NASA Technical Reports Server (NTRS) 20080005128: Medical applications of artificial olfactometry

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by  NASA Technical Reports Server (NTRS)

United States Patent
(12) (io) Patent No.: US 6,841,391 B2
Lewis et al. (45) Date of Patent: Jan. 11,2005
MEDICAL APPLICATIONS OF ARTIFICIAL (List continued on next page.)
OLFACTOMETRY
FOREIGN PATENT DOCUMENTS
Inventors: Nathan S. Lewis, La Canada, CA (US);
WO WO 94104916 * 311994 .......... GOlN131122
Erik J. Severin, Hayward, CA (US);
WO WO 95133848 1211995
Bernard Wong, Los Angeles, CA (US); WO WO 9607901 311996 .......... GOlN133100
David M. Kelso, Wilmette, IL (US); WO WO 97108337 311997 ............ C12Q11104
Beth C. Munoz, Pasadena, CA (US) WO WO 98129563 711998 ............ C12Q11104
WO WO 98136272 811998 .......... GOlN133100
Assignees: Smiths Detection-Pasadena, Inc., WO WO 98139409 911998 ............ C12M11134
Pasadena, CA (US); California WO WO 98139470 911998 ............ C12Q11104
Institute of Technology, Pasadena, CA WO WO 99109407 211999 .......... GOlN131122
WO WO 99109408 211999 .......... GOlN131122
(US)
WO WO 99165386 1211999
Notice: Subject to any disclaimer, the term of this
OTHER PUBLICATIONS
patent is extended or adjusted under 35
U.S.C. 154(b) by 44 days.
Greenfield, P. “Aromascan sniffs out medical applications.”
Clinica, May 23, 1994, pp. 2&21.
Appl. No.: 09/855,277
Parry, A.D., et al., “Leg ulcer odour detection identifies
Filed: May 14, 2001 beta-haemolytic streptococcal infection,” J. Wound Care,
4(9): 404-6 (10195).
Prior Publication Data
Chandiok, S., et al., “Screening for bacterial vaginosis: a
US 200110041366 A1 Nov. 15, 2001 novel application of artificial nose technology,” J. Clin.
Path., 50(9):79&791 (9197).
Related U.S. Application Data
Craven, M.A. et al., “Bacteria Detection and Classification
Using Artificial Neural Networks in Conjunction with an
Continuation of application No. 091336,428, filed on Jun.
Electronic Nose,” Proceedings of the 2nd International Con-
17, 1999, now Pat. No. 6,319,724.
ference on Neural Networks and Expert Systems in Medi-
Provisional auulication No. 60/091.179. filed on Jun. 30.
1998, and pr&ional application No. 601090,012, filed on cine and Healthcare, pp 226-234 (1996).
Jun. 19, 1998.
(List continued on next page.)
Int. Cl? ................................................ GOlN 33/00
U.S. C1. .................... 436/149; 4361151; 422182.01;
Primary Examiner-Jill Warden
422182.02; 422183; 422184; 422190; 73123.3;
Assistant Examinerqwayne K Handy
73123.36
(74) Attorney, Agent, or Firmqoley & Lardner LLP
Field of Search ................................. 4361149, 151,
4361172, 900; 422168.1, 82.01, 82.02, 82.05, (57) ABSTRACT
82.06, 82.08, 83, 84, 94, 98; 73123.3, 23.34,
23.35, 23.36 The present invention provides methods for detecting the
presence of an analyte indicative of various medical
References Cited conditions, including halitosis, periodontal disease and other
diseases are also disclosed.
U.S. PATENT DOCUMENTS
3,897,679 A 811975 Guild ......................... 73161.1 9 Claims, 8 Drawing Sheets
US 6.841.3 91 B2
Page 2
U.S. PATENT DOCUMENTS 5.814. 524 A 911998 Walt et a1 ................... 4361518
5.848. 975 A * 1211998 Phillips ...................... 6001532
4.670. 401 A 611987 Cutlet et a1 ................... 436165 5.971. 937 A * 1011999 Ekstrom ..................... 6001532
4.749. 553 A 611988 Lopez et a1 ................... 422184 6.057. 162 A * 512000 Rounbehler et a1 ......... 4361119
5.239. 483 A 811993 Weir 6.067. 989 A * 512000 Katzman .................... 1281898
5.479. 815 A 111996 White et a1 .................. 73123.3
6.170. 318 B1 * 112001 Lewis ....................... 73123.34
5.546. 931 A 811996 Rusz ..................... 1281203.12
6.244. 096 B1 * 612001 Lewis et a1 .................. 73123.2
5.571. 401 A 1111996 Lewis et a1 ................. 2051787
6.282. 441 B1 * 812001 Raymond et a1 ............ 6001513
5.739. 412 A 411998 Stock et a1 .................. 73123.3
6.319. 724 B1 * 1112001 Lewis et a1 ................. 4361169
5.787. 885 A * 811998 Lemelson ................... 1281632
5.807. 701 A 911998 Payne et a1 ................... 435134
5.814. 474 A 911998 Berndt ........................ 435134 * cited by examiner
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