Multiple Myeloma - An Overview

284 Pages·2011·5.464 MB·English

by  A. Gupta

MULTIPLE MYELOMA –
AN OVERVIEW

Edited by Ajay Gupta
Multiple Myeloma – An Overview
Edited by Ajay Gupta

Published by InTech
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First published January, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

Multiple Myeloma – An Overview, Edited by Ajay Gupta
p. cm.
ISBN 978-953-307-768-0
free online editions of InTech
Books and Journals can be found at
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Contents

Preface IX
Part 1 Multiple Myeloma:
Disease Biology and It's Therapeutic Applications 1
Chapter 1 Proteasome Inhibitors in
the Treatment of Multiple Myeloma 3
Lisa J. Crawford and Alexandra E. Irvine
Chapter 2 Regulatory Cells and Multiple Myeloma 33
Karthick Raja Muthu Raja and Roman Hajek
Chapter 3 Effects of Recombinant Human Tumor Necrosis
Factor-α and Its Combination with Native Human
Leukocyte Interferon-α on P3-X63-Ag8.653
Mouse Myeloma Cell Growth 61
Andrej Plesničar, Gaj Vidmar,
Borut Štabuc and Blanka Kores Plesničar
Chapter 4 Cellular Immunotherapy Using Dendritic
Cells Against Multiple Myeloma 75
Je-Jung Lee, Youn-Kyung Lee and Thanh-Nhan Nguyen-Pham
Chapter 5 Targeted Inhibition of Multiple Proinflammatory
Signalling Pathways for the Prevention
and Treatment of Multiple Myeloma 93
Radhamani Kannaiyan, Rohit Surana, Eun Myoung Shin,
Lalitha Ramachandran, Gautam Sethi and Alan Prem Kumar
Chapter 6 The SUMOylation Pathway as a Potential Therapeutic
Target in Multiple Myeloma 129
James J. Driscoll
Chapter 7 Therapeutic Approaches for Targeting Hypoxia-Inducible
Factor in Multiple Myeloma 137
Keita Kirito
VI Contents

Chapter 8 The Contribution of Prognostic Factors to the Better
Management of Multiple Myeloma Patients 145
Marie-Christine Kyrtsonis, Dimitrios Maltezas,
Efstathios Koulieris, Katerina Bitsani, Ilias Pessach,
Anna Efthymiou, Vassiliki Bartzis,
Tatiana Tzenou and Panayiotis Panayiotidis
Part 2 Multiple Myeloma Management:
Issues and Considerations 175
Chapter 9 Solitary Plasmacytoma of Bone 177
Jianru Xiao, Wending Huang, Xinghai Yang and Honglin Teng
Chapter 10 Solitary Bone and Extramedullary Plasmacytoma 185
Galina Salogub, Ekaterina Lokhmatova and Sergey Sozin
Chapter 11 Multiple Myeloma and Dentistry 207
Ajaz Shah, Suhail Latoo and Irshad Ahmad
Chapter 12 Renal Disease in Multiple Myeloma 219
Guray Saydam, Fahri Sahin and Hatice Demet Kiper
Chapter 13 Stem Cell Mobılızatıon in Multıple Myeloma 241
Şule Mine Bakanay and Taner Demirer
Chapter 14 The Current Role of Stem Cell Transplantation
in Multiple Myeloma 263
Ajay Gupta

Preface

Multiple myeloma is a malignant disorder characterized by the proliferation of plasma
cells. It accounts for 10% of hematological cancers and 1% of all cancers. The disease is
uniformly fatal with a median survival of approximately three years with
conventional chemotherapy, although the outlook has improved with the integration
of newer therapies including high-dose therapy followed by autologous stem cell
transplantation.
Much insight has been gained into the molecular pathways that lead to myeloma and
indeed much more remains to be done. The understanding of these pathways is closely
linked to their therapeutic implications and is stressed upon in the initial chapters.
The role of multiple pro-inflammatory pathways, hypoxia inducing factor, tumor
necrosis factor, proteasomes , sumoylation pathways and their therapeutic importance
is examined as is the role of experimental therapies like dendritic cell therapy.
Recently, the introduction of newer agents such as bortezomib, lenalidomide,
thalidomide, liposomal doxorubicin, etc. has led to a flurry of trials aimed at testing
various combinations in order to improve survival. Higher response rates observed
with these agents have led to their integration into induction therapies. It has raised
questions in terms of redefining the inclusion criteria/timing and expected benefits of
stem cell transplantation.
The role of various new therapies vis a vis transplantation has also been examined.
Recent advances in the management of plasmacytomas , renal dysfunction, dentistry
as well as mobilization of stem cells in the context of myeloma have also found
exclusive mention. These areas are clinically very relevant and are often neglected in
text books on multiple myeloma. A complete book on the topic would be too
exhaustive: as such, since brevity is the soul of wit our attempt has been to present
before the reader a comprehensive yet brief text on this important subject.

Ajay Gupta
MD, DM, CCST (UK), Senior Consultant,
Medical Oncology, Max Cancer Centre, Saket, New Delhi,
India