Table Of Content

Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease CONTENTS VOLUME 184, Nos. 1 & 2, July 1998 BIOENERGETICS OF THE CELL: QUANTITATIVE ASPECTS Drs. Valdur A. Saks, Renée Ventura-Clapier, Xavier Leverve, Michel Rigoulet and André Rossi, guest editors Preface What do we not know of cellular bioenergetics? — A general view on the state of the art Part I: Bioenergetics of mitochondria: /n vitro and in vivo studies M.D. Brand: Top-down elasticity analysis and its application to energy metabolism in isolated mitochondria and intact cells O.V. Demin, B.N. Kholodenko and V.P. Skulachev: A model of O->~ generation in the complex III of the electron transport chain M. Rigoulet, X. Leverve, E. Fontaine, R. Ouhabi and B. Guerin: Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces X. Leverve, B. Sibille, A. Devin, M.-A. Piquet, P. Espi¢ and M. Rigoulet: Oxidative phosphorylation in intact hepatocytes: Quantitative characterization of the mechanisms of change in efficiency and cellular consequences N. Averet, V. Fitton, O. Bunoust, M. Rigoulet and B. Guérin: Yeast mitochondrial metabolism: From in vitro to in situ quantitative study V.A. Saks, V.I. Veksler, A.V. Kuznetsov, L. Kay, P. Sikk, T. Tiivel, L. Tranqui, J. Olivares, K. Winkler, F. Wiedemann and W:S. Kunz: Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo L. Rappaport, P. Oliviero and J.L. Samuel: Cytoskeleton and mitochondrial morphology and function A. Devin, P. Espieé, B. Guérin and M. Rigoulet: Energetics of swelling in isolated hepatocytes: A comprehensive study Part II: Energy transfer networks: Molecular physiology of kinases, lessons from transgenic mice, mathematical theories ). Schlattner, M. Forstner, M. Eder, O. Stachowiak, K. Fritz-Wolf andT . Wallimann: Functional aspects of the X-ray structure of mitochondrial creatine kinase: A molecular physiology approach . Stachowiak, U. Schlattner, M. Dolder and T. Wallimann: Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: Implications for cellular function and mitochondrial structure Qin, Z. Khuchua, J. Cheng, J. Boero, R.M. Payne and A.W. Strauss: Molecular characterization of the creatine kinases and some historical perspectives P.P. Dzeja, R.J. Zeleznikar and N.D. Goldberg: Adenylate kinase: Kinetic behavior in intact cells indicates it is integral to multiple cellular processes K. Steeghs, F. Oerlemans,A . de Haan,A . Heerschap, L. Verdoodt, M. de Bie, W. Ruitenbeek,A . Benders, C. Jost, J. van Deursen, P. Tullson, R. Terjung, P. Jap, W. Jacob, D. Pette and B. Wieringa: Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies K. Nicolay, F.A. van Dorsten, T. Reese, M.J. Kruiskamp, J.F. Gellerich and C.J.A.van Echteld: In situ measurements of creatine kinase flux by NMR. The lessons from bioengineered mice M.K. Aliev, F.A. van Dorsten, M.G. Nederhoff, C.J.A. van Echteld,V .V eksler, K. Nicolay and V.A. Saks: Mathematical model of compartmentalized energy transfer: Its use for analysis and interpretation of *'P-NMR studies of isolated heart of creatine kinase deficient mice 229 R. Ventura-Clapier, A. Kuznetsov, V. Veksler, E.B oehm and K. Anflous: Functional coupling of creatine kinases in muscles: Species and tissue specificity 247 G.J. Kemp, D.N. Manners, J.F. Clark, M.E. Bastin and G.K. Radda: Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/myofibril system in muscle 289 V. Saks, P. Dos Santos, F.N. Gellerich and P. Diolez: Quantitative studies of enzyme-substrate compartmentation, functional 307 coupling and metabolic channelling in muscle cells Part III: Metabolic signalling and calcium: Regulation of mitochondrial oxidative phosphorylation in vivo B.N. Kholodenko, J.M. Rohwer, M. Cascante and H.V. Westerhoff: Subtleties in control by metabolic channelling and enzyme organization J.H.G.M. van Beek, X. Tian, C.J. Zuurbier, B. de Groot, C.J.A. van Echteld, M.H.J. Eijgelshoven and J.B. Hak: The dynamic regulation of myocardial oxidative phosphorylation: Analysis of the response time of oxygen consumption B. Korzeniewski: Is it possible to predict any properties of oxidative phosphorylation in a theoretical way? R.G. Hansford and D. Zorov: Role of mitochondrial calcium transport in the control of substrate oxidation L.S. Jouaville, F. Ichas and J.-P. Mazat: Modulation of cell calcium signals by mitochondria Part IV: Bioenergetics in medicine F, Di Lisa and P. Bernardi: Mitochondrial function as a determinant of recovery or death in cell response to injury I.E. Hassinen, K.H. Vuorinen, K. Ylitalo and A. Ala-Rami: Role of cellular energetics in ischemia-reperfusion and ischemic preconditioning of myocardium A. Rossi, L. Kay and V. Saks: Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: A potential cause for altered energy transfer in cardiac muscle? T. Letellier, M. Malgat, R. Rossignol and J.-P. Mazat: Metabolic control analysis and mitochondrial pathologies E.K. Seppet, A. Kaasik, A. Minajeva, K. Paju, J.J. Ohisalo, R. Vetter and U. Braun: Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to B-adrenergic agonists in atria M.L. Guerrero-Ontiveros andT . Wallimann: Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Down-regulation of the expression of creatine transporter isoforms in skeletal muscle S. Neubauer, M. Horn, D. Hahn and K. Kochsiek: Clinical cardiac magnetic resonance spectroscopy — present state and future directions B. Beauvoit and B. Chance: Time-Resolved Spectroscopy of mitochondria, cells and tissues under normal and pathological conditions Index to Volume 184