Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats

404 Pages·2022·11.513 MB·English

by  Jaanus Harro

Neuromethods 190
Jaanus Harro Editor
Psychiatric
Vulnerability,
Mood, and Anxiety
Disorders
Tests and Models in
Mice and Rats
N
EUROMETHODS
SeriesEditor
Wolfgang Walz
University ofSaskatchewan
Saskatoon, SK,Canada
Forfurther volumes:
http://www.springer.com/series/7657
Neuromethodspublishescutting-edgemethodsandprotocolsinallareasofneuroscienceas
wellastranslationalneurologicalandmentalresearch.Eachvolumeintheseriesofferstested
laboratoryprotocols,step-by-stepmethodsforreproduciblelabexperimentsandaddresses
methodologicalcontroversiesandpitfallsinordertoaidneuroscientistsinexperimentation.
Neuromethodsfocusesontraditionalandemergingtopicswithwide-rangingimplicationsto
brain function, such as electrophysiology, neuroimaging, behavioral analysis, genomics,
neurodegeneration,translationalresearchandclinicaltrials.Neuromethodsprovidesinvesti-
gators and trainees with highly useful compendiums of key strategies and approaches for
successful research in animal and human brain function including translational “bench to
bedside”approachestomentalandneurologicaldiseases.
Psychiatric Vulnerability, Mood,
and Anxiety Disorders
Tests and Models in Mice and Rats
Edited by
Jaanus Harro
Chair of Neuropsychopharmacology, Institute of Chemistry, University of Tartu, Tartu, Estonia
Editor
JaanusHarro
ChairofNeuropsychopharmacology,
InstituteofChemistry
UniversityofTartu
Tartu,Estonia
ISSN0893-2336 ISSN1940-6045 (electronic)
Neuromethods
ISBN978-1-0716-2747-1 ISBN978-1-0716-2748-8 (eBook)
https://doi.org/10.1007/978-1-0716-2748-8
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Preface to the Series
Experimental life sciences have two basic foundations: concepts and tools. The Neuro-
methods series focuses on the tools and techniques unique to the investigation of the
nervous system and excitable cells. It will not, however, shortchange the concept side of
thingsascarehasbeentakentointegratethesetoolswithinthecontextoftheconceptsand
questions under investigation. In this way, the series is unique in that it not only collects
protocols but also includes theoretical background information and critiques which led to
themethodsandtheirdevelopment.Thus,itgivesthereaderabetterunderstandingofthe
origin of the techniques and their potential future development. The Neuromethods
publishing program strikes a balance between recent and exciting developments like those
concerningnewanimalmodelsofdisease,imaging,invivomethods,andmore established
techniques, including, for example, immunocytochemistry and electrophysiological tech-
nologies.Newtraineesinneurosciencesstillneedasoundfootingintheseoldermethodsin
order toapplyacriticalapproachtotheir results.
Under theguidanceofitsfounders,AlanBoultonandGlenBaker,theNeuromethods
serieshasbeenasuccesssinceitsfirstvolumepublishedthroughHumanaPressin1985.The
seriescontinuestoflourishthroughmanychangesovertheyears.Itisnowpublishedunder
theumbrellaofSpringerProtocols.Whilemethodsinvolvingbrainresearchhavechangeda
lot since theseriesstarted, thepublishingenvironmentand technologyhavechanged even
more radically. Neuromethods has the distinct layout and style of the Springer Protocols
program,designedspecificallyfor readabilityandeaseofreferenceinalaboratorysetting.
Thecarefulapplicationofmethodsispotentiallythemostimportantstepintheprocess
of scientific inquiry. In the past, new methodologies led the way in developing new dis-
ciplines in the biological and medical sciences. For example, physiology emerged out of
anatomyinthenineteenthcenturybyharnessingnewmethodsbasedonthenewlydiscov-
eredphenomenonofelectricity.Nowadays,therelationshipsbetweendisciplinesandmeth-
ods are more complex. Methods are now widely shared between disciplines and research
areas. New developments in electronic publishing make it possible for scientists that
encounter new methods to quickly find sources of information electronically. The design
of individual volumes and chapters in this series takes this new access technology into
account. Springer Protocols makes it possible to download single protocols separately. In
addition, Springer makes its print-on-demand technology available globally. A print copy
canthereforebeacquiredquicklyandforacompetitivepriceanywhereintheworld.
Saskatoon,SK,Canada WolfgangWalz
v
Preface
Worldwide, mood and anxiety disorders place the largest burden on mental health, and in
turn,disordersofthebrainarethelargestsourceofhealthlossacrossalldiseases.Ourability
tocombatthesepsychiatricdisordershasgrownwitheachdecade,andourunderstandingof
the underlying genetics and neurobiology is improving and much facilitated by recent
technologicaladvances.Nonetheless,thereisamajorperceivedunmetneedinthemanage-
mentofmoodandanxietydisordersandconsequentlyamassiveresearcheffort,asreflected
in the accelerating growth of the number of scientific publications. Such an expansive
growth is also well observable in animal modelling literature. It is a both gratifying and
worrisome trend, the former because animal models provide the necessary molecular and
cellularprecision, thelatter becauseexpansioncan gowithreduction ofrigourinmethod-
ology.Theappropriateuseofmethodsishowevereverimportantlestthedisappointmentof
lay public, and drug regulation authorities with the perceived slow growth of innovation
wereattributedtoanimalmodels.
Additionallytothecontinueduseofmanytraditionalanimaltestsandmodels,techno-
logical conceptual advances have taken place since the two previous successful volumes
edited by Todd Gould for Neuromethods. Several novel techniques now becoming com-
monplace in neuroscience will permit to elicit and monitor behaviour with high precision.
These have also helped to raise the role of the rat as an experimental animal closer to the
range it occupied before the rise of the mighty mouse. This also makes it necessary to
reconsider the classic tests and models that have helped us to where we are now. Genetic
studies in human patients and careful observation of animals in mood and anxiety models
convergein thesuggestion that vulnerabilityand resilience factorsshould beincludedinto
modeling.Thus,thiscollectionofchapterswillrefreshtheviewonclassictestsandmodels
and proceed to include novel methods likely to aid in understanding mood and anxiety
disorders and foster precision medicine. The authors are world-renowned scientists who
have made important discoveries by means of using the models they describe in detail.
Behaviour is complex, so the background sections bear particular importance. It is never-
theless the careful description of how to plan and conduct the experiments and how to
interprettheresultsthatdistinguishesthisbook.Godisinthedetail.
Tartu,Estonia JaanusHarro
vii
Contents
PrefacetotheSeries ........................................................... v
Preface ..................................................................... vii
Contributors................................................................. xi
1 AnimalModelsofMoodandAnxietyDisorders:ThePursuit
ofStandardizationandRecognitionoftheComplexNeurobiology
ofHumanMentalHealth........... ....... ....... ........ ....... ........ 1
JaanusHarro
2 TheOpenFieldTest ....... ........ ....... ....... ........ ....... ........ 9
VooteleV˜oikarandS.ClareStanford
3 TheLight–DarkBoxTestintheMouse ..... ....... ........ ....... ...... .. 31
SolalBlochandCatherineBelzung
4 TheOlfactoryBulbectomizedRodentRemainsaValuablePreclinical
ModelofDepressionandAntidepressantActivity.... ........ ....... ........ 43
MichelleRocheandJohnP.Kelly
5 MarbleBuryinginMice .... ........ ....... ....... ........ ....... ........ 71
JeffreyM.WitkinandJodiL.Smith
6 HowtheSucrosePreferenceSucceedsorFailsasaMeasurement
ofAnhedonia....... ....... ........ ..... .. ...... ....... .. .... ... ........ 89
TatyanaStrekalova
7 AVogelConflictTestUsingFoodReinforcementinMice .... ....... ........ 103
JeffreyM.WitkinandJodiL.Smith
8 FearConditioninginLaboratoryRodents .......... ........ ....... ........ 119
IrisMu¨llerandMarkusFendt
9 LearnedHelplessnessinRodents .... ....... ....... ........ ....... .. ...... 161
KenniaMouraSilveiraandSaˆmiaJoca
10 ChronobiologyofMoodStates:IntroducingCircadian
AnimalModels ..... ....... ........ ....... ....... ........ ....... ........ 185
JorgeMendoza,No¨emiBillon,GuillaumeVanotti,andVivianePallage
11 TelemetryinRatsandMice:MethodologicalConsiderationsandExample
StudiesofStressandAnxietyinGround-BasedSpaceflightAnalogs........... 201
LaurieL.Wellman,AustinM.Adkins,HargsoonYoon,
RichardA.Britten,andLarryD.Sanford
12 UtilityandImplementationofOralCorticosteroidExposure
inBehavioralNeuroscienceResearchwithRodents .......... ....... ........ 223
MichelleK.Sequeira,JaneR.Taylor,andShannonL.Gourley
13 AnimalModelsforMania........... ..... .. ....... ........ ....... ........ 233
KirstenSchmerderandNadjaFreund
14 SocialBehaviorTestinginMice:SocialInterest,Recognition,
andAggression..... ....... ........ ....... ....... ........ ....... ........ 279
AmyE.Clipperton-AllenandDamonT.Page
ix
x Contents
15 RodentModelsforStudyingtheImpactofVariationinEarlyLife
Mother–InfantInteractionsonMoodandAnxiety........... ....... ........ 309
HannahE.LappandFrancesA.Champagne
16 PrinciplesofRecordingRodentUltrasonicVocalizations ..... ....... ........ 329
StefanM.BrudzynskiandSylvieGranon
17 DevelopmentofaSelectively-BredMouseModelofDominance
andSubmissiveness:TechnicalConsiderations....... ........ ....... ........ 353
AlbertPinhasov,ElenaShmerkin,LevLibergod,MichaelKirby,
OryanAgranyoni,LiudmilaVinnikova,andDebpaliSur
18 PredictionofSusceptibility/ResilienceTowardAnimalModels
ofPost-traumaticStressDisorder(PTSD) .......... ........ ....... ........ 379
MariaMorena,GiuliaFedericaMancini,andPatriziaCampolongo
Index ...................................................................... 397
Contributors
AUSTIN M.ADKINS (cid:129) SleepResearchLab,Center forIntegrativeNeuroscienceand
InflammatoryDiseases,PathologyandAnatomy,EasternVirginiaMedicalSchool,
Norfolk,VA,USA
ORYANAGRANYONI (cid:129) DepartmentofMolecularBiologyandAdelsonSchoolofMedicine,Ariel
University,Ariel,Israel
CATHERINEBELZUNG (cid:129) UMR1253,iBrain,Universite´deTours,Inserm,Tours,France
NOE¨MIBILLON (cid:129) InstituteofCellularandIntegrativeNeurosciences,CNRSUPR-3212
UniversityofStrasbourg,Strasbourg,France
SOLALBLOCH (cid:129) UMR1253,iBrain,Universite´deTours,Inserm,Tours,France
RICHARDA.BRITTEN (cid:129) Center forIntegrativeNeuroscienceandInflammatoryDiseases,
EasternVirginiaMedicalSchool,Norfolk,VA,USA
STEFANM.BRUDZYNSKI (cid:129) DepartmentofPsychology,BrockUniversity,St.Catharines,ON,
Canada
PATRIZIACAMPOLONGO (cid:129) DepartmentofPhysiologyandPharmacology,SapienzaUniversity
ofRome,Rome,Italy;NeuropsychopharmacologyLaboratory,EuropeanCenter forBrain
Research,SantaLuciaFoundation,Rome,Italy
FRANCES A.CHAMPAGNE (cid:129) DepartmentofPsychology,UniversityofTexasatAustin,Austin,
TX,USA
AMYE.CLIPPERTON-ALLEN (cid:129) DepartmentofNeuroscience,UFScrippsBiomedicalResearch,
Jupiter,FL,USA
MARKUSFENDT (cid:129) InstituteforPharmacologyandToxicology,Otto-von-GuerickeUniversity
Magdeburg,Magdeburg,Germany;Center forBehavioralBrainSciences,Otto-von-
GuerickeUniversityMagdeburg,Magdeburg,Germany
NADJA FREUND (cid:129) ResearchDivisionExperimentalandMolecularPsychiatry,LWL
UniversityHospital,Ruhr-UniversityBochum,Bochum,Germany;Departmentof
Psychiatry,PsychotherapyandPreventiveMedicine,Ruhr-UniversityBochum,Bochum,
Germany
SHANNONL.GOURLEY (cid:129) DepartmentsofPediatricsandPsychiatry,EmoryUniversitySchool
ofMedicine,EmoryNationalPrimateResearchCenter,Atlanta,GA,USA
SYLVIEGRANON (cid:129) CNRS,InstitutdesNeurosciencesParis-Saclay,Universite´Paris-Saclay,
Gif-sur-Yvette,France
JAANUSHARRO (cid:129) ChairofNeuropsychopharmacology,InstituteofChemistry,Universityof
Tartu,Tartu,Estonia;PsychiatryClinic,NorthEstoniaMedicalCentre,Tallinn,Estonia
SAˆMIAJOCA (cid:129) SchoolofPharmaceuticalSciencesofRibeiraoPreto,UniversityofSa˜oPaulo,
Sa˜oPaulo,Brazil;DepartmentofBiomedicine,AarhusUniversity,Aarhus,Denmark
JOHNP.KELLY (cid:129) GalwayNeuroscienceCentre,UniversityofGalway,Galway,Ireland;
PharmacologyandTherapeutics,SchoolofMedicine,UniversityofGalway,Galway,Ireland
MICHAELKIRBY (cid:129) DepartmentofMolecularBiologyandAdelsonSchoolofMedicine,Ariel
University,Ariel,Israel
HANNAHE.LAPP (cid:129) DepartmentofPsychology,UniversityofTexasatAustin,Austin,TX,
USA
LEVLIBERGOD (cid:129) DepartmentofMolecularBiologyandAdelsonSchoolofMedicine,Ariel
University,Ariel,Israel
xi