Table Of ContentNeurosecretion -
The Final Neuroendocrine
Pathway
VI International Symposium on Neurosecretion,
London 1973
Edited by
Francis Knowles and Lutz Vollrath
With 92 Figures
Springer-Verlag Berlin Heidelberg GmbH 1974
Sir FRANCIS KNOWLES F.R.S.t, Professor of Anatomy, King's College, Strand, London
WC2R 2LS, Great Britain
LUTZ VOLLRATH, Professor of Anatomy, King's College, Strand, London WC2R 2LS, Great
Britain. Present address: Anatomisches Institut der Johannes-Gutenberg-Universitat,
D-6500 Mainz, Saarstr. 19-21jFederal Republic of Germany
Ubrary of Congress Cataloging in Publication Data
Neurosecretion - the final neuroendocrine pathway.
International Symposium on Neurosecretion, 6th, London, 1973.
1. Neurosecretion-Congresses. 2. Neuroendocrinology-Congresses. I. KNOWLES, Sir FRANCIS GERALD WILLIAM,
bart., 1915- ed. II. VOLLRATH, LUTZ, 1936- . III. Title. [DNLM: 1. Neurosecretion-Congresses.
W3IN92Q 1973n!WL312 1611973n] QP356.4.159 1973 591.1'88 74-13218
ISBN 978-3-662-12589-2 ISBN 978-3-662-12587-8 (eBook)
DOI 10.1007/978-3-662-12587-8
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© by Springer-Verlag Berlin Heidelberg 1974.
Originally published by Springer-Verlag Berlin Heidelberg New York in 1974.
Softcover reprint of the hardcover 1st edition 1974
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Preface
This volume marks the end of twenty years of neurosecretion during which
there were five symposia, namely Naples (1953), Lund (1957), Bristol (1961),
Strasbourg (1966), and Kiel (1970). In comparison with these symposia an
exceptionally large number of papers were read at this the sixth symposium,
in London, and for economic reasons it has not been possible to publish all the
papers in extenso. The editors have therefore been obliged to undertake the
unenviable work of selection, a task made all the more difficult by the excel
lence and importance of contributions of the symposium. We felt that it was
of the utmost importance at this moment in the history of neurosecretion
to present as complete a picture as possible of the present state of the subject
in relation to the past and opportunities for the future. We have therefore
given some preference to papers with a strong review element, research
papers in areas of current importance and contributions which deal with
recently developed techniques with promise for the future. We have more
over attempted to strike some balance between the different areas of research
on neurosecretion so that the volume as a whole may be of interest to the
general reader, and that he will find in it a reasonably coherent pattern of
thought which demonstrates neurosecretion as the final neuroendocrine
pathway.
We have attempted a certain degree of uniformity of spelling, symbols,
etc. but in cases where there is some difference of opinion, as in spelling which
differs on both sides of the Atlantic or in a word such as "neuron/neurone"
which seems to have no geographical boundaries we have not attempted any
value judgements but have left the spelling as it was intended by the authors.
Finally we should like to acknowledge our gratitude to the authors who
met our demands in the preparation of manuscripts and especially to those
who responded so splendidly to the request that they should not write in
their mother tongue but, instead, in English so that the volume could have
complete uniformity of language. A special mention should also be made of
those who presented results of great importance in the symposium yet are
represented in this volume by abstracts only. They knew, and we knew,
that their work should be presented in a longer form yet they accepted with
out complaint the need for selection so that the many areas of research in
neurosecretion could each be adequately represented.
VI Preface
Acknowledgements: The members of the VI International Symposium
on Neurosecretion are all indebted to the following for financial support of
our symposium: Ciba-Geigy (U. K.) Ltd; Hoechst Pharmaceuticals; Impe
rial Chemical Industries Ltd; Organon International B. V. Some members
of the symposium were given financial aid by British Council.
The success of the symposium was in no small measure due to the enthusi
asm and efforts of Miss Wendy Charnell and Miss Jeannie Paterson, who did
the essential secretarial and art work. The organisers of the symposium are
deeply indebted to these and the many other helpers for their assistance.
London, Summer 1974
FRANCIS KNOWLES
LUTZ VOLLRATH
It is with deep regret that owing to his sudden and unexpected death on
July 13th, 1974, Sir Francis Knowles is unable to see the completion and
publication of this present volume. Especially so because he found great
pleasure and satisfaction in both the organising of the VI International
Symposium on Neurosecretion, into which he put so much effort, and in
editing the present Proceedings of this conference. Sir Francis' review,
published as the Introduction to the present volume, of twenty years of
neurosecretion in which he played such an important role reflects very
clearly that neurosecretion has lost both a great pioneer and an aris
tocratic ambassador. He was one of the few who attended all six Symposia
on Neurosecretion held so far and he will be greatly missed by all.
LUTZ VOLLRATH
Contents
Dr. Manfred Gabe 1916-1973
I. Introduction
KNOWLEs,F.: Twenty Years of Neurosecretion. With 2 Figures. 3
II. Peptidergic Neurosecretion
A. Classical Neurosecretion
a ) Morphology
STUTINSKY,F.: Morphological and Physiological Reactions of the Supraoptic
and Paraventricular Nuclei. With 3 Figures. . . . . . . . . . . . . 15
BURLET,A., MARCHETTI,J., and DUHEILLE,J.: Immunohistochemistry of
Vasopressin: Study of the Hypothalamo-Neurohypophysial System
of Normal, Dehydrated and Hypophysectomized Rats. With 3 Figures. 24
DREIFUSS,J.J., NORDMANN,J.J., AKERT,K., SANDRI,C., and MOOR,H.: Exo
Endocytosis in the Neurohypophysis as Revealed by Freeze-Fracturing.
With 2 Figures . . . . . . . . . . . . . . . . . . . . . . . . . 31
STERBA, G.: Ascending Neurosecretory Pathways of the Peptidergic Type.
With 4 Figures . . . . . . . . . . . . . . . . . . . . . . . . . 38
MASON,C.A. andNIsHIOKA,R.S.: The Use of the Cobalt Chloride-Ammonium
Sulfide Precipitation Technique for the Delineation of Invertebrate and
Vertebrate Neurosecretory Systems. With 3 Figures . . . . . . . . . 48
RAABE,M., BAUDRY,N., GRILLOT,J.P., and PROVANSAL,A.: The Perisympa
thetic Organs of Insects. With 2 Figures and 1 Plate . . . . . . . . . 59
b) Biochemistry and General Physiology
PICKERING,B.T., JONES,C.VV., and BURFORD,G.D.: Biochemical Aspects of
the Hypothalamo-Neurohypophysial Neurone. With 4 Figures .... 72
NORsTRoM,A.: The Heterogeneity of the Neurohypophysial Pool of Neuro
physin. With 2 Figures. . . . . . . . . . . . . . . . . . . . . . 86
LEDERIS,K., BERN,H.A., MEDAKOVIC,M., CHAN,D.K.O., NISHIOKA,R.S.,
LETTER,A., SWANSON,D., GUNTHER,R., TEsANovIC,M., and HORNE,B.:
Recent Functional Studies on the Caudal Neurosecretory System of
Teleost Fishes. With 2 Figures. . . . . . . . . . . . . . . . . . . 94
BLISS, D. E. and HOPKINS, P. M.: Bioassay and Characterization of Crustacean
Limb Growth-Controlling Factors. With 3 Figures . . . . . . . . . . 104
VIII Contents
c) Electrophysiology
CRoss,B.A.: The Neurosecretory Impulse. With 3 Figures 115
LINCOLN,D. W.: Dynamics of Oxytocin Secretion. With 2 Figures. 129
B. Hypophysiotropic Neurosecretion
MARTINI, L.: Recent Advances in the Study of the Hypothalamic Releasing
Factors. With 9 Figures. . . . . . . . . . . . . . . . . . . . . . 135
BARRY,J. and DUBOIS,M.P.: Study of the Preoptico-Infundibular LH-RH
Neurosecretory Pathway in Female Guinea-Pigs during Gestation and the
Oestrous Cycle. With 11 Figures. . . . . . . . . . . . . . . . . . 148
OKSCHE,A., OEHMKE,H.J., and HARTWIG,H.G.: A Concept of Neuroendo-
crine Cell Complexes. With 4 Figures. . . . . . . . . . . . . . . . 154
SCOTT,D.E., PAULL,W.K., KOZLowSKI,G.P., KROBISCH DUDLEY,G., and
KNIGGE,K.M.: Cellular Localization of Thyrotropic Releasing Factor
(TRF) after Intraventricular Administration. With 4 Figures. . . . . 165
DIERICKX,K.: Identification of Adenohypophysiotropic Neurohormone
Producing Neurosecretory Cells in Rana temporaria. With 3 Figures . . 170
VANOORDT,P.G.W.J., Goos,H.J.Th., PEUTE,J., and TERLou,M.: Structural
and Functional Aspects of Two Types of Gomori-Negative Neurosecretory
Centres in the Caudal Hypothalamus of Amphibia. With 3 Figures. 182
PETER, R. E. and McKEOWN, B. A.: Control of Prolactin Secretion in the
Goldfish, Carassius auratus. With 2 Figures . . . . . . . . . . . . . 193
MEURLING,P. and LARSSON,L.: Pars Intermedia Control with and without
Innervation-Studies in Elasmobranchs and a Lizard. With 2 Figures 198
III. Aminergic Mechanisms in Neuroendocrine Control
BJORKLUND,A., FALcK,B., NOBIN,A., and STENEVI,U.: Organization of the
Dopamine and Noradrenaline Innervation of the Median Eminence
Pituitary Region in the Rat. With 3 Figures. . . . . . . . . . . . . 209
FuxE,K., GOLDSTEIN,M., HOKFELT,T., JONSSON,G., and LOFSTROM,A.: New
Aspects on the Catecholamine Innervation of the Hypothalamus and the
Limbic System. . . . . . . . . . . . . . . . . . . . . . . . . . 223
LICHTENSTEIGER, W.: Extrahypothalamic Influences on the Tubero-Infundi-
bular Dopamine Neurones and the Secretion of Luteinizing Hormone (LH)
and Prolactin. With 1 Figure . . . . . . . . . . . . . . . . . . . 229
MULLER, E. E. and COCCHI, D.: Brain Monoamines and the Control of Growth
Hormone Release. With 1 Figure. . . . . . . . . . . . . . . . . . 241
RICHARDs,J.G. and TRANzER,J.P.: The Characterization of Monoaminergic
Nerve Terminals in the Brain by Fine Structural Cytochemistry. With
5 Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . 246
McKENNA, O. C. and RosENBLuTH,J.: Sensory and Secretory Catecholamine
Containing Cells Bordering the Third Ventricle of the Toad Brain. With
2 Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . 260
Contents IX
IV. Summaries
FuxE,K., HOKFELT,T., JONSSON,G., and LOFSTROM,A.: Aminergic Mechan-
isms in Neuroendocrine Control. With 2 Figures. . . . . . . . .. 266
VOLLRATH,L.: New Trends in Vertebrate Neurosecretion. With 1 Figure .. 276
SCHARRER,B.: New Trends in Invertebrate Neurosecretion. With 2 Figures. 285
BARGMANN, W.: Concluding Remarks . . . . . . . . . . . . . . . . . 288
v.
Abstracts . . . 2!H
List of Participants 331
Subject Index. . . 337
