Numerical Analysis for the Hemodynamics in unruptured Cerebral Aneurysms

101 Pages·2016·3.15 MB·English

United Arab Emirates University
Scholarworks@UAEU
Theses Electronic Theses and Dissertations
4-2016
Numerical Analysis for the Hemodynamics in
unruptured Cerebral Aneurysms
Hashem Mhd Hicham Alargha
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Recommended Citation
Hicham Alargha, Hashem Mhd, "Numerical Analysis for the Hemodynamics in unruptured Cerebral Aneurysms" (2016).Theses. 334.
https://scholarworks.uaeu.ac.ae/all_theses/334
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Declaration of Original Work

I, Hashem Mhd Hicham Alargha, the undersigned, a graduate student at the United Arab
Emirates University (UAEU), and the author of this thesis entitled “Numerical Analysis
For The Hemodynamics In Unruptured Cerebral Aneurysms”, hereby, solemnly declare
that this thesis is my own original research work that has been done and prepared by me
under the supervision of Dr. Mohammad Omar Hamdan, in the College of Engineering
at UAEU. This work has not previously been presented or published, or formed the basis
for the award of any academic degree, diploma or a similar title at this or any other
university. Any materials borrowed from other sources (whether published or
unpublished) and relied upon or included in my thesis have been properly cited and
acknowledged in accordance with appropriate academic conventions. I further declare
that there is no potential conflict of interest with respect to the research, data collection,
authorship, presentation and/or publication of this thesis.

Student’s Signature: Date: ________________
iii

Copyright

Copyright © 2016 by Hashem Mhd Hicham AlArgha
All Rights Reserved
iv

Advisory Committee

1) Advisor: Dr. Mohammad Omar Hamdan
Title: Associate Professor
Department of Mechanical Engineering
College of Engineering

2) Co-advisor: Dr. Waseem Aziz
Title: Lecturer of Neurosurgery
Department of Neurosurgery
College of Medicine, Alexandria University
Neurovascular surgeon, Tawam Hospital, UAE

3) Co-advisor: Dr. Emad Elnajjar
Title: Associate Professor
Department of Mechanical Engineering
College of Engineering, UAE University

4) Co-Advisor: Dr. Ali Alnaqbi
Title: Associate Professor
Department of Mechanical Engineering
College of Engineering, UAE University
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Abstract

A cerebral aneurysm is a vascular disorder characterized by abnormal focal dilation of a
brain artery which is considered as a serious and potentially life-threatening condition.
Cerebral aneurysms affect around 2%-5% of adults and they are fatal and can rupture with
an overall mortality rate of more than 50%. Through computational fluid dynamics
investigation, this study is offering a closer look into the initiation growth and rupture of
cerebral aneurysms. Four focus points are studied in this thesis which are sensitivity
analysis of blood viscosity in aneurysms, the effect of cerebral aneurysm size on wall
stresses and strain, hazard effects of gravitational forces on aneurysms and the use of
porous media to model aneurysm coiling treatment method.
This study highly contributes to the advancement of our vision about different aneurysm
variables, such as the blood velocity, pressure, wall shear stress and the aneurysm wall
stresses and strains. The study aims to provide information for the healthy and diseased
cardiovascular functions and to assist in predicting the risk of aneurysm rupture. It
provides surgeons with a better understanding of the aneurysm hemodynamics which
supports optimal medical treatments.
Keywords: Newtonian, Aneurysm, Computational Fluid Dynamics, Gravity, Porous,
Cerebral.
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Title and Abstract (in Arabic)

ةقزمتم ريغلا ةيغامدلا ةيومدلا ةيعولأل يعضوملا ددمتلا يف ةيومدلا ةرودلا مييقتل يددعلا ليلحتلا
صخلملا
و ةيغامدلا ةيومدلا ةيعولأا نرا دج يف لصحي يعيبط ريغ براطضا وه غامدلا يف ةيومدلا ةيعولأا ددمت
نيغلابلا نم %5-%2 ةبسن ىلع غامدلا يف ةيومدلا ةيعولأا ددمت رثؤي .ةايحلل ةددهمو ةريطخ ةلاح ددمتلا اذه ربتعي
ددمتلا مييقتل ةيليلحتلا ةيددعلا تاسرادلا للاخ نم .%50لا ىدعتت ةافولا ةبسن نإف يومدلا ءاعولا قزمت لاح يفو
،ومنو ،ءدب ىلع ةصحاف ةرظن مدقت ةسرا دلا هذه نإف ةقزمتم ريغلا و ةقزمتملا ةيغامدلا ةيومدلا ةيعولأل يعضوملا
ةيساسح ليلحت )1 :يه ةيساسأ طاقن عبرأ ةسرا د ىلع زيكرتلا ثحبلا اذه يف مت .غامدلا يف ةيومدلا ةيعولأا ،قزمتو
ةيكيناكملا صئاصخلا ىلع ةيغامدلا ةيعولأا يف تاددمتلا مجح ريثأت )2 ؛ةيغامدلا ةيعولأا ددمت يف مدلا ةجوزل
مادختسا ليلحت )4 ؛غامدلا يف ةيومدلا ةيعولأا ددمت ىلع ةيبذاجلا ىوق رطاخمو ترايثأت )3 ؛يومدلا ءاعولا رادجل
.غامدلا يف ةيومدلا ةيعولأا ددمت جلاع يف ةيماسملا لئاسولا
لثم ةيغامدلا ةيومدلا ةيعولأا يف ةددعتملا ترا يغتملا لوح ةيبطلا ةيؤرلا عاستا يف ريبك دح ىلإ مهاست ةسرا دلا هذه
ةيفاكلا تامولعملا ريفوت ىلإ ةسرا دلا هذه فدهتو .يرادجلا صقلا داهجاو يدوماعلا داهجلإاو طغضلا و مدلا ةعرس
ثوحبلل ةادأ ةسرا دلا هذه رفوتو .اهقزمت ةيلباق و رطخ ةفرعم ىلع ةدعاسملل ةبرطضملاو ةميلسلا ةيومدلا ةيعولأا نع
ةيبط ةرادلإو ةيومدلا ةيعولأا يف مدلا اكيمانيدل لضفأ مهفل باصعلأا ةحرا ج ءابطأو ثاحبلأا زكرا م لبق نم ةيلبقتسملا
.ىلثم
.ةيغامد ،ةيماسم ،ةيبذاج ،ةيومدلا ةيعو لأا ددمت ،مدلا مأ ،ةينوتوين :ةسيئرلا ثحبلا ميهافم
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Acknowledgements

First and Foremost praise is to Allah, the Almighty, the greatest of all, on whom
ultimately we depend for sustenance and guidance. I would like to thank almighty Allah
for giving me opportunity, determination and strength to do my research. His continuous
grace and mercy was with me throughout my life and ever more during the tenure of my
research. I would like to thank the one that is my friend, my teacher and my advisor, Dr.
Mohammad O. Hamdan for his unwavering support and enthusiasm throughout this
research endeavor. Our discussions of research ideas allowed me to come up with this new
idea that crosses between many different areas of research and involves a lot of
multidisciplinary topics that greatly reinforced my academic knowledge and professional
expertise, actually I would like to thank him deeply from my heart. Also, I would like to
thank my medical field advisor Dr. Waseem H. Aziz for his continuous support, aid and
giving me the chance to work in cooperation with Tawam Hospital as a computational
fluid dynamic researcher. Many thanks for Dr. Emad Elnajjar and Dr. Ali Alnaqbi for their
support and advice during the thesis preparation. Many thanks to Eng. Youssef Shabaan
and all engineers and lab technicians across the Mechanical Engineering Department that
provided me with the necessary equipment and guidance. Finally, I warmly thank my
family and friends for their immense support and motivation that they provided which
helped bring the best out of me towards the success of my educational and professional
journeys.