Contributors to Volume II CHARLES A. BARRACLOUGH LIS OLESEN LARSEN MILDRED ELWERS BAR-SELA ROBERT D. LISK M. T. CLEGG LEOLA LORENZEN VAUGHN CRITCHLOW RONALD R. NOVALES L. L. DOYLE ANDREAS OKSCHE WILLIAM ETKIN JACK H. OPPENHEIMER DONALD S. FARNER CHARLES H. PHOENIX WILLIAM F. GANONG ANTONIA VERNADAKIS ERNEST M. GOLD U. S. VON EULER ROBERT W. GOY FRED E. WILSON IRVINE R. HAGADORN DIXON M. WOODBURY C. BARKER J0RGENSEN RICHARD J. WURTMAN JULIAN I. KITAY WILLIAM C. YOUNG NEUROENDOCRINOLOGY EDITED BY LUCIANO MARTINI ISTITUTO DI FARMACOLOGIA E DI TERAPIA UNIVERSITA DEGLI STUDI MDLAN, ITALY AND WILLIAM F. GANONG DEPARTMENT OF PHYSIOLOGY UNIVERSITY OF CALIFORNIA SCHOOL OF MEDICINE SAN FRANCISCO MEDICAL CENTER SAN FRANCISCO, CALIFORNIA VOLUME II ACADEMIC PRESS New York and London 1967 COPYRIGHT © 1967 BY ACADEMIC PRESS INC. ALL RIGHTS RESERVED. NO PART OF THIS BOOK MAY BE REPRODUCED IN ANY FORM, BY PHOTOSTAT, MICROFILM, OR ANY OTHER MEANS, WITHOUT WRITTEN PERMISSION FROM THE PUBLISHERS. ACADEMIC PRESS INC. Ill Fifth Avenue, New York, New York 10003 United Kingdom Edition published by ACADEMIC PRESS INC. (LONDON) LTD. Berkeley Square House, London W.l LIBRARY OF CONGRESS CATALOG CARD NUMBER: 66-26256 PRINTED IN THE UNITED STATES OF AMERICA List of Contributors Numbers in parentheses indicate the pages on which the authors' contributions begin. CHARLES A. BARRACLOUGH, Department of Physiology, School of Medi- cine, University of Maryland, Baltimore, Maryland (61) MILDRED ELWERS BAR-SELA, Department of Anatomy, College of Medi- cine, Baylor University, Texas Medical Center, Houston, Texas (101) M. T. CLEGG, Department of Animal Husbandry, University of Cali- fornia, Davis, California (1) VAUGHN CRITCHLOW, Department of Anatomy, College of Medicine, Baylor University, Texas Medical Center, Houston, Texas (101) L. L. DOYLE, Department of Obstetrics and Gynecology, University of California, San Francisco, California (1) WILLIAM ETKIN, Department of Anatomy, Albert Einstein College of Medicine, Yeshiva University, and The City College of New York, New York, New York (261) DONALD S. FARNER, Department of Zoology, University of Washington, Seattle, Washington (529) WILLIAM F. GANONG, Department of Physiology, School of Medicine, University of California Medical Center, San Francisco, California (377, 583) ERNEST M. GOLD, Department of Medicine, University of California Center for the Health Sciences and Veterans Administration, Los Angeles, California (377) ROBERT W. GOY, Oregon Regional Primate Research Center, Beaverton, Oregon, and University of Oregon Medical School, Portland, Oregon (163) IRVINE R. HAGADORN, Department of Zoology, The University of North Carolina, Chapel Hill, North Carolina (439) C. BARKER J0RGENSEN, Zoophysiological Laboratory A, University of Copenhagen, Copenhagen, Denmark (485) JULIAN I. KITAY, Departments of Medicine and Physiology, School of Medicine, University of Virginia, Charlottesville, Virginia (641) Lis OLESEN LARSEN, Zoophysiological Laboratory A, University of Copen- hagen, Copenhagen, Denmark (485) v VI LIST OF CONTRIBUTORS ROBERT D. LISK, Department of Biology, Princeton University, Princeton, New Jersey (197) LEOLA LORENZEN, Department of Physiology, School of Medicine, Uni- versity of California Medical Center, San Francisco, California (583) RONALD R. NOVALES, Department of Biological Sciences, Northwestern University, Evanston, Illinois (241) ANDREAS OKSCHE, Anatomisches Institut der Universität, Giessen, Ger- many (529) JACK H. OPPENHEIMER, Endocrine Research Laboratory, Medical Divi- sion, Montefiore Hospital and Medical Center, New York, New York (665) CHARLES H. PHOENIX, Oregon Regional Primate Research Center, Beaverton, Oregon, and University of Oregon Medical School, Port- land, Oregon (163) ANTONIA VERNADAKIS, Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah (335)1 U. S. VON EULER, Fysiologiska Instituitionen, Karolinska Institut, Stock- holm, Sweden (283) FRED E. WILSON, Department of Zoology, Washington State University, Pullman, Washington (529)2 DIXON M. WOODBURY, Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah (335) RICHARD J. WURTMAN, Unit of Experimental Medicine, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, and Section on Pharmacology, Labo- ratory of Clinical Science, National Institutes of Mental Health, Bethesda, Maryland (19) WILLIAM C. YOUNG, Oregon Regional Primate Research Center, Beaver- ton, Oregon, and University of Oregon Medical School, Portland, Oregon (163)3 1 Present address: Department of Physiology, University of California, Berkeley, California. 2 Present address: Department of Zoology, Kansas State University, Manhattan, Kansas. 3 Deceased. Preface The two volumes of this treatise are designed to provide a survey of all aspects of the rapidly expanding science of neuroendocrinology. Only in recent years have the relations between the nervous system and the endocrine system come under intensive scrutiny, but their interactions have already been shown to be multiple and diverse. This diversity is reflected in the range of subjects covered; there are chapters on: neural control of endocrine function; the effects of hormones on the brain; brain-endocrine interrelations during various phases of development; and the comparative aspects of neuroendocrine integration. The rela- tion of brain chemistry to endocrine function, the effect of drugs on neuroendocrine mechanisms, and the new discipline of clinical neuro- endocrinology have also been considered. Consequently, not only neuro- physiologists and endocrinologists, but pharmacologists, zoologists, bio- chemists, psychologists, and those in clinical medicine will find the treatise of interest. Parts of neuroendocrinology have been discussed in other works, but this is the first treatise of which we are aware in which an attempt has been made to cover all ramifications of neuroendocrinol- ogy. We believe it can be used both as a text for advanced students and as a reference source. The individual chapters have been written by experts in their fields. Each author was instructed to make his chapter a survey of the present status of the subject he covered, without attempting to review it in an exhaustive or encyclopedic fashion. Those concerned with research methods and procedures will be interested in Chapter 4 in which the techniques of stereotaxis and making lesions are described and in the appendix to this chapter in which references to the stereotaxic atlases available for various animal species are provided. Authors were encouraged to present their own opinions on contro- versial subjects, and many of them have done so. Consequently, there is not complete agreement on all subjects from chapter to chapter. How- ever, the individual authors have done a good job of supporting their points of view with relevant data and references, so the reader may explore the controversies in depth and draw his own conclusions. The preparation of this treatise was marred by the untimely death of three outstanding neuroendocrinologists who were working on contribu- tions to it. This treatise is dedicated to these three individuals—John D. Green, Giuseppe Mangili, and William C. Young. July, 1967 LUCIANO MARTINI WILLIAM F. GANONG vu Contents of Volume 1 CHAPTER 1. Neuroendocrine Integrating Mechanisms William F. Ganong CHAPTER 2. The Anatomy of the Hypothalamus and Pituitary Gland Peter M. Daniel CHAPTER 3. Limbic and Other Neural Pathways That Regulate Endo- crine Function /. de Groot CHAPTER 4. Stereotaxic Techniques and the Production of Lesions Vernon Rowland APPENDIX: Bibliography of Stereotaxic and Other Brain Atlases Ar- ranged by Species /. de Groot CHAPTER 5. Neurosecretion Howard A. Bern and Francis G. W. Knowles CHAPTER 6. Control of Vasopressin Secretion Wilbur H. Sawyer and Elliott Mills CHAPTER 7. Neural Control of Oxytocin Secretion B. A. Cross CHAPTER 8. Hypothalamic Releasing Factors and the Neurovascular Link between the Brain and the Anterior Pituitary S. M. McCann and A. P. S. Dhariwal CHAPTER 9. Control of Adrenocorticotropic Hormone Secretion Giuseppe Mangili, Marcella Motta, and Luciano Martini CHAPTER 10. Adrenocorticotropic Hormone Secretion in the Fetus and Infant Karmela Milkovic and Stevan Milkovic CHAPTER 11. Neural and Other Mechanisms Regulating Aldosterone Secretion Patrick J. Mulrow CHAPTER 12. Control of Thyrotropic Hormone Secretion Seymour Reichlin XV xvi CONTENTS OF VOLUME I CHAPTER 13. Control of Growth Hormone Secretion Antonio Pecile and Eugenio E. Müller CHAPTER 14. Control of Gonadotropin Secretion in the Male Julian M. Davidson CHAPTER 15. Control of Gonadotropin Secretion in the Female Bêla Flerko CHAPTER 16. Control of Mammary Growth and Lactation Joseph Mettes Author Index—Subject Index ERRATUM NEUROENDOCRINOLOGY, VOLUME I (L. MARTINI AND W. F. GANONG, eds.) The hst 9 lines on p. 146 should read: of the teleost Carassius auratus (goldfish). Single-unit extracellular records have also been acquired from the hypothalamus of several mammalian species. None of the mammalian studies has revealed action potentials of unusual duration; however, it was not possible to say that any individual cell recorded was definitely neurosecretory. Bennett and Fox (1962) have commented on the possible significance not only of the long action potentials but also of the very slow conduc- tion velocities recorded by them from the terminations of the caudal neurons. It is possible that these features are related to the need for XVll CHAPTER 17 Role in Reproductive Physiology of Afferent Impulses from the Genitalia and Other Regions M. T. CLEGG and L L. DOYLE I. Introduction 1 II. Innervation of the Reproductive Tract 2 III. The Role of Peripheral Nerves in Reproductive Processes in the Male 4 IV. The Role of Peripheral Nerves in Reproductive Processes in the Female 5 V. Modification of Gonadal Function by Manipulation of the Genital Tract 7 A. Effects of Uterine Distention 7 B. Intrauterine Foreign Bodies 8 C. Effects of Removal of Uterus 9 VI. Exteroceptive Stimuli Influencing Reproductive Processes .... 11 A. Olfactory Stimuli 11 B. Visual Stimuli 13 C. Auditory Stimuli 14 VII. Summary and Conclusions 15 References 15 I. Introduction The involvement of neuroendocrine reflex mechanisms in a variety of reproductive functions is implied by a number of observations. In reflex ovulators such as the rabbit, cat, and ferret, stimuli applied to the ex- ternal genitalia result in pituitary gonadotropin release and ovulation, whereas in some spontaneous ovulators such as the rat and mouse, this same stimulus causes pseudopregnancy. Olfactory stimuli supplied by strange male mice block pregnancy. A seasonal change in length of day- light appears to be the important factor regulating or monitoring annual cycles of gonadal activity in many species. The influence of psychic stimuli on reproductive function has been clearly demonstrated. For ex- ample, when rams are placed with ewes shortly before the breeding sea- son, the females display estrous activity; breeding and conception occur 1