Polymer Based Systems on Tissue Engineering, Replacement and Regeneration PDF
Preview Polymer Based Systems on Tissue Engineering, Replacement and Regeneration
Polymer Based Systems on Tissue Engineering, Replacement and Regeneration NATO Science Series A Series presenting the results of scientific meetings supported under the NATO Science Programme. The Series is published by IOS Press, Amsterdam, and Kluwer Academic Publishers in conjunction with the NATO Scientific Affairs Division Sub-Series I. Life and Behavioural Sciences IOS Press II. Mathematics, Physics and Chemistry Kluwer Academic Publishers III. Computer and Systems Science IOS Press IV. Earth and Environmental Sciences Kluwer Academic Publishers V. Science and Technology Policy IOS Press The NATO Science Series continues the series of books published formerly as the NATO ASI Series. The NATO Science Programme offers support for collaboration in civil science between scientists of countries of the Euro-Atlantic Partnership Council. The types of scientific meeting generally supported are "Advanced Study Institutes" and "Advanced Research Workshops", although other types of meeting are supported from time to time. The NATO Science Series collects together the results of these meetings. The meetings are co-organized bij scientists from NATO countries and scientists from NATO's Partner countries - countries of the CIS and Central and Eastern Europe. Advanced Study Institutes are high-level tutorial courses offering in-depth study of latest advances in afield. Advanced Research Workshops are expert meetings aimed at critical assessment of a field, and identification of directions for future action. As a consequence of the restructuring of the NATO Science Programme in 1999, the NATO Science Series has been re-organised and there are currently Five Sub-series as noted above. Please consult the following web sites for information on previous volumes published in the Series, as well as details of earlier Sub-series. http://www.nato.int/science http://www.wkap.nl http://www.iospress.nl http://www.wtv-books.de/nato-pco.htm Series II: Mathematics, Physics and Chemistry - Vol. 86 Polymer Based Systems on Tissue Engineering, Replacement and Regeneration edited by Rui L. Reis Department of Polymer Engineering, University of Minho, Guimaraes, Portugal and Daniel Cohn Casali Institute of Applied Chemistry, The Hebrew University, Jerusalem, Israel Springer-Science+Business Media, B.V. Proceedings of the NATO Advanced Study Institute on Polymer Based Systems on Tissue Engineering, Replacement and Regeneration Alvor, Algarve, Portugal 15-25 October 2001 A C.I.P. Catalogue record for this book is available from the Library of Congress. ISBN 978-1-4020-1001-9 ISBN 978-94-010-0305-6 (eBook) DOI 10.1007/978-94-010-0305-6 Printed on acid-free paper All Rights Reserved © 2002 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 2002 Softcover reprint of the hardcover 1st edition 2002 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. TABLE OF CONTENTS CONTRIBUTORS ................•.•...........................................•............................•................... ix Welcome Addresses PREFACE R. L. REIS 3 30 YEARS OF R&D IN PORTUGAL C.A.A. BERNARDO 7 Overview on Polymeric Biomaterials and Biodegradable Polymers POLYMERIC BIOMATERIALS IN MEDICAL SYSTEMS Y. IKADA 13 BIODEGRADABLE POLYMERS FOR ORTHOPAEDIC APPLICATIONS C.M. AGRAWAL 25 POLYMERIC MATRICES FOR RELEASE OF GROWTH FACTORS, HORMONES AND OTHER BIOACTIVE AGENTS A. GALLARDO, G.A. ABRAHAM, C. ELVIRA, B. VAZQUEZ, J. SAN ROMAN 37 Novel Systems, Hydrogels and Bone Cements MEMBRANES AND HYDROGELS IN RECONSTRUCTIVE SURGERY D. BAKOS, J. KOLLER 55 KEY-PROPERTIES AND RECENT ADVANCES IN BONE CEMENTS TECHNOLOGY B. VAZQUEZ, G.A. ABRAHAM, C. ELVIRA, A. GALLARDO AND J. SAN ROMAN 69 SOY PROTEIN-BASED SYSTEMS FOR DIFFERENT TISSUE REGENERATION APPLICATIONS C.M. VAZ, L.A. de GRAAF, R.L. REIS, A.M. CUNHA 93 VI Characterization of Polymeric Systems and Scaffolds IN VITRO TESTING OF POLYMERIC SCAFFOLDS C. M. AGRAWAL 113 CHARACTERIZATlON OF DEGRADABLE POLYMERS FOR ORTHOPEDIC APPLICATlON Examining Tyrosine-Derived Polycarbonates for Tissue Engineering ofBone S.D. ABRAMSON, A. SEYDA, P. SIDNEY SIT, J. KOHN 125 DYNAMIC MECHANICAL ANALYSIS IN POLYMERS FOR MEDICAL APPLICATlONS J.F. MANO, R.L. REIS, A.M. CUNHA 139 Surface Modification, Functionalization and Osteoconductivity MACROMOLECULAR DESIGN OF NEW SYNTHETIC BIODEGRADABLE MEDICAL POLYMERS Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences F. RYPAcEK 167 SURFACE TREATMENTS AND PRE-CALCIFICATION ROUTES TO ENHANCE CELL ADHESION AND PROLIFERATION A.L. OLIVEIRA, LB. LEONOR,C. ELVIRA, M.C. AZEVEDO, L PASKULEVA, R.L.EIS 183 Tissue Engineering and Regeneration ofBone and Cartilage BONE TISSUE ENGINEERING USING STARCH BASED SCAFFOLDS OBTAINED BY DIFFERENT METHODS M.E. GOMES, A. SALGADO, R.L. REIS 221 BONE TISSUE ENGINEERING BY CELL TRANSPLANTATION G.N. BANCROFT, A.G. MIKOS 251 CULTURED BONE ON BIOMATERIAL SUBSTRATES A Tissue Engineering Approach to Treat Bone Defects S.c. MENDES, J.D. DE BRUIJN, C.A. VAN BLITTERSWIJK 265 INJECTABLE BIODEGRADABLE MATERIALS FOR ORTHOPAEDIC TISSUE ENGINEERING J.S. TEMENOFF, A.G. MIKOS 299 Vll TISSUE ENGINEERING OF ELASTIC CARTILAGE BY USING SCAFFOLD/ CELL CONSTRUCTS WITH DIFFERENT PHYSICAL AND CHEMICAL PROPERTIES D. W. HUTMACHER, X. FU, B. K. TAN, J-T. SCHANTZ 313 CRANIOFACIAL BONE TISSUE ENGINEERING USING MEDICAL IMAGING, COMPUTATIONAL MODELING, RAPID PROTOTYPING, BIORESORBABLE SCAFFOLDS AND BONE MARROW ASPIRATES, D.W. HUTMACHER, D. ROHNER, V. YEOW, S.T. LEE, A. BRENTWOOD, J-T. SCHANTZ 333 Tissue Engineering and Regeneration ofOther Tissues BIODEGRADABLE POLYMERS AS SCAFFOLDS FOR TISSUE ENGINEERING AND AS TISSUE REGENERATION INDUCERS Y. IKADA 357 SCAFFOLDING ARTERIAL TISSUE D. COHN, G. MAROM 371 TISSUE-ENGINEERED VASCULAR GRAFTS FOR SMALL-DIAMETER ARTERIAL REPLACEMENT M.J.B. WISSINK, J. FEIJEN 391 Industrial and Innovation Opportunities AN EXPLORATORY ANALYSIS OF THE DETERMINANTS OF INNOVATION IN THE EMERGING TISSUE ENGINEERING INDUSTRY N. PANGARKAR, D.W. HUTMACHER 409 INDEX 419 CONTRIBUTORS ABRAHAM, G.A, Instituto de Ciencia y Tecnologia de Polimeros, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain ABRAMSON, S.D., Department of Chemistry, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903 AGRAWAL, C. M., Center for Clinical Bioengineering and Department of Orthopaedics,The University of Texas Health Science Center at San Antonio, San Antonio, TX28229 AZEVEDO, M.C., Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal BAKOS, D., Faculty of Chemical and Food Technology, STU, Radlinskiho 9, 812 37 Bratislava, Slovak Republic BANCROFT, G.N., Department of Bioengineering, Rice University, 6100 Main, Houston, TX, 77005-1892, U.SA BERNARDO, C.A, Department of Polymer Engineering, University ofMinho, 4800-058 Guimariies. Portugal BRENTWOOD, A, Department of Reconstructive Surgery, University Hospital Basel, Switzerland COHN, D., Casali Institute of Applied Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel CUNHA, AM., Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal DE BRUUN, J.D., IsoTis NY, Professor Bronkhorstlaan 10, 3723 MB Bilthoven, The Netherlands DE GRAAF, L.A, ATO B. V., P.D. Box 17, 6700-AA Wageningen, the Netherlands ELVIRA, c., Instituto de Ciencia y Tecnologia de Polimeros, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain IX x FEIJEN, J., Institute for Biomedical Technology, Polymer Chemistry and Biomaterials Group, Department ofChemical Technology, University ofTwente, P.O. Box 217, 7500 AE Enschede, The Netherlands. FU, X., Department ofPlastic Surgery, Singapore General Hospital GALLARDO, A., Instituto de Ciencia y Tecnologia de Polimeros, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain GOMES, M.E., Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal HUTMACHER, D.W., Department of Bioengineering & Department of Orthopedic Surgery, Faculty ofMedicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260 IKADA, Y., Institute for Frontier Medical Sciences, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan KOHN, J., Department of Chemistry, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903 KOLLER, J., Centre for Burns and Reconstructive Surgery, Central Tissue Bank, Ruiinov General Hospital, Ruiinovskti 6, 82606 Bratislava, Slovak Republic LEE, S.T., Department ofPlastic Surgery, Singapore General Hospital LEONOR, I.B., Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal MANO, J.F., Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal MAROM, G., Casali Institute ofApplied Chemistry, The Hebrew University ofJerusalem, Jerusalem 91904, Israel MENDES, S.c., IsoTis NV, Professor Bronkhorstlaan 10, 3723 MB Bilthoven, The Netherlands MIKOS, A.G., Department of Bioengineering, Rice University, 6100 Main, Houston, TX, 77005-1892, U.S.A Xl OLIVEIRA, AL, Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal PANGARKAR, N., Faculty of Business Administration, National University of Singapore FBA2 17, Law Link, Singapore 117591 PASKULEVA, I., Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal RBIS, R.L, Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal ROHNER, D., Department of Plastic Surgery, Singapore General Hospital, National University Singapore RypACEK, F. Institute ofMacromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovskf Sq. 2, 16206 Prague 6, Czech Republic SALGADO, A, Department of Polymer Engineering, University of Minho, 4800-058 Guimariies. Portugal SAN RoMAN, J., Instituto de Ciencia y Tecnologia de Polimeros, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain SCHANTZ, J-T., Laboratory for Biomedical Engineering, National University Singapore SEYDA, A, Department of Chemistry, Rutgers, The State University ofNew Jersey, New Brunswick, NJ 08903 SIT, P.S., Department of Chemistry, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903 TAN, B.K., Department ofPlastic Surgery, Singapore General Hospital TEMENOFF, J.S., Department of Bioengineering, Rice University, 6100 Main, Houston, IX, 77005-1892, USA VAN BLITIERSWIJK, C.A, IsoTis NV, Professor Bronkhorstlaan 10, 3723 MB Bilthoven, The Netherlands
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