New Frontiers in Mammary Pathology PDF
Preview New Frontiers in Mammary Pathology
NEW FRONTIERS IN MAMMARY PATHOLOGY NEW fRONTIERS IN MAMMARY PATHOLOGY Edited by K. H. Hollmann Marie-lAnnelongue Surgieal Center Le Plessis Robinson, Franee J. de Brux Institute of Pa thology and Applied Cytology Paris, Franee and J. M. Verley Marie-lAnnelongue Surgieal Center Le Plessis Robinson, Franee PLENUM PRESS· NEW YORK AND LONDON Library of Congress Cataloging in Publication Data Main entry under title: New frontiers in mammary pathology. Bibliography: p. Includes index. 1. Breast-Diseases. 2. Breast-Cancer. I. Hollmann, K. H. 11. Brux, Jean deo III. Verley, J. M. [DNLM: 1. Breast neoplasms-Pathology-Congresses. 2. Breast neo plasms-Therapy-Congresses. WP 870 N533 1979] RG491.N48 618.1'9 81-1547 ISBN 978-1-4757-0021-3 ISBN 978-1-4757-0019-0 (eBook) AACR2 DOI 10.1007/978-1-4757-0019-0 Proceedings of the first Symposium on Mammary Pathology, organized by the International Society against Breast Cancer, and held December 3-7, 1979, in Paris, France © 1981 Plenum Press, New York Softcover reprint ofthe hardcover 1st edition 1981 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE The first Symposium on ~iammary Pathology organized by the International Society against Breast Cancer was held in Paris on December 3-7, 1979. The programme was divided into sections with morning lectures on current topics in mammary pathology given by invited speakers, followed by discussions, and, in the afternoon, emphasis on practical work, such as slide seminars, technical explanations of tissue and cell preparations for histology, cytology, electron microscopy and tissue culture work. The morning sessions were held at the Racing Club of France, 5 rue Eble, 75007 Paris and the organizers of the meeting wish to thank the RCF andits President, Mr. R. Menard for their kindness and generous help in the arrangement of the symposium. The afternoon workshops too~ place at the Institut de Pathologie et de Cytologie Appliquee {Director Professor J. de Brux) , rue des BeIles Feuilles, Paris XVI, with the help of staff members from this Institute. The editors of the Proceedings of the Symposium wish to thank the contributors for their help in providing manuscripts for publication and for complying with the instructions given by the editors and the Plenum p;ubli shing Company. Financial supports providea by the Ligue Nationale Fran9aise contre le Cancer and the FEGEFLUC are gratefully acknowledged. It is hoped that the present volume will provide stimuli for future work on clinical and basic research in mammary pathology. K. H. Hollmann v CONTENTS Marnmary gland differentiation and hormonal influences. . . . . . . . • . . . . . . . . . . . . . . . . . . . . . . . 1 K.H. Hollmann Early lesions of the human marnmary gland and their relationship to precancerous lesions of other species.......................... 27 S.R. Wellings, M. DeVau1t, Virginia Jenfoft, J. Richards, J. Yang, S. Nandi, R. Guzman, and L.J. Faulkin Natural history of benign breast tumors.......... 51 J. de Brux Cystosarcoma phyllodes.. ......................... 73 F. Cabanne Aspiration cytology and cyto-prognosis of breast lesions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 A. Zajdela and M.A. de Maublanc Heterotransplantation of human mammary carcinoma ce1ls. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 L. Ozzel1o and M. Sordat Human breast tumor cells in cu1ture ; new concepts in mammary carcinogenesis................. 117 E.Y. Lasfargues and W.G. Coutinho Elastosis in human breast cancer. Part I. Morphological studies..................... 145 J.J. Adnet, P. Birembaut, R. Sadrin, D. Gaillard, C. Pastisson, L. Robert, H. Dousset, anä W.V. Bogomo1etz vii viii CONTENTS Elastosis in human breast cancer. Part 11. Bio- chemical studies........ ........ .......... 163 L. Robert, W. Hornebeck, D. Brechemier and J.J. Adnet Fibronectin in breast cancers.................... 175 P. Birembaut, J.J. Aönet, J. Labat-Robert, F. Mercantini, and L. Robert Immunotherapy of spontaneously arising rat mammary tumours. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185 R.W. Baldwin, M.V. Pimm and N. Willmott Morphological aspects of immunotherapy in breast cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 J.M. Verley, K.H. Hollmann, R. Villet and J. Reynier Regression in normal and pathological mammary tissues. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223 J. de Brux The natural history of human breast cancer....... 239 M. Tubiana, A.J. Valleron and E. Malaise Tumor associated markers in breast cancer........ 255 P. Franchimont, P.F. Zangerle, J. Collette, C. Colin, P. Osterrieth, J.C. Hendrick, J.R. van Cauwenberge, and J. Hustin Contribution of estrogen receptors to the stragegy of breast cancer treatment....... 267 J.C. Heuson, M.D., R. Paridaens, M.D., E. Ferrazzi, M.D., N. Legros, G. Leclercq, Ph.D., and R.J. Sylvester, M.S. Hormonal dependence of benign breast disease, gynecomastia and breast cancer............ 287 B. de Lignieres and P. Mauvais-Jarvis List of invited speakers......................... 309 Index. . . . • . . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . . . 311 GLAND DIFFERENTIATION AND HORMONAL INFLUENCES r~RY I<. H. Hollmann Hopital Marie-Lannelongue 133 avenue äe la R~sistance 92350 Le Plessis Robinson, France Phylogenetically, marnrnary glands appeared in the animal kingdorn about 100 million years ago, when the era of the egg-laying dinosaurs declineä. At this time milk secretion became vital for the nourishment of an immature off spring and has remained so until our times. Für only a few decades has the modern technical world increasingly replaced suckling by artificial nutrition. Marnrnary glanäs are paired organs. Their number is grossly related to the number of newborns and varies trom species to species and even in the same species, e.g., in rodents from 2 (guinea pig) to 14 (hamster) (for details see Anaerson, 1978). The fundamental architecture of the gland consists oi dichotomically branching ducts and terminal lobules. The main ducts or galactophores originate in the nipple. In some marnrnals, as in the cow, there is only one galacto phore (opening) per teat, whereas in others, as in humans, there are 15 and more (up to 25). Each galactophore in the mature animal arises enmryo logically from a primary sprout as represented in Fig. 1, redrawn from Anderson (1978). Different developmental stages may be distinguisheä in the fOllowing sequence : Band - streak - line-crest hillock-buä-early teat formation - primary sprout - secondary sprout - canalization of primary sprout ( = formation of galactophore) . 2 K. H. HOLLMANN Band Streak Line Crest • Hillock. A· ·~ . . Bud .. ~.; Early teat formation Primary sprout Seeondary sprout Canalization of primary sprout Fig. 1. Sequential steps in mammary gland development. Sehematie representation from histologie eross seetions. ( Rearawn fram Anderson, 1978 ). DIFFERENTIATION AND HORMONAL INFLUENCES 3 Fig. 2. Unstimulated mammary tree with branching ducts but almost no alveoli. ( Whole mount, x 28 ). Fig. 3. Stimulateä man®ary tree with developing alveoli under the hormonal influence of beginning preg nancy. ( Whole mount, x 16 ). 4 K. H. HOLLMANN Fig. 4. Formation oi terminal lobules in a hormonally stimulated gland. (Whoie mount, x 33 ). Outer limit of lobule A. ,\.--X.... d " , / ", ETD I \ ("B"ductl I \ I \ ~------~~------~ I I ( 11 .. . I . ", ....... "., "-------- --- I ITD ("C"ductl ,, , ~ TDlU Fig. 5. Terminal ductal lobular unit ( '!Dill ). ( Slightly m::xiified fram Wellings and Wolfe, 1978 ). E'!D = extralobular terminal duct I'!D = intralobular terminal duct d = ductule ( or acinus / alveolus A, B, C, D indicate ducts of different ( decreasing ) size.
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