MEDICAL RADIOLOGY Diagnostic Imaging Editors: A.1. Baert,Leuven K.Sartor,Heidelberg Springer-Verlag Berlin Heidelberg GmbH M.F. Reiser · M. Takahashi · M. Modic c. R. Becker (Eds.) Multislice CT 2nd Revised Edition With Contributionsby T.Banno.U.Baum.W.Bautz·C.R.Becker-H.Bitterling.D.Boeing'M.Dobritz R.Eibel- B.B.Ertl-Wagner·M.Essig'R.Fischbach·W.Flatz .D.Fleischmann·T.Flohr N.Pujii-M.Funke-E.Grabbe·H.Grees .P.Herzog' R.-T.Hoffmann·1.Jager K.Katada- B.Klingemann.G.Kohl-M.Lell-U.G.Mueller-Lisse.U.1.Mueller-Lisse H.-D.Nagel .M.Nakane-Y.Nakayama-A.Nomayr-B.Ohnesorge-M.F.Reiser W.Romer-S.Schaller- C.Scherf'-U.J.Schoepf'-M.Takahasi.M.Wintermark B.J.Wintersperger.Y.Yamashita Forewordby A.1. Baert With 259 Figures in 410 Separate Illustrations,58 in Color and38 Tables " Springer MAXIMILIAN F.REISER,MD Professor,InstituteofClinical Radiology Ludwig-Maximilians-University Klinikum Grosshadern Marchioninistrasse15 81377Miinchen Germany MUTSUMASATAKAHASHI,MD InternationalImagingCenter 1-2-23Kuhonji Kumamoto862-0976 Japan MICHAELMODIC,MD Professor,DepartmentofRadiology Cleveland Clinic Foundation 9500EuclidAvenue Cleveland, OH44195 USA CHRISTOPH R.BECKER,MD InstituteofClinical Radiology Ludwig-Maximilians-University KlinikumGrosshadern Marchioninistrasse15 81377Miinchen Germany MEDICAL RADIOLOGY' Diagnostic Imaging and Radiation Oncology SeriesEditors:A.1. Baert.1.W. Brady-H.-P.Heilmann· M.Molls- K.Sartor Continuation of Handbuch der medizinischen Radiologie EncyclopediaofMedicalRadiology ISBN978-3-662-05381-2 ISBN978-3-662-05379-9 (eBook) DOI 10.1007/978-3-662-05379-9 LibraryofCongress Cataloging-in-PublicationData MultisliceCTIM.F.Reiser...letal.](eds.);with contributionsbyT.Banno;foreword by A.L.Baert>-2nd rev.ed p.;em.--(Medicalradiology) Includes bibliographicalreferences and index. I.Tomography. I.Reiser,Maximilian. II.Banno,T.(Tatuo) III.Series. [DNLM:I.Tomography,X-RayComputed--methods. WN206M9612004] RC78.7.T6M8552004 616.07'572--dc22 2003066714 Thisworkissubjecttocopyright.Allrights arereserved,whetherthewholeorpartofthematerialisconcerned,specifi callythe rights oftranslation,reprinting,reuse of illustrations,recitations,broadcasting,reproduction on microfilm or inanyotherway,and storage indata banks.Duplicationofthis publicationorpartsthereofispermittedonlyunderthe provisionsoftheGermanCopyrightLawofSeptember9,1965,initscurrentversion,andpermissionforusemust always beobtainedfrom Springer-Verlag.Violations areliableforprosecutionundertheGermanCopyrightLaw. httpllwww.springeronline.com ©Springer-VerlagBerlinHeidelberg2004 OriginallypublishedbySpringer-VerlagBerlinHeidelbergNewYorkin2004. Softcoverreprintofthehardcover2ndedition2004 Theuseofgeneral descriptive names,trademarks,etc.inthispublicationdoesnotimply,evenintheabsenceofaspecific statement,thatsuchnames areexemptfromtherelevantprotectivelawsandregulations andthereforefreeforgeneraluse. Productliability:Thepublisherscannotguaranteetheaccuracyofanyinformationaboutdosageandapplicationcontained inthisbook.Ineverycasetheusermust checksuchinformationbyconsultingtherelevant literature. Cover-Designand Typesetting:VerlagsserviceTeichmann,69256Mauer 21/3150xq- 543210- Printedonacid-freepaper Foreword This is the second, revised edition of the very successful volume on multislice CT published only 2 years ago.A second edition became necessary so swiftly due to the rapidtechnical developments in multi-detectorrowtechnology; ahuge amountofnew experimental and clinical data has recently become available. This book is the most comprehensive up-to-date work on all aspects of the clinical applications ofthis fascinating imagingtechnique. Itcontains information on the very latest developments in the field,aswellasnumerous superb illustrations. I am very much indebted to the editors of this volume, M.F. Reiser,M.Takahashi, M.Modic and C.R.Becker- allrenowned internationalexperts in computertomogra phy - for the immense dedication and tireless effort involvedin preparing and editing this superb volume in a record briefperiod of time.I would like to congratulate the editors and the contributingauthors,allselected for theirexceptionalexpertise,on the outstanding qualityofthe different chapters and the wide range of topics covered. This work will be of great help as a daily source of reference for all radiologists involvedin CTimagingand willprovide asolid base ofinformation for radiologists in training.Itwillalsobeofgreat interesttothe differentmedical and surgical subspecial istswhowanttolearnmoreaboutthe excitingwaysinwhichthisimaging techniquecan improve the clinicalmanagementoftheirpatients.Iam confident thatthis outstanding volume willmeet the same successwith the readership as the previousvolumes ofour series MedicalRadiology - Diagnostic Imaging. Leuven ALBERT1.BAERT Preface Five years ago, the introduction of 4-detector row CT aroused the desire to acquire isotropic or at least near-isotropic image resolution for any application. However,the practical accomplishment was limited at that time. In the meantime, multi-detector rowCT(MDCT)scannerswith 8and 16detector rowsare widely available alloverthe world.Thislast generationCTscannermade many ofthe wishes awakened by4-detec tor-row CTpracticable in general practice.Nowadays,established clinical applications such asMDCTangiographyassume greaterimportanceindailyroutine.Also,the scope ofMDCTapplications expands or requires different investigation strategies. Toexploit the full potential of MDCT,fundamental knowledge about the technique and optimal investigation strategies in terms of patient preparation,contrast medium administration and image interpretation ismandatory. On the occasion ofthe Second International Symposium on MultisliceCTin Starn berg, Germanyin April 2002wewere able to gather a number ofrenowned experts to demonstrate the new possibilities ofthe latest MDCTtechnology.With the experience of these contributors,wewere able to collectthe expertise and knowledge of different aspects ofwell-established applications and new clinical indications. This current edition of "Multislice CT" is being published to coincide with the Third International Symposium on Multislice CT in Starnberg in January 2004.This conference has the mission to educate the participants inMDCTskillsratherthanjust presenting the recent developments in technology and research. The book will per fectly support this mission with its profound discussion of different applications and investigation strategies. Wearegrateful toProf.Albert Baertforstimulatingustoeditagainthisvolume ofthe "Medical Radiology" series.The publisher, Springer-Verlag, enthusiasticallysupported the idea and provideduswith invaluable assistance.Wehope this bookwillbevaluable to allthose interested in MDCT. Munich MAXIMILIAN F.REISER Kumamoto MUTSUMASATAKAHASHI Cleveland MICHAELMODIC Munich CHRISTOPH R.BECKER Contents Multi-Row:TechnicalConcepts . Design,Technique,and Future PerspectiveofMultisliceCTScanners T.FLOHR,B.OHNESORGE,S.SCHALLER...................................... 3 2 Radiation DoseIssueswith MSCT H.-D.NAGEL 17 3 ContrastMedium DeliveryforVascularMDCT:Principles and Rationale D.FLEISCHMANN......................................................... 27 4 VisualizationofLargeImageDataVolumesUsingPACSand AdvancedPostprocessingMethods S.SCHALLER,D.BOEING,B.KLINGEMANN,C.SCHERF,G.KOHL,T.FLOHR ........ 35 Brain....................................................................... 43 5 UsefulnessofIsotropicVolumetricDatainNeuroradiologicalDiagnosis K.KATADA,N.FUJII,T.BANNO,M.NAKANE .................................. 45 6 Imaging Pathologiesinthe PosteriorFossawith MSCT M.EsSIG................................................................ 53 7 CervicocranialMSCTA R.-T.HOFFMANN,B.B.ERTL-WAGNER,M.F.REISER........................... 59 8 Perfusion CTImaging ofAcuteIschemicBrainInjurywith MSCT M.WINTERMARK......................................................... 69 Ear,NeckandThroat......................................................... 75 9 TemporalBoneImaging with MultisliceCT L.JAGER 77 10 Morphologic and FunctionalAssessmentofHeadand NeckTumors withMultisliceCT M.LELL,W.ROMER,H.GREESS,A.NOMAYR,U.BAUM,W.BAUTZ................ 85 11 StagingofLaryngealand HypopharyngealCancerUsingMSCT W.H.FLATZand L.JAGER 93 x Contents Chest ...................................................................... 107 12 Lung CancerScreening P.HERZOG............................................................... 109 13 MultisliceCTin Focal andDiffuseLungDiseaseswithSpecialEmphasis on CoronalandSagittalMPRs R.EIBEL ................................................................ 119 14 ImagingofPatientswithMucoviscidosis H.BITTERLING........................................................... 131 15 MultisliceCTImagingofPulmonaryEmbolism U.J.SCHOEPF............................................................ 137 16 CoronaryCalciumScreening R.FISCHBACH........................................................... 149 17 MultisliceComputedTomographyAngiographyoftheCoronaryArteries C.R.BECKER............................................................ 159 Abdomen.................................................................. 171 18 CTAngiographyoftheAortaandItsMajorBranchesbyMultidetectorCT Y.NAKAYAMA,Y.YAMASHITA,M.TAKAHASHI 173 19 MSCTin theEvaluationofInflammatoryBowelDiseases H.BITTERLING........................................................... 185 20 BiphasicContrast-EnhancedMSCToftheLiver M.FUNKEandE.GRABBE ...................................... 195 21 CTPortographybyMultidetectorCT Y.NAKAYAMA,Y.YAMASHITA,M.TAKAHASHI................................. 199 22 MDCT oftheKidney U.G.MUELLER-LISSEandU.1.MUELLER-LISSE .............................. 211 23 MultisliceCTin theDiagnosisofPancreaticThmors U.BAUM,A.NoMAYR,M.LELL,W.BAUTZ 233 24 MultisliceSpiralCTin PreoperativeStagingofRectalCarcinoma A.NOMAYR,U.BAUM,M.LELL,H.GREESS,M.DOBRITZ,W.A.BAUTZ............ 245 25 MDCTAngiographyofPeripheralArteries B.J.WINTERSPERGER ..................................................... 255 SubjectIndex............................................................ 269 ListofContributors 275 Multi-Row: Technical Concepts 1 Design, Technique, and Future Perspective of Multislice CT Scanners THOMAS FLOHR,BERND OHNESORGE,STEFAN SCHALLER CONTENTS scannerintroduced in 1993(Elscint TWIN).In 1998, allmajorCTmanufacturersintroducedfour-slice CT 1.1 Introduction 3 systems,typicallywith rotation times of 0.5s,which 1.2 DetectorDesign,Dose,and DoseReduction 4 brought about considerable improvements of scan 1.2.1 DetectorDesign 4 1.2.2 Doseand DoseReduction 5 speed, transverse resolution and utilization of the 1.3 Image Reconstruction 6 tube output (KLINGENBECK-REGN et al. 1999;Hu et 1.3.1 Definition ofthe SpiralPitch 6 al. 2000;OHNESORGE et al. 1999). The examination 1.3.2 TheCone-Angle Problem and MultisliceSpiral time for standard protocols could be significantly ReconstructionApproaches 6 reduced,which is clinically important in avarietyof 1.3.3 AdaptiveMultiplePlaneReconstruction 7 1.4 ECG-SynchronizedMultisliceCT instances, such as in dealing with trauma or unco forCardiothoracicApplications 9 operative patients. Alternatively, the scan range that 1.4.1 ECGTriggering and ECGGating 9 could be covered within a certain scan time was 1.4.2 AdaptiveCardio-volumeReconstruction 10 extendedcorrespondingly,asfor oncological screen 1.5 Future Perspectives ofMultisliceCT 12 ing or for CTangiographies of the extremities.Most References 15 important,however,turned out to be the capacityto scan a given volume in a given time with consider ablysmallerslicewidth,thus toapproachthe idealof 1.1 isotropic resolution.Thorax and abdomen examina Introduction tions could now routinelybe performed with 1mm or 1.25mm collimatedslicewidth.Asaconsequence, The introduction of spiral CTin the early 1990slaid volumetric viewing and diagnosis in a volumetric thefoundationforafundamentalimprovementinCT mode have become integrated elements of the rou imaging(KALENDERetal.1990;CRAWFORDand KING tineworkflow.Newapplicationshavebeen introduced 1990).Forthefirsttimevolumedata couldbeacquired in clinical practice, the most important application without misregistration of anatomical details, which beingcardiacCT.With agantryrotationtimeof0.5s initiatedthedevelopmentofthree-dimensionalimage and dedicated image reconstruction approaches, the processingtechniques such asmulti-planarreforma temporal resolution ofan image could be reduced to tions (MPRs),maximumintensityprojections(MIPs), 250ms and below (KACHELRIESS et al.2000a;OHNE surface-shaded displays (SSPs)or volume-rendering SORGE et al.2000),which proved to be sufficient for techniques (VRTs). However, as a consequence of motion-free imaging of the heart in the mid- to increasing clinical demands single-slice spiral CT end-diastolic phase at low to moderate heart rates. with 1s gantry rotation time soon encountered The improvedtransverse resolution with 4xl mm or its limitations. The ideal of isotropic resolution, of 4x1.25mmcollimationincombinationwith excellent acquiring image voxels with comparable sizes in all low-contrastdetectabilityallowedforhigh-resolution three dimensions, could only be met by a substan CTAsofthecoronaryarteries(ACHENBACHetal.2000; tial reduction of the scan range (KALENDER 1995). BECKER et al. 2000;KNEZ et al. 2000; Nieman et al. The first step towards larger volume coverage and 2001).Inthe meantimefirstclinicalstudieshavedem improved transverse resolution was a two-slice CT onstrated the potential of multislice CT to not only detect butclassifylipid, fibrous and calcifiedplaques inthe coronaryarteriesaccordingtotheirCTdensity (SCHROEDER et al.2001). T.FLOHR,PhD;B.OHNESORGE,PhD;S.SCHALLER,PhD SiemensMedicalSolutions,ComputedTomography,Siemens Despiteallpromisingadvances,clinical challenges strasse1,91301 Forchheim,Germany and limitations remain for four-slice CT systems.