Neurodevelopment and Schizophrenia PDF
Preview Neurodevelopment and Schizophrenia
Neurodevelopment and Schizophrenia Sincetheearly1990s,developmentalneurobiologyhasmadeimportantstridestowardseluci- datingthepathophysiologyofpsychiatricdisorders.Nowherehasthislinkbetweenbasicscience andclinicalinsightsbecomemoreevidentthaninthefieldofschizophreniaresearch.Inthis volume,theeditorsbringtogethersomeofthemostactiveinvestigatorsinthisfield.Eachcon- tributorprovidesanup-to-dateoverviewoftherelevantresearch,includingdirectionsforfurther investigation. Thebookbeginswithasectiononadvancesindevelopmentalneurobiology.Thisisfollowed bysectionsonetiologicalandpathophysiologicaldevelopments,andmodelsthatintegratethis knowledge.Thefinalsectionaddressestheclinicalinsightsthatemergefromthedevelopmental modelsandsetsthesceneforfutureeffortsatearlydetectionandpreventionofschizophrenia. Thisbookwillbevaluabletoresearchersinpsychiatryandneurobiology,studentsinmedicine andpsychology,andallmentalhealthpractitioners. http://avaxhome.ws/blogs/ChrisRedfield Neurodevelopment and Schizophrenia Editedby Matcheri S. Keshavan UniversityofPittsburghandWesternPsychiatricInstituteandClinic, Pittsburgh,PAandWayneStateUniversity,Detroit,MI,USA James L. Kennedy UniversityofTorontoCentreforMentalHealthandAddiction, Toronto,Canada and Robin M. Murray King’sCollegeLondonandInstituteofPsychiatry,London,UK published by the press syndicate of the university of cambridge ThePittBuilding,TrumpingtonStreet,Cambridge,UnitedKingdom cambridge university press TheEdinburghBuilding,CambridgeCB22RU,UK 40West20thStreet,NewYork,NY10011–4211,USA 477WilliamstownRoad,PortMelbourne,VIC3207,Australia RuizdeAlarco´n13,28014Madrid,Spain DockHouse,TheWaterfront,CapeTown8001,SouthAfrica http://www.cambridge.org (cid:1)C CambridgeUniversityPress2004 Thisbookisincopyright.Subjecttostatutoryexceptionand totheprovisionsofrelevantcollectivelicensingagreements, noreproductionofanypartmaytakeplacewithout thewrittenpermissionofCambridgeUniversityPress. Firstpublished2004 PrintedintheUnitedKingdomattheUniversityPress,Cambridge TypefacesMinion10.5/14pt.andFormata SystemLATEX2ε [tb] AcatalogrecordforthisbookisavailablefromtheBritishLibrary LibraryofCongressCataloginginPublicationdata Neurodevelopmentandschizophrenia/[editedby]MatcheriS.Keshavan, JamesL.Kennedy,RobinM.Murray. p. cm. Includesbibliographicalreferencesandindex. ISBN0521823315(hardback) 1.Schizophrenia–Etiology. 2.Schizophrenia–Pathophysiology. 3.Developmentalneurobiology. 4.Brain–Growth. I.Keshavan,MatcheriS.,1953– II.Kennedy,JamesL. III.Murray,Robin,M. [DNLM:1.Brain–growth&development. 2.Schizophrenia–etiology. 3.Brain–abnormalities. 4.Models,neurological. 5.Neurobiology–methods. WM203N49318 2004] RC514.N4433 2004 616.89(cid:2)8071–dc22 2004045710 ISBN0521823315hardback ThepublisherhasuseditsbestendeavorstoensurethattheURLsforexternalwebsitesreferredtointhis bookarecorrectandactiveatthetimeofgoingtopress.However,thepublisherhasnoresponsibilityfor thewebsitesandcanmakenoguaranteethatasitewillremainliveorthatthecontentisorwillremain appropriate. Everyefforthasbeenmadeinpreparingthisbooktoprovideaccurateandup-to-dateinformationthatis inaccordwithacceptedstandardsandpracticeatthetimeofpublication.Nevertheless,theauthors,editors, andpublishercanmakenowarrantiesthattheinformationcontainedhereinistotallyfreefromerror,not leastbecauseclinicalstandardsareconstantlychangingthroughresearchandregulation.Theauthors, editors,andpublisherthereforedisclaimallliabilityfordirectorconsequentialdamagesresultingfromthe useofmaterialcontainedinthisbook.Readersarestronglyadvisedtopaycarefulattentiontoinformation providedbythemanufacturerofanydrugsorequipmentthattheyplantouse. Contents Listofcontributors page viii Foreword xiii Preface xvii Part I Basic aspects 1 Genesandbraindevelopment 3 TimothyA.Klempan,PierandreaMuglia,andJamesL.Kennedy 2 Braindevelopmentinhealthychildrenandadolescents:magnetic resonanceimagingstudies 35 JayN.Giedd,MichaelA.Rosenthal,A.BlytheRose,JonathanD.Blumenthal, ElizabethMolloy,RichardR.Dopp,LivS.Clasen,DanielJ.Fridberg,andNitinGogtay 3 Cognitivedevelopment:functionalmagneticresonanceimagingstudies 45 BeatrizLunaandJohnA.Sweeney 4 Cognitivedevelopmentinadolescence:cerebralunderpinnings,neural trajectories,andtheimpactofaberrations 69 StephenJ.Wood,CinziaR.DeLuca,VickiAnderson,andChristosPantelis 5 Brainplasticityandlong-termfunctionafterearlycerebralinsult:the exampleofverypretermbirth 89 MatthewAllin,ChiaraNosarti,LarryRifkin,andRobinM.Murray Part II Etiological factors 6 Dodegenerativechangesoperateacrossdiagnosticboundaries?The caseforglucocorticoidinvolvementinmajorpsychiatricdisorders 111 CarmineM.ParianteandDavidCotter 7 Velo-cardio-facialsyndrome(deletion22q11.2):ahomogeneous neurodevelopmentalmodelforschizophrenia 121 StephanEliezandCarlFeinstein v vi Contents 8 Canstructuralmagneticresonanceimagingprovideanalternative phenotypeforgeneticstudiesofschizophrenia? 138 ColmMcDonaldandRobinM.Murray 9 Nutritionalfactorsandschizophrenia 156 SahebaraoP.Mahadik 10 Schizophrenia,neurodevelopment,andepigenetics 174 ArturasPetronis 11 Earlyenvironmentalriskfactorsforschizophrenia 191 MaryCannon,KimberlieDean,andPeterB.Jones 12 Transcriptomesinschizophrenia:assessingalteredgeneexpressionwith microarrays 210 DavidA.Lewis,KarolyMirnics,andPatLevitt 13 Istherearoleforsocialfactorsinacomprehensivedevelopmentmodel forschizophrenia? 224 JaneBoydell,JimvanOs,andRobinM.Murray 14 Howdoesdrugabuseinteractwithfamilialanddevelopmentalfactors intheetiologyofschizophrenia? 248 Chih-KenChenandRobinM.Murray Part III Pathophysiology 15 Developmentaldysregulationofthedopaminesystemandthe pathophysiologyofschizophrenia 273 AnthonyA.Grace 16 Thedevelopmentof“mis-wired”limbiclobecircuitryinschizophrenia andbipolardisorder 295 FrancineM.Benes 17 Developmentofthalamocorticalcircuitryandthepathophysiologyof schizophrenia 310 DarleneS.MelchitzkyandDavidA.Lewis 18 Xchromosome,estrogen,andbraindevelopment:implicationsfor schizophrenia 330 MichaelCraig,WilliamCutter,RayNorbury,andDeclanMurphy 19 Premorbidstructuralabnormalitiesinschizophrenia 347 StephenM.Lawrie vii Contents 20 Neurodegenerativemodelsofschizophrenia 373 L.FredrikJarskog,JohnH.Gilmore,andJeffreyA.Lieberman 21 Doesdisorderedbraindevelopmentoccuracrossdiagnostic boundaries? 390 ChristianW.Kreipke,DavidR.Rosenberg,andMatcheriS.Keshavan Part IV Clinical implications 22 Canoneidentifypreschizophreniachildren? 415 EugeniaKravariti,PaolaDazzan,PaulFearon,andRobinM.Murray 23 High-riskstudies,braindevelopment,andschizophrenia 432 MatcheriS.Keshavan 24 Developmentalmodelsandhypothesis-drivenearlyinterventionsin schizophrenia 455 MatcheriS.KeshavanandBarbaraA.Cornblatt Index 473 Theplatesaresituatedbetweenpages190and191. Contributors MatthewAllin MaryCannon InstituteofPsychiatryatTheMaudsleyand DivisionofPsychologicalMedicine, DepartmentofPsychiatry,King’sCollege InstituteofPsychiatry,DeCrespigny London,DeCrespignyPark,London Park,DenmarkHill,London SE58AF,UK SE58AF,UK VickiAnderson Chih-KenChen DepartmentofPsychology,University DepartmentofPsychiatry,ChangGung ofMelbourneandtheMurdoch MemorialHospital,222Mai-ChinRoad, Children’sResearchInstitute,Royal Keelung,Taiwan Children’sHospital,Melbourne, Australia LivS.Clasen ChildPsychiatryBranch,NationalInstitute FrancineM.Benes ofMentalHealth,NationalInstitutesof PrograminStructuralandMolecular Health,Bethesda,MD20892, Neuroscience,McLeanHospital,Belmont USA andPrograminNeuroscienceand DepartmentofPsychiatry,Harvard BarbaraA.Cornblatt MedicalSchool,Boston,MA, RecognitionandPrevention(RAP) USA Program,444LakevilleRoad,LakeSuccess, NY11042,USA JonathanD.Blumenthal ChildPsychiatryBranch,NationalInstitute DavidCotter ofMentalHealth,National DivisionofPsychologicalMedicine, InstitutesofHealth,Bethesda, InstituteofPsychiatry,DeCrespignyPark, MD20892,USA DenmarkHill,LondonSE58AF,UK JaneBoydell MichaelCraig InstituteofPsychiatryatTheMaudsleyand DivisionofPsychologicalMedicine, DepartmentofPsychiatry,King’sCollege InstituteofPsychiatry,DeCrespignyPark, London,DeCrespignyPark,London DenmarkHill,London SE58AF,UK SE58AF,UK viii ix Listofcontributors WilliamCutter CarlFeinstein DivisionofPsychologicalMedicine, StanfordUniversitySchoolofMedicine, InstituteofPsychiatry,DeCrespignyPark, 401QuarryRoad,Stanford,CA DenmarkHill,London 94305–5719,USA SE58AF,UK DanielJ.Fridberg PaolaDazzan ChildPsychiatryBranch,National DivisionofPsychologicalMedicine, InstituteofMentalHealth,National InstituteofPsychiatry,DeCrespigny InstitutesofHealth,Bethesda,MD20892, Park,DenmarkHill,London USA SE58AF,UK JayN.Giedd KimberlieDean ChildPsychiatryBranch,National DivisionofPsychologicalMedicine, InstituteofMentalHealth,National InstituteofPsychiatry,DeCrespignyPark, InstitutesofHealth,Bethesda,MD20892, DenmarkHill,LondonSE58AF,UK USA CinziaR.DeLuca JohnH.Gilmore DepartmentsofPsychologyandPsychiatry, DepartmentofPsychiatry,UNCConte UniversityofMelbourneandMelbourne CenterforNeuroscienceofMental NeuropsychiatryCentre,Sunshine Disorders,UniversityofNorthCarolina Hospital,Melbourne, SchoolofMedicine,ChapelHill,NC27599, Australia USA RichardR.Dopp NitinGogtay ChildPsychiatryBranch,National ChildPsychiatryBranch,NationalInstitute InstituteofMentalHealth,National ofMentalHealth,NationalInstitutesof InstitutesofHealth,Bethesda,MD20892, Health,Bethesda,MD20892, USA USA StephanEliez AnthonyA.Grace DivisionofChildandAdolescent DepartmentofNeuroscience, Psychiatry,UniversityofGenevaSchoolof 458CrawfordHall,Universityof Medicine,41CheminCrts-de-Champel, Pittsburgh,Pittsburgh,PA15206, 1206Geneva,Switzerland USA PaulFearon L.FredrikJarskog DivisionofPsychologicalMedicine, DepartmentofPsychiatry,UNCConte InstituteofPsychiatryatthe CenterforNeuroscienceofMental MaudsleyNHSTrust,DeCrespignyPark, Disorders,UniversityofNorthCarolina DenmarkHill,LondonSE58AF, SchoolofMedicine,ChapelHill,NC27599, UK USA
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