Nanobiomaterials Science, Development and Evaluation

341 Pages·2017·9.869 MB·English

by  Mehdi Razavi, Avnesh Thakor (eds.)

Nanobiomaterials Science, Development
and Evaluation
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Woodhead Publishing Series in Biomaterials
Nanobiomaterials
Science, Development
and Evaluation
Edited by
Mehdi Razavi
Avnesh Thakor
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Contents
List of Contributors ix
1 Introduction 1
Mehdi Razavi
References 5
2 Particles/Fibers/Bulk 7
Nasim Kiaie, Farzaneh Aavani and Mehdi Razavi
2.1 Introduction 7
2.2 Organic biomaterials 8
2.3 Inorganic biomaterials 11
2.4 Organic–inorganic biomaterials 17
2.5 Concluding remarks 19
2.6 Future research 20
2.7 Conflict of interest 20
References 20
3 Porous scaffolds 27
Ebru Altuntaş, Burcu Özkan and Gülgün Yener
3.1 Tissue engineering 27
3.2 Scaffolds 27
3.3 The critical structural and chemical requirements of scaffolds 28
3.4 Scaffolding biomaterials 30
3.5 Naturally derived biopolymers 31
3.6 Synthetic biopolymers 33
3.7 Calcium phosphate bioceramics 36
3.8 Bioactive glasses 36
3.9 Glass–ceramics 37
3.10 Scaffold fabrication techniques 38
3.11 Conclusion 48
References 49
4 Naturally based and biologically derived nanobiomaterials 61
Mehdi Razavi, Kai Zhu and Yu S. Zhang
4.1 Introduction 61
4.2 Polysaccharide-based nanomaterials 62
4.3 Collagen-based nanobiomaterials 69
4.4 Carbon-based nanobiomaterials 75
4.5 Conclusions and future perspectives 80
vi Contents
4.6 Conflict of interest 81
4.7 Acknowledgment 81
References 81
5 Nanogels for biomedical applications: Drug delivery, imaging,
tissue engineering, and biosensors 87
Magdalini Tsintou, Cang Wang, Kyriakos Dalamagkas,
Ding Weng, Yi-Nan Zhang and Wanting Niu
Abbreviations 87
5.1 Introduction 88
5.2 Materials and methods for selected nanogel systems 89
5.3 Nanogels as carriers for bioactive molecules delivery 93
5.4 Tissue engineering applications—potential applications of
nanogels in selected fields 100
5.5 Nanogels in oncology 102
5.6 Biosensor 107
5.7 Conclusion and future prospective 113
References 114
Further Reading 124
6 Lipid-based nanobiomaterials 125
Parisa Nazemi and Mehdi Razavi
6.1 Introduction 125
6.2 Applications 125
6.3 Classification of SLNs 126
6.4 Classification of NLC 126
6.5 Preparation methods 127
6.6 Conclusion 131
References 131
7 Peptide-based nanobiomaterials 135
Yasemin Budama-Kilinc, Burak Ozdemir and Kubra Gozutok
7.1 Introduction 135
7.2 Peptides 135
7.3 Peptide nanomaterials 135
7.4 Advantages of peptide-based nanomaterials 136
7.5 Applications of peptide-based nanomaterials 136
7.6 Conclusion and future trends 142
Acknowledgment 142
References 143
8 Nanoparticles hybridization to engineer biomaterials for drug delivery 147
M. Rezaa Mohammadi, Wenchao Sun, Mohammed Inayathullah and
Jayakumar Rajadas
8.1 Introduction 147
8.2 Nanoparticles hybridization techniques 148
8.3 Polymer–biomacromolecule hybrid 153
Contents vii
8.4 Bioinspired hybrid 154
8.5 NPs hybridization to overcome biological barriers 156
8.6 Conclusion 159
References 159
9 Nanotherapeutics in the management of infections and cancer 163
Madalina Elena Grigore, Alina Maria Holban and
Alexandru Mihai Grumezescu
9.1 Introduction 163
9.2 Nanotherapeutics with antimicrobial properties 164
9.3 Nanotherapeutics with antitumor properties 172
9.4 Conclusions 181
References 181
10 Nanostructured coatings for biomaterials 191
Farideh Ordikhani, Fatemeh Mohandes and Abdolreza Simchi
10.1 Introduction 191
10.2 Biocompatible nanostructured coatings 192
10.3 Antibacterial coatings 196
10.4 Conclusion and future directions 202
References 202
11 Evaluation techniques 211
Serap Yesilkir-Baydar, Olga N. Oztel, Rabia Cakir-Koc and
Ayse Candayan
11.1 Introduction 211
11.2 Structural characterizations using microscopy techniques 211
11.3 Biomechanical properties 215
11.4 Cell/biomaterials interactions 216
11.5 Stem cells 217
11.6 Biocorrosion 217
11.7 Biodegradation 219
11.8 In vitro assessments 220
11.9 In vivo assessments 223
11.10 Conclusion 226
11.11 Future aspects 226
References 227
12 Nanotoxicity 233
Samad Ahadian and Milica Radisic
12.1 Introduction 233
12.2 In vitro cell-based toxicity assays 235
12.3 Analysis of toxicity in vivo 237
12.4 Nanomaterial toxicity 237
12.5 Future trends 242
12.6 Conclusions 243
References 243
viii Contents
13 Immune response to nanobiomaterials 249
Anzelika Schreiber and Frank Witte
13.1 Introduction 249
13.2 The effect of particle size 249
13.3 The immune system responds to nanobiomaterials 250
13.4 The effect of surface properties in biological systems 251
13.5 How primary and secondary states of nanobiomaterials
interfere with biological environments 253
13.6 Health risks of nanobiomaterials 256
References 258
Further Reading 260
14 Safety, regulatory issues, long-term biotoxicity, and the processing
environment 261
Mehdi Razavi and Amirsalar Khandan
14.1 Introduction 261
14.2 Safety factors 262
14.3 Nanoparticle biomaterials safety 262
14.4 Targets of drug deliver targets and hazard assessment 263
14.5 Reaction of nanoparticles for clinical applications 264
14.6 Characterization for different exposure routes 269
14.7 Legal aspects of biomaterials 270
14.8 Long-term testing in vivo 271
14.9 Global regulatory strategy and intended use 272
14.10 Biological and environment reaction 272
14.11 Conclusions and future trends 272
References 273
15 Practical aspects 281
Serda Kecel-Gunduz, Sefa Celik and Aysen E. Ozel
15.1 Introduction 281
15.2 Part I: Nanomaterials and their types 282
15.3 Part II: The uses of nanomaterials 286
15.4 Part III: Common nanoparticles and their harmful effects 289
15.5 Conclusions and future directions 293
References 293
16 Summary and future of nanomaterials in medicine/biomaterials 301
M. Miraftab
16.1 What are nanomaterials and why are they important? 301
16.2 What is their application in healthcare and medicine? 304
16.3 Modified implants 308
16.4 What are their potentials and future prospects? 309
16.5 Conclusion 310
References 311
Index 315
List of Contributors
Farzaneh Aavani Amirkabir University of Technology, Tehran, Iran
Samad Ahadian University of Toronto, Toronto, ON, Canada
Ebru Altuntaş Istanbul University, Istanbul, Turkey
Yasemin Budama-Kilinc Yildiz Technical University, Istanbul, Turkey
Rabia Cakir-Koc Yildiz Technical University, Istanbul, Turkey
Ayse Candayan Bogazici University, Istanbul, Turkey
Sefa Celik Istanbul University, Istanbul, Turkey
Kyriakos Dalamagkas Harvard Medical School, Boston, MA, United States;
University College of London, London, United Kingdom; Weiss Memorial Hospital,
Chicago, IL, United States
Kubra Gozutok Yildiz Technical University, Istanbul, Turkey
Madalina Elena Grigore University Politehnica of Bucharest, Bucharest, Romania
Alexandru Mihai Grumezescu University Politehnica of Bucharest, Bucharest,
Romania
Alina Maria Holban Department of Microbiology and Immunology, Faculty of
Biology and Research Institute of the University of Bucharest, University of
Bucharest, Bucharest, Romania
Mohammed Inayathullah Biomaterials and Advanced Drug Delivery Laboratory,
Stanford University School of Medicine, Palo Alto, CA, United States; Cardiovascular
Pharmacology Division, Cardiovascular Institute, Stanford University School of
Medicine, Stanford, CA, United States
Serda Kecel-Gunduz Istanbul University, Istanbul, Turkey
Amirsalar Khandan Islamic Azad University, Isfahan, Iran