Protecting the Frontline in Biodefense Research: The Special Immunizations Program

185 Pages·2011·0.88 MB·English

by  Committee on Special Immunizations Program for Laboratory Personnel Engaged in Research on Countermeasures for Select Agents and National Research Council

PROTECTING THE FRONTLINE IN
BIODEFENSE
RESEARCH
The Special Immunizations Program
Committee on Special Immunizations Program for Laboratory Personnel
Engaged in Research on Countermeasures for Select Agents
Board on Life Sciences
Division on Earth and Life Studies
THE NATIONAL ACADEMIES PRESS 500 Fifth Street NW Washington, DC 20001
NOTICE: The project that is the subject of this report was approved by the Governing
Board of the National Research Council, whose members are drawn from the councils
of the National Academy of Sciences, the National Academy of Engineering, and the
Institute of Medicine. The members of the committee responsible for the report were
chosen for their special competences and with regard for appropriate balance.
This project was supported by Contract HHSP23320042509XI (Task Order
HHSP23337007T) between the National Academy of Sciences and the Department of
Health and Human Services. The content of this publication does not necessarily refect
the views or policies of the Department of Health and Human Services, nor does men-
tion of trade names, commercial products, or organizations imply endorsement by the
U.S. government.
International Standard Book Number-13: 978-0-309-20924-3
International Standard Book Number-10: 0-309-20924-2
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COMMITTEE ON SPECIAL IMMUNIZATIONS PROGRAM
FOR LABORATORY PERSONNEL ENGAGED IN RESEARCH
ON COUNTERMEASURES FOR SELECT AGENTS
DONALD S. BURKE (Chair), Dean, Graduate School of Public Health;
UPMC-Jonas Salk Chair in Global Health; Associate Vice Chancellor for
Global Health; and Director, Center for Vaccine Research, University of
Pittsburgh, Pittsburgh, Pennsylvania
W. EMMETT BARKLEY, President, Proven Practices, Bethesda, Maryland
GERARDO CHOWELL, Assistant Professor, School of Human Evolution
and Social Change, Arizona State University; Research Associate, Fogarty
International Center, U.S. National Institutes of Health, Tempe, Arizona
ALAN S. CROSS, Professor of Medicine, Center for Vaccine Development,
University of Maryland School of Medicine, Baltimore, Maryland
STEPHEN W. DREW, President, Drew Solutions LLC, Summit, New Jersey
KATHRYN M. EDWARDS, Sarah Sell Professor of Pediatrics; Director,
Vanderbilt Vaccine Research Program, Vanderbilt University, Nashville,
Tennessee
ROBERT J. HAWLEY, Independent Consultant, Biological Safety,
1
Biosecurity and Biosurety Issues, Frederick, Maryland
THOMAS G. KSIAZEK, Professor, Department of Pathology and
Department of Microbiology and Immunology; Director, National
Biodefense Training Center; Senior Staff Scientist and Director,
High Containment Operations Core, Galveston National Laboratory,
University of Texas Medical Branch at Galveston, Galveston, Texas
THOMAS P. MONATH, Partner, Pandemic and Biodefense Fund, Kleiner
Perkins Caufeld and Byers; Adjunct Professor, Harvard School of Public
Health, Cambridge, Massachusetts
PETER A. PATRIARCA, Senior Clinical Consultant, Biologics Consulting
Group, Inc., Bethesda, Maryland
HOLLY A. TAYLOR, Assistant Professor, Department of Health Policy and
Management, Bloomberg School of Public Health; Core Faculty, Berman
Institute of Bioethics, Johns Hopkins University, Baltimore, Maryland
THOMAS E. WALTON, Former Associate and Acting Deputy
Administrator for Veterinary Services, Animal and Plant Health
Inspection Service, U.S. Department of Agriculture (retired), Eloy,
Arizona
1
Senior Advisor, Science, Midwest Research Institute, Frederick, Maryland, until April 2011
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Staff
KATHERINE BOWMAN, Study Director and Senior Program Offcer
ADAM FAGEN, Study Director and Senior Program Offcer (until June
2010)
CARL-GUSTAV ANDERSON, Program Associate
NORMAN GROSSBLATT, Senior Editor
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BOARD ON LIFE SCIENCES
KEITH R. YAMAMOTO (Chair), University of California, San Francisco,
California
BONNIE L. BASSLER, Princeton University, Princeton, New Jersey
VICKI L. CHANDLER, Gordon and Betty Moore Foundation, Palo Alto,
California
SEAN EDDY, Howard Hughes Medical Institute, Janelia Farm Research
Campus, Ashburn, Virginia
MARK D. FITZSIMMONS, John D. and Catherine T. MacArthur
Foundation, Chicago, Illinois
DAVID R. FRANZ, Midwest Research Institute, Frederick, Maryland
DONALD E. GANEM, University of California, San Francisco, California
LOUIS J. GROSS, University of Tennessee, Knoxville, Tennessee
JO HANDELSMAN, Yale University, New Haven, Connecticut
CATO T. LAURENCIN, University of Connecticut Health Center,
Farmington, Connecticut
BERNARD LO, University of California, San Francisco, California
ROBERT M. NEREM, Georgia Institute of Technology, Atlanta, Georgia
CAMILLE PARMESAN, University of Texas, Austin, Texas
MURIEL E. POSTON, Skidmore College, Saratoga Springs, New York
ALISON G. POWER, Cornell University, Ithaca, New York
BRUCE W. STILLMAN, Cold Spring Harbor Laboratory, Cold Spring
Harbor, New York
CYNTHIA WOLBERGER, Johns Hopkins University School of Medicine,
Baltimore, Maryland
MARY WOOLLEY, Research!America, Alexandria, Virginia
Staff
FRANCES E. SHARPLES, Director
JO L. HUSBANDS, Scholar/Senior Project Director
JAY B. LABOV, Senior Scientist/Program Director for Biology Education
KATHERINE BOWMAN, Senior Program Offcer
MARILEE K. SHELTON-DAVENPORT, Senior Program Offcer
INDIA HOOK-BARNARD, Program Offcer
ANNA FARRAR, Financial Associate
CARL-GUSTAV ANDERSON, Program Associate
AMANDA MAZZAWI, Senior Program Assistant
SAYYEDA AYESHA AHMED, Senior Program Assistant
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Acknowledgments
This report has been reviewed in draft form by individuals chosen for their
diverse perspectives and technical expertise in accordance with procedures
approved by the National Research Council’s Report Review Committee. The
purpose of the independent review is to provide candid and critical comments
that will assist the institution in making its published report as sound as pos-
sible and to ensure that the report meets institutional standards of objectivity,
evidence, and responsiveness to the study charge. The review comments and
draft manuscript remain confdential to protect the integrity of the deliberative
process. We thank the following individuals for their review of this report:
R. Mark Buller, Saint Louis University School of Medicine
Arturo Casadevall, Albert Einstein College of Medicine of Yeshiva
University
Janet Garber, Garber Consulting, LLC
Adolfo García-Sastre, Mount Sinai School of Medicine
John Grabenstein, Merck & Co., Inc.
Barbara Johnson, Johnson & Associates, LLC
Gigi Kwik Gronvall, University of Pittsburgh Medical Center
Steven Projan, MedImmune
Pierre Rollin, Centers for Disease Control and Prevention
Although the reviewers listed above have provided many constructive
comments and suggestions, they were not asked to endorse the conclusions
or recommendations nor did they see the fnal draft of the report before its
release. The review of this report was overseen by Adel Mahmoud, Princeton
University. Appointed by the National Research Council, he was responsible
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