PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY An International Review Journal Volumes 71 and 72 Volume Contents, Author Index and Subject Index © PERGAMON Progress in Biophysics & Molecular Biology November 1999 EDITORS D. NOBLE, University Laboratory of Physiology, Oxford OX1 3PT T. L. BLUNDELL, University of Cambridge, Department of Biochemistry, Cambridge CB2 1OW T. PAWSON, Samuel Lunenfeld Institute, Mount Sinai Hospital, Toronto, Canada M5G 1X5 Publication information: Progress in Biophysics & Molecular Biology (ISSN 0079-6107). For 1999, volumes 71-72 are scheduled for publication. Subscription prices are available upon request from the Publisher or from the Regional Sales Office nearest you or from this journal’s website (http://www.elsevier.nl/locate/pbiomolbio). Further information is available on this journal and other Elsevier Science products through Elsevier’s website: (http://www.elsevier.nl). 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Periodicals postage is paid at Rahway, NJ. Progress in Biophysics & Molecular Biology (ISSN 0079-6107) is published as 2 volumes per year, 4 issues per volume (January, February, April, May, June, August, October and November) by Elsevier Science Ltd., The Boulevard, Langford Lane, Kidlington, Oxford OXS 1GB, UK. The US subscription price is $1326.00 per year. POSTMASTER: Send address corrections to: Progress in Biophysics & Molecular Biology, Elsevier Science, Customer Support Department, PO Box 945, New York, NY 10159-0945. Distributed in the USA by Mercury Airfreight International, 365 Blair Road, Avenel, NJ 07001. © 1999 Elsevier Science Ltd. All rights reserved. Author Service Department For queries relating to the general submission of articles (including electronic text and artwork) and the status of accepted manuscripts, please contact the Author Service Department: E-mail: authors(Welsevier.co.uk; Fax: +44 (0) 1865 843905; Tel: +44 (0) 1865 843900. Advertising information Advertising orders and enquiries can be sent to: USA, Canada and South America: Mr Tino de Carlo, The Advertising Department, Elsevier Science Inc., 655 Avenue of the Americas, New York, NY 10010-5107, USA; phone: (+1) (212) 633 3815; fax: (+1) (212) 633 3820; e-mail: [email protected]. Japan: The Advertising Department, Elsevier Science K.K., 9-15 Higashi- Azabu |-chome, Minato-ku, Tokyo 106-0044, Japan; phone: (+81) (3) 5561 5033; fax: (+81) (3) 5561 5047. Europe and ROW: Rachel Gresle-Farthing, The Advertising Department, Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK; phone: (+ 44) (1865) 843565; fax: (+ 44) (1865) 843976; e-mail: r.gresle-farthing(@elsevier.co.uk CONTENTS OF VOLUME 71 Number 1 Foccussed Issue Mechano-electric feedback of the heart Editors Note Mechano-electric feedback in the heart D. Noble Preface M. Lab Mechanosensitivity as an integrative system in heart: an audit M. J. Lab Modulation of ions channels and membrane receptors activities by mechanical interventions in cardiomyocytes: possible mechanisms for mechanosensitivity Olivier Cazorla, Caroline Pascarel, Fabien Brette and J.-Y. Le Guennec The role of calcium in the response of cardiac muscle to stretch S.C. Calaghan and E. White Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models P. Kohl, P. Hunter and D. Noble Cardiac mechano-electric feedback in man: clinical relevance P. Taggart and P. M. I. Sutton Number 2 Stability and folding of domain proteins R. Jaenicke Ab initio characterization of building units in peptides and proteins A. G. Csaszar and A. Perczel Numbers 3-4 Focussed Issue Signal Transduction Editors Introduction T. Pawson The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication C. M. Smith, E. Radzio-Andzelm, Madhusudan, P. Akamine and S. S. Taylor Structural analysis of receptor tyrosine kinases S. R. Hubbard Recognition and regulation of primary-sequence motifs by signaling modular domains Z. Songyang Regulation of antigen receptor function by protein tyrosine kinases J. Bubeck-Wardenburg, J. Wong, K. Fiitterer, R. Pappu, C. Fu, G. Waksman and A. C. Chan Adaptor proteins and T-cell antigen receptor signaling L. E. Samelson The STAT family of proteins in cytokine signaling K. Shuai The role of SHIP in growth factor induced signalling M. Huber, C. D. Helgason, J. E. Damen, M. Scheid, V. Duronio, L. Liu. M. D. Ware, R. K. Humphries and G. Krystal Signaling through focal adhesion kinase D. D. Schlaepfer, C. R. Hauck and D. J. Sieg MAP kinase pathways M. H. Cobb Applications of mass spectrometry to signal transduction K. A. Resing and N. G. Ahn The protein kinase resource and other bioinformation resources C. M. Smith CONTENTS OF VOLUME 72 Number 1 Genome-based structural biology Dmitrij Frishman and Hans-Werner Mewes Understanding the structure and function of catalases: clues from molecular evolution and in vitro mutagenesis Marcel Zamocky and Franz Koller Hormonal control of cardiac ion channels and transporters Y. Shimoni Number 2 Regulation of transmitter release from retinal bipolar cells M. Tachibana Annealing in crystallography: a powerful optimization tool Axel T. Brunger, Paul D. Adams and Luke M. Rice Evolution of the genetic code Brian K. Davis Number 3 Density modification for macromolecular phase improvement Kevin D. Cowtan and Kam Y. J. Zhang The evolutionary transition from monomeric to oligomeric proteins: tools, the environment, hypotheses Giuseppe D’Alessio The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction Karen L. Craig and Mike Tyers Number 4 Dynamics of intrinsic electrophysiological properties in spinal cord neurones Raul E. Russo and Jorn Hounsgaard Structure and dynamics of membrane proteins as studied by infrared spectroscopy José Luis R. Arrondo and Felix M. Goni