Pesticide composition comprising propamocarb-fosetylate and an insecticidally active substance

12 Pages·2015·1.52 MB·English

USOO8969392B2
(12) United States Patent (10) Patent No.: US 8,969,392 B2
Van Den Eynde et a1. (45) Date of Patent: Mar. 3, 2015
(54) PESTICIDE COMPOSITION COMPRISING (52) US. Cl.
PROPAMOCARB-FOSETYLATE AND AN USPC .......................... .. 514/3 65; 514/341; 514/3 83
INSECTICIDALLY ACTIVE SUBSTANCE (58) Field of Classi?cation Search
USPC ........................................................ .. 514/365
(75) Inventors: Koen Van Den Eynde, Merchtem (BE); See application ?le for complete search history.
Marc AndrieuX, Erkrath (DE); Heike
Hungenberg, Langenfeld (DE); (56) References Cited
Wolfgang Thielert, Odental (DE); Anne
Suty-Heinze, Langenfeld (DE) U.S. PATENT DOCUMENTS
6,339,103 B1 1/2002 De’ath et a1.
(73) Assignee: Bayer Cropscience AG, Monheim am
2005/0065034 A1 3/2005 Miele et a1.
Rhein (DE)
2006/0166898 A1* 7/2006 Chen ............................. .. 514/22
2007/0060579 A1 3/ 2007 Wachendorff-Neumann et a1.
Notice: Subject to any disclaimer, the term of this 2008/0051457 A1 2/2008 Nakan et a1.
patent is extended or adjusted under 35 2008/0221167 A1 9/2008 Fischer et a1.
2008/0293566 A1 11/2008 Suty-Heinze et a1.
U.S.C. 154(b) by 0 days.
FOREIGN PATENT DOCUMENTS
(21) App1.No.: 13/539,989
W0 W0 9942468 A1 * 8/1999
(22) Filed: Jul. 2, 2012 WO 2007/101547 9/2007
OTHER PUBLICATIONS
(65) Prior Publication Data
US 2012/0270843 A1 Oct. 25, 2012 International Search Report for PCT/EP07/64424, mailed Apr. 1,
2008.
Related US. Application Data
* cited by examiner
(62) Division of application No. 12/520,808, ?led as
application No. PCT/EP2007/064424 on Dec. 21, Primary Examiner * Layla Soroush
2007, now Pat. No. 8,236,830. (74) Attorney, Agent, or Firm * Miles & Stockbridge PC
(30) Foreign Application Priority Data (57) ABSTRACT
The present invention relates to a pesticide composition
Dec. 22, 2006 (EP) ................................... .. 06127172 intended for protecting plants, crops or seeds against phyto
pathogenic fungi or damaging insects, and the corresponding
(51) Int. Cl. methods of treatment using the said composition. More pre
A01N 43/78 (2006.01) cisely, the subject of the present invention is a pesticide com
A61K 31/425 (2006.01) position based on propamocarb-fosetylate, an insecticide
A01N 43/00 (2006.01) active substance and optionally a further fungicide active
A61K 31/44 (2006.01) substance.
A01N 43/64 (2006.01)
A61K 31/41 (2006.01) 15 Claims, No Drawings
US 8,969,392 B2
1 2
PESTICIDE COMPOSITION COMPRISING Some mixtures with other fungicide active substances are
PROPAMOCARB-FOSETYLATE AND AN mentioned. However, this document is silent with regard to
INSECTICIDALLY ACTIVE SUBSTANCE any results orbiological activity of such potential mixtures. In
particular, this document does not report any activity to spe
CROSS REFERENCE TO RELATED ci?cally control seed diseases with propamocarb-fosetylate
APPLICATIONS mixtures nor this document discloses any mixture of propam
ocarb-fosetylate with any insecticide active substance. There
This application is a Divisional of US. patent application is also no mention in this document of any particular result or
Ser. No. 12/520,808 ?led Jun. 22, 2009, which is a §371 biological activity of any mixture of propamocarb-fosetylate
National Stage Application of PCT/ EP2007/ 064424 ?led with an insecticide active substance.
Dec. 21, 2007, which claims priority to EP 06127172.2 ?led In international patent application WO-2007/101547 there
Dec. 22, 2006, the entire contents of each are herein incorpo are generically disclosed numerous mixtures of some phtala
rated by reference in their entireties. mide insecticide compounds with known fungicide sub
stances. The association of these insecticide compounds with
15
BACKGROUND OF THE INVENTION propamocarb-fosetylate has not been speci?cally disclosed
nor has been subject to any experimentation. Such an asso
1. Field of the Invention ciation does not form part of the present invention.
The present invention relates to a pesticide composition In a main aspect, the present invention provides a compo
intended for protecting plants, crops or seeds against fungal sition comprising:
diseases or insect damages, and the corresponding methods of A) propamocarb-fosetylate and
protection by application of the said composition. More pre B) an insecticide compound
cisely, the subject of the present invention is a pesticide com in an A/B weight ratio ranging from 1/ 1,000 to 1,000/ 1;
provided that insecticide compound B differs from com
position based on propamocarb-fosetylate and an insecticide
pounds of formula (I)
active substance or compound and optionally a further fun
gicide active substance or compound.
2. Description of Related Art
(1)
As regards pesticide activity, in particular for the protection CH3
of crops, one of the problems at the heart of the research Hal 0 *
studies carried out in this technical ?eld is the improvement of 30 sozcn3
N
performances, in particular in terms of biological activity and H R
in particular in terms of maintaining such an activity over CF3
time. H
N F
SUMMARY OF THE INVENTION 35 O CF3
H3C
The present invention provides a pesticide composition
which can be used, in particular by the farmer, for controlling
the pest infesting crops and in particular for controlling wherein:
insects or diseases of corn, beet, cotton, canola, beans, pea Hal represents a chlorine atom, a bromine atom or a iodine
nuts vegetables, luceme, soybean, market garden crops, turf, atom;
wood, tree and horticultural plants, for example Pylhium on R represents hydrogen or methyl and * may represent a
corn. The pesticide compounds useful for the protection of carbon atom in R- or S-con?guration.
The present invention advantageously provides a pesticide
plants must be endowed with an ecotoxicity which is reduced
to the minimum. As far as possible, they should not be dan 45 composition which is completely high-performing in particu
lar as regards its ef?cacy against pests and the perenniallity of
gerous or toxic to the operator during use. The economic
this e?icacy so as to be able to reduce the doses of chemical
factor should of course not be overlooked in the search for
novel pesticide agents. products spread in the environment for combating pest dam
Propamocarb-fosetylate is a known compound having as ages or attacks of plants or crops.
chemical name dimethyl-[3-(propoxycarbonylamino)pro 50 The invention provides a pesticide composition capable to
pyl]ammonium-O-ethylphosphonate and which is repre be more active and active for longer, and which therefore has
sented by the following formula: a lower dose, but which is also less toxic, in particular in the
treatment of plants and particularly the foliar and seed treat
ments of fungal diseases or the control of insects, for
0 55 example, of cereals, cotton, peanut, bean, beet, canola, Solan
\NHMNAOA/
aceae, grapevine, vegetables, luceme, soybean, market gar
den crops, turf, wood or horticultural plants.
The composition according to the invention allows control
ling a broad variety of insects or fungi. For example, the
60 pesticide composition according to the invention exhibits an
improved ef?cacy against fungus like Plasmodiophoro
mycetes, Oomycetes, Chytridiomycetes, Zygomycetes,
Basidiomycetes, Deuteromycetes and Ascomycetes.
This compound is described in international patent appli All these objectives or advantages, among others, were
cation WO-99/42468. Some fungicide activity is reported 65 achieved by ?nding a pesticide composition comprising pro
with regard to the straight use of this compound to control pamocarb-fosetylate; an insecticide compound and option
Plasmopara vilicola. ally a further fungicide compound. Such a composition sur
US 8,969,392 B2
3 4
prisingly and unexpectedly allows a very high and perennial chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis
insecticide or anti-fungal e?icacy against a broad spectrum of permethrin, clocythrin, cycloprothrin, cy?uthrin, cyha
insects or fungi and in particular against those responsible for lothrin, cypermethrin (alpha, beta-, theta-, zeta-), cyphe
diseases or damages of corn for example to Oomycetes. Other nothrin, deltamethrin, empenthrin (IR-isomer),
insect pests or diseases of corn can be controlled With the esfenvalerate, etofenprox, fen?uthrin, fenpropathrin,
pesticide composition according to the invention, in particu fenpyrithrin, fenvalerate, ?ubrocythrinate, ?ucythri
lar the control of Ascomycetes or Basidiomycetes. nate, ?ufenprox, ?umethrin, ?uvalinate, fubfenprox,
The pesticide composition according to the invention may gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cy
also be used for the treatment of bacterial or virus diseases. halothrin, meto?uthrin, permethrin (cis-, trans-), pheno
Insects or nematodes that can be controlled With the pesti thrin (1r-trans isomer), prallethrin, pro?uthrin, prot
cide composition according to the invention include a broad rifenbute, pyresmethrin, resmethrin, RU15525,
variety of these damaging organisms. sila?uofen, tau-?uvalinate, te?uthrin, terallethrin, tet
ramethrin (—1r-isomer), tralomethrin, trans?uthrin,
DETAILED DESCRIPTION OF A PREFERRED ZXI8901 , pyrethrins (pyrethrum); for example DDT; for
EMBODIMENT example a compound of the type oxadiaZine like indox
acarb;
For the composition according to the invention, insecticide B4) a compound capable to modulate acetylcholine recep
compound B is preferably selected in the list consisting of: tor, for example a compound of the type spinosyn like
B1) a compound capable to act as an acetylcholine receptor spinosad;
agonist or antagonist, for example a compound of the 20 B5) a compound capable to act as GABA-gated chloride
type chloronicotinyl like acetamiprid, clothianidin, channel antagonist, for example a compound of the type
dinotefuran, imidacloprid, imidaclothiZ also known as cyclodiene organochlorine like camphechlor, chlor
(2E)-1-[(2-chloro-1,3 -thiazol-5-yl)methyl] -N-nitroimi dane, endosulfan, gamma-HCH, HCH, heptachlor, lin
dazolidin-2-imine, nitenpyram, nithiaZine, thiacloprid; dane, methoxychlor; a compound of the type ?prole like
thiamethoxam; nicotine, bensultap, cartap, (2E)-1-[(2 25 acetoprole, ethiprole, ?pronil, vaniliprole;
chloro-1 ,3 -thiazol-5-yl)methyl] -3 ,5 -dimethyl-N-nitro B6) a compound capable to activate the chloride channel,
1,3 ,5 -triaZinan-2-imine; for example a compound of the type mectin like aver
B2) a compound capable to inhibit acetylcholinesterase mectin, emamectin, emamectin-benzoate, ivermectin,
(ACHE), for example a compound of the type carbamate milbemycin;
like alanycarb, aldicarb, aldoxycarb, allyxycarb, ami 30 B7) a compound capable to mimic a juvenile hormone like
nocarb, bendiocarb, benfuracarb, bufencarb, butacarb, diofenolan, epofenonane, fenoxycarb, hydroprene,
butocarboxim, butoxycarboxim, carbaryl, carbofuran, kinoprene, methoprene, pyriproxifen, triprene;
carbosulfan, cloethocarb, dimetilan, ethiofencarb, B8) a compound capable to act as an ecdysone agonist or
fenobucarb, fenothiocarb, formetanate, furathiocarb, disruptor, for example a compound of the type diacyl
isoprocarb, metam-sodium, methiocarb, methomyl, 35 hydrazine like chromafenozide, halofenoZide, methoxy
metolcarb, oxamyl, pirimicarb, promecarb, propoxur, fenozide, tebufenozide;
thiodicarb, thiofanox, trimethacarb, XMC, xylylcarb; B9) a compound capable to inhibit chitin biosynthesis, for
triazamate; a compound of the type organophosphate example a compound of the type benzoylurea like bis
like acephate, azamethiphos, aZinphos (-methyl, -ethyl), tri?uoron, chlo?uazuron, di?ubenzuron, ?uazuron,
bromophos-ethyl, bromfenvinfos (-methyl), butathio 40 ?ucycloxuron, ?ufenoxuron, hexa?umuron, lufenuron,
fos, cadusafos, carbophenothion, chlorethoxyfos, chlo novaluron, novi?umuron, pen?uoron, te?ubenzuron,
rfenvinphos, chlormephos, chlorpyrifos (-methyl/ tri?umuron; buproerin; cyromaZine;
ethyl), coumaphos, cyanofenphos, cyanophos, B10) a compound capable to inhibit oxidative phosphory
chlorfenvinphos, demeton-s-methyl, demeton-s-meth lation or to disrupt ATP, like diafenthiuron; for example
ylsulphon, dialifos, diaZinon, dichlofenthion, dichlor 45 a compound of the type organotin like azocyclotin,
vos/ddvp, dicrotophos, dimethoate, dimethylvinphos, cyhexatin, fenbutatin-oxide;
dioxabenzofos, disulfoton, epn, ethion, ethoprophos, B1 1) a compound capable to uncouple oxidative phospho
etrimfos, famphur, fenamiphos, fenitrothion, fensul rylation via disruption of H proton gradient, for example
fothion, fenthion, ?upyrazofos, fonofos, formothion, a compound of the type pyrrole like chlorfenapyr; a
fosmethilan, fosthiazate, heptenophos, iodofenphos, 50 compound of the type dinitrophenole like binapacyrl,
iprobenfos, isazofos, isofenphos, isopropyl o-salicylate, dinobuton, dinocap, DNOC;
isoxathion, malathion, mecarbam, methacrifos, metha B12) a compound capable to inhibit site I electron trans
midophos, methidathion, mevinphos, monocrotophos, port, for example a compound of the type METI like
naled, omethoate, oxydemeton-methyl, parathion (-me fenazaquin, fenpyroximate, pyrimidifen, pyridaben,
thyl/-ethyl), phenthoate, phorate, phosalone, phosmet, tebufenpyrad, tolfenpyrad; hydramethylnon; dicofol;
55
pho sphamidon, pho sphocarb, phoxim, pirimiphos (-me B13) a compound capable to inhibit site II electron trans
thyl/-ethyl), profenofos, propaphos, propetamphos, pro port like rotenone;
thiofos, prothoate, pyraclofos, pyridaphenthion, pyri B14) a compound capable to inhibit site III electron trans
dathion, quinalphos, sebufos, sulfotep, sulprofos, port like acequinocyl, ?uacrypyrim;
tebupirimfos, temephos, terbufos, tetrachlorvinphos, 60 B15) a compound capable to act as a microbial disruptor of
thiometon, triazophos, triclorfon, vamidothion; insect midgut or intestinal membrane like stains of
B3) a compound capable to modulate the sodium channel Bacillus Zhuringiensis;
or to block the voltage dependant sodium channel, for B16) a compound capable to inhibit lipid synthesis, for
example a compound of the type pyrethroid like acri example a compound of the type tetronic acid insecti
nathrin, allethrin (d-cis-trans, d-trans), beta-cy?uthrin, 65 cide like spirodiclofen, spiromesifen or a compound of
bifenthrin, bioallethrin, bioallethrin-s-cyclopentyl-iso the type tetramic acid insecticide like spirotetramat also
mer, bioethanomethrin, biopermethrin, bioresmethrin, known as carbonic acid cis-3-(2,5-dimethylphenyl)-8
US 8,969,392 B2
5 6
methoxy-2-oxo-1 -azaspiro [4 .5] dec -3 -en-4 -yl ethyl ron; propamocarb-fosetylate and methamidophos;
ester (CAS-reg-no 203313-25-1) and 3-(2,5-dimeth propamocarb-fosetylate and methiocarb; propamocarb-fos
ylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5]dec-3-en etylate and methomyl; propamocarb -fo setylate and methoxy
4-yl ethyl carbonate also known as carbonic acid 3-(2, fenozide; propamocarb-fosetylate and milbemycin; propam
5 -dimethylphenyl)-8-methoxy-2-oxo-1-azaspiro[4.5] ocarb-fosetylate and nitenpyram; propamocarb-fosetylate
dec-3-en-4-yl ethyl ester (CAS-reg-no 382608-10-8); and novaluron; propamocarb-fosetylate and profenofos; pro
B17) a compound of the type carboxamide like ?onicamid; pamocarb-fosetylate and pymetroZine; propamocarb-fosety
B18) a compound capable to act as an octopaminergic late and rynaxapyr; propamocarb-fosetylate and spinosad;
agonist like amitraZ; propamocarb-fosetylate and spirodiclofen; propamocarb
B19) a compound capable to inhibit magnesium-stimu fosetylate and spiromesifen; propamocarb-fosetylate and
lated ATP-ase like propargite; spirotetramate; propamocarb-fosetylate and tebufenozide;
B20) a compound of the type BDCA or capable to act as a propamocarb-fosetylate and tebufenozide; propamocarb -fos
ryanodin receptor agonist like rynaxypyr or phthala etylate and tebufenpyrad; propamocarb-fosetylate and
mides, e.g. ?ubendiamide also known as N2-[1,1-dim tebufenpyrad; propamocarb-fosetylate and tebupirimphos;
ethyl-2-(methylsulfonyl)ethyl] -3-iodo-N1 - [2 -methyl propamocarb-fosetylate and te?ubenzuron; propamocarb
4-[1,2,2,2-tetra?uoro-1 -(tri?uoromethyl)ethyl] fosetylate and te?uthrin; propamocarb-fosetylate and thia
phenyl]-1,2-benzenedicarboxamide (CAS-reg-no cloprid; propamocarb-fosetylate and thiamethoxam; pro
272451-65-7); pamocarb-fosetylate and thiodicarb; propamocarb-fosetylate
B21) a compound of the type nereistoxin analogue insec and triazophos tri?umuron; propamocarb-fosetylate and imi
ticide like thiocyclam hydrogen oxalate, thiosultap-so 20 daclothiZ; propamocarb-fosetylate and (2E)-1-[(2-chloro-1,
dium; 3 -thiazol-5 -yl)methyl] -3 ,5 -dimethyl-N-nitro-1 ,3 ,5 -triaZi
B22) a compound of the types biologica, hormones or nan-2-imine.
pheromones like azadirachtin, Bacillus spec., Beauveria Even more preferably, the composition according to the
spec., codlemone, Melarrhizium spec., Paecilomyces invention comprises propamocarb-fosetylate and abamectin;
spec., thuringiensin, Verticillium spec.; 25 propamocarb-fosetylate and acetamiprid; propamocarb-fos
B23) a compound of unknown or non-speci?c mode of etylate and aldicarb; propamocarb-fosetylate and beta-cy
action, for example a compound of the type fumigant ?uthrin; propamocarb-fosetylate and carbofuran; propam
like aluminium phosphide, methyl bromide, sulfuryl ocarb-fosetylate and chlorpyrifos-E; propamocarb-fosetylate
?uoride; a compound of the type selective feeding and clothianidin; propamocarb-fosetylate and cypermethrin;
blocker like cryolite, ?onicamid, pymetroZine; a com 30 propamocarb-fosetylate and cyromaZine; propamocarb-fos
pound of the type mite growth inhibitor like clofenteZ etylate and deltamethrin; propamocarb-fosetylate and
ine, etoxazole, hexythiazox; amido?umet, benclothiaz, di?ubenzuron; propamocarb-fosetylate and emamectin-ben
benzoximate, bifenazate, bromopropylate, buproerin, zoate; propamocarb-fosetylate and ethiprole; propamocarb
chinomethionat, chlordimeforrn, chloro-benZilate, chlo fosetylate and ?pronil; propamocarb-fosetylate and gamma
ropicrin, clothiazoben, cycloprene, cy?umetofen, dicy cyhalothrin; propamocarb-fosetylate and imidacloprid;
35
clanil, fenoxacrim, fentrifanil, ?ubendiamide, ?ubenZ propamocarb-fosetylate and L-cyhalothrin; propamocarb
imine, ?ufenerim, ?utenZin, gossyplure, fosetylate and lufenuron; propamocarb-fosetylate and
hydramethylnone, japonilure, metoxadiazone, petro methiocarb; propamocarb-fosetylate and methoxyfenozide;
leum, piperonyl butoxide, potassium oleate, pyra?u propamocarb-fosetylate and pymetroZine; propamocarb-fos
prole, pyridalyl, pyriprole, sul?uramid, tetradifon, tetra 40 etylate and rynaxapyr; propamocarb-fosetylate and spinosad;
sul, triarathene, verbutin. propamocarb-fosetylate and spirodiclofen; propamocarb
More preferably, the composition according to the inven fosetylate and spiromesifen; propamocarb-fosetylate and
tion comprises propamocarb-fosetylate and abamectin; pro spirotetramate; propamocarb-fosetylate and tebufenozide;
pamocarb-fosetylate and acephate; propamocarb-fosetylate propamocarb-fosetylate and tebufenpyrad; propamocarb
and acetamiprid; propamocarb-fosetylate and acrinathrin; 45 fosetylate and te?uthrin; propamocarb-fosetylate and thia
propamocarb-fosetylate and aldicarb; propamocarb-fosety cloprid; propamocarb-fosetylate and thiamethoxam; pro
late and alpha-cypermethrin; propamocarb-fosetylate and pamocarb-fosetylate and thiodicarb; propamocarb-fosetylate
beta-cy?uthrin; propamocarb-fosetylate and bifenthrin; pro and tri?umuron; propamocarb-fosetylate and imidaclothiZ;
pamocarb-fosetylate and carbaryl; propamocarb-fosetylate preferred composition according to the invention comprises
and carbofuran; propamocarb-fosetylate and chlorfenapyr; 50 propamocarb-fosetylate and (2E)-1-[(2-chloro-1,3-thiazol
propamocarb-fosetylate and chlor?uazuron; propamocarb 5 -yl)methyl] -3 ,5 -dimethyl-N-nitro-1,3,5-triaZinan-2-imine.
fosetylate and chlorpyrifos-E; propamocarb-fosetylate and Still even more preferably, the composition according to
clothianidin; propamocarb-fosetylate and cy?uthrin; pro the invention comprises propamocarb-fosetylate and abam
pamocarb-fosetylate and cypermethrin; propamocarb-fos ectin; propamocarb-fosetylate and aldicarb; propamocarb
etylate and cyromaZine; propamocarb-fosetylate and delta 55 fosetylate and beta-cy?uthrin; propamocarb-fosetylate and
methrin; propamocarb-fosetylate and di?ubenzuron; chlorpyrifos-E; propamocarb-fosetylate and clothianidin;
propamocarb-fosetylate and dinotefuran; propamocarb-fos propamocarb-fosetylate and cyromaZine; propamocarb-fos
etylate and emamectin-benzoate; propamocarb-fosetylate etylate and deltamethrin; propamocarb-fosetylate and
and ethiprole; propamocarb-fosetylate and fenpyroximate; di?ubenzuron; propamocarb-fosetylate and emamectin-ben
propamocarb-fosetylate and ?pronil; propamocarb-fosety zoate; propamocarb-fosetylate and ?pronil; propamocarb
60
late and ?onicamid; propamocarb-fosetylate and ?ubendia fosetylate and gamma-cyhalothrin; propamocarb-fosetylate
mide; propamocarb-fosetylate and ?ufenoxuron; propam and imidacloprid; propamocarb-fosetylate and L-cyhalo
ocarb-fosetylate and gamma-cyhalothrin; propamocarb thrin; propamocarb-fosetylate and methiocarb; propam
fosetylate and hexa?umuron; propamocarb-fosetylate and ocarb-fosetylate and pymetroZine; propamocarb-fosetylate
imidacloprid; propamocarb-fosetylate and indoxacarb; pro 65 and rynaxapyr; propamocarb-fosetylate and spinosad; pro
pamocarb-fosetylate and L-cyhalothrin; propamocarb-fos pamocarb-fosetylate and spirodiclofen; propamocarb-fosety
etylate and lepimectin; propamocarb-fosetylate and lufenu late and spiromesifen; propamocarb-fosetylate and spirotet
US 8,969,392 B2
7 8
ramate; propamocarb-fosetylate and tebufenozide; C1) a compound capable to inhibit the nucleic acid synthe
propamocarb-fosetylate and tebufenpyrad; propamocarb sis like benalaxyl, benalaxyl-M, bupirimate, clozylacon,
fosetylate and te?uthrin; propamocarb-fosetylate and thia dimethirimol, ethirimol, furalaxyl, hymexazol,
methoxam; propamocarb-fosetylate and thiodicarb; propam mefenoxam, metalaxyl, metalaxyl-M, ofurace, oxa
ocarb-fosetylate and imidaclothiZ; propamocarb-fosetylate 5 dixyl, oxolinic acid;
and (2E)-1-[(2-chloro-1,3-thiazol-5 -yl)methyl] -3, 5-dim C2) a compound capable to inhibit the mitosis and cell
ethyl -N-nitro- 1 ,3 ,5 -triaZinan-2-imine. division like benomyl, carbendaZim, diethofencarb,
ethaboxam, fuberidazole, pencycuron, thiabendazole,
For the composition according to the invention the A/B
thiophanate-methyl, zoxamide;
weight ratio preferably ranges from 1/ 125 to 125/1; more
C3) a compound capable to inhibit the respiration for
preferably from 1/25 to 25/1.
example
According to another aspect of the present invention, in the
as Cl-respiration inhibitor like di?umetorim;
pesticide composition according to the invention, the com
as CH-respiration inhibitor like boscalid, carboxin, fen
pound ratio A/B can be advantageously selected so as to furam, ?utolanil, furametpyr, furmecyclox, mepronil,
produce a synergistic effect. The term synergistic effect is oxycarboxin, penthiopyrad, thi?uzamide;
understood to mean in particular that de?ned by Colby in an
as CHI-respiration inhibitor like amisulbrom, azox
article entitled “Calculation of the synergistic and antagonis ystrobin, cyazofamid, dimoxystrobin, enestrobin,
tic responses of herbicide combinations” Weeds, (1967), 15, famoxadone, fenamidone, ?uoxastrobin, kresoxim-me
pages 20-22. thyl, metominostrobin, orysastrobin, picoxystrobin,
The latter article mentions the formula: 20 pyraclostrobin, tri?oxystrobin;
C4) a compound capable of to act as an uncoupler like
dinocap, ?uaZinam, meptyldinocap;
C5) a compound capable to inhibit ATP production like
fentin acetate, fentin chloride, fentin hydroxide, silthio
25 fam;
wherein E represents the expected percentage of inhibition of C6) a compound capable to inhibitAA and protein biosyn
thesis like andoprim, blasticidin-S, cyprodinil, kasuga
the pest for the combination of the two compounds at de?ned
mycin, kasugamycin hydrochloride hydrate, mepanipy
doses (for example equal to x and y respectively), X is the
rim, pyrimethanil;
percentage of inhibition ob served for the pest by compoundA
at a de?ned dose (equal to x), Y is the percentage of inhibition 30 C7) a compound capable to inhibit the signal transduction
like fenpiclonil, ?udioxonil, quinoxyfen;
observed for the pest by compound B at a de?ned dose (equal
C8) a compound capable to inhibit lipid and membrane
to y). When the percentage of inhibition observed for the
synthesis like biphenyl, chlozolinate, edifenphos, etridi
combination is greater than E, there is a synergistic effect. azole, iodocarb, iprobenfos, iprodione, isoprothiolane,
The term “synergistic effect” also means the effect de?ned 35 procymidone, propamocarb or propamocarb-hydro
by application of the Tammes method, “lsoboles, a graphic
chloride, pyrazophos, tolclofos-methyl, vinclozolin;
representation of synergism in pesticides”, Netherlands J our
C9) a compound capable to inhibit ergosterol biosynthesis
nal of Plant Pathology, 70 (1964), pages 73-80.
like aldimorph, azaconazole, bitertanol, bromucona
In a further aspect, the present invention provides a com Zole, cyproconazole, diclobutrazole, difenoconazole,
position comprising:
A) propamocarb-fosetylate; 40 diniconazole, diniconazole-M, dodemorph, dodemorph
acetate, epoxiconazole, etaconazole, fenarimol, fen
B) an insecticide compound and buconazole, fenhexamid, fenpropidin, fenpropimorph,
C) a further fungicide compound in anA/B/C weight ratio
?uquinconazole, ?urprimidol, ?usilazole, ?utriafol, fur
ranging from 1/ 1,000/ 1,000 to 1/0.001/0.001; provided
conazole, furconazole-cis, hexaconazole, imazalil,
that insecticide compound B differs from compounds of
45 imazalil sulfate, imibenconazole, ipconazole, metcona
formula (I)
Zole, myclobutanil, nafti?ne, nuarimol, oxpoconazole,
paclobutrazol, pefurazoate, penconazole, prochloraZ,
propiconazole, prothioconazole, pyributicarb,
(1) pyrifenox, simeconazole, spiroxamine, tebuconazole,
CH3
Hal 0 * 50 terbina?ne, tetraconazole, triadimefon, triadimenol, tri
SOZCH3 demorph, tri?umizole, triforine, triticonazole, unicona
N Zole, viniconazole, voriconazole;
H
C10) a compound capable to inhibit cell wall synthesis like
CF3
benthiavalicarb, bialaphos, dimethomorph, ?umorph,
H
N F iprovalicarb, mandipropamid, polyoxins, polyoxorim,
55
validamycin A;
O CF3
C1 1) a compound capable to inhibit melanine biosynthesis
H3C like carpropamid, diclocymet, fenoxanil, phthalide,
pyroquilon, tricyclazole;
wherein: 60 C12) a compound capable to induce a host defence like
Hal represents a chlorine atom, a bromine atom or a iodine acibenzolar-S-methyl, probenazole, tiadinil;
atom; C13) a compound capable to have a multisite action like
* represents a carbon atom in R- or S-con?guration. Bordeaux mixture, captafol, captan, chlorothalonil, cop
In addition to propamocarb-fosetylate and an insecticide per naphthenate, copper oxide, copper oxychloride, cop
compound B as herein-de?ned, the composition according to 65 per preparations such as copper hydroxide, copper sul
the invention can comprise a further fungicide compound C phate, dichlo?uanid, dithianon, dodine, dodine free
preferably selected in the list consisting of: base, ferbam, ?uorofolpet, folpet, guazatine, guazatine

US 8,969,392 B2
11 12
The latter article mentions the formula: such as silica, alumina or silicates, in particular aluminium or
magnesium silicates. The solid ?llers which are suitable for
granules are as follows: natural, crushed or broken rocks,
such as calcite, marble, pumice, sepiolite and dolomite; syn
E=X Y 2-—
+ + 100 thetic granules of inorganic or organic ?ours; granules of
organic material such as sawdust, coconut shell, corn ear or
envelope, or tobacco stem; kieselguhr, tricalcium phosphate,
wherein E represents the expected percentage of inhibition of
powdered cork or adsorbent carbon black; water-soluble
the pest for the combination of the three compounds at
polymers, resins, waxes; or solid fertilizers. Such composi
de?ned doses (for example equal to x, y and Z respectively), X
tion may, if so desired, contain one or more compatible agents
is the percentage of inhibition observed for the pest by com
such as wetting agents, dispersing agents, emulsi?ers or
poundA at a de?ned dose (equal to x), Y is the percentage of
colourings which, when they are solid, may also act as dilu
inhibition observed for the pest by compound B at a de?ned
ents.
dose (equal to y) and Z is the percentage of inhibition
The ?llers may also be liquid, for example: water, alcohols,
observed for the pest by compound C at a de?ned dose (equal
in particular butanol or glycol, as well as ethers or esters
to Z). When the percentage of inhibition observed for the thereof, in particular methyl glycol acetate; ketones, in par
combination is greater than E, there is a synergistic effect. ticular acetone, cyclohexanone, methyl ethyl ketone, methyl
The term “synergistic effect” also means the effect de?ned isobutyl ketone or isophorone; petroleum fractions such as
by application of the Tammes method, “lsoboles, a graphic paraf?nic or aromatic hydrocarbons, in particular xylenes or
representation of synergism in pesticides”, Netherlands J our 20 alkylnaphthalenes; mineral or plant oils; aliphatic chlorohy
nal of Plant Pathology, 70 (1964), pages 73-80. drocarbons, in particular trichloroethane or methylene chlo
The pesticide composition according to the invention may ride; aromatic chlorohydrocarbons, in particular chloroben
comprise from 0.00001 to 100%, preferably from 0.001 to zenes; water-soluble or highly polar solvents such as
80%, of active compounds, whether these compounds are dimethylforrnamide, dimethyl sulphoxide, N,N-dimethyl-ac
combined, or whether they are in the form of two or more 25 etamide or N-methylpyrrolidone; N-octylpyrrolidone, lique
active ingredients used separately. ?ed gases; or the like, whether they are taken separately or as
More generally, the pesticide composition according to the a mixture.
invention may eventually also comprise one or more other The surfactant can be an emulsi?er, a dispersing agent or a
active substances selected from fungicide, herbicide, insecti wetting agent, of ionic or nonionic type or a mixture of these
cide or plant growth regulator active compounds. 30 surfactants. Among those surfactants there are used, for
In addition to these additional active agents, the pesticide example, polyacrylic acid salts, lignosulphonic acid salts,
composition according to the invention may also comprise phenolsulphonic or naphthalenesulphonic acid salts, poly
any other adjuvants or auxiliary agent useful in plant protec condensates of ethylene oxide with fatty alcohols or fatty
tion formulations such as, for example, an agriculturally suit acids or fatty esters or fatty amines, substituted phenols (in
able inert carrier and optionally an agriculturally suitable 35 particular alkylphenols or arylphenols), ester-salts of sulpho
surfactant. succinic acid, taurine derivatives (inparticular alkyl taurates),
For its practical use, the pesticide composition according to phosphoric esters of alcohols or of polycondensates of ethyl
the invention can be used alone or in formulations containing ene oxide with phenols, fatty acid esters with polyols, or
one or the other of the active ingredients or alternatively both sulphate, sulphonate or phosphate functional derivatives of
of them together, in combination or association with one or 40 the compounds described above. The presence of at least one
more other compatible components which are, for example, surfactant is generally essential when the active ingredients
solid or liquid ?llers or diluents, adjuvants, surfactants or and/or the inert ?ller are insoluble or only sparingly soluble in
equivalents, which are suitable for the desired use and which water and when the ?ller for the said composition to be
are acceptable for uses in agriculture. The formulations can applied is water.
be of any type known in the sector that is suitable for appli 45 The formulations may also contain other additives such as
cation onto all types of cultures or crops. These formulations, adhesives or dyes.Adhesives such as carboxymethylcellulose
which can be prepared in any manner known by the skilled or natural or synthetic polymers in the form of powders,
person, also form part of the invention. granules or matrices, such as gum arabic, latex, polyvinylpyr
The formulations may also contain ingredients of other rolidone, polyvinyl alcohol or polyvinyl acetate, natural
types, such as protective colloids, adhesives, thickeners, 50 phospholipids, such as cephalins or lecithins, or synthetic
thixotropic agents, penetrating agents, oils for spraying, sta phospholipids canbe used in the formulations. It is possible to
bilisers, preserving agents (in particular mould-proo?ng or use colourings such as inorganic pigments, such as, for
biocide agents), sequestering or chelating agents or the like. example: iron oxides, titanium oxides, Prussian blue; organic
More generally, the compounds used in the invention can be colouring stuffs, such as those of the alizarin, azo or metal
combined with any solid or liquid additives corresponding to 55 phthalocyanin type; or of trace elements such as iron, man
the usual formulation techniques. ganese, boron, copper, cobalt, molybdenum or zinc salts.
The term “?ller” means an organic or inorganic, natural or The form of the pesticide composition according to the
synthetic component with which the active components are invention can be selected in a large number of formulations,
combined to facilitate its application, for example, onto the such as aerosol dispenser; suspension of capsules; cold fog
plants, the seeds or the soil. This ?ller is consequently gen 60 ging concentrate; dustable powder; emulsi?able concentrate;
erally inert and it must be acceptable (for example acceptable aqueous/aqueous type emulsion; oil/inverse type emulsion;
for agronomic uses, in particular for treating plants). encapsulated granule; ?ne granule; suspension concentrate
The ?ller can be solid, for example clays, natural or syn for seed treatment; compressed gas; gas generating product;
thetic silicates, silica, resins, waxes, solid fertilizers (for granule; hot fogging concentrate; macrogranule; microgran
example ammonium salts), natural soil minerals, such as 65 ule; oil-dispersible powder; oil miscible suspension concen
kaolins, clays, talc, lime, quartz, attapulgite, montmorillo trate; oil-miscible liquid; paste; plant rodlet; powder for dry
nite, bentonite or diatomaceous earths, or synthetic minerals, seed treatment; seeds coated with a pesticide; smoke maydle;
US 8,969,392 B2
13 14
smoke cartridge; smoke generator; smoke pellet; smoke dients (A) or (B), optionally (C). Such a method can be
rodlet; smoke tablet; smoke tin; soluble concentrate; soluble extended to the further application of compound (C).
powder; solution for seed treatment; suspension concen The dose of active compound usually applied in the method
trate (:?owable concentrate); ultra low volume liquid; ultra of treatment according to the invention is generally and
low volume suspension; vapour releasing product; water advantageously
dispersible granules or tablets; water dispersible powder for for foliar treatments: from 0.1 to 10,000 g/ha, preferably
slurry treatment; water-soluble granules or tablets; water
from 10 to 1,000 g/ha, more preferably from 50 to 300
soluble powder for seed treatment; wettable powder.
g/ha; in case of drench or drip application, the dose can
The pesticide composition according to the present inven
even be reduced, especially while using inert substrates
tion covers not only the compositions which are ready to be
like rockwool or perlite;
applied to the crop by means of a suitable device, such as a
for seed treatment: from 2 to 200 g per 100 kilogram of
spraying device, but also the commercial concentrated com
seed, preferably from 3 to 150 g per 100 kilogram of
position which have to be diluted before application to the
seed;
crop.
for soil treatment: from 0.1 to 10,000 g/ha, preferably from
The pesticide composition herein described is used in gen
eral for application to growing plants, or to sites where crops 1 to 5,000 g/ha.
The doses herein indicated are given as illustrative
are grown or intended to grow, or for the treatment, coating or
?lm-coating of seeds. examples of the method according to the invention. A person
According to the present invention, seeds may comprise skilled in the art will know how to adapt the application doses,
any propagation materials, like for example seeds, fruit, 20 notably according to the nature of the plant or crop to be
tubers, grains, roots, rhizomes, parts of plants. treated.
The pesticide composition according to the invention may Under speci?c conditions, for example according to the
also be applied to the vegetation and in particular to the leaves nature of the phytopathogenic fungus to be treated or insect to
infested or capable of being infested with the phytopatho control, a lower dose may offer adequate protection. Certain
genic fungi or damaged by insects. Another method of apply 25 climatic conditions, resistance or other factors like the nature
ing the pesticide composition according to the invention is to of the phytopathogenic fungi or damaging insect to be elimi
add a formulation containing the active ingredients to the nated or the degree of infestation, for example, of the plants
irrigation water.
with these fungi, may require higher doses of combined active
According to another object of the present invention, there ingredients.
is provided a method for controlling the phytopathogenic 30 The optimum dose usually depends on several factors, for
fungi or damaging insects of plants, crops or seeds, charac
example on the type of phytopathogenic fungus to be treated
terized in that an agronomically effective and substantially
or insect to control, on the type or level of development of the
non-phytotoxic quantity of a pesticide composition according
infested plant, on the density of vegetation, or alternatively on
to the invention is applied as seed treatment, foliar applica
the method of application.
tion, stem application, drench or drip application or chemi 35
Without it being limiting, the crop treated with the pesti
gation to the seed, the plant or to the fruit of the plant or to soil
cide composition or combination according to the invention
or to inert substrate (e.g. inorganic substrates like sand, rock
wool, glasswool; expanded minerals like perlite, vermiculite, is, for example, grapevine, but this could be cereals, veg
zeolite or expanded clay), Pumice, Pyroclastic materials or etables, lucerne, soybean, market garden crops, turf, wood,
stuff, synthetic organic substrates (e.g. polyurethane), 40 tree or horticultural plants.
organic substrates (e.g. peat, composts, tree waste products The method of treatment according to the invention may
like coir, wood ?bre or chips, tree bark) or to a liquid substrate also be useful to treat propagation material such as tubers or
(e.g. ?oating hydroponic systems, Nutrient Film Technique, rhizomes, but also seeds, seedlings or seedlings pricking out
Aeroponics) wherein the plant is growing or in which it is and plants or plants pricking out. This method of treatment
desired to grow. 45 may also be useful to treat roots. The method of treatment
The expression “are applied to the plants to be treated” is according to the invention may also be useful to treat the
understood to mean, for the purposes of the present invention, over-ground parts of the plant such as trunks, stems or stalks,
that the pesticide composition which is the subject of the leaves, ?owers and fruit of the concerned plant.
invention can be applied by means of various methods of Among the plants that can be protected by the method
treatment such as: 50 according to the invention, mention can be made of cotton;
spraying onto the aerial parts of the said plants a liquid ?ax; vine; fruit or vegetable crops such as Rosaceae sp. (for
comprising one of the said compositions, instance pip fruit such as apples and pears, but also stone fruit
dusting, the incorporation into the soil of granules or pow such as apricots, almonds and peaches), Ribesioidae sp.,
ders, spraying, around the said plants, and in the case of Juglandaceae sp., Belulaceae sp., Anacardiaceae sp.,
trees injection or daubing, 55 Fagaceae sp., Moraceae sp., Oleaceae sp., Aclimidaceae sp.,
coating or ?lm-coating the seeds of the said plants with the Lauraceae sp., Musaceae sp. (for instance banana trees and
aid of a plant-protection mixture comprising one of the plantins), Rubiaceae sp., Th eaceae sp., Slerculiceae sp.,
said compositions. Rulaceae sp. (for instance lemons, oranges and grapefruit);
The method according to the invention may either be a Solanaceae sp. (for instance tomatoes), Liliaceae sp., Aster
curing, preventing or eradicating method. In this method, a 60 aceae sp. (for instance lettuces), Umbelliferae sp., Cruciferae
composition used can be prepared beforehand by mixing the sp., Chenopodiaceae sp., Cucurbilaceae sp., Papilionaceae
two or more active compounds according to the invention. sp. (for instance peas), Rosaceae sp. (for instance strawber
According to an alternative of such a method, it is also ries); major crops such as Graminae sp. (for instance maize,
possible to apply simultaneously, successively or separately lawn or cereals such as wheat, rice, barley and triticale),
compounds (A) and (B) and optionally (C) so as to have the 65 Asleraceae sp. (for instance sun?ower), Cruciferae sp. (for
conjugated (A)/(B) (optionally (C)) effects, of distinct com instance colza), Fabacae sp. (for instance peanuts), Papilion
positions each containing one of the two or three active ingre aceae sp. (for instance soybean), Solanaceae sp. (for instance
US 8,969,392 B2
15 16
potatoes), Chenopodiaceae sp. (for instance beetroots); hor Cochliobolus diseases, caused for example by Cochliobo
ticultural and forest crops; as well as genetically modi?ed lus salivus;
homologues of these crops. Collelolrichum diseases, caused for example by Collelol
The composition according to the invention may also be richum lindemulhanium;
used in the treatment of genetically modi?ed organisms with Cycloconium diseases, caused for example by Cycloco
the compounds according to the invention or the agrochemi nium oleaginum;
cal compositions according to the invention. Genetically Diaporlhe diseases, caused for example by Diaporlhe
modi?ed plants are plants into genome of which a heterolo
cilri;
gous gene encoding a protein of interest has been stably
Elsinoe diseases, caused for example by Elsinoefawcellii;
integrated. The expression “heterologous gene encoding a
Gloeosporium diseases, caused for example by Gloeospo
protein of interest” essentially means genes which give the
rium laelicolor;
transformed plant new agronomic properties, or genes for
Glomerella diseases, caused for example by Glomerella
improving the agronomic quality of the modi?ed plant.
cingulala;
The composition according to the invention may also be
Guignardia diseases, caused for example by Guignardia
used against fungal diseases liable to grow on or inside tim
bidwelli;
ber. The term “timber” means all types of species of wood,
Leplosphaeria diseases, caused for example by Lep
and all types of working of this wood intended for construc
tion, for example solid wood, high-density wood, laminated Zosphaeria maculans; Leplosphaeria nodorum;
wood, and plywood. The method for treating timber accord Magnaporlhe diseases, caused for example by Mag
ing to the invention mainly consists in contacting one or more 20 naporlhe grisea;
compounds according to the invention, or a composition Mycosphaerella diseases, caused for example by
according to the invention; this includes for example direct Mycosphaerella graminicola; Mycosphaerella
application, spraying, dipping, injection or any other suitable arachidicola; Mycosphaerella?jiensis;
means. Phaeosphaeria diseases, caused for example by
Among the diseases of plants or crops that can be con 25 Phaeosphaeria nodorum;
trolled by the method according to the invention, mention can Pyrenophora diseases, caused for example by Pyreno
be made of: phora Zeres;
Powdery mildew diseases such as: Ramularia diseases, caused for example by Ramularia
Blumeria diseases, caused for example by Blumeria grami collo-cygni;
nis; 30 Rhynchosporium diseases, caused for example by Rhyn
Podosphaera diseases, caused for example by
chosporium secalis;
Podosphaera leucotricha;
Seploria diseases, caused for example by Seploria apii or
Sphaerolheca diseases, caused for example by Sphaerolh
Seploria lycopercisi;
ecafuliginea;
Zj/phuhl diseases, caused for example by Zj/phuhz incar
Uncinula diseases, caused for example by Uncinula new 35
nale;
[or ;
Venturia diseases, caused for example by Venturia
Rust diseases such as:
Gymnosporangium diseases, caused for example by Gym inaequal is ;
nosporangium sabinae; Root and stem diseases such as:
Hemileia diseases, caused for example by Hemileia vasla 40 Corlicium diseases, caused for example by Corlicium
graminearum;
Zrix ;
Phakopsora diseases, caused for example by Phakopsora Fusarium diseases, caused for example by Fusarium
pachyrhizi or Phakopsora meibomiae; oxysporum;
Puccinia diseases, caused for example by Puccinia recon Gaeumannomyces diseases, caused for example by Gaeu
dile; 45 mannomyces graminis;
Uromyces diseases, caused for example by Uromyces Rhizoclonia diseases, caused for example by Rhizoclonia
appendiculalus;
solani ;
Oomycete diseases such as: Tapesia diseases, caused for example by Tapesia acufor
Bremia diseases, caused for example by Bremia laclucae;
mis;
Peronospora diseases, caused for example by Peronospora 50 Th ielaviopsis diseases, caused for example by Thielaviop
pisi or P. brassicae;
sis basicola;
Phylophlhora diseases, caused for example by Phyloph
Ear and panicle diseases such as:
[hora infeslans;
Allernaria diseases, caused for example by Allernaria
Plasmopara diseases, caused for example by Plasmopara
vilicola; 55 AspsePrPg-i;l lus diseases, caused for example by Aspergillus
Pseudoperonospora diseases, caused for example by
?avus;
Pseudoperonospora humuli or Pseudoperonospora
Cladosporium diseases, caused for example by Cladospo
cubensis;
Pylhium diseases, caused for example by Pylhium rium spp.;
Claviceps diseases, caused for example by Claviceps pur
ultimum ; 60
Leafspot, leaf blotch and leaf blight diseases such as: purea;
Allernaria diseases, caused for example by Allernaria Fusarium diseases, caused for example by Fusarium cul
solani; momm;
Cercospora diseases, caused for example by Cercospora Gibberella diseases, caused for example by Gibberella
belicola ; 65 zeae;
Cladiosporum diseases, caused for example by Cladiospo Monographella diseases, caused for example by
rium cucumerinum; Monographella nivalis ;
US 8,969,392 B2
17 18
Smut and bunt diseases such as: pests from the order of Orthoptera for example Achela
Sphacelolheca diseases, caused for example by Sphace domesticus, Gryllolalpa spp., Locusla migratoria
latheca reiliana; migratorioides, Melanoplus spp., Schislocerca gre
?llelia diseases, caused for example by ?llelia caries; garia;
Urocyslis diseases, caused for example by Urocyslis pests from the order of Blattaria for example Blalla orien
Zalis, Periplanela americana, Leucophaea maderae,
occulla;
Blallella germanica;
Uslilago diseases, caused for example by Uslilago nuda ;
pests from the order of Dermaptera for example For?cula
Fruit rot and mould diseases such as:
auricularia;
Aspergillus diseases, caused for example by Aspergillus
pests from the order of lsoptera for example Reliculilermes
Bolrylis diseases, caused for example by Bolrylis cinerea; SPP-;
pests from the order of Phthiraptera for example Pediculus
Penicillium diseases, caused for example by Penicillium
humanus corporis, Haemalopinus spp., Linognalhus
expansum; spp., Trichodecles spp., Damalinia spp.;
Sclerolinia diseases, caused for example by Sclerolinia
pests from the order of Thysanoptera for example Herci
scleroliorum ; nolhripsfemoralis, Thrips Zabaci, Thrips palmi, Fran
Verticilium diseases, caused for example by Verticilium
kliniella accidentalis;
alboalrum; pests from the order of Heteroptera for example Euryga
Seed and soilborne decay, mould, Wilt, rot and damping-off sler spp., Dysdercus inlermedius, Piesma quadrala,
diseases: 20 Cimex leclularius, Rhodniusprolixus, Trialoma spp;
Fusarium diseases, caused for example by Fusarium cul pests from the order of Homoptera for example Aleurodes
momm; brassicae, Bemisia Zabaci, Trialeurodes vaporariorum,
Phylophlhora diseases, caused for example by Phyloph Aphis gossypii, Brevicoryne brassicae, Cryplomyzus
[hora caclorum; ribis, Aphis fabae, Aphis pomi, Eriosoma lanigerum,
Pylhium diseases, caused for example by Pylhium ulti 25 Hyaloplerus arundinis, Phylloxera vaslalrix, Pemphi
mum; gus spp., Macrosiphum avenae, Myzus spp., Phorodon
Rhizoclonia diseases, caused for example by Rhizoclonia humuli, Rhopa-losiphumpadi, Empoasca spp., Euscelis
solani ; bilobalus, Nepholellix cincliceps, Lecanium corni, Sal's
Sclerolium diseases, caused for example by Sclerolium selia 0leae, Laodelphax slrialellus, Nilaparvala lugens,
rolfsii; 30 Aonidiella auranlii, Aspidiolus hederae, Pseudococcus
Microdochium diseases, caused for example by Micro spp., Psylla spp;
dochium nivale ; pests from the order of Lepidoptera for example Pectino
Canker, broom and dieback diseases such as: phora gossypiella, Bupaluspiniarius, Chemalobia bru
Neclria diseases, caused for example by Neclria galligena; mala, Lilhocollelis blancardella, Hyponomeula
Blight diseases such as: 35 padella, Plulella xyloslella, Malacosoma neuslria,
Monilinia diseases, caused for example by Monilinia laxa; Euproclis chrysorrhoea, Lymanlria spp., Bucculalrix
Leaf blister or leaf curl diseases such as: Zhurberiella, Phyllocnislis cilrella, Agrolis spp., Euxoa
Taphrina diseases, caused for example by Taphrina defor spp., Fellia spp., Earias insulana, Heliolhis spp.,
mans; Mameslra brassicae, Panolis?ammea, Spodoplera spp.,
Decline diseases of wooden plants such as: 40 Trichoplusia ni, Carpocapsa pomonella, Pieris spp.,
Esca diseases, caused for example by Phaemoniella Chilo spp., Pyrausla nubilalis, Epheslia kuehniella,
clamydospora; Galleria mellonella, Hneola bisselliella, ?nea pel
Eulypa dyeback, caused for example by Eulypa lala; lionella, Hofmannophila pseudosprelella, Cacoecia
Dutch elm disease, caused for example by Ceralocyslsc podana, Capua reliculana, Chorisloneura fumiferana,
uhnk 45 Clysia ambiguella, H0m0na magnanima, Torlrix viri
Diseases of ?owers and Seeds such as: dana, Cnaphalocerus spp., Oulema oryzae;
Bolrylis diseases, caused for example by Bolrylis cinerea ; pests from the order of Coleoptera for example Anobium
Diseases of tubers such as: punclalum, Rhizoperlha dominica, Bruchidius obleclus,
Rhizoclonia diseases, caused for example by Rhizoclonia Acanlhoscelides obleclus, Hylolrupes bajulus, Agelas
solani 50 Zica alni, Leplinolarsa decemlineala, Phaedon cochle
Helminlhosporium diseases, caused for example by Helm ariae, Diabrolica spp., Psylliodes chrysocephala, Epil
inlhosporium solani. achna variveslis, Alomaria spp., Oryzaephilus
The damaging insects of crops Which can be controlled at surinamensis, Anthonomus spp., Silophilus spp., Olior
any development stage by using the pesticide composition rhynchus sulcalus, Cosmopoliles sordidus, Ceulhor
according to the invention include: 55 rhynchus assimilis, Hypera poslica, Dermesles spp.,
pests from the order of lsopoda for example Oniscus asel Trogoderma spp., Anthrenus spp., Allagenus spp., Lyc
lus, Armadillidium vulgare, Porcellio scaber; Zus spp., Mel igelhes aeneus, Plinus spp., Niplus h0l0leu
pests from the order of Diplopoda for example Blaniulus cus, Gibbiumpsylloides, Tr ibolium spp., Tenebrio mali
gullulalus; Zor, Agrioles spp., Conoderus spp., Melolonlha
pests from the order of Chilopoda for example Geophilus 60 melolonlha, Amphimallon solslilialis, Costelylra
carpophagus, Sculigera spp.; zealandica, Lissorhoplrus oryzophilus;
pests from the order of Symphyla for example Sculigerella pests from the order of Hymenoptera for example Diprion
immaculala; spp., Hoplocampa spp., Lasius spp., Monomorium
pests from the order of Thysanura for example Lepisma pharaonis, Vespa spp;
saccharina; pests from the order of Diptera for example Aedes spp.,
pests from the order of Collembola for example Onychi Anopheles spp., Culex spp., Drosophila melanogasler,
urus armalus; Musca spp., Fannia spp., Calliphora erythrocephala,