Jeserich et al. (Eds.) Molecular Signaling and Regulation in Glial Cells Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Santa Clara Singapur Tokyo Jeserich et al. (Eds.) Molecular Signaling and Regulation in Glial Cells A Key to Remyelination and Functional Repair With 120 Figures and 17 Tables Springer PROF. DR. GUNNAR JESERICH PROF. DR. CHRISTIANE RICHTER-LANDSBERG Universitiit Osnabriick Universitiit Oldenburg FB Biologie/Chemie FB Biologie Barbarastr. 11 Postfach 2503 D-49069 Osnabriick D-26111 Oldenburg PROF. DR. HANS H. ALTHAUS PROF. DR. ROLF HEUMANN Max-Planck-Institut fiir Universitiit Bochum Experimentelle Medizin Molekulare Neurobiochemie Hermann-Reinsstr.3 Universitiitsstr. 150 D-37075 Gottingen D-4480 1 Bochum ISBN-13: 978-3-642-64501-3 e-ISBN-13: 978-3-642-60669-4 001: 10.1007/978-3-642-60669-4 CIP-Data applied for Die Deutsche Bibliothek -CIP-Einheitsaufnahme Molecular signaling and regulation in glial cells: a key to remyelination and functional repair led by G. Jeserich ... -Berlin; Heidelberg; New York; Barcelona; Budapest; Hong Kong; London; Milan; Paris; Santa Clara; Singapore; Tokyo; Springer 1997 ISBN-13: 978-3-642-64501-3 NE: Jeserich, Gunnar [Hrsg.] This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this oblication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1997 Softcover reprint of the hardcover 1st edition 1997 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover Design: D & P Heidelberg Camera ready by editors SPIN 10526684 31/3137 5 43210 -Printed on acid free paper - VI 1 H.G. Luesse, 2 W. Bruck, 3 H.W. Miiller, 4 J.-M. Matthieu, 5 P. Rieckmann, 6 J. Strelau, 7 F. Aloisi, 8 M. Yoshida, 9 H.S. Keirstead, 10 N. Pringle, 11 K.A. Nave, 12 R. Ankerhold, 13 J.E. Merrill, 14 A.L. Gard, 15 P. Shrager, 16 G. Rohde, 17 S.J. Moorman, 18 R.M. Gould, 19 R. Matsas, 20 H. Rabe, 21 C. Stichel, 22 R. Heumann, 23 M. Heinrich, 24 P. Remde, 25 J. Trotter, 26 R. Franklin, 27 N. Scolding, 28 E. Yavin, 29 A. Brand, 30 R. Hempel, 31 J. de Vellis, 32 L. Hudson, 33 C. Richter-Landsberg, 34 S. Nona, 35 G. Almazan, 36 G. Jeserich, 37 A. Espinosa de los Monteros, 38 H.H. Althaus, 39 J. Gehrmann, 40 M. Dubois-Dalcq, 41 S.G. Amur-Umatjee. VII Almazan. Guillermina Aloisi, Francesca McGill University, Istituto Superiore di Sanita Dept. Pharmacology Viale Regina Elena 299 3655 Drummond Street, Room 1321 1-00161 Rome, Italy Montreal, Quebec H3GlY6, Canada FAX:+ 39 -6-4957821 FAX:+ 1 -514 -398-6690 Email: [email protected] Email: [email protected] Althaus, Bans B. Ankerhold, Richard MPI Experimentelle Medizin Fakultat Biologie, Hermann Reinstr. 3 Universitat Konstanz D-37075 Gottingen Universitatsstr. 10 FAX:+ 49 -551 -3899 -388 D-78464 Konstanz Email: [email protected] FAX:+ 49 -7531 88-38 94 Email: [email protected] Amur-Umarjee, Shashi G. 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Medicine Department of Anatomy Univ. Cambridge Institute of Medical Biology Cambridge CB2 2QQ, UK University of Odense FAX:+ 44 - 1223 -337610 DK-5000 Odense Email: [email protected] FAX:+ 45 -65 -906321 VIII Gard, Anthony L. Gehrmann, Jochen University of South Alabama Institut fur Neuropathologie der College of Medicine Abt. fur Pathologie der Universitat Mobile, AL 36688, USA CH-8091 Zurich FAX:+ 1 -334 -460 -6771 FAX:+ 41 - 12554402 Email: [email protected] Email: [email protected] Gould, Robert M. Heumann, Rolf NY State Institute f. Basic Research Lehrstuhl f. Molekulare in Developmental Disabilities Ncurobiochemie 150 Forest Hill Road Ruhr-Universitat Bochum Staten Island, 10314 NY, USA Universitatsstr. 150 FAX:+ 1 -718 -698 -7169 D-44801 Bochum FAX:+ 49 -234 -7094105 Hudson, Lynn D. Jeserich, Gunnar NINDS, NIH AG Zoophysiologie Buildg. 36, Rm 5004 Universitat Osnabrock, Barbarastr. 11 Bethesda, MD 20892, USA 49069 Osnabrock FAX:+ 1 -301 -496 -0899 FAX:+ 49 -541 -9692870 Email: [email protected] Email :[email protected]. uni- osnabrueck.de Keirstead, Hans S. Matsas,Rebecca MRC Cambridge Ctr f. Brain Repair Inst. Pasteur Hellenique Dept. Clinical Veterinary Medicine 127, Vas Sofias Avenue University of Cambridge GR-1l521 Athens. Greece Cambridge CB2 2PY, UK FAX:+ 30 - 16423498 FAX:+ 44 - 1223 -337610 Email: [email protected] Matthieu, Jean-Marie Merrill, Jean E. Lab. de Neurochimie UCSF San Francisco Service de Pediatrie, CHUV Berlex Biosciences, POB 4099 CH-1O II Lausanne 5049 San Pablo Avenue FAX:+ 41 -21 -3143477 Richmond, CA 94804-0099, USA Email: [email protected] FAX:+ 1-510 -669 -4244 Moorman, Stephen J. Muller, Hans Werner Dept. Anatomy and Cell Biology Abt. Neurologie der University of North Texas Heinrich-Heine Universitat Dusseldorf Health Sci Ctr at Fort Worth Moorenstr. 51 Fort Worth, TX 76107, USA 40225 Dusseldorf FAX:+1 -817 -735 -2610 FAX:+ 49 -211 -311 -8485 Email: [email protected] IX Nave. Klaus Armin Nona, Sam Zentrum Molek. BioI. Heidelberg UMIST, Dept. Optomet.& Vision Sc. 1m Neuenheimer Feld Dev. Neurobiol. Lab., Box 88 D-6900 Heidelberg Manchester M60 lQD, UK FAX:+ 49 -6221 -565894 FAX:+ 44 - 1611 -236 -0409 Email:[email protected] Email: [email protected] Pringle, Nigel Privat, Alain MRC-Lab Molec. Cell BioI. U336 INSERM Gowerstr. USTL Case Courrier 106 London WCIE 6BT, UK Place Eugene Batallion FAX:+ 44 - 171 -380 -7805 F-34095 Montpellier Cedex 05 Email: [email protected] France FAX:+ 33 -67 - 143318 Richter-Landsberg, Christiane Rieckmann, Paul Fachbereich Biologie Neurologische Klinik der Abt. Molekulare Neurobiologie Universitat Gottingen Universiat Oldenburg, Postfach 2503 37075 Gottingen 26111 Oldenburg FAX:+ 49 -551 -398405 FAX:+ 49 -441 -798 -3223 Email: [email protected] Rodriguez, Moses Scolding, Neil Mayo CliniclFoundation Neurology Unit, Univ. Cambridge Department of Immunology Addenbrookes Hospital, Hills Road 200 First Sreet Souhtwest Cambridge CB2 2QQ, UK Rochester, MN 55905, USA FAX:+ 44 - 1223 -336941 FAX:+ 1 -507 -284 - 1637 Email:[email protected] Shrager, Peter Sontheimer, Harry W. Univ. Rochester, Medical Ctf. Neurobiol. Research Ctr. Dept. Physiol. Box 642 University of Alabama 601 Elmwood Avenue 1719 6th Avenue S Circ Rochester, NY 14642, USA Birmingham, AL 35294, USA FAX:+ 1 -716 -461 -3259 FAX:+ 1 -205 -934 -6571 Email: [email protected] Email: Stichel, Christiane Trotter, Jacqueline Abt. Neurologie der Abt. 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