Pre-Menopause, Menopause and Beyond, Volume 5: Frontiers in Gynecological Endocrinology PDF
Preview Pre-Menopause, Menopause and Beyond, Volume 5: Frontiers in Gynecological Endocrinology
ISGE Series Series Editor: Andrea R. Genazzani Martin Birkhaeuser Andrea R. Genazzani Editors Pre-Menopause, Menopause and Beyond Volume 5 Frontiers in Gynecological Endocrinology ISGE Series Series Editor Andrea R. Genazzani More information about this series at http://www.springer.com/series/11871 Martin Birkhaeuser • Andrea R. Genazzani Editors Pre-Menopause, Menopause and Beyond Volume 5: Frontiers in Gynecological Endocrinology Editors Martin Birkhaeuser Andrea R. Genazzani Professor emeritus for Gynaecological International Society of Gynecological Endocrinology and Reproductive Medicine Endocrinology University of Bern Pisa, Italy Bern, Switzerland Copyright owner: ISGE (International Society of Gynecological Endocrinology) ISSN 2197-8735 ISSN 2197-8743 (electronic) ISGE Series ISBN 978-3-319-63539-2 ISBN 978-3-319-63540-8 (eBook) https://doi.org/10.1007/978-3-319-63540-8 Library of Congress Control Number: 2017960823 © International Society of Gynecological Endocrinology 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Proceedings of the International Society of Gynecological Endocrinology (ISGE) Winter School 2017 This volume contains the lectures presented at the 6th ISGRE 2017 Winter School, held in Madonna di Campiglio between 22 and 26 January 2017. Important recent developments in our knowledge of premenopause and meno- pause, with their respective clinical implications and therapies, have encouraged the faculty to organize this Winter School. The following chapters have been selected: • Menopause: symptoms and neuroendocrine impact: endocrine and neuroendo- crine biological changes from menopause to aging—brain impact of sex steroids withdrawal of the menopause—importance and modern management of climac- teric symptoms • Intracrinology: its role in menopause • Menopause: bone and cardiovascular impact: how to maintain healthy bones after menopause—the effect of menopause and HRT on coronary heart disease— how to prevent cardiovascular disorders: influence of gonadal steroids • Menopause symptoms: the optimal therapies—recent changes and advances • The breast: benign breast diseases, BRCA mutation, and breast cancer • Infertility in late reproductive age: importance of autoimmunity—treatment after the age of 40—oocyte donation in menopausal women • Thyroid function and pregnancy outcome after ART—what is the evidence? Thyroid disorders in climacteric women • Polycystic ovary and metabolic syndrome: implications of cardiometabolic dys- function—metabolic changes during menopausal transition—role of Metformin in climacteric women—weight and body composition management after menopause • Surgical challenges after menopause: problems and solutions linked to them pel- vic floor, bladder dysfunction, and urinary incontinence v vi Preface On behalf of the ISGRE faculty, it is our pleasure to invite you to profit from the accumulated scientific and clinical knowledge assembled in these proceedings of our highly successful Winter School 2017. Bern, Switzerland Martin Birkhaeuser Pisa, Italy Andrea R. Genazzani Contents Part I Menopause: Symptoms and Neuroendocrine Impact 1 Intracrinology: The New Science of Sex Steroid Physiology in Women ................................ 3 Fernand Labrie 2 From Menopause to Aging: Endocrine and Neuroendocrine Biological Changes ....................... 17 Alessandro D. Genazzani, Andrea Giannini, and Antonella Napolitano 3 Brain Impact of Sex Steroid Withdrawal at Menopause .......... 35 Nicola Pluchino and Andrea R. Genazzani 4 Climacteric Symptoms: Importance and Management ........... 43 Martin Birkhaeuser Part II Fertility 5 Progress in Recommendations on Menopause, MHT and POI ..... 79 Nick Panay 6 Female Infertility and Autoimmunity .......................... 85 Paolo Giovanni Artini and Patrizia Monteleone Part III Thyroid Disorders, Polycystic Ovary and Metabolic Syndrome 7 Oocyte Donation in Perimenopausal and Menopausal Women ..... 95 Basil Tarlatzis and Julia Bosdou 8 Thyroid Disorders in Climacteric Women ...................... 103 Anna Brona, Andrzej Milewicz, Justyna Kuliczkowska- Płaksej, and Marek Bolanowski vii viii Contents 9 Thyroid Function and Pregnancy Outcome After ART: What Is the Evidence? ...................................... 113 Gesthimani Mintziori, Dimitrios G. Goulis, and Basil C. Tarlatzis 10 PCOS: Implications of Cardiometabolic Dysfunction ............. 119 Bart C.J.M. Fauser 11 Why Metformin Is so Important for Prevention and Therapy in Climacteric Women ...................................... 127 Justyna Kuliczkowska-Plaksej, Andrzej Milewicz, Anna Brona, and Marek Bolanowski 12 Metabolic Changes and Metabolic Syndrome During the Menopausal Transition ................................... 141 Alessandro D. Genazzani, Alessia Prati, and Giulia Despini 13 Weight and Body Composition Management After Menopause: The Effect of Lifestyle Modifications .......................... 153 Irene Lambrinoudaki, Eleni Armeni, and Nikolaos Tsoltos Part IV Bone and Cardiovascular Impact 14 Healthy Bones After Menopause: What Has to Be Done? ......... 165 Martin Birkhaeuser 15 The Effect of Menopause and HRT on Coronary Heart Disease .... 187 John C. Stevenson 16 How to Prevent Cardiovascular Disorders: Influence of Gonadal Steroids on the Heart ............................. 195 Svetlana Vujovic, Milina Tancic-Gajic, Ljiljana Marina, Zorana Arizanovic, Zorana Stojanovic, Branko Barac, Aleksandar Djogo, and Miomira Ivovic Part V Benign Breast Diseases, BRCA Mutation and Breast Cancer 17 Risk-Reducing Surgery and Treatment of Menopausal Symptoms in BRCA Mutation Carriers (and Other Risk Women) ........... 205 Piero Sismondi, Marta D’Alonzo, Paola Modaffari, Viola Liberale, Valentina Elisabetta Bounous, Andrea Villasco, and Nicoletta Biglia 18 Benign Breast Disease During Women’s Life .................... 215 Svetlana Vujovic Contents ix 19 Treatment of Menopausal Symptoms in Breast Cancer Survivors ........................................... 223 Piero Sismondi, Valentina Elisabetta Bounous, Valentina Tuninetti, Viola Liberale, Martina Gallo, and Nicoletta Biglia 20 Myoinositol and Inositol Hexakisphosphate in the Treatment of Breast Cancer: Molecular Mechanisms ...................... 233 Mariano Bizzarri, Simona Dinicola, and Alessandra Cucina Part VI Menopause Symptoms: The Therapies 21 The True Risks of HRT ...................................... 245 John C. Stevenson 22 Menopause Hormone Therapy Customization .................. 253 Irene Lambrinoudaki and Eleni Armeni 23 GSM/VVA: Advances in Understanding and Management ........ 261 Nick Panay 24 Intravaginal DHEA for the Treatment of Vulvovaginal Atrophy, Intracrinology at Work ...................................... 269 Fernand Labrie Part VII Surgical Challenges After Menopause: Problems and Solutions 25 Bladder Dysfunction and Urinary Incontinence After the Menopause: Hormones, Drugs, or Surgery? ................. 287 Eleonora Russo, Andrea Giannini, Marta Caretto, Paolo Mannella, and Tommaso Simoncini 26 When is Tubectomy and When Ovarectomy/Adnexectomy Indicated at Necessary Hysterectomies Beyond the Reproductive Age? ...................................... 293 Liselotte Mettler 27 Pelvic Floor Reconstructive Surgery in Ageing Women: Tailoring the Treatment to Each Woman’s Needs ................ 303 Marta Caretto, Andrea Giannini, Eleonora Russo, Paolo Mannella, and Tommaso Simoncini Index ......................................................... 317 Part I Menopause: Symptoms and Neuroendocrine Impact
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