Table Of Content

AUTHOR INDEX Adams,S. 347 Durham, S.K. 93 Allander,S. V. 93, 159 Dye, S. 367 Allouche,M. 35 Andress,D.L. 337 Ehrenborg,E. 159 Ankrapp,D.K. 357 Anzo,M. 457 Farley,J.R. 465 Arai,T. 357 Fauser,B.C.J.M. 397 Arvigo, A. 231 Fernihough, J. 293 Aso,T. 457 Firth,S.M. 215, 223 Flick-Smith,H.C. 367 Bach,L.A. 329 Flint,D. 409 Bagi,C. 347 Fowlkes, J.L. 255 Ballard, F.J. 385 Franks,S. 293 Bang, P. 285 Froesch,E.R. 167 Barber,M. 409 Fujii, K. 457 Barreca, A. 231 Barritault,D. 25 Gallaher,B.W. 189 Baxter,R.C. 141,215, 223,475 Garrouste,F.L. 197 Baylink,D.J. 465 Giordano,G. 231 Beers, T. 273 Giudice,L.C. 397 Bikfalvi, A. 35 Gluckman, P.D. 189 Binoux,M. 311 Gosteli-Peter,M. A. 167 Bloemen,R. 377 Green, B. 437 Blum, W.F. 481 Grewal, A. 437 Boisclair, Y.R. 151 Groyer,A. 103 Braulke, T. 175, 265 Gucev,Z. 503 Breier,B.H. 189 Brismar,K. 449 Hampton, A. 293 Busby, W.H. 357 Harding, J.E. 189 Hartmann, H. 175 Cadepond, F. 103 Harvey,M.B. 1 Caruelle,D. 25 Hasegawa, T. 457 Cataldo, N.A. 397 Hasegawa, Y. 457 Cerro,J.A. 437 Henninghausen,L. 433 Chambéry,D. 103 Hilding, A. 449 Chandrasekher, Y.A . 397 Hill,R. A. 367 Chu,S. 347 Hintz,R.L. 79 Clarke,J.B. 357 Holly, J.M.P. 293 Clarke, N.M. 475 Hoogerbrugge,C. 377 Claussen,M. 265 Hsieh,S. 151 Clemmons, D.R. 319, 357 Huynh Hung 495 Cohen, F.J. 151 Cohen, P. 273 Jibard,N. 103 Conover,C. A. 301 Jones, J.1. 319, 357 Courty,J. 25 Cwyfan Hughes, S.C. 293 Kam Chan 209 Czick,M. 437 Karas,M. 513 Katz,L. 273 D’Ercole, A.J. 417 Kaye,P.L. 1 Dai,Z. 417 Kleinman, D. 513 Danilenko,M. 513 Konii,H. 457 Delbé, J. 25 Kotoh,S. 457 DeLeon,L. 347 Delhanty,P.J.D. 141 Laaroubi,K. 25 Doerr,M.E. 319 Lacson,R. 119 Donnelly, M.J. 293 Lalou,C. 311 Dunshea, F.R. 385 Lassarre,C. 311 AUTHOR INDEX Lee,C. ¥. 241 Saftig, P. 265 LeRoith,D. 433,513 Scharf, J.-G. 175 Levison,S.W. 181 Scheimann, A. O. Levy, J. 513 Schlapfer, I. 167 Lewitt,M.S. 475 Schmid, Ch. 167 Lindgren, B. 449 Schmidt, B. 265 Liu,C. 347 Schmidt,D. 347 Logan, A. 409 Schuller, A. 437 Luthman,H. 159 Schweizer-Groyer, Scott, F.P. 475 Mason,H.D. 293 Sengupta, P. 119 Mehls,O. 481 Serra,D.M. 255 Minuto, F. 231 Seto,D. 151 Mohan, S. 465 Sharoni, Y. 513 Molnar, P. 425 Solberg, P. 273 Moore, J. 347 Sommer, A. 347 Miiller,H.L. 503 Spencer,E.M. 209 Murphy, L.J. 425 Suh, D.-S. 131 Suwanichkul, A. 93 Nagase,H. 255 Suzuki, K. 255 Nam, T.J. 34 Neau,E. 103 Thrailkill,K.M. 255 Neifer,K. 265 Tonner, E. 409 Neuenschwander, S. 433 Ténshoff, B. 481 Ng,L. 503 Travers,M. 409 Ngyuen,H. 119 Tripier,S.G. 197 Nunn, $8. 273 Tsuchiya, Y. 457 O’Donnell,S.L. 181 Unterman,T. 119 Oehler,D. 119 Oh, Y. 503 Vacherot, F. 25 Ooi,G.T. 131, 151 Van den Brande, J.L. 377 Voci, A. 231 Pell, J. M. 367 van Buul-Offers,S. 377 Peters,C. 265 van Dessel, H.J.H.M. 397 Pintar, J.E. 437 van der Stappen, J. 293 Pollak, M. 495 von Figura, K. 265 Pommier, G. J. Ponzani,P. 231 Walton, P.E. 385 Powell, D. R. a, Be Wasserman,R.M. 93 Wendland,M. 265 Quarrie, L. Werther,G. A. 329 Wilde,C. 409 Rajah, R. 273 Wood, T.L. 181, 433 Rajkumar, K. 425 Ramadori,G. 175 Xu,S. 293 Rechler,M.M. 131, 151, 241 Reijnen-Gresnigt, R. 377 Yap,O.W.S. 397 Remacle-Bonnet, M.M. 197 Ye,P. 417 Roberts Jr,C.T. 513 Rosenfeld, R.G. 503 Zapf, J. 167, 265 Russo, V.C. 329 Zhou, Y 131 SUBJECT/KEY WORD INDEX 150 K IGF complex 231 la.25-dihydroxyvitamin D, 167 . 3°;UT 417 293 Forkhead 119 Accessory factor 131 Functional compensation 437 Acid-labile subunit 175, 231 Ageing 465 Gelatinase 255 ALS 141, 151, 215, 241, 347 Gene structure 141, 159 Antibody 367 Gene targeting 265, 437 Antiestrogen 495 GH 409 Antiproliferation 503 GH regulation 151 Apoptosis 409, 433 Glucocorticoid 103,119 ARE 417 Glucocorticoid response element (GRE) 131 Glucose intolerance 425 Binding 223 Glycosaminoglycan 503 Bioavailability 285 Growth 367,377,425 Bone cells 465 Growth effects 385 Bone formation 465 Growth factors 1, 25, 181 Brain 417 Growth hormone 385, 481 Breast 495 Growth retardation 481 Breast cancer 503 y-NGF 273 Breast cancer cells 319 Hematopoiesis 35 C-terminal 209 Heparin 25, 357 C/EBP 119 Heparin affin regulatory peptide 25 Camp 103 Heparin-binding growth associated molecule 25 Cathepsin D 265, 301 Hepatocyte 119 Cathepsins 273 Hepatocytes 231 Cell association 215 HMGI 93 Cell growth inhibition HNF3 93, 103 Cell membrane 329 Homeobox genes 159 Chemotaxis 319 Hormone response unit 103 Chicken 159 Human 449 Chromosomal localization 159 Hyperglycemia 425 Chronic renal failure 481 hIGFBP-1 417 Clearance 449 CNTF 181 IGF 151, 209, 397, 437, 475 Collagen 319 IGF analogues 385 Complementary DNA _ 159 IGF binding protein-3 (IGFBP-3) 285 Complex formation 215 IGF binding proteins 385 Cytokines 35, 181 IGF bioavailability 311 IGF receptor 197 DBP 93, 103 IGF-I 189, 231, 329, 377, 385, 433 Dexamethasone 131 IGF-I and IGF-II 301 Diabetes mellitus 449 IGF-I receptor 513 Differentiation 197 IGF-I-IGFBP-3 complex 377 DNA synthesis 167 IGF-I/IGFBP-3 347 DNA-protein interactions 103 IGF-II 231 IGFBP 189, 197, 209, 265, 273, 397, 437, 475 E.coli 209 IGFBP proteases 273 EGF | IGFBP-1 93,449 Endometrial cancer 513 IGFBP-2 329 Epithelial cells 197 IGFBP-3 215, 223, 231, 241 Estrogen 495 433, 457, 495, 503 Evolution 159 IGFBP-3 protease 241 Extracellular matrix 167, 337,357 IGFBP-3 proteolytic activity 457 SUBJECT/KEY WORD INDEX IGFBP-3 receptor 311, 503 Osteoporosis 465 IGFBP-4 and IGFBP-5 301 Osteosarcoma 301 IGFBPs 513 Ovary 397 IGFs 311 IGS 1 Parathyroid hormone 167 IL-lb 181 PCOS 397 Implantation 1 Peritoneal fluid 293 Insulin 1, 103, 119 Pharmacokinetic bioavailability Insulin resistance 449 Pigs 385 Insulin response element (IRE) 131 Placenta 437 Insulin-like growth factor binding protein Plasmin system 285 Insulin-like growth factor binding protein Plasminogen 285 (IGFBP) 255, 367 Pleiotrophin 25 Insulin-like growth factor binding protein-5 Polarity 197 (IGFBP-5) 337 Population studies 449 Insulin-like growth factor binding proteins Potentiation of hormone activity 481 Pre-eclampsia 475 Insulin-like growth factor 119, 481 Pregnancy 475 Insulin-like growth factor (IGF) Preimplantation | Insulin-like growth factor I Production rate Insulin-like growth factor-I (IGF-I) Prolactin 409 Insulin-like growth factor-II 175 Promoter 119, Insulin-like growth factors 159 Protease 397 Interstitial collagenase 255 Proteolysis 265, 293,311 Interstitial fluid 293 PSA 273 Involution 433 IRE 93 Rat 141, 347 Rat brain 329 Kupffer cells 175 Rat liver 231 Reprogramming 189 Lactation 433 Leukemia 35 Serine protease 357 LIF 1 Serum 449 Liver 93 Sheep 189 Liver-enriched trans-acting factors 103 Smooth muscle cells 319 Lymph 449 Snell dwarf mice 377 Somatomedin 357 Mammary 409 Sorting 197 Mammary glands 433 Spleen 437 Matrix metalloproteinase (MMP) 255 Stromelysin 255 Metabolic effects of IGFs 425 Synovial fluid 293 Mitogenic 25 MMPs 273 T3 231 Monkey 347 Tamoxifen 495,513 Mutagenesis 215, 223 Ternary complex 141, 151 mRNA stability 41 TGFBl 231 Therapeutic administration of IGF-I N-glycosylation 223 Tissue plasminogen activator (tPA) N-terminal 209 Transcription 103,119 Neurotrophic factors 181 Transgenic 433 Nuclear factor(HNF) 131 Transgenic mice 417 Trauma 181 Octreotide 231 Tyrosine phosphorylation 513 Olfactory bulb 329 Organ explants 265 Undernutrition 189 Organomegaly 425 Uterus 437, 495 Osteoblast 337 Osteoblasts 301 Vitronectin 319