Principles of Bone Biology

1934 Pages·2008·53.66 MB·english

by  Bilezikian

C Dheadpitcear t1ion
Gideon A. Rodan
We pay special tribute in this Third Edition of Principles of also the first recipient of the ASBMR Excellence in
Bone Biology to one of the original three editors, Gideon Mentorship award, an Award that has been named for
Rodan, who passed away after a long illness on January him in perpetuity. After moving to the pharmaceutical
1, 2006. Gideon was a wonderful scientist who made out- industry in 1984 to lead research and development in
standing contributions to our understanding of bone cell bone biology and osteoporosis at Merck, Gideon fulfilled
biology and to the treatment of metabolic bone diseases. one of his obligations to that position many times over
His quiet but highly effective leadership style, superb intel- by selecting and then developing alendronate as a treat-
lect and major scientific achievements brought together ment for osteoporosis. This achievement set the bar for
bone and mineral investigators from all over the world. He all future drug development programs in osteoporosis.
was a beloved friend whose insight, empathy and sense of Most remarkably at Merck, however, Gideon retained and
humor enriched our lives. Gideon’s wisdom and breadth of developed even further the rigorous academic approach
knowledge were invaluable in selecting and evaluating the to bone biology that had always characterized him, wher-
contributions to the first two editions of this book. ever he was. In his never-ending quest to teach, to train,
Gideon’s education in mathematics and basic sciences and to learn, Gideon was helped enormously by his wife,
in Israel, and his PhD at the Weitzman Institute on physi- Sevgi, also his lifelong co-worker .
cochemical aspects of mineral metabolism, provided the We all owe much to the innovative thought that Gideon
fuel for a career of sustained achievement and scholar- brought to all levels of bone and mineral research. His
ship. He began his academic career at the University of great contributions directed our thinking and our concepts
Connecticut Dental School, rapidly became Chairman of for an entire generation that has followed him. Gideon
the Department of Oral Biology, and built a program of would have contributed as much to this third Edition as he
research that brought that School to great prominence. He did to the first two Editions. It is with the greatest admi-
was a mentor supreme, with a large number of students, ration and respect that we dedicate this Third Edition of
post-doctoral trainees and close colleagues who went on Principles of Bone Biology to his memory.
to have successful careers. They remained intensely loyal
to him. A former President of the American Society of T. J. Martin, L. G. Raisz and J. P. Bilezikian.
Bone and Mineral Research (ASBMR), Gideon was
Principles of Bone Biology, 3rd Edition
xiii
Copyright © 2008 by Academic Press. Inc. All rights of reproduction in any form reserved.
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