaos and Emergent Function in Living Systems PDF
Preview Self-Organized Biological Dynamics and Nonlinear Control: Toward Understanding Complexity, Chaos and Emergent Function in Living Systems
SELF-ORGANIZEDBIOLOGICALDYNAMICSAND NONLINEARCONTROL The growing impact of nonlinear science on biology and medicine is fundamentally changingourviewoflivingorganismsanddiseaseprocesses.Thisbookintroducesthe applicationto biomedicineof a broad range of interdisciplinaryconcepts from non- linear dynamics, such as self-organization, complexity, coherence, stochastic reson- ance,fractals,andchaos. The book comprises 18 chapters written by leading figures in the field. It covers experimentalandtheoreticalresearch,aswellastheemergingtechnologicalpossibili- ties such as nonlinear control techniques for treating pathological biodynamics, includingheartarrhythmiasandepilepsy.Thechaptersreviewself-organizeddynam- ics at all major levels of biological organization, ranging from studies on enzyme dynamicstopsychophysicalexperimentswithhumans.Emphasisisonquestionssuch ashowlivingsystemsfunctionasawhole,howtheytransduceandprocessdynamical information,andhowtheyrespondtoexternalperturbations.Theinvestigatedstimuli cover a variety of different influences, including chemical perturbations, mechanical vibrations, thermal fluctuations, light exposures and electromagnetic signals. The interaction targets include enzymes and membrane ion channels, biochemical and geneticregulatorynetworks,cellularoscillatorsandsignalingsystems,andcoherentor chaoticheartandbraindynamics.Amajorthemeofthebookisthatanyintegrative model of the emergent complexity observed in dynamical biology is likely to be beyondstandard reductionistapproaches.It also outlinesfuture researchneedsand opportunitiesrangingfromtheoreticalbiophysicstocellandmolecularbiology,and biomedicalengineering. JAN WALLECZEK is Head of the Bioelectromagnetics Laboratory and a Senior ResearchScientistintheDepartmentofRadiationOncologyatStanfordUniversity SchoolofMedicine.HestudiedbiologyattheUniversityofInnsbruck,Austria,and thenwas a Doctoral Fellow and ResearchAssociate at the Max-Planck Institute of MolecularGeneticsinBerlin.Subsequently,hemovedtoCalifornia,wherehewasa ResearchFellowintheResearchMedicineandRadiationBiophysicsDivisionatthe Lawrence Berkeley National Laboratory, University of California, Berkeley, and at the Veterans Administration Medical Center in Loma Linda before founding the BioelectromagneticsLaboratory at Stanford University in 1994. His recent publica- tionsincludetopicssuchasthenonlinearcontrolofbiochemicaloscillators,coherent electron spin kinetics in magnetic field control of enzyme dynamics, nonlinear bio- chemicalamplification,andstochasticresonanceinbiologicalchaospatterndetection. Jan Walleczek is a Founding Fellow of the Fetzer Institute, a Chair of the Gordon ResearchConferenceonBioelectrochemistry,andanEditorialBoardmemberofthe journalBioelectromagnetics. XXXXXX SELF-ORGANIZED BIOLOGICAL DYNAMICS AND NONLINEAR CONTROL TowardUnderstandingComplexity,ChaosandEmergentFunction inLivingSystems EDITED BY JAN WALLECZEK DepartmentofRadiationOncology,StanfordUniversity Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo Cambridge University Press The Edinburgh Building, Cambridge , United Kingdom Published in the United States by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9780521624367 © Cambridge University Press 2000 This book is in copyright. Subject to statutory exception and to the provision of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published in print format 2000 ISBN-13 978-0-511-06608-5 eBook (NetLibrary) ISBN-10 0-511-06608-2 eBook (NetLibrary) ISBN-13 978-0-521-62436-7 hardback ISBN-10 0-521-62436-3 hardback Cambridge University Press has no responsibility for the persistence or accuracy of s for external or third-party internet websites referred to in this book, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. Contents Listofcontributors pagevii Preface xi Thefrontiersandchallengesofbiodynamicsresearch JanWalleczek 1 PartI Nonlineardynamicsinbiologyandresponsetostimuli 13 1 Externalsignalsandinternaloscillationdynamics:principalaspects andresponseofstimulatedrhythmicprocesses FriedemannKaiser 15 2 Nonlineardynamicsinbiochemicalandbiophysicalsystems:from enzymekineticstoepilepsy RaimaLarter,RobertWorthand BrentSpeelman 44 3 Fractalmechanismsinneuronalcontrol:humanheartbeatandgait dynamicsinhealthanddisease Chung-KangPeng,Jeffrey M.HausdorffandAryL.Goldberger 66 4 Self-organizingdynamicsinhumansensorimotorcoordinationand perception MingzhouDing,YanqingChen,J.A.ScottKelsoand BettyTuller 97 5 Signalprocessingbybiochemicalreactionnetworks AdamP.Arkin 112 PartII Nonlinearsensitivityofbiologicalsystemstoelectromagnetic stimuli 145 6 Electricalsignaldetectionandnoiseinsystemswithlong-range coherence PaulC.Gailey 147 7 Oscillatorysignalsinmigratingneutrophils:effectsoftime-varying chemicalandelectricfields HowardR.Petty 173 8 Enzymekineticsandnonlinearbiochemicalamplificationin responsetostaticandoscillatingmagneticfields JanWalleczek andClemensF.Eichwald 193 v vi Contents 9 Magneticfieldsensitivityinthehippocampus StefanEngstro¨m, SuzanneBawinandW.RossAdey 216 PartIII Stochasticnoise-induceddynamicsandtransportinbiological systems 235 10 Stochasticresonance:lookingforward FrankMoss 236 11 Stochasticresonanceandsmall-amplitudesignaltransductionin voltage-gatedionchannels SergeyM.Bezrukovand IgorVodyanoy 257 12 Ratchets,rectifiers,anddemons:theconstructiveroleofnoisein freeenergyandsignaltransduction R.DeanAstumian 281 13 Cellulartransductionofperiodicandstochasticenergysignals byelectroconformationalcoupling TianY.Tsong 301 PartIV Nonlinearcontrolofbiologicalandotherexcitablesystems 327 14 Controllingchaosindynamicalsystems KennethShowalter 328 15 Electromagneticfieldsandbiologicaltissues:fromnonlinear responsetochaoscontrol WilliamL.DittoandMarkL.Spano 341 16 Epilepsy:multistabilityinadynamicdisease JohnG.Milton 374 17 Controlandperturbationofwavepropagationinexcitable systems OliverSteinbockandStefanC.Mu¨ller 387 18 Changingparadigmsinbiomedicine:implicationsforfuture researchandclinicalapplications JanWalleczek 409 Index 421 Contributors W.RossAdey DepartmentofBiomedicalSciences,UniversityofCaliforniaatRiverside,Riverside,CA 92521,USA AdamP.Arkin PhysicalBiosciencesDivision,E.O.LawrenceBerkeleyNationalLaboratory,Berkeley, CA94720,USA R.DeanAstumian Departments of Surgery and of Biochemistry and Molecular Biology, University of Chicago,Chicago,IL60637,USA SuzanneBawin Research Service, Veterans Administration Medical Center, Loma Linda, CA 92357, USA SergeyM.Bezrukov LaboratoryofPhysicalandStructuralBiology,NICHD,NationalInstitutesofHealth, Bethesda,MD20892-0924,USA YanqingChen Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton,FL33431-0991,USA MingzhouDing Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton,FL33431-0991,USA WilliamL.Ditto LaboratoryforNeuralEngineering,GeorgiaTech/EmoryBiomedicalEngineeringDe- partment,GeorgiaInstituteofTechnology,Atlanta,GA30332-0535,USA ClemensF.Eichwald Bioelectromagnetics Laboratory, Department of Radiation Oncology, School of Medi- cine,StanfordUniversity,Stanford,CA94305-5304,USA StefanEngstro¨m DepartmentofNeurology,VanderbiltUniversityMedicalCenter,NashvilleTN37212- 3375,USA vii viii Listofcontributors PaulC.Gailey DepartmentofPhysicsandAstronomy,OhioUniversity,Athens,OH45701,USA AryL.Goldberger Margret & H. A. Rey Laboratory for Nonlinear Dynamics in Medicine, Harvard MedicalSchool,BethIsraelDeaconessMedicalCenter,Boston,MA02215,USA JeffreyM.Hausdorff Margret & H. A. Rey Laboratory for Nonlinear Dynamics in Medicine, Harvard MedicalSchool,BethIsraelDeaconessMedicalCenter,Boston,MA00215,USA FriedemannKaiser NonlinearDynamicsGroup, Institute of AppliedPhysics, TechnicalUniversity,Darm- stadt,D-64289,Germany J.A.ScottKelso Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton,FL33431,USA RaimaLarter Department of Chemistry, Indiana University—Purdue University at Indianapolis, Indianapolis,IN46202,USA JohnG.Milton DepartmentofNeurology,UniversityofChicagoHospitals,Chicago,IL60637,USA FrankMoss Laboratory for Neurodynamics, Department of Physics and Astronomy, University of MissouriatStLouis,StLouis,MO63121,USA StefanC.Mu¨ller Institut fu¨r Experimentelle Physik—Biophysik, Universita¨tsplatz 2, Otto-von-Guericke- Universita¨tMagdeburg,Magdeburg,D-39106,Germany Chung-KangPeng Margret & H. A. Rey Laboratory for Nonlinear Dynamics in Medicine, Harvard MedicalSchool,BethIsraelDeaconessMedicalCenter,Boston,MA02215,USA HowardR.Petty DepartmentofBiologicalSciences,WayneStateUniversity,Detroit,MI48202,USA KennethShowalter Department of Chemistry, West Virginia University, Morgantown, WV 26506-6045, USA MarkL.Spano NavalSurfaceWarfareCenter,SilverSpring,MD20817,USA BrentSpeelman Department of Chemistry, Indiana University—Purdue University at Indianapolis, Indianapolis,IN46202,USA OliverSteinbock Institut fu¨r Experimentelle Physik—Biophysik, Universita¨tsplatz 2, Otto-von-Guericke- Universita¨tMagdeburg,Magdeburg,D-39106,Germany Listofcontributors ix TianY.Tsong Department of Biochemistry, Molecular Biology and Biophysics, University of Min- nesota,StPaul,MN55108,USA BettyTuller Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton,FL33431-0991,USA IgorVodyanoy OfficeofNavalResearchEurope,223OldMaryleboneRoad,London,NW15TH,UK JanWalleczek Bioelectromagnetics Laboratory, Department of Radiation Oncology, School of Medi- cine,StanfordUniversity,Stanford,CA94305-5304,USA RobertWorth Department of Neurosurgery, Indiana University—Purdue University at Indianapolis, Indianapolis,IN46202,USA
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