NASA Technical Reports Server (NTRS) 20170001257: Method of Stamping Surface-Enhance Raman Spectroscopy for Label-Free

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(12) United States Patent (io) Patent No.: US 9,546,958 B2
Shih (45) Date of Patent: Jan. 17, 2017
(54) METHOD OF STAMPING (58) Field of Classification Search
SURFACE-ENHANCE RAMAN CPC .... GO1N 21/65; GO1N 21/656; GO1N 21/658;
SPECTROSCOPY FOR LABEL-FREE, GO1J 3/02; GO1J 3/44
MULTIPLEXED, MOLECULAR SENSING See application file for complete search history.
AND IMAGING
(56) References Cited
(71) Applicant: UNIVERSITY OF HOUSTON U.S. PATENT DOCUMENTS
SYSTEM, Houston, TX (US)
2004/0009298 Al * 1/2004 Moran ................... H05K 3/182
(72) Inventor: Wei-Chuan Shih, Houston, TX (US) 427/304
2012/0081703 Al 4/2012 Moskovits et al.
(73) Assignee: UNIVERSITY OF HOUSTON 2012/0309080 Al 12/2012 Cunningham et al.
2014/0002816 Al 1/2014 Liu et al.
SYSTEM, Houston, TX (US)
2014/0104606 Al 4/2014 Shih
(*) Notice: Subject to any disclaimer, the term of this
FOREIGN PATENT DOCUMENTS
patent is extended or adjusted under 35
U.S.C. 154(b) by 72 days. Wo 2006/134376 A2 12/2006
(21) Appl. No.: 14/699,025
OTHER PUBLICATIONS
(22) Filed: Apr. 29, 2015 Lee, Chang H., et al.; Paper Based SERS Swab for Rapid Trace
Detection on Real-World Surfaces; Applied Materials & Interfaces,
(65) Prior Publication Data
vol. 2, No. 12, 3429-3435, 2010.
US 2015/0308960 Al Oct. 29, 2015 (Continued)
Primary Examiner Abdullahi Nur
(74) Attorney, Agent, or Firm Jackson Walker LLP
Related U.S. Application Data
(57) ABSTRACT
(60) Provisional application No. 61/985,984, filed on Apr.
The present disclosure relates the use of a stamping surface
29, 2014.
enhanced Raman scattering (S-SERS) technique with nano-
(51) Int. Cl. porous gold disk( NPGD)p lasmonic substrates to produce a
GOIJ 3/44 (2006.01) label-free, multiplexed molecular sensing and imaging tech-
GOIN 21/65 (2006.01) nique. A NPGD SERS substrate is stamped onto a surface
B82Y 30100 (2011.01) containing one or more target molecules, followed by SERS
GOIJ 3102 (2006.01) measurement of the target molecules located between the
surface and SERS substrate. The target molecules may be
(52) U.S. Cl.
deposited on the surface, which may be a carrier substrate
CPC ............. GOIN 21/658 (2013.01); B82Y 30100
such as polydimethylsiloxane (PDMS).
(2013.01); GOIJ 3102 (2013.01); GOIJ 3144
(2013.01) 21 Claims, 11 Drawing Sheets
Rx,,m stilt 9 'i
US 9,546,958 B2
Page 2
(56) References Cited
OTHER PUBLICATIONS
Li, Jian Feng, et al.; Shell-Isolated Nanoparticle-Enhanced Raman
Spectroscopy; Nature, vol. 464, 392-395, 2010.
Qi, Ji, et al.; Surface-Enhanced Raman Spectroscopy With Mono-
lithic Nanoporous Gold Disk Substrates; Nanoscale, vol. 5, 4105-
4109, 2013.
Wang, Hui, et al; Quantitative Analysis of Creatinine in Urine by
Metalized Nanostructured Parylene, vol. 15, No. 2, 027004-1-5,
2010.
Korean Intellectual Property Office; International Search Report and
Written Opinion; PCT Application No. PCT/US2015/028135; Jul.
29, 2015.
* cited by examiner
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