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Questions & Answers About Human Papilloma Virus (HPV) (100 Questions & Answers about) PDF

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Don S. Dizon, MD, FACP, is a 1991 graduate of the University Other books in the 100 Questions & Answers series of Rochester School of Medicine and Dentistry. He trained in Internal Medicine at Yale-New Haven Hospital and in Medical Acne Endometriosis Myelodysplastic Syndromes Oncology at Memorial Sloan-Kettering Cancer Center, where Adult ADHD Epilepsy Myeloma, 2e he received a Career Development Award from the American Advanced and Metastatic Erectile Dysfunction, 2e Osteoporosis and Osteopenia, 2e Breast Cancer Esophageal Cancer, 2e Ovarian Cancer, 2e Society of Clinical Oncology for work on platinum drug resis- Aging Skin Fibromyalgia Overactive Bladder and tance. He later joined the Developmental Therapeutics faculty Alcoholism Gastric Cancer Urinary Incontinence and Gynecology Disease Management Team of Memorial Sloan-Kettering Cancer Allergies Gastroesophageal Reflux Pancreatic Cancer, 2e Center. In 2003 he left New York City and assumed his current role as the Director Alzheimer’s Disease Disease (GERD): A Lahey Panic Disorder, 2e of Medical Oncology for the Program in Women’s Oncology of Women & Infants Anorexia Nervosa Clinic Guide Parkinson Disease, 2e Hospital of Rhode Island. In 2005 he helped establish the state’s first Center for Anxiety Gastrointestinal Stromal Peripheral Artery Disease Arthritis Tumors (GIST) Plastic Surgery Sexuality, Intimacy, and Fertility for women with cancer. In 2005 he was elected Fel- Asthma Head and Brain Injuries Prostate Cancer, 2e low of the American College of Physicians. He also serves as Medical Director of Autism Head and Neck Cancer Prostate Disease the Program’s Integrative Care Program. Nationally, he continues to pursue research Bipolar (Manic-Depressive) Heart Attack and Related Psoriasis, 2e in the novel treatments of both breast and gynecological cancers and is active in the Disorder Cardiac Problems Schizophrenia, 2e Gynecologic Oncology Group, serving on Phase I, Developmental Therapeutics, and Bladder Cancer Hepatitis C: A Lahey Clinic Sinusitis and Other Sinus Bone Marrow and Stem Cell Guide Diseases Cervix committees. Currently he is the President of the National Consortium of Transplantation High Blood Pressure Sleep and Sleep Disorders, 2e Breast Centers. Brain Tumors, 2e (Hypertension) Spine Disorders Breast Cancer, 3e Hip Replacement Sports Nutrition and Exercise Michael L. Krychman, MD, is the Medical Director of Sexual Breast Surgery HIV and AIDS Stroke: A Lahey Clinic Guide Medicine at Hoag Hospital, and the Executive Director of the Breastfeeding How To Quit Smoking Thyroid Disorders Southern California Center for Sexual Health and Survivorship Cancer and Fertility Hysterectomy Valvular Heart Disease Cancer Symptoms and Cancer Infertility von Willebrand Disease Medicine, both located in Newport Beach, CA. He is presently Treatment Side Effects, 2e Influenza Vulvar Cancer and Other Associate Clinical Attending at the University of Southern Cal- Caring for Family or Friends Kidney Cancer Diseases of the Vulva and ifornia and University of California Irvine. He is the former Co- with Cancer, 2e (1e Spanish Kidney Dialysis the Vagina Director of The Sexual Medicine and Rehabilitation Program at version available) Kidney Disease Women Living with Cancer: Memorial Sloan-Kettering Cancer Center and was an associate clinical attending Celiac Disease and SPRUE: A Kidney Disease and A Practical Guide for Lahey Clinic Guide Hypertension Survivorship faculty member at Cornell-Weil Medical School in New York City. Dr. Krychman Cervical Cancer Leukemia, 2e Women’s Sexual Wellness and holds licenses from 3 states (CA, PA, NY), and is a board certified OB/GYN. He is a Childhood Immunizations Life After Cancer: A Survivor’s Vitality clinical sexologist and AASECT-certified sexual counselor, with a Masters in Public Chronic Illness Guide Your Child’s ADHD Health and Human Sexuality. Fluent in French and English, Dr. Krychman obtained Chronic Obstructive Pulmonary Liver Cancer, 2e Your Child’s Asthma his doctorate in medicine and masters in surgery from McGill University School of Disease (COPD) Liver Transplantation: A Your Child’s Cancer Medicine in Montreal, where he was named a “Great Distinction Medical Scholar.” Colorectal Cancer, 2e Lahey Clinic Guide Your Child’s Depression and Communicating with your Lung Cancer, 2e Bipolar Disorder Dr. Krychman’s clinical interests include sexual pain disorders, loss of libido, chronic Healthcare Provider Lymphedema Your Child’s Epilepsy medical illness, as well as breast cancer sexuality. He has a special interest in survivor- Congestive Heart Failure Lymphoma, 2e Your Child’s Obesity ship medicine, which focuses on reduction of recurrence, risk reduction, and optimiz- Crohn’s Disease and Ulcerative Macular Degeneration Your Child’s Obsessive ing general health while maximizing quality of life. He is a well-known speaker who Colitis: A Lahey Clinic Melanoma and Other Skin Compulsive Disorder is featured locally, nationally, and internationally. Dr. Krychman is on the editorial Guide, 2e Cancers Your Child’s Schizophrenia Deep Vein Thrombosis and Men’s Health Your Digestive Health: A Lahey board for the Journal of Sexual Medicine, Current Sexual Medicine Reports, and serves Pulmonary Embolism Menopause Clinic Guide as a reviewer on many other sexual medicine journals. Dr. Krychman is a committee Depression, 2e Mesothelioma, 2e Your High-Risk Pregnancy member of the International Conference on Sexual Medicine in Paris 2009 and was Diabetes Migraine, 2e Your Sports Injury the guest professor for human sexuality in Oxford, England. He has been featured in Eating Disorders Multiple Sclerosis the New York Times, US News and World Report, The Wall Street Journal, Health Maga- zine, Marie Claire, Coast, Cosmopolitan, and many others. He has also been on “Better in Bed” with Dr. Laura Berman on Oprah radio several times and is often featured in the media. www.jbpub.com 81620_FMxx_FINAL.QXP 1/15/10 11:14 AM Page i Questions & Answers About Human Papilloma Virus (HPV) Don S. Dizon, MD, FACP Program in Women’s Oncology Women & Infants Hospital of Rhode Island The Warren Alpert Medical School of Brown University Providence, RI Michael L. Krychman, MD Medical Director of Sexual Medicine, Hoag Memorial Hospital Presbyterian Executive Director of the Southern California Center for Sexual Health and Survivorship Medicine Associate Clinical Professor, University of Southern California AASECT Certified Sexual Counselor 81620_FMxx_FINAL.QXP 1/15/10 12:00 PM Page ii World Headquarters Jones and Bartlett Publishers Jones and Bartlett Publishers Jones and Bartlett Publishers 40 Tall Pine Drive Canada International Sudbury, MA 01776 6339 Ormindale Way Barb House, Barb Mews 978-443-5000 Mississauga, Ontario L5V 1J2 London W6 7PA [email protected] Canada United Kingdom www.jbpub.com Jones and Bartlett’s books and products are available through most bookstores and online book- sellers. To contact Jones and Bartlett Publishers directly, call 800-832-0034, fax 978-443-8000, or visit our website, www.jbpub.com. Substantial discounts on bulk quantities of Jones and Bartlett’s publications are available to corporations, professional associations, and other qualified organizations. For details and specific discount information, contact the special sales department at Jones and Bartlett via the above contact information or send an email to [email protected]. Copyright © 2011 by Jones and Bartlett Publishers, LLC All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission from the copyright owner. The authors, editor, and publisher have made every effort to provide accurate information. However, they are not responsible for errors, omissions, or for any outcomes related to the use of the contents of this book and take no responsibility for the use of the products and procedures described. Treatments and side effects described in this book may not be applicable to all people; likewise, some people may require a dose or experience a side effect that is not described herein. Drugs and medical devices are discussed that may have limited availability controlled by the Food and Drug Administration (FDA) for use only in a research study or clinical trial. Research, clinical practice, and government regulations often change the accepted standard in this field. When consideration is being given to use of any drug in the clinical setting, the healthcare provider or reader is responsible for determining FDA status of the drug, reading the package insert, and reviewing prescribing information for the most up-to-date recommendations on dose, precautions, and contraindications, and determining the appropriate usage for the product. This is especially important in the case of drugs that are new or seldom used. Production Credits Executive Publisher: Christopher Davis Cover Design: Carolyn Downer Editorial Assistant: Sara Cameron Cover Images: © Jason Stitt/ Associate Production Editor: Leah Corrigan ShutterStock, Inc., © Monkey Business Senior Marketing Manager: Barb Bartoszek Images/Dreamstime.com, © Monkey Manufacturing and Inventory Supervisor: Business Images/Dreamstime.com Amy Bacus Printing and Binding: Malloy, Inc. Composition: Glyph International Cover Printing: Malloy, Inc. Library of Congress Cataloging-in-Publication Data Dizon, Don S. Questions & answers about human papilloma virus (HPV) / Don S. Dizon, Michael L. Krychman. p. cm. Includes index. ISBN 978-0-7637-8162-0 (alk. paper) 1. Papillomavirus diseases—Miscellanea. 2. Papillomaviruses—Miscellanea. 3. Generative organs—Infections—Miscellanea. I. Krychman, Michael L. II. Title. III. Title: Questions and answers about human papilloma virus (HPV). RC168.P15D59 2011 616.9’11—dc22 2009052706 6048 Printed in the United States of America 14 13 12 11 10 10 9 8 7 6 5 4 3 2 1 81620_FMxx_FINAL.QXP 1/15/10 11:14 AM Page iii Dedication As always, I want to thank my publisher, Chris Davis, and friends at Jones and Bartlett for the opportunity to collaborate with Michael on this book.This book is dedicated to my spouse, Henry, and our children, Isabelle, Harrison, and Sophia, who are my support and inspiration for the work I do. I also want to dedicate it to the best parents in the world, Millionita and Modesto Dizon, who gave me every opportunity in the world to succeed from our little island in the South Pacific. This is also for my sisters, Michelle, Maerica, Precy, and Marie; their husbands, Mel, Ben, and Ed; and my niece and nephew, Stella and Jude. Lastly, I want to dedicate this to the people on my home island of Guam. Although far away, it will always be home to me. —Don S.Dizon,MD,FACP To my healthcare team, I thank you for your support. For my par- ents, the Franconis and Krychmans—a special thank you for the unconditional encouragement during my career. To my co-author Don Dizon, I am thankful for our friendship and am honored to have you as an esteemed colleague in oncology and sexual medi- cine. To my good friend and colleague, Susan, who has always encouraged me— your friendship has been a source of inspiration. For Bryanna, I hope all this talk about HPV has not completely scared you. Thank you to Chris Davis and the Jones and Bartlett team for their hard work and dedication. And last but not least, for all the men and women, young and old, married, single, divorced, heterosexual and homosexual, who are desperate for education about HPV, its effects, and its treat- ment.I do hope this book can help ease the suffering and distress. —Michael L.Krychman,MD 81620_FMxx_FINAL.QXP 1/15/10 11:14 AM Page iv 81620_FMxx_FINAL.QXP 1/15/10 11:14 AM Page v Contents Introduction ix Part 1:The Basics 1 Questions 1–7explain the basics of a virus and how it can affect the human body: • What is a virus? • Do viruses infect humans in the same way? • How do viruses make humans sick once they enter the body? Part 2:Basics About HPV 7 Questions 8–15introduce basic facts about the Human Papilloma Virus, including: • How is HPV spread? • What kinds of diseases are caused by HPV? • How can you test for HPV? Part 3:HPV and Cervical Disease 19 Questions 16–19discuss the relationships between HPV and other cervical diseases: • What is cervical dysplasia? • Are there different types of dysplasia? • How is it treated? Part 4:HPV and Genital Warts 25 Questions 20–26review genital warts, including their diagnosis and treatment options: • What are external genital warts (EGW)? • How are warts treated? • Are there non-surgical therapies for wart treatment? 81620_FMxx_FINAL.QXP 1/15/10 11:14 AM Page vi QUESTIONS & ANSWERS ABOUT HUMAN PAPILLOMA VIRUS (HPV) Part 5:HPV and Cervical Cancer 31 Questions 27–34discuss the relationship between cervical cancer and HPV: • What exactly is cervical cancer? • How big of a problem is cervical cancer? • How is cervical cancer treated? Part 6:HPV and Vaginal Cancer 39 Questions 35–41explain the basics of vaginal cancer: • How common is vaginal cancer? • How is vaginal cancer diagnosed? • How is it staged? Part 7:HPV and Vulvar Cancer 43 Questions 42–49discuss the symptoms and treatment options available for those diagnosed with vulvar cancer: • How do women present with vulvar cancer? • Is there a precancerous lesion of the vulva? • What is the primary treatment for vulvar cancer? Part 8:HPV and Penile Cancer 49 Questions 50–56discuss the relationship between penile cancer in men and HPV: • What are the symptoms of penile cancer? • How common is cancer of the penis? • Can it be prevented? Part 9:HPV and Anal Cancer 55 Questions 57–60provide an overview of anal cancer as it relates to HPV: • What are some of the signs or symptoms of anal cancer? • How is it diagnosed? • How is it treated? Part 10:HPV and Head and Neck Cancers 61 Questions 61–66discuss how HPV and different head and neck cancers are associated: • What are the signs and symptoms of head and neck cancers? • How are they staged? • How are head and neck cancers treated? vi 81620_FMxx_FINAL.QXP 1/15/10 11:14 AM Page vii QUESTIONS & ANSWERS ABOUT HUMAN PAPILLOMA VIRUS (HPV) Part 11:Prevention and Education 69 Questions 67–75present important information regarding the prevention of HPV and associated cancers: C • What should I tell my partner about being HPV positive? o n • I would like to prevent HPV-associated cancers. What can I do? t e n • If I am pregnant, will being HPV positive be a factor in the delivery t s of my baby? Part 12:HPV Vaccination:What You Should Know 81 Questions 76–89explain common misconceptions and inquiries regarding the HPV vaccination: • What is the cervical cancer vaccine? • What are the side effects to the vaccine? • How long are you protected after you’ve had the vaccine? Glossary 93 Index 97 vii 81620_FMxx_FINAL.QXP 1/15/10 11:14 AM Page viii

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Written by two expert physicians in the field, Questions & Answers About Human Papilloma Virus(HPV) provides authoritative answers to the most commonly asked questions about HPV. This concise guide features current, easy-to-understand information on the virus, related cancers and other diseases, vac
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