ROLE OF RNA AND DNA IN BRAIN FUNCTION TOPICS IN THE NEUROSCIENCES Other books in the series: Rami Rahamimoff and Sir Bernard Katz, eds.: Calcium, Neuronal Function and Transmitter Release. ISBN 0-89838-791-4. Robert C.A. Frederickson, ed.: Neuroregulation of Autonomic, Endocrine and Immune Systems. ISBN 0-89838-800-7. ROLE OF RNA AND DNA IN BRAIN FUNCTION A Molecular Biological Approach edited by Antonio Giuditta Department of General and Environmental Physiology University of Naples, ITA L Y Barry B. Kaplan Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine, USA Claire Zomzely-Neurath Office of Naval Research London Branch, UNITED KINGDOM Martinus Nijhoff Publishing a member of the Kluwer Academic Publishers Group Boston / Dordrecht / Lancaster Distributors for North America: Kluwer Academic Publishers 101 Philip Drive Assinippi Park Norwell, Massachusetts 02061, USA Distributors for the UK and Ireland: Kluwer Academic Publishers MTP Press Limited Falcon House, Queen Square Lancaster LAI IRN, UNITED KINGDOM Distributors for all other countries: Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 AH Dordrecht, THE NETHERLANDS The picture on the cover originally appeared in KOS magazine, edited by Franco Maria Ricci (via Durini 19, 20122 Milano, Italy) in the issue of January I, 1986, and is reprinted with permission. Library of Congress Cataloging-in-Publication Data Role of RNA and DNA in brain function. (Topics in the neurosciences) Based on the Symposium "Role of DNA in Brain Activity" held in Ravello, Italy on May 27-29, 1985, as a satellite meeting of the 10th Meeting of the International Society for Neurochemistry, held in Riva del Garda, Italy on 19-24 May 1985. Includes indexes. 1. Brain-Congresses. 2. Neurogenetics-Congresses. 3. Gene expression-Congresses. 4. Nerve proteins Congresses. 5. Nucleic acids-Congresses. I. Giuditta, Antonio. II. Kaplan, Barry B. III. Zomzely-Neurath, Claire. IV. Symposium "Role of DNA in Brain Activity" (1985 : Ravello, Italy) V. International Society for Neurochemistry. Meeting (lOth : 1985 : Riva, Italy) VI. Series. [DNLM: 1. Brain-physiology-congresses. 2. DNA-physiology-congresses. 3. RNA-physiology Congresses. QU 58 R7443 1985] QP376.R64 1986 591.1 '88 86-12525 ISBN-13: 978-0-89838-814-5 e-ISBN-13: 978-1-4613-2321-1 001: 10. 1007/978-1-4613-2321-1 Copyright © 1986 by Martinus Nijhoff Publishing Reprint of the original edition 1986 All rights reserved. No part of this publication my be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Martinus Nijhoff Publishing, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061. CONTENTS LIST OF CONTRIBUTORS ix PREFACE xi ACKNOWLEDGEMENTS xiii I. BRAIN GENE PRODUCTS 1. A COMPARATIVE STUDY OF THE DIVERSITY OF GENE EXPRESSION IN BRAIN 1 B.B. Kaplan. A.E. Gioio. C. Perrone Capano and A. Giuditta 2. MESSENGER RNA IN THE BRAIN 10 W.E. Hahn. N. Chaudhari. J. Sikela and G. Owens 3. GENE EXPRESSION IN THE MAMMALIAN BRAIN 23 J.G. Sutcliffe. R.D. McKinnon and A.-P. Tsou 4. EXPRESSION OF BRAIN-SPECIFIC PROTEINS 32 R.J. Milner 5. MESSENGER RNA IS PRESENT IN THE AXOPLASM OF SQUID GIANT AXONS 42 A. Giuditta. T. Hunt. C. Perrone Capano. L. Santella and B.B. Kaplan II. CLONING AND EXPRESSION OF BRAIN GENES 6. MOLECULAR GENETICS OF TYROSINE HYDROXYLASE 57 J. Mallet. A. Berod. F. B1anot. C. Boni. M. Buda. N. Faucon Biguet. B. Grima, Ph. Horellou, J. -F. Julien, A. Lamouroux and J. Powell vi 7. ANALYSIS OF SYNAPSIN I AND G-SUBSTRAT E GENE EXPRESSION BY eDNA CLONING AND IN SITU HYBRIDIZATION HISTOCHEMISTRY 71 L.J. DeGennaro, M. W. Kilimann and C.A. Haas 8. THE EXPRESSION OF MICROTUBULE PROTEINS DURING THE DEVELOPMENT OF THE NERVOUS SYSTEM 81 1. Ginzburg and U. Z. Littauer 9. REGULATION OF EXPRESSION OF THE HUMAN PROENKEPHALIN GENE IN HETEROLOGOUS CELL SYSTEMS 90 E. Herbert, M. Comb, G. Thomas, D. Liston, A. Seasholtz, H. Rosen and B. Thorne 10. THE REGULATION OF PROOPIOMELANOCORTIN GENE EXPRESSION BY ESTROGEN IN THE RAT HYPOTHALAMUS 112 J.L. Roberts, J.N. Wilcox and M. Blum III. THE MOLECULAR BIOLOGY OF NEUROLOGICAL DISEASES 11. DNA ANALYSIS OF DUCHENNE AND BECKER MUSCULAR DYSTROPHIES 123 K.E. Davies, H.R. Dorkins, S. McGlade, S.P. Ball, S. J. Kenwrick, T. Smith, S. Forrest, L. Wilson, 1. Lavenir, A. Speer and Ch. Coutelle 12. GENETIC ANALYSIS OF THE FRAGILE X-MENTAL RETARDATION SYNDROME WITH POLYMORPHIC DNA MARKERS 131 1. Oberli, G. Camerino, B. Arveiler, J. Boue, M. G. Mattei, J.F. Mattei and J.L. Mandel 13. BRAIN MESSENGER RNA IN ALZHEIMER'S DISEASE 142 M.R. Morrison, W.S. T. Griffin and C.L. White, III 14. THE EFFECT OF TRISOMY-21 (DOWN'S SYNDROME) ON BRAIN TRANSCRIPTION 160 L. Lim, C. Hall, T. Leung and S. Whatley vii IV. BRAIN DNA A. Neuronal Chromatin Structure and DNA Content 15. NEURONAL CHROMATIN DURING DEVELOPMENT 174 I.R. Brown 16. POST-TRANSLATIONAL MODIFICATIONS OF CHROMOSOMAL PROTEINS IN NEURONAL AND GLIAL NUCLEI FROM DEVELOPING RAT BRAIN 182 I. Serra and A.M. Giuffrida 17. DNA CONTENT IN NEURONS 197 O. Bernocchi and E. Scherini B. Enzymes Related to DNA Metabolism 18. ENZYMOLOGY OF DNA REPLICATION AND REPA IR IN BRAIN 211 C.c. Kuenzle 19. BRAIN DNases AND THEIR FUNCTIONAL IMPORTANCE 224 K. Subba Rao 20. POLYADP-RIBOSE POLYMERASE AND ADP-RIBOSYLATION REACTION 233 P. Mandel, C. Niedergang, M.E. IUel, H. Thomassin and A. Masmoudi c. DNA Turnover 21. DNA SYNTHESIS AND CELL NUMBER HOMEOSTASIS IN THE BRAIN 247 V. Mares 22. BRAIN DNA CHANGES DURING LEARNING 256 S. Reinis viR 23. ROLE OF DNA IN BRAIN INFORMATION PROCESSING 268 A. Giuditta, M. V. Ambrosini, F. Morelli, C. Perrone Capano, T. Menna, C. Buono, C. Lamberti, A. Cerbone and A. Sadile V. SPECIAL LECTURE 24. RNA AND LEARNING 280 H. Hyden VI. POSTERS 25. MOLECULAR GENETICS OF THE NERVE CELL ADHESION MOLECULE N-CAM: EVIDENCE FOR MULTIPLE, DEVELOPMENTA LLY REGULATED, mRNA SPECIES 294 G. Gennarini, M.R. Hirsch, M. Hirn and C. Goridis 26. THE CHARACTERIZATION OF eDNAs ENCODING BRAIN-SPECIFIC AND UBIQUITOUS mRNA BY HYBRID-SELECTED TRANSLATION 296 C. Hall, T. Leung and L. Lim 27. OPIOID PEPTIDE PRECURSORS IN THE AMPHIBIAN XENOPUS LAEVIS 299 G.J.M. Martens, O. Civelli and E. Herbert 28. SENSITIVE HYBRIDIZATION TECHNIQUES AS POWERFUL TOOLS IN MOLECULAR GENETICS TO IDENTIFY BRAIN-SPECIFIC GENE PRODUCTS 303 T.A. Rhyner, A.A. Borbe/y and J. Mallet 29. MOLECULAR CLONING AND NUCLEOTIDE SEQUENCES OF eDNA AND GENOMIC DNA FOR THE RAT BRAIN S-I00 PROTEIN 308 Y. Takahashi, R. Kuwano, H. Usui, T. Maeda and T. Iwanaga AUTHOR INDEX 313 SUBJECT INDEX 315 LIST OF CONTRIBUTORS G. Bernocchi, Dipartimento di Biologia Animale, Universita di Pavia, Piazza Botta 10, 1-21700 Pavia, Italy I.R. Brown, Department of Zoology, University of Toronto, West Hill, Ontario, MIC lA4 Canada G. Camerino, Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via S. Epifanio 14, 27100 Pavia, Italy K.E. Davies, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, England L.J. DeGennaro, Abteil ung Neurochemie, Max-Pl anck-Inst itut fUr Psi chi atrie, Am Klopferspitz 18A, D-8033 Planegg-Martinsried, FRG G. Gennarini, Centre d' Immunologie INSERM-CNRS, Case 906, F-13288 Marseille, France I. Ginzburg, Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel A. Giudttta, Dipartimento di Fisiologia Generale e Ambientale, Universita di Napoli, Via Mezzocannone 8, 80134 Naploli, Italy A.M. Giuffrida, Istituto di Chimica Biologica, Facolta di Medicina, Universita di Catania, Viale A. Doria 6, 95100 Catania, Italy W.E. Hahn, Department of Anatomy, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, Colorado 80262, USA C. Hall, Department of Neurochemistry, Institute of Neurology, The National Hospital, Queen Square, London WCIN 3BG, England Eo Herbert, Insti tute of Bi omedi cal Research and Department of Bi ochemi stry, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97201, USA H. Hyden, Institute of Neurobiology, Faculty of Medicine, Faculty of Medicine, University of G6teborg, Fack S-400 33 G6teborg 33, Sweden B.B. Kaplan, Molecular Neurobiology Program, Department of Psychiatry, Western Psychiatric Institute & Clinic, 3811 O'Hara Street, Pittsburgh, Pennsylvania 15213, USA c.c. Kuenzle, Institut fUr Pharmakologie und Biochemie, Universitat ZUrich-Irchel, Winterthurerstr 190, CH-8057 ZUrich, Switzerland x L. Lim, Department of Neurochemistry, Institute of Neurology, The National Hospital, Queen Square, London WCIN 3BG, England J. Mallet, Laboratoire de Neurobiologie, Cellulaire et Moleculaire, CNRS, F-9II90 Gif-sur-Yvette, France P. Mandel, Centre de Neurochimie, CNRS, 5 rue Blaise Pascal, F-67084 Strasbourg, France V. Mares, Institute of Physiology, Czechoslovak Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czechoslovakia G.J.M. Martens, Department of Zoology, Faculty of Science, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands R.J. Milner, Division of Preclinical Neuroscience and Endocrinology, Research Institute of Scripps Clinic, 10666 Torrey Pines Road, La Jolla, California 92037, USA M.R. Morrison, Department of Neurology, University of Texas, Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA s. Reinis, Department of Psychology, University of Waterloo, Waterloo, Ontario, N2L 3Gl Canada T. A. Rhyner, Laboratoire de Neurobiologie, Cellulaire et Moleculaire, CNRS, F-91190 Gif-sur-Yvette, France J.l. Roberts, Center for Reproductive Sciences, Columbia University, 630 West 168th Street, New York, New York 10032, USA K. Subba Rao, School of Life Sciences, University of Hyderabad, 500 134 Hyderabad, AP, India J.G. Sutcliffe, Department of Molecular Biology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA Y. Takahashi, Department of Neuropharmacology, Brain Research Institute, Niigata University, Asahimachi I, Niigata City 951, Japan
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