Molecular and Cellular Endocrinology of the Testis PDF
Preview Molecular and Cellular Endocrinology of the Testis
Ernst Schering Research Foundation Workshop Supplement 1 Molecular and Cellular Endocrinology of the Testis Ernst Schering Research Foundation Workshop Editors: Gunter Stock Ursula-F. Habenicht Vol. 5 Sex Steroids and the Cardiovascular System Editors: P. Ramwell, G. Rubanyi, E. Schillinger Vol. 6 Transgenic Animals as Model Systems for Human Diseases Editors: E. F. Wagner, F. Theuring Vol. 7 Basic Mechanisms Controlling Term and Preterm Birth Editors: K. Chwalisz, R. E. Garfield Vol. 8 Health Care 2010 Editors: C. Bezold, K. Knabner Vol. 9 Sex Steroids and Bone Editors: R. Ziegler, J. Pfeilschifter, M. Brautigam Vol. 10 Non-Genotoxic Carcinogenesis Editors: A. Cockburn, L. Smith Vol. 11 Cell Culture in Pharmaceutical Research Editors: N. E. Fusenig, H. Graf Supplement 1 Molecular and Cellular Endocrinology of the Testis Editors: G. Verhoeven, U.-F. Habenicht Ernst Schering Research Foundation Workshop, Supplement 1 Molecular and Cellular Endocrinology of the Testis G. Verhoeven, U.-F. Habenicht Editors With 55 Figures Springer-Verlag Berlin Heidelberg GmbH ISBN 978-3-662-22191-4 ISBN 978-3-662-22189-1 (eBook) DOI 10.1007/978-3-662-22189-1 CIP data applied for This work is subject to copyright. All rights are reserved, whether the whole or part ofthe material is concerned, specifically the rights of translation, reprinting, reuse of illustra- tions, recitation, broadcasting, reproduction on microfilms or in any other way, and stor- age in data banks. Duplication of this publication or parts thereof is permitted only under the provisions oftheGerman Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag Berlin Heidelberg. Violations are liable for prosecution under the German Copyright Law. ©Springer-Verlag Berlin Heidelberg 1994 Originally published by Springer-Verlag Berlin Heidelberg New York in 1994 Softcoverreprint of the hardcover Ist edition 1994 The use of generat descriptive names, registered names, trademarks, etc. in this publica- tion does not impty, even in the absence of a specific Statement, that such names are ex- empt from the relevant proteelive taws and regutations and therefore free for generat use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant titerature. Typesetting: RTS, Wiesenbach SPIN: lOt 33 978 21/3130-5 4 3 2 1 0- Printedon acid-free paper Preface The European Workshops on Molecular and Cellular Endocrinology of the Testis have become by now a well-established tradition. Thanks to their special format, the quality of the main lectures and miniposters, and the vivid discussions, they enjoy the ever-increasing interest and active participation of all European scientists working in the field. Moreover, since the very beginning they have attracted investigators from all over the world. The most recent "Testis Workshop" was held in De Panne, Belgium, from 27-3\ March, 1994. As always, the frame- work of the workshop was provided by a series of lectures delivered by a panel of internationally recognized authorities. These lectures are ga- thered in the present volume of the Ernst Schering Foundation Work- shop series. Together with the Miniposter book they constitute an excel- lent written account of the Proceedings of the 8th European Testis Workshop. The testis undoubtedly represents one of the most complex and in- triguing tissues in the body. Both its endocrine function, the secretion of male sex hormones, and its exocrine role, the production of mature spermatozoa, continue to raise startling questions to clinicians, physi- ologists, endocrinologists, and scientists involved in fundamental re- search. Few organs maintain and support a differentiation process as complicated as spermatogenesis; few tissues continually display both mitotic and meiotic cell cyles in such a stringently controlled fashion or a comparable need for coordinated endocrine and local control. As a consequence, the testis has become a preferred model for basic research VI Preface on cell differentiation, cell cycle control, environmental and paracrine modulation of cell function, hormone action, signal transduction, and regulation of gene expression. Recent advances in cell isolation cell culture techniques, molecular biology, and genetic techniques such as development of transgenic animals, have found eager applications in research on molecular and cellular endocrinology of the testis. The pre- sent volume offers an elective, but representative, sample of the pro- gress that has been made. A final chapter summarizes the impact that this type of research has had and will have with respect to the clinical diagnosis and treatment of male reproductive dysfunction. The authors deserve our special thanks not only for delivering excellent state-of-the-art lectures, but also for providing nicely prepa- red manuscripts well before the meeting. We are also glad to acknowledge the continuous and enthusiastic support and assistance of Focko Rommerts, coorganizer of the mee- ting, of the Permanent Scientific Committee of the Testis Workshops, and of the members of the Local Organinzing Committee as listed be- low. C. Verhoeven Permanent Scientific Committee of the European Workshops on Molecular and Cellular Endocrinology of the Testis Brian Cooke, London; Vidar Hansson, Oslo; lIpo Huhtaniemi, Turku; Eberhard Nie- schlag, Munster; Martin Ritzen, Stockholm; Focko F.G. Rommerts, Rotterdam; Jose Saez, Lyon; Mario Stefanini, Rome; Guido Verhoeven, Leuven. Organizing Committee of the 8th European Workshop on Molecular and Cellular Endocrinology of the Testis Guido Verhoeven, Leuven; Walter Heyns. Leuven; Dirk Vanderschueren, Leuven; Ursu- la-F. Habenicht, Berlin; Focko F.G. Rommerts, Rotterdam. Table of Contents Hormonal Receptors in the Genital Tract A. Chauchereau. A. Mantel, K. Delabre, M. Misrahi, P. Lescop, M. Perrat-Applanat, H. Loosfelt, M.T. Vu Hai, N. Chinea, C. Meduri, J.-F. Savauret, and E. Milgram . ............... 1 2 Transplantation of Male and Female Germ and Somatic Cells R.C. Casden . ...................................... 15 3 Proliferation and Differentiation of Testicular Interstitial Cells: Aspects of Leydig Cell Development in the (Pre)Pubertal and Adult Testis K.J. Tcerds, MB. Veldhui::en-Tsoerkan, F.F.G. Rommerts, D.C. de Rooij, and JH. Dorrington ..... 37 4 Regulation of the Acute Production of Steroids in Steroidogenic Cells D.M. Stocco and B.J. Clark . .......................... 67 5 Extracellular Matrix Elements, Cell Adhesion Molecules, and Signal Transduction in the Control of Sertoli Cell Function M.D~ ........................................... ~ VIII Table of Contents 6 Interactions Between Androgens, Sertoli Cells and Genn Cells in the Control of Spennatogenesis R.M. Sharpe, C. McKinnell, T. McLaren, M.Millar, T.P. West, S. Maguire, I. Gaughan, V. Syed, B. legou, lB. Kerr, and P.TK Saunders ............................... 115 7 Cell Cycle Checkpoints in Male and Female Genn Cells D.F. Albertini . .................................... 143 8 Signal Transduction in Mammalian Spennatozoa G.S. Kopf, P. Kalab, P. Leclerc, X.P. Ning, D. Pan, and P. Visconti . ............................ 153 9 Diversity and Regulation of cAMP-Dependent Protein Kinases K. Tasken, B.S. Skdlhegg, K.A. Tasken, R. Solberg, F.O. Levy, T. Lea, T. lahnsen, and V. Hansson . .......... 185 10 The Nuclear Respone to cAMP During Spermatogenesis: The Key Role of Transcription Factor CREM P. Sassone-Corsi . ................................. 219 II Transgenic Animals and the Study of Gonadal Function M.M. Matzuk ..................................... 253 12 Clinical Relevance and Irrelevance of Molecular and Cellular Research on the Testis E. Nieschlag ...................................... 273 List of Contributors Albertini, D.F. Department of Anatomy and Cellular Biology, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA Chauchereau, A. Hormones et Reproduction, INSERM Unite 135, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France Clark, B . .T. Department of Biochemistry and Molecular Biology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA Delabre. K. Hormones et Reproduction, INSERM Unite 135, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France de Raaij, D.C. Department of Cell Biology, Section of Cell Proliferation and Differentiation, Medical School, Utrecht University, P.O. Box 80.157, 3508 TD Utrecht, The Netherlands Dorringtoll,l.H. Banting and Best Department of Medical Research, University of Toronto, C.H. Best Institute, 112 College Street, Toronto, Ontario, M5G IL6 Canada Dvm. M. Department of Cell Biology, Georgetown University Medical Center, :1900 Reservoir Road, NW, Washington, DC 20007, USA
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