TrimSize:170mmx244mm Dale ffirs.tex V3-07/08/2015 11:42A.M. Pageii TrimSize:170mmx244mm Dale ffirs.tex V3-07/08/2015 11:42A.M. Pagei MRI Basic Principles and Applications TrimSize:170mmx244mm Dale ffirs.tex V3-07/08/2015 11:42A.M. Pageii TrimSize:170mmx244mm Dale ffirs.tex V3-07/08/2015 11:42A.M. Pageiii MRI Basic Principles and Applications Brian M. Dale, PhD MBA Mark A. Brown, PhD Richard C. Semelka, MD FIFTH EDITION TrimSize:170mmx244mm Dale ffirs.tex V3-07/08/2015 11:42A.M. Pageiv Thiseditionfirstpublished2015©2015byJohnWiley&Sons,Ltd Registeredoffice:JohnWiley&Sons,Ltd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK Editorialoffices:9600GarsingtonRoad,Oxford,OX42DQ,UK 111RiverStreet,Hoboken,NJ07030-5774,USA Fordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapplyfor permissiontoreusethecopyrightmaterialinthisbookpleaseseeourwebsiteat www.wiley.com/wiley-blackwell Therightoftheauthortobeidentifiedastheauthorofthisworkhasbeenassertedinaccordancewiththe UKCopyright,DesignsandPatentsAct1988. Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,or transmitted,inanyformorbyanymeans,electronic,mechanical,photocopying,recordingorotherwise, exceptaspermittedbytheUKCopyright,DesignsandPatentsAct1988,withoutthepriorpermissionofthe publisher. 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LibraryofCongressCataloging-in-PublicationData Dale,BrianM.,author. MRI:basicprinciplesandapplications/BrianM.Dale,MarkA.Brown,andRichardC.Semelka.–Fifth edition. p.;cm. PrecededbyMRI/MarkA.Brown,RichardC.Semelka.4thed.c2010. Includesbibliographicalreferencesandindex. ISBN978-1-119-01305-1(pbk.) I.Brown,MarkA.,1955-,author.II.Semelka,RichardC.,author.III.Brown,MarkA.,1955-MRI. Precededby(work):IV.Title. [DNLM:1.MagneticResonanceImaging–methods.WN185] RC78.7.N83 616.07′548–dc23 2015015322 AcataloguerecordforthisbookisavailablefromtheBritishLibrary. Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprintmaynot beavailableinelectronicbooks. Setin9.5/13pt,MeridienLTStdbySPiGlobal,Chennai,India. 1 2015 TrimSize:170mmx244mm Dale ftoc.tex V3-07/08/2015 5:17P.M. Pagev Contents Preface,ix ABRstudyguidetopics,xi 1 Productionofnetmagnetization,1 1.1 Magneticfields,1 1.2 Nuclearspin,2 1.3 Nuclearmagneticmoments,4 1.4 Larmorprecession,4 1.5 Netmagnetization,6 1.6 Susceptibilityandmagneticmaterials,8 2 Conceptsofmagneticresonance,10 2.1 Radiofrequencyexcitation,10 2.2 Radiofrequencysignaldetection,12 2.3 Chemicalshift,14 3 Relaxation,17 3.1 T1relaxationandsaturation,17 3.2 T2relaxation,T2*relaxation,andspinechoes,21 4 Principlesofmagneticresonanceimaging–1,26 4.1 Gradientfields,26 4.2 Sliceselection,28 4.3 Readoutorfrequencyencoding,30 4.4 Phaseencoding,33 4.5 Sequencelooping,35 5 Principlesofmagneticresonanceimaging–2,39 5.1 Frequencyselectiveexcitation,39 5.2 Compositepulses,44 5.3 Rawdataandimagedatamatrices,46 5.4 Signal-to-noiseratioandtradeoffs,47 5.5 Rawdataandk-space,48 5.6 Reducedk-spacetechniques,51 5.7 Reorderedk-spacefillingtechniques,54 5.8 Otherk-spacefillingtechniques,56 5.9 Phased-arraycoils,58 5.10 Parallelacquisitionmethods,60 v TrimSize:170mmx244mm Dale ftoc.tex V3-07/08/2015 5:17P.M. Pagevi vi Contents 6 Pulsesequences,65 6.1 Spinechosequences,67 6.2 Gradientechosequences,70 6.3 Echoplanarimagingsequences,75 6.4 Magnetization-preparedsequences,77 7 Measurementparametersandimagecontrast,86 7.1 Intrinsicparameters,87 7.2 Extrinsicparameters,89 7.3 Parametertradeoffs,91 8 Signalsuppressiontechniques,94 8.1 Spatialpresaturation,94 8.2 Magnetizationtransfersuppression,96 8.3 Frequency-selectivesaturation,99 8.4 Nonsaturationmethods,101 9 Artifacts,103 9.1 Motionartifacts,103 9.2 Sequence/Protocol-relatedartifacts,105 9.3 Externalartifacts,119 10 Motionartifactreductiontechniques,126 10.1 Acquisitionparametermodification,126 10.2 Triggering/Gating,127 10.3 Flowcompensation,132 10.4 Radial-basedmotioncompensation,134 11 Magneticresonanceangiography,135 11.1 Time-of-flightMRA,137 11.2 PhasecontrastMRA,141 11.3 Maximumintensityprojection,144 12 Advancedimagingapplications,147 12.1 Diffusion,147 12.2 Perfusion,153 12.3 Functionalbrainimaging,156 12.4 Ultra-highfieldimaging,158 12.5 Noblegasimaging,159 13 Magneticresonancespectroscopy,162 13.1 Additionalconcepts,162 13.2 Localizationtechniques,167 13.3 Spectralanalysisandpostprocessing,169 13.4 Ultra-highfieldspectroscopy,173 TrimSize:170mmx244mm Dale ftoc.tex V3-07/08/2015 5:17P.M. Pagevii Contents vii 14 Instrumentation,177 14.1 Computersystems,177 14.2 Magnetsystem,180 14.3 Gradientsystem,182 14.4 Radiofrequencysystem,184 14.5 Dataacquisitionsystem,186 14.6 Summaryofsystemcomponents,187 15 Contrastagents,189 15.1 Intravenousagents,190 15.2 Oralagents,195 16 Safety,196 16.1 Basemagneticfield,197 16.2 Cryogens,197 16.3 Gradients,198 16.4 RFpowerdeposition,198 16.5 Contrastmedia,199 17 Clinicalapplications,200 17.1 GeneralprinciplesofclinicalMRimaging,200 17.2 Examinationdesignconsiderations,202 17.3 Protocolconsiderationsforanatomicalregions,203 17.4 Recommendationsforspecificsequencesand clinicalsituations,218 Referencesandsuggestedreadings,222 Index,225 TrimSize:170mmx244mm Dale ftoc.tex V3-07/08/2015 5:17P.M. Pageviii
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