Nanoarchitectonics for Smart Delivery and Drug Targeting Alina Maria Holban Department of Microbiology and Immunology, Faculty of Biology & Research Institute of the University of Bucharest, Bucharest, Romania Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania Alexandru Mihai Grumezescu Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania AMSTERDAM • BOSTON • HEIDELBERG • LONDON NEW YORK • OXFORD PARIS • SAN DIEGO • SAN FRANCISCO • SINGAPORE • SYDNEY • TOKYO William Andrew is an imprint of Elsevier William Andrew is an imprint of Elsevier The Boulevard, Langford Lane, Kidlington, Oxford, OX5 1GB, United Kingdom 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States Copyright © 2016 Elsevier Inc. 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Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library ISBN: 978-0-323-47347-7 For information on all William Andrew publications visit our website at https://www.elsevier.com/ Publisher: Matthew Deans Acquisition Editor: Simon Holt Editorial Project Manager: Sabrina Webber Production Project Manager: Susan Li Designer: Greg Harris Typeset by Thomson Digital List of Contributors J. Abraham VIT University, School of Biosciences and Technology, Microbial Biotechnology Laboratory, Vellore, Tamil Nadu, India B.A. Aderibigbe Department of Chemistry, University of Fort Hare, Alice, South Africa H. Afshar Mechanical Engineering Department, East Tehran Branch, Islamic Azad University, Tehran, Iran V. Aina Department of Chemistry and NIS Interdepartmental Centre, University of Turin, Turin, Italy N. Alam Formulation & Drug Delivery Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India S. Banerjee Implants, Devices & Drug Delivery Systems (IDS) Laboratory, Centre for Bio-design (CBD), Translational 3 Health Science & Technology Institute (THSTI), Faridabad, Haryana, India A. Bhatt Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India R. Bohara Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur, Maharashtra, India M.L. Bruschi State University of Maringá, Department of Pharmacy, Laboratory of Research and Development of Drug Delivery Systems, Maringá, Brazil D. Casotti Department of Physics and Earth Sciences, University of Ferrara, Ferrara, Italy G. Cerrato Department of Chemistry and NIS Interdepartmental Centre, University of Turin, Turin, Italy xix xx List of Contributors D. Chen College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou; Key Lab of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, CAS, Fuzhou, P.R. China A.A. Chuturgoon Discipline of Medical Biochemistry and Chemical Pathology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa G. Cruciani Department of Physics and Earth Sciences, University of Ferrara, Ferrara, Italy A. D’Souza Department of Bioscience and Bioengineering, Indian Institute of Technology-Bombay (IIT-B), Mumbai, India C. Dalwadi Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science & Technology (CHARUSAT), Changa, Gujarat, India M. Ding College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, P.R. China R.D. Dubey Formulation & Drug Delivery Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India S.P. Egusquiaguirre NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU); Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain B. Evrard Laboratory of Pharmaceutical Technology and Biopharmacy—CIRM, University of Liege, Liege, Belgium R. Fekrazad Laser Research Center in Medical Sciences, AJA University of Medical Sciences; International Network For Photo Medicine And Photo Dynamic Therapy (INPMPDT), Universal Scientific Education and Research Network (USERN), Tehran, Iran A. Frère Laboratory of Pharmaceutical Technology and Biopharmacy—CIRM, University of Liege, Liege, Belgium M. Ghassemi Mechanical Engineering Department, K.N. Toosi University of Technology, Tehran, Iran List of Contributors xxi E. Ghedini Department of Molecular Science and Nanosystems, Ca’ Foscari University Venice, INSTM Consortium Venice RU, Mestre, Italy T.K. Giri NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata Group of Institutions, Kolkata, West Bengal, India N. Giribabu Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia M. Gogoi Department of Biomedical Engineering, North-Eastern Hill University, Shillong, Meghalaya, India P.N. Gupta Formulation & Drug Delivery Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India E. Gurnany Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India M.R. Habibi Research Institute of Petroleum Industry, Tehran, Iran M. Hamidi Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC) and Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran L.-Y. Hao School of Materials Science and Engineering, Jinling Institute of Technology, Nanjing, P.R. China R.M. Hernández NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU); Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain X.-H. Hu School of Materials Science and Engineering, Jinling Institute of Technology, Nanjing, P.R. China M. Igartua NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU); Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain xxii List of Contributors A. Jain Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India A. Jain Pharmaceutics Research Laboratory, Department of Pharmaceutics, Ravishankar College of Pharmacy, Bhopal, Madhya Pradesh, India R. Jain Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India M. Kaur University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India R.K. Kesrevani School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India O. Konur Yildirim Beyazit University, Faculty of Engineering and Natural Sciences, Department of Materials Engineering, Ankara, Turkey M.R. Koshkaki Biomaterials and Tissue Engineering Research Group, Breast Cancer Research Center (BCRC), Academic Center for Education, Culture and Research (ACECR), Tehran, Iran N. Kumar Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India L. Kumari Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India Y. Luengo Department of Biomaterials and Bioinspired Material, Materials Science Institute of Madrid (ICMM)/CSIC, Madrid, Spain S. Maiti Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India K. Majidzadeh-A Biomaterials and Tissue Engineering Research Group, Breast Cancer Research Center (BCRC), Academic Center for Education, Culture and Research (ACECR); Tasnim Biotechnology Research Center, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran List of Contributors xxiii A. Maleki Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC) and Department of Pharmaceutical Nanotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran M. Marciello Department of Biomaterials and Bioinspired Material, Materials Science Institute of Madrid (ICMM)/CSIC, Madrid, Spain G. Martra Department of Chemistry and NIS Interdepartmental Centre, University of Turin, Turin, Italy A. Modi Pharmaceutics Research Laboratory, Department of Pharmaceutics, Adina Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India M.P. Morales Department of Biomaterials and Bioinspired Material, Materials Science Institute of Madrid (ICMM)/CSIC, Madrid, Spain D. Mottet Protein Signalisation and Interaction—GIGA, University of Liege, Liege, Belgium H.E. Mukaya Department of Applied Chemical Technology, University of Johannesburg, Doornfontein Campus, Johannesburg, South Africa V. Nichele Department of Molecular Science and Nanosystems, Ca’ Foscari University Venice, INSTM Consortium Venice RU, Mestre, Italy M. Nikhalat Laser Research Center of Dentistry, Tehran University of Medical Sciences, Tehran, Iran H. Nokhbatolfoghahaei Laser Research Center of Dentistry, Tehran University of Medical Sciences, Tehran, Iran S.V. Otari Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur, Maharashtra, India P.M. Outuki State University of Maringá, Department of Pharmacy, Laboratory of Research and Development of Drug Delivery Systems, Maringá, Brazil xxiv List of Contributors B.-D. Park Department of Wood Science and Technology, Kyungpook National University, Daegu, Republic of Korea G. Patel Department of Pharmaceutics and Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science & Technology (CHARUSAT), Changa, Gujarat, India S. Patra Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India S.H. Pawar Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur, Maharashtra, India J.L. Pedraz NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU); Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain A. Phulukdaree Discipline of Medical Biochemistry and Chemical Pathology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa G. Piel Laboratory of Pharmaceutical Technology and Biopharmacy—CIRM, University of Liege, Liege, Belgium J. Pillai Implants, Devices & Drug Delivery Systems (IDS) Laboratory, Centre for Bio-design (CBD), Translational 3 Health Science & Technology Institute (THSTI), Faridabad, Haryana, India F. Pinna Department of Molecular Science and Nanosystems, Ca’ Foscari University Venice, INSTM Consortium Venice RU, Mestre, Italy P.V. Rao Faculty of Agro Based Industry, University Malaysia Kelantan, Campus Jeli, Kelantan, Malaysia N. Salleh Department of Physiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia A. Saneja Formulation & Drug Delivery Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India List of Contributors xxv A. Sarwal University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India A. Seyfoori Biomaterials and Tissue Engineering Research Group, Breast Cancer Research Center (BCRC), Academic Center for Education, Culture and Research (ACECR); School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran A. Shahidian Mechanical Engineering Department, K.N. Toosi University of Technology, Tehran, Iran A. Sharma Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Patiala, Punjab, India A.K. Sharma Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences & Research, New Delhi, India S. Sharma University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India R. Shegokar Freie Universität Berlin, Institute of Pharmacy, Department Pharmaceutics, Biopharmaceutics, and NutriCosmetics, Berlin, Germany M. Signoretto Department of Molecular Science and Nanosystems, Ca’ Foscari University Venice, INSTM Consortium Venice RU, Mestre, Italy Silki University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India N. Singh VIT University, School of Biosciences and Technology, Microbial Biotechnology Laboratory, Vellore, Tamil Nadu, India I. Singh Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Patiala, Punjab, India V.R. Sinha University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India xxvi List of Contributors N.D. Thorat Department of Physics & Energy, University of Limerick; Materials & Surface Science Institute, University of Limerick, Limerick, Ireland; Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur, Maharashtra, India C. Tiloke Discipline of Medical Biochemistry and Chemical Pathology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa S.A.M. Tofail Department of Physics & Energy, University of Limerick; Materials & Surface Science Institute, University of Limerick, Limerick, Ireland M. Villa Nova State University of Maringá, Department of Pharmacy, Laboratory of Research and Development of Drug Delivery Systems, Maringá, Brazil H.M. Yadav Department of Materials Science and Engineering, University of Seoul, Seoul, South Korea X.-J. Zhang School of Materials Science and Engineering, Jinling Institute of Technology, Nanjing, P.R. China