Neuroinflammation and CNS Disorders

420 Pages·2014·6.79 MB·English

by  Nicola Woodroofe, Sandra Amor

Neuroinflammation
and CNS Disorders
Editors Nicola Woodroofe Sandra Amor

Neuroinflammation and
CNS Disorders

Neuroinflammation and
CNS Disorders
Editedby
Nicola Woodroofe
Sheffield Hallam University
Sandra Amor
VU Amsterdam
Thiseditionfirstpublished2014 C⃝2014byJohnWiley&Sons,Ltd
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NeuroinflammationandCNSdisorders/[editedby]NicolaWoodroofeandSandraAmor.
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Includesbibliographicalreferencesandindex.
ISBN978-1-118-40641-0(cloth)
I.Woodroofe,Nicola,editorofcompilation.II.Amor,Sandra,editorofcompilation.
[DNLM: 1. NeurodegenerativeDiseases–immunology. 2. AutoimmuneDiseases–
physiopathology. 3. CentralNervousSystemDiseases–immunology. 4. CentralNervous
SystemDiseases–physiopathology. 5. Inflammation–physiopathology.WL358.5]
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1 2014
Contents
List of Contributors vii
Preface xiii
Introduction xv
About the Companion Website xxi
1 Immune Privilege of the Brain 1
IngoBechmannandNicolaWoodroofe
2 Innate Immunity in the CNS – A Focus on the Myeloid Cell 9
CraigS.Moore,BryceA.DurafourtandJackP.Antel
3 Adaptive Immune Responses in the CNS 37
DavidMale
4 Ageing and the Immune Response in the CNS 59
DivyaD.A.Raj,BartJ.L.EggenandHendrikusW.G.M.Boddeke
5 Brain Repair: The Role of Endogenous and Transplanted Neural
Stem Cells 89
MarcoBacigaluppi,EricaButti,CeciliaLaterza,DonatellaDeFeo,
LucaPeruzzotti,AriannaMerlini,MelaniaCusimanoandGianvitoMartino
6 Neuroinflammation in Alzheimer’s, Parkinson’s and
Huntington’s Diseases 111
MagdalenaSastre,LoukiaKatsouri,AmyBirch,AlexanderRenziehausen,
DavidT.Dexter,RobertR.CrichtonandRobertaJ.Ward
7 CNS Infections 151
S.LouiseCosby,SareenGalbraithandDerekHealy
8 Neuroimmunology of Amyotrophic Lateral Sclerosis 185
JennyS.Henkel,DavidR.Beers,WeihuaZhaoandStanleyH.Appel
vi CONTENTS
9 Demyelinating Disorders of the CNS 211
LauraPeferoen,MoniekKattenbelt,LentheLodder,PaulvanderValk,
JohannesM.vanNoortandSandraAmor
10 Other Autoimmune Disorders: Systemic Lupus Erythematosus,
Primary Sjo¨gren’s Syndrome, Gluten-related Neurological
Dysfunction and Paraneoplastic Neurological Syndromes 235
MariosHadjivassiliou
11 Inflammation in the Pathogenesis of Depression 261
ThomasJ.ConnorandAndrewHarkin
12 Immune Responses in the CNS in Epilepsy 289
JanBauer,BethanLang,SaroshR.IraniandAnnamariaVezzani
13 Inflammatory Mediators and Dysfunction of the Neurovascular
Unit following Ischaemia Reperfusion 317
PhilipA.Barber
14 Spinal Cord Injury 339
JohnC.Gensel
15 Immune Responses to Tumours in the CNS 363
PaulGielen,PaulvanderValkandPieterWesseling
Index 385
List of Contributors
SandraAmor
Department of Pathology, VU University Medical Center, Amsterdam,
the Netherlands; and Neuroimmunology Unit, Blizard Institute, Barts and
The London School of Medicine and Dentistry, Queen Mary University of
London,London,UK
JackP.Antel
Department of Neurology and Neurosurgery, Montreal Neurological
Institute,McGillUniversity,Montreal,Quebec,Canada
StanleyH.Appel
Department of Neurology, Houston Methodist Neurological Institute, The
Houston Methodist Hospital Research Institute, The Houston Methodist
Hospital,Houston,Texas,USA
MarcoBacigaluppi
Neuroimmunology Unit, Institute of Experimental Neurology (INSpe),
DivisionofNeuroscience,SanRaffaeleScientificInstitute,Milan,Italy
PhilipA.Barber
Calgary Stroke Program; and Departments of Clinical Neurosciences and
Radiology,HotchkissBrainInstitute,UniversityofCalgary,Alberta,Canada
JanBauer
Department of Neuroimmunology, Center for Brain Research, Medical
UniversityofVienna,Vienna,Austria
IngoBechmann
InstituteofAnatomy,Universita¨tLeipzig,Leipzig,Germany
viii LISTOFCONTRIBUTORS
DavidR.Beers
Department of Neurology, Houston Methodist Neurological Institute, The
Houston Methodist Hospital Research Institute, The Houston Methodist
Hospital,Houston,Texas,USA
AmyBirch
Centre for Neuroinflammation and Neurodegeneration, Division of Brain
Sciences,ImperialCollegeLondon,London,UK
HendrikusW.G.M.Boddeke
Department of Neuroscience, Section Medical Physiology, University
of Groningen, University Medical Centre Groningen, Groningen, the
Netherlands
EricaButti
Neuroimmunology Unit, Institute of Experimental Neurology (INSpe),
DivisionofNeuroscience,SanRaffaeleScientificInstitute,Milan,Italy
S.LouiseCosby
Centre for Infection and Immunity, School of Medicine, Dentistry and
Biomedical Sciences, Medical Biology Centre, Queen’s University Belfast,
Belfast,UK
RobertR.Crichton
Universite´ CatholiquedeLouvain,Louvain-la-Neuve,Belgium
MelaniaCusimano
Neuroimmunology Unit, Institute of Experimental Neurology (INSpe),
DivisionofNeuroscience,SanRaffaeleScientificInstitute,Milan,Italy
DonatellaDeFeo
Neuroimmunology Unit, Institute of Experimental Neurology (INSpe),
DivisionofNeuroscience,SanRaffaeleScientificInstitute,Milan,Italy
DavidT.Dexter
Centre for Neuroinflammation and Neurodegeneration, Division of Brain
Sciences,ImperialCollegeLondon,London,UK
BryceA.Durafourt
Department of Neurology and Neurosurgery, Montreal Neurological
Institute,McGillUniversity,Montreal,Quebec,Canada