Perry's The Chemotherapy Source Book PDF
Preview Perry's The Chemotherapy Source Book
Perry’s The Chemotherapy Source Book G R F I F T H E D I T I O N V d e t i n U r i . s - EDITO&R s 9 n Mic9hael C. Perry, MD, MS, MACP* a r i iProfessor Emeritus s h Nellie B. Smith Chair in Oncolorgy Emeritus a e Division of Hematology/Medical Oncology t p Department of Internal Medicine . University of Missouri p Ellis Fischel Cancer Center i v Columbia, Missouri *Deceased ASSOCIATE EDITORS Donald C. Doll, MD Carl E. Freter, MD, PhD, FACP Professor Emeritus Professor of Clinical Medicine Division of Hematology/Medical Oncology Nellie B. Smith Chair in Oncology Department of Internal Medicine Director, Division of Hematology/Medical Oncology University of Missouri Department of Internal Medicine Ellis Fischel Cancer Center University of Missouri Columbia, Missouri Ellis Fischel Cancer Center Columbia, Missouri tahir99 UnitedVRG vip.persianss.ir Senior Executive Editor: Jonathan W. Pine, Jr. Senior Product Manager: Emilie Moyer Vendor Manager: Alicia Jackson Senior Manufacturing Coordinator: Benjamin Rivera Director of Marketing: Caroline Foote Designer: Teresa Mallon Production Services: S4Carlisle FIFTH Edition © 2012 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business Two Commerce Square 2001 Market Street Philadelphia, PA 19103, USA LWW.com Fourth Edition © 2008 by Lippincott Williams & Wilkins; Third Edition, © 2001 Lippincott Williams & Wilkins; Second Edition, © 1996 Williams & Wilkins; First Edition, © 1992 Williams & Wilkins G R All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storageV and retrieval system without written permission from the copyright owner, except for brief quotations d embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the abeove-mentioned copyright. t i n Printed in China U r i . Library of Congress Cataloging-in-Publication Data s - The chemotherapy source book. — 5th ed. / editors, Michael C. Perry, associate editors, Donald & s C. Doll, Carl E. Freter. 9 n p. ; cm. 9 a Includes bibliographical references and index. r ISBN 978-1-4511-0145-4 (alk. paper) i si h I. Perry, Michael C. (Michael Clinton), 1945- II. Doll, Donald C. III. Freter, Carl E. r [DNLM: 1. Neoplasms—drug theraapy. 2. Antineoplastic Agents—therapeutice use. QZ 267] 616.99’4061—dc23 t 2012001228 p . Care has been taken to confirm the accuracy of the inforpmation presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for i errors or omissions or for any consequences from applicatvion of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6:00 pm, EST. 10 9 8 7 6 5 4 3 2 1 tahir99 UnitedVRG vip.persianss.ir Dedication and Memorial This fifth edition of The Chemotherapy Source Book is fondly dedicated to Dr. Michael C. Perry. Through his energy and vision The Chemotherapy Source Book was born in 1992. To quote Dr. Perry in his preface in the first edi- tion, “The idea for this book arose from my frustration at having to consult mul- tiple sources for frequent, simple ques- tions. I concluded that although there were many excellent texts for medi- cal oncologists, there was no one text to satisfy my needs. I developed the outline of the book over the next sev- eral months, bouncing ideas off of col- leagues whenever they came into range. In preparing this book, I have been con- cerned with the practicing oncologist. I have imagined it as a well-worn text, growing dog-eared with use, rather than Michael C. Perry, MD gathering dust on a shelf. With the pos- 1945-2011 sible exception of a reviewer, I doubt anyone will intentionally sit down to read it cover-to-cover. I anticipate that a reader may read a chapter here and there as his or her interest dictates or use it to look up a specific point. I have resisted the temptation to make a multi-authored book read as if it were written by a single individual, and I would prefer that each chapter be thought of as a scholarly essay by the contributor(s).” Sadly, Dr. Perry passed away before this edition of The Chemotherapy Source Book could be completed. Dr. Donald Doll and Dr. Carl Freter have attempted the task of compiling, editing, and finishing the current edition. As we do this, we know that Dr. Perry is looking down on us smiling at our foibles and mistakes, which we are sure he is just itching to correct. Dr. Perry was many things to many people. He was a consummate physician, a talented educator of great generosity, and a tireless researcher in translational science and clinical trials to improve cancer care, and to impart the knowledge of how to improve cancer care to his students after him. Dr. Perry was also the consummate gen- tleman, friend, confidant, and raconteur whose presence among us we will forever miss. Donald C. Doll, MD Carl E. Freter, MD tahir99 UnitedVRG vip.persianss.ir tahir99 UnitedVRG vip.persianss.ir Preface Perry’s The Chemotherapy Source Book, now in its fifth edi- edition. Changes in management that have become evident tion, was the first comprehensive book to piece together all since the previous edition are documented. The content has current information on the chemotherapeutic management also been streamlined to provide essential information for of cancer patients, and has now become a standard in many the busy practitioner. circles. It provides information on the choice of chemother- In summary, Perry’s The Chemotherapy Source Book is apeutic agents, the use of combination chemotherapy, and meant to serve as a “one-stop shop” for information on the toxicity of individual drugs. Organized by site, this is the the choice of chemotherapeutic agents, treatment outlines, only book of its kind to focus strictly on the clinical practice grading of side effects, and dose modification. It is our hope of chemotherapy. There are other, smaller, texts (pocket that the fifth edition provides a practical reference for the size) but none as complete. use of chemotherapy in oncology practice that is concise yet This edition features updated drug information—over complete in its coverage of essential drug information for 20 new drugs have been added as well as new indications the busy clinician in private practice, hospital-based posi- for existing ones. Moreover, the use and unique side effects tions, and academia alike. of tyrosine kinase inhibitors, multitargeted agents, vascular endothelial growth factor inhibitors, novel monoclonal anti- Donald C. Doll, MD bodies, and immunotherapy have been incorporated in this Carl E. Freter, MD Passages from the Preface are adapted from the proposal documents drafted by Michael C. Perry for this edition. tahir99 UnitedVRvG vip.persianss.ir Preface to the First Edition The idea for this book arose from my frustration at having modifications in renal and hepatic failure. It also has chap- to consult multiple sources for frequent, simple questions. ters on gonadal toxicity and second malignancies, the most I concluded that although there were many excellent texts recently recognized toxicities of successful chemotherapy. for medical oncologists, there was no one text to satisfy my The vexing problem of chemotherapy in pregnancy is also needs. I developed the outline for the book over the next addressed. several months, bouncing ideas off of colleagues whenever The fourth section is a listing of combination chemo- they came into range. therapy programs and the appropriate references. It is one In preparing this book, I have been concerned with the man’s opinion (mine) of the most important historical and practicing oncologist. I have imagined it as a well-worn current regimens likely to be in use. I realize that this listing text, growing dog-eared with use, rather than gathering will not please everyone and that programs now in vogue dust on a shelf. With the possible exception of a reviewer, may be replaced, hopefully by those offering higher com- I doubt anyone will intentionally sit down to read it cover- plete response rates and improved survival. to-cover. I anticipate that a reader may read a chapter here The fifth section, drug administration, is aimed at the and there as his or her interest dictates or use it to look up pharmacist or nurse preparing chemotherapy, and the nurse a specific point. I have resisted the temptation to make a who administers the therapy and interacts with the pharma- multi-authored book read as if it were written by a single cist, patient, and physician. individual, and I would prefer that each chapter be thought In Section Six, selected authorities address the therapy of as a scholarly essay by the contributor(s). of specific tumors based on current knowledge. I anticipate Section One deals in a practical way with the principles that this section will receive heavy use and may elicit differ- of chemotherapy, that is, the rationale, scientific basis, and ing opinions. various settings in which the drugs are currently used. The I am grateful to my administrative assistants, Beth Van subsection on routes of administration explores the advan- Hove and Patty Moore, for their assistance and patience, to tages and disadvantages of each route. As in other sections my wife Nancy and daughters Rebecca and Katherine for of the book, I have been fortunate to attract authors who are allowing me to neglect them while I attempt to complete the authorities in their areas. text, to my contributors for their enthusiasm and expertise, Section Two, on chemotherapeutic drugs, discusses com- and to my teachers whom I have tried to emulate. A special mercially available drugs by class, emphasizing their mecha- thanks also goes to the reference librarians, here and else- nisms of action, pharmacology, toxicity, etc. in nine chapters. where, who helped with the elusive references, sources, and There is also an extensive review on current investigational searches. The editors and staff at Williams & Wilkins have agents to aid the oncologist, nurse, pharmacologist, etc. who been most helpful and supportive, especially Tim Satterfield, may need information regarding these agents. This informa- Jonathan Pine, Carol Eckhart, and Charles Zeller. Their tion is not readily available in one source elsewhere. advice and suggestions have made this a far better book than Section Three includes 16 chapters by authorities on any effort of my own. I hope you enjoy our efforts. the management of chemotherapeutic drug toxicity by organ system and incorporates guidelines for dosage Michael C. Perry, MD vi tahir99 UnitedVRG vip.persianss.ir Contributors Taher Abu Hejleh, MBBS Anne Hudson Blaes, MD, MS Hematology-Oncology Fellow Assistant Professor Division of Hematology, Oncology and Blood & Marrow Department of Medicine Transplantation, Department of Internal Medicine University of Minnesota University of Iowa Hospitals and Clinics Minneapolis, Minnesota Iowa City, Iowa Ravi K. Bobba, MD Susan K. Ailor, MD Fellow Associate Professor Division of Hematology/Medical Oncology Department of Dermatology University of Missouri University of Missouri Columbia, Missouri Columbia, Missouri Rolando D. Breier, MD Clay M. Anderson, MD, FACP Division of Hematology/Medical Oncology Medical Director University of Missouri NorthCare Hospice and Palliative Care Columbia, Missouri Palliative Care Michael T. Brennan, DDS, MHS North Kansas City Hospital Associate Chairman North Kansas City, Missouri Department of Oral Medicine James O. Armitage, MD Carolinas Medical Center The Joe Shapiro Professor of Medicine Charlotte, North Carolina Department of Internal Medicine Francis Buadi, MB ChB University of Nebraska Medical Center Assistant Professor Omaha, Nebraska Division of Hematology, Department of Medicine Lynn S. Ashby, MD Mayo Clinic NeuroOncology Program Rochester, Minnesota Barrow Neurological Institute Mohamad A. Cherry, MD Phoenix, Arizona Assistant Professor Stacey H. Bain, PhD Department of Internal Medicine, Hematology Oncology Section Vice President University of Oklahoma School of Medicine Clinical Product Development Oklahoma City, Oklahoma BioNumerik Pharmaceuticals, Inc. Nicholas W. Choong, MD San Antonio, Texas Assistant Professor Daniel J. Becker, MD Division of Hematology and Oncology Division of Hematology/Oncology, Department of Internal Medical College of Wisconsin Medicine Milwaukee, Wisconsin St. Luke’s Roosevelt Hospital Rashmi Chugh, MD Assistant Clinical Professor of Medicine Assistant Professor Department of Internal Medicine Department of Internal Medicine Columbia University University of Michigan Medical School New York, New York University of Michigan Hospitals Philip J. Bierman, MD Ann Arbor, Michigan Professor Gerald H. Clamon, MD Department of Internal Medicine Professor University of Nebraska Medical Center Department of Internal Medicine Omaha, Nebraska University of Iowa School of Medicine Susan Blackwell, MHS, PA-C Iowa City, Iowa Senior Physician Assistant Christopher R. Cogle, MD Department of Medicine Associate Professor Division of Hematology and Oncology Division of Hematology/Oncology, Department of Medicine Duke University Medical Center University of Florida Durham, North Carolina Gainesville, Florida tahir99 UnitedvViRiG vip.persianss.ir viii Contributors John T. Cole, MD Carl E. Freter, MD, PhD, FACP Chairman, South Shore Clinics Professor of Clinical Medicine Departmet of Hematology and Oncology Nellie B. Smith Chair in Oncology Ochsner Health System Director, Division of Hematology/Medical Oncology Hematology and Oncology Department of Internal Medicine Louisiana State University Health Sciences Center University of Missouri New Orleans, Louisiana Ellis Fischel Cancer Center Columbia, Missouri Jeffrey Crawford, MD George Barth Geller Professor for Research in Cancer, Teresa A. Gilewski, MD Chief of Division of Medical Oncology Associate Attending Department of Medicine Department of Medicine Duke University Medical Center Memorial Sloan-Kettering Cancer Center Durham, North Carolina New York, New York Paul S. Dale, MD James H. Goldie, MD, FRCPC Chief Emeritus Clinical Professor of Medicine Surgical Oncology BC Cancer Research Center Professor University of British Columbia Clinical Surgery Vancouver, British Columbia, Canda University of Missouri Keith Goldstein, MD Columbia, Missouri Oncology and Hematology Associates Rajiv Dhand, MD, FCCP, FACP, FAARC Tamarac, Florida Professor of Medicine Ramaswamy Govindan, MD Internal Medicine Professor of Internal Medicine University of Missouri Department of Internal Medicine Columbia, Missouri Washington University School of Medicine Donald C. Doll, MD St. Louis, Missouri Professor Emeritus Stephen L. Graziano, MD Division of Hematology/Medical Oncology Professor Department of Internal Medicine Department of Medicine University of Missouri State University of New York Upstate Medical University Ellis Fischel Cancer Center Syracuse, New York Columbia, Missouri F. Anthony Greco, MD Steven M. Duffy, MD Director Fellow Sarah Cannon Cancer Center Division of Hematology and Oncology, Sarah Cannon Research Institute Department of Medicine Nashville, Tennessee Upstate Medical University Syracuse, New York Morris D. Groves, MD, JD Associate Professor William D. Ensminger, MD, PhD Department of Neuro-Oncology Professor of Internal Medicine The University of Texas MD Anderson Cancer Center Professor of Pharmacology Houston, Texas University of Michigan Ann Arbor, Michigan Barbara A. Gruner, MD Assistant Professor Justin D. Floyd, DO Department of Child Health Cancer Care Specialists of Central Illinois University of Missouri Crossroads Cancer Center Columbia, Missouri Effingham, Illinois Assistant Professor of Clinical Medicine Vamsi P. Guntur, MD, MSc Department of Internal Medicine Assistant Professor of Medicine Washington University School of Medicine Division of Pulmonary, Critical Care and Environmental Medicine St. Louis, Missouri Department of Internal Medicine University of Missouri Arthur D. Forman, MD Columbia, Missouri Associate Professor Department of Neuro-Oncology Shadi Haddadin, MD MD Anderson Cancer Center Division of Hematology/Medical Oncology Houston, Texas University of Missouri Columbia, Missouri tahir99 UnitedVRG vip.persianss.ir Contributors ix John D. Hainsworth, MD C. Daniel Kingsley, MD, FACP Chief Scientific Officer Clinical Assistant Professor Sarah Cannon Research Institute Department of Internal Medicine Nashville, Tennessee University of Alabama at Birmingham, Huntsville Clearview Cancer Institute Monique A. Hartley, MD, MS Huntsville, Alabama Staff Physician Department of Medicine Catherine E. Klein, MD New York University Medical Center Professor of Medicine New York, New York University of Colorado Woodhull Medical Center Aurora, Colorado Brooklyn, New York Chief, Hematology/Medical Oncology Veterans Affairs Eastern Colorado Health Care System Frederick H. Hausheer, MD, FACP Denver, Colorado Chairman & Chief Executive Officer BioNumerik Pharmaceuticals, Inc. Mark Klein, MD San Antonio, Texas Assistant Professor Associate Professor University of Minnesota Medical Oncology Veterans Affairs Medical Center The Johns Hopkins Oncology Center Minneapolis, Minnesota Baltimore, Maryland Rami S. Komrokji, MD Mark I. Hunter, MD Clinical Director Assistant Professor of Medicine Department of Malignant Hematology Obstetrics, Gynecology, and Women’s Health Moffitt Cancer Center & Research Institute Director, Gynecologic Oncology Associate Professor University of Missouri Department of Oncologic Sciences Columbia, Missouri University of South Florida Tampa, Florida Maha H. Hussain, MD, FACP Professor of Medicine and Urology Robert A. Kyle, MD Department of Internal Medicine Professor of Medicine, Laboratory Medicine and Pathology University of Michigan Hematology Ann Arbor, Michigan Mayo Clinic College of Medicine Rochester, Minnesota Preetesh Jain, MD, DM Research Scholar Rajesh V. Lalla, DDS, PhD, CCRP, DABOM The Chronic Lymphocytic Leukemia Research and Treatment Assistant Professor Program Section of Oral Medicine Feinstein Institute For Medical Research University of Connecticut Health Center North Shore Long Island-Jewish Health System Department of Dentistry Manhasset, New York John Dempsey Hospital Farmington, Connecticut Carl G. Kardinal, MD, FACP Margaret Proctor Mulligan Professor of Clinical Medicine Victor A. Levin, MD Division of Hematology/Medical Oncology Emeritus Professor Department of Internal Medicine Department of Neuro-Oncology University of Missouri The University of Texas MD Anderson Cancer Center Columbia, Missouri Houston, Texas Department of Neurosurgery and Neurosciences Ramesh Khanna, MD Kaiser Permanente Karl D. Nolph, MD, Chair in Nephrology Redwood City, California Division of Nephrology Professor of Medicine Jeanette A. Linebaugh, MSN, OCN, CCRP University of Missouri Research Manager Columbia, Missouri Clinical Trials Office University of Missouri Radwan F. Khozouz, MD Ellis Fischel Cancer Center Fellow Columbia, Missouri Division of Hematology/Medical Oncology University of Missouri Alan F. List, MD Columbia, Missouri Executive Vice President and Physician-in-Chief Senior Member, Department of Malignant Hematology H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida tahir99 UnitedVRG vip.persianss.ir x Contributors Gary R. MacVicar, MD Howard Ozer, MD, PhD Assistant Professor Section Chief Division of Hematology/Oncology, Department of Internal Medicine Section Hematology/Oncology Medicine University of Illinois at Chicago Northwestern University Feinberg School of Medicine Interim Director UIC Cancer Center Northwestern Memorial Hospital UIC Cancer Center Chicago, Illinois University of Illinois at Chicago Chicago, Illinois Maurie Markman, MD Cancer Treatment Centers of America Christos Papageorgio, MD, PhD, FACP Philadelpiha, Pennsylvania SSM Cancer Care Society of Operating Guidelines Regional Research Alliance Stephen C. Medlin, DO, FACP Director Associate Professor St. Louis, Missouri Myeloma Institute for Research and Therapy University of Arkansas Medical Sciences Roy A. Patchell, MD Little Rock, Arkansas Chairman Department of Neurology Stacia C. Miles, MD Barrow Neurological Institute Section Chairman Phoenix, Arizona Department of Dermatology Austin Diagnostic Clinic Steven Z. Pavletic, MD Austin, Texas Head, Graft-versus-Host and Autoimmunity Unit Experimental Transplantation and Immunology Branch Daniel Morgensztern, MD National Cancer Institute Assistant Professor Bethesda, Maryland Division of Medical Oncology, Department of Medicine Yale University School of Medicine Michael C. Perry, MD, MS, MACP* Firm Chief for Medical Oncology Professor Emeritus Smilow Cancer Hospital Nellie B. Smith Chair in Oncology Emeritus New Haven, Connecticut Division of Hematology/Medical Oncology Department of Internal Medicine Patrick G. Morris, MB BCh, MSc University of Missouri Special Fellow Ellis Fischel Cancer Center Breast Cancer Medicine Service Columbia, Missouri Memorial Sloan-Kettering Cancer Center New York, New York Douglas E. Peterson, DMD, PhD Professor of Oral Medicine Alfred I. Neugut, MD, PhD Department of Oral Health and Diagnostic Sciences Professor University of Connecticut School of Dental Medicine Departments of Medicine and Epidemiology Co-Chair, Program in Head & Neck Cancer and Oral Oncology College of Physicians and Surgeons and Mailman School of Public Neag Comprehensive Cancer Center Health, Columbia University University of Connecticut Health Center Division of Medical Oncology Farmington, Connecticut New York Presbyterian Hospital New York, New York Bruce A. Peterson, MD Professor of Medicine Michael B. Nicholl, MD Department of Medicine Assistant Professor University of Minnesota Medical School Department of Surgery Minneapolis, Minnesota Surgical Oncology University of Missouri Kanti R. Rai, MD Columbia, Missouri Chief Division of Hematology-Oncology Larry Norton, MD Long Island Jewish Medical Center Deputy Physician-in-Chief for Breast Cancer Programs New Hyde Park, New York Medicine Professor of Medicine Memorial Sloan-Kettering Cancer Center Departments of Medicine New York, New York Albert Einstein College of Medicine Sonia Okuyama, MD Bronx, New York Assistant Professor Division of Medical Oncology University of Colorado School of Medicine Denver Health Medical Center Denver, Colorado *Deceased tahir99 UnitedVRG vip.persianss.ir
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