2 SEVENTH EDITION PRINCIPLES AND PRACTICE OF GYNECOLOGIC ONCOLOGY Dennis S. Chi, MD Deputy Chief Head of Ovarian Cancer Surgery Gynecology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York, New York Andrew Berchuck, MD Director Division of Gynecologic Oncology Department of Obstetrics and Gynecology Director Gynecologic Cancer Program Duke Cancer Institute Duke University Medical Center Durham, North Carolina Don S. Dizon, MD, FACP Clinical Co-Director Gynecologic Oncology Massachusetts General Hospital Cancer Center Associate Professor Harvard Medical School Boston, Massachusetts 3 Catheryn Yashar, MD Professor Chief of Breast and Gynecologic Services Medical Director La Jolla University of California, San Diego San Diego, California 4 Acquisitions Editor: Ryan Shaw Editorial Coordinator: Dave Murphy Senior Production Project Manager: Alicia Jackson Design Coordinator: Holly McLaughlin Manufacturing Coordinator: Beth Welsh Marketing Manager: Rachel Mante Leung Prepress Vendor: S4Carlisle Publishing Services Seventh edition Copyright © 2017 Wolters Kluwer. Copyright © 2013, 2009, 2005, 2001, 1996, 1992 by Lippincott Williams & Wilkins, A Wolters Kluwer business. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in China Library of Congress Cataloging-in-Publication Data Names: Chi, Dennis S., editor. | Berchuck, Andrew, editor. | Dizon, Don S., editor. | Yashar, Catheryn M., editor. Title: Principles and practice of gynecologic oncology / [edited by] Dennis S. Chi, Andrew Berchuck, Don S. Dizon, Catheryn Yashar. Description: Seventh edition. | Philadelphia: Wolters Kluwer Health, [2017] | Includes bibliographical references and index. Identifiers: LCCN 2016048223 | ISBN 9781496380395 Subjects: | MESH: Genital Neoplasms, Female Classification: LCC RC280.G5 | NLM WP 145 | DDC 616.99/465—dc23 LC record available at https://lccn.loc.gov/2016048223 This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. 5 This work is no substitute for individual patient assessment based upon health care professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data, and other factors unique to the patient. The publisher does not provide medical advice or guidance, and this work is merely a reference tool. Health care professionals, and not the publisher, are solely responsible for the use of this work, including all medical judgments, and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and health care professionals should consult a variety of sources. When prescribing medication, health care professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings, and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work. LWW.com 6 Dedication T his book is dedicated to our families: Hae-Young Chi and children Jessica, Stephanie, and Andrew Chi; Amy Berchuck and children Samuel, Jacob, and Benjamin Berchuck; Henry Stoll and children Isabelle, Harrison, and Sophia Dizon-Stoll; Arnold Yashar and children William, Jacob, and Drew Yashar. Their patience, good humor, encouragement, and love have inspired us throughout our careers. In this regard, they have each made significant contributions to this book. We would also like to express our gratitude to our own esteemed professors who guided and mentored us, and to all of the colleagues we have worked alongside, learned from, and taught over the years. The Gynecologic Oncology community that the readers of this book belong to is dedicated to the advancement of knowledge in the field and its application to outstanding patient care. The considerable progress we have achieved together in the understanding, diagnosis, treatment, and prevention of these cancers is presented in this book. On behalf of the Gynecologic Oncology community, we dedicate this edition of Principles and Practice of Gynecologic Oncology to the brave and courageous patients we all serve, and take inspiration in the oath we all share. HIPPOCRATIC OATH I swear to fulfill, to the best of my ability and judgment, this covenant: I will respect the hard-won scientific gains of those physicians in whose steps I walk, and gladly share such knowledge as is mine with those who are to follow. I will apply, for the benefit of the sick, all measures which are required, avoiding those twin traps of overtreatment and therapeutic nihilism. I will remember that there is art to medicine as well as science, and that warmth, sympathy, and understanding may outweigh the surgeon's knife or the chemist’s drug. I will not be ashamed to say “I know not,” nor will I fail to call in my colleagues when the skills of another are needed for a patient’s recovery. I will respect the privacy of my patients, for their problems are not disclosed to me that the world may know. Most especially must I tread with care in matters of life and death. Above all, I must not play at God. I will remember that I do not treat a fever chart, a cancerous growth, but a sick human being, whose illness may 7 affect the person’s family and economic stability. My responsibility includes these related problems, if I am to care adequately for the sick. I will prevent disease whenever I can, for prevention is preferable to cure. I will remember that I remain a member of society, with special obligations to all my fellow human beings, those sound of mind and body as well as the infirm. If I do not violate this oath, may I enjoy life and art, respected while I live and remembered with affection thereafter. May I always act so as to preserve the finest traditions of my calling and may I long experience the joy of healing those who seek my help. 8 International Editorial Board Ali Ayhan, PhD Professor and Chairman Department of Gynecologic Oncology Baskent University School of Medicine Ankara, Turkey Uziel Beller, MD Professor and Chairman Department of Gynecology Shaare Zedek Medical Center The Hebrew University of Jerusalem Jerusalem, Israel Prof. Adriana Bermudez, MD, PhD Chair, Gynecologic Oncology Unit Buenos Aires University Hospital Buenos Aires, Argentina Dr. Jorge A. Brañes, MD Profesor Asociado División de Obsteticia y Ginecología Facultad de Medicina Pontificia Universidad Católica de Chile Santiago, Chile Luis M. Chiva, MD, PhD Head of Department of Gynecology Oncology President of the Educational Committee Departments of Gynecologic and Medical Oncology The University of Texas MD Anderson Cancer Center Madrid, Spain Adjunct Professor of University of Texas Houston, Texas Dr. Carien L. Creutzberg, MD Professor of Radiation Oncology Department of Radiation Oncology Leiden University Medical Centre 9 Leiden, The Netherlands Lynette Denny, MBChB, MMEDm, PhD, FCOG (SA) Professor and Head of Obstetrics and Gynaecology University of Cape Town/Groote Schuur Hospital Cape Town, South Africa Gustavo Ferraris, MD, PhD Academic Director Radiation Oncology Specialty Catholic University of Córdoba Medical Director Department of Radiation Therapy Centro Médico Dean Funes Córdoba, Argentina Michael L. Friedlander, PhD, FRACP Conjoint Professor of Medicine Department of Medicine University of New South Wales Sydney, Australia Keiichi Fujiwara, MD, PhD Professor and Director Gynecologic Oncology Saitama Medical University International Medical Center Hidaka-City, Saitama, Japan Dr. Paweł Knapp, MD, PhD Professor Department of Gynaecology and Gynaecologic Oncology Medical University of Bialystok Bialystok, Poland Alexandra Leary, MD, PhD Medical Oncologist Gynecology Unit Lead, Gynecology Translational Research Laboratory Gustave Roussy Cancer Centre Villejuif, France Helen MacKay, MBChB, BSc, MRCP, MD Head, Division of Medical Oncology & Hematology Sunnybrook Odette Cancer Centre Associate Professor 10