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Access to the eBook is limited to the first individual who redeems the PIN, located on the inside cover of this book, at expertconsult.inkling.com and may not be transferred to another party by resale, lending, or other means. i OB/GYN This page intentionally left blank OB/GYN FOURTH EDITION AMANDA MULARZ, MD Clinical Instructor David Geffen School of Medicine at UCLA Los Angeles, California; Maternal-Fetal Medicine Fellow Department of Obstetrics and Gynecology Ronald Reagan-UCLA Medical Center Los Angeles, California STEVEN DALATI, MD Assistant Clinical Professor of Obstetrics and Gynecology David Geffen School of Medicine at UCLA Los Angeles, California; Department of Obstetrics and Gynecology Olive View-UCLA Medical Center Sylmar, California RYAN PEDIGO, MD Assistant Professor David Geffen School of Medicine at UCLA Los Angeles, California; Attending Physician and Clerkship Director Department of Emergency Medicine Harbor-UCLA Medical Center Torrance, California 1600 John F. Kennedy Blvd. Ste 1800 Philadelphia, PA 19103-2899 OB/GYN SECRETS ISBN: 978-0-323-39922-7 Copyright © 2017 by Elsevier, Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechani- cal, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permis- sions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copy- right Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any lia- bility for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Previous editions copyrighted 2003, 1997, and 1991 by Mosby, an imprint of Elsevier, Inc. Library of Congress Cataloging-in-Publication Data Ob/gyn secrets (Frederickson) Ob/gyn secrets / [edited by] Amanda Mularz, Steven Dalati, Ryan Pedigo.-- Fourth edition. p. ; cm. -- (Secrets series) Includes bibliographical references and index. ISBN 978-0-323-39922-7 (pbk. : alk. paper) I. Mularz, Amanda, editor. II. Dalati, Steven, editor. III. Pedigo, Ryan, editor. IV. Title. V. Series: Secrets series. [DNLM: 1. Genital Diseases, Female--Examination Questions. 2. Pregnancy Complications--Examination Questions. 3. Pregnancy. WP 18.2] RG111 618.076--dc23 2015036610 Executive Content Strategist: James Merritt Content Development Specialist: Margaret Nelson Publishing Services Manager: Patricia Tannian Project Manager: Stephanie Turza Book Designer: Ryan Cook Printed in United States of America Last digit is the print number: 9 8 7 6 5 4 3 2 1 To my husband, and all who contributed their time and effort to make this possible; many thanks. A.M. To my colleagues, friends, and amazing wife, whose effort and energy made this publication possible. S.D. To all of my mentors and teachers throughout my journey who have always been there to support me, guide me, and drive me to be better. R.P. This page intentionally left blank CONTENTS TOP 100 SECRETS 1 I General GynecoloGy CHAPTER 1 THE MENSTRUAL CYCLE 7 Jacob Casey, MD, and Judy H. Chen, MD CHAPTER 2 PREMENSTRUAL SYNDROME AND DYSMENORRHEA 11 Alin Lina Akopians, MD, PhD CHAPTER 3 ABNORMAL UTERINE BLEEDING 15 Hannah Newmark, MD CHAPTER 4 ENDOMETRIOSIS AND ADENOMYOSIS 18 Julia Switzer, MD CHAPTER 5 LEIOMYOMATOUS UTERUS 21 Elena Martinez, MD CHAPTER 6 ANOVULATION 25 Jacob Casey, MD, and Judy H. Chen, MD CHAPTER 7 FEMALE SEXUAL DYSFUNCTION 28 Whitney Sigala, MD CHAPTER 8 MENOPAUSE 31 Rachel Rosenheck, MD, and Judy H. Chen, MD CHAPTER 9 BENIGN LESIONS OF THE VULVA AND VAGINA 36 Susan Park, MD CHAPTER 10 LOWER GENITAL TRACT INFECTIONS 40 Manpreet Singh, MD CHAPTER 11 PELVIC INFLAMMATORY DISEASE 46 Mary Anne M. Baquing, MD CHAPTER 12 ECTOPIC PREGNANCY 49 Ryan Pedigo, MD CHAPTER 13 INDUCED ABORTION 54 Lirona Katzir, MD CHAPTER 14 CONTRACEPTION 58 Elena Martinez, MD CHAPTER 15 BENIGN ADNEXAL MASSES 65 Carrie E. Jung, MD CHAPTER 16 ACUTE AND CHRONIC PELVIC PAIN 69 Judy H. Chen, MD CHAPTER 17 URINARY INCONTINENCE 74 Erin Mellano, MD, and Cecilia K. Wieslander, MD vii viii CONTENTS CHAPTER 18 PELVIC ORGAN PROLAPSE 79 Zaid Q. Chaudhry, MD, and Cecilia K. Wieslander, MD CHAPTER 19 BREAST DISEASE 84 Susan Park, MD CHAPTER 20 INTIMATE PARTNER VIOLENCE 88 Mae Zakhour, MD II reproductive endocrinoloGy CHAPTER 21 PUBERTY 90 Michelle S. Özcan, MD, and Travis W. McCoy, MD CHAPTER 22 AMENORRHEA 96 Michelle S. Özcan, MD, and Travis W. McCoy, MD CHAPTER 23 INFERTILITY 102 Lauren W. Sundheimer, MD, and Travis W. McCoy, MD CHAPTER 24 OVULATION INDUCTION AND IN VITRO FERTILIZATION 108 Alexandra Walker, DO, and Travis W. McCoy, MD CHAPTER 25 SPONTANEOUS ABORTION AND RECURRENT PREGNANCY LOSS 113 Paul Buzad, MD, and Travis W. McCoy, MD CHAPTER 26 HIRSUTISM AND POLYCYSTIC OVARIAN SYNDROME 118 Danny Younes, MD, and Travis W. McCoy, MD III GynecoloGic oncoloGy CHAPTER 27 PRECANCEROUS LESIONS OF THE LOWER GENITAL TRACT 122 Lisa Garcia, MD CHAPTER 28 VULVAR AND VAGINAL CANCER 126 Ramy Eskander, MD CHAPTER 29 CERVICAL CANCER 131 Ramy Eskander, MD CHAPTER 30 ENDOMETRIAL HYPERPLASIA AND UTERINE CANCER 135 Ramy Eskander, MD CHAPTER 31 OVARIAN CANCER 139 Ramy Eskander, MD, and Mae Zakhour, MD CHAPTER 32 GESTATIONAL TROPHOBLASTIC DISEASE 146 Ramy Eskander, MD IV General obstetrics CHAPTER 33 NORMAL PHYSIOLOGY OF PREGNANCY 149 Stacy M. Yadava, MD CHAPTER 34 PATHOPHYSIOLOGY OF THE PLACENTA 152 Carlos Rangel, MD CHAPTER 35 PRECONCEPTION COUNSELING 155 Anna Karina Celaya, MD CHAPTER 36 COMPREHENSIVE PRENATAL CARE 157 Hai-Lang Duong, MD