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Metastasis: Clinical and Experimental Aspects PDF

489 Pages·1980·11.977 MB·English
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METASTASIS Clinical and Experimental Aspects Proceedings of the EORTC Metastasis Group International Conference on Clinical and Experimental Aspects of Metastasis, London, April 21-23, 1980 edited by K. HELLMANN Imperial Cancer Research Fund London, England P. HILGARD Bristol-Myers International Brussels, Belgium S. ECCLES Institute of Cancer Research Sutton, Surrey, England • 1980 SPRINGER-SCIENCE+BUSINESS MEDIA, B.V. ISBN 978-94-009-8927-6 ISBN 978-94-009-8925-2 (eBook) DOI 10.1007/978-94-009-8925-2 Copyrigh t © 1980 by Springer Science+Business Media Dordrecht OriginaJly published by MartÎnus Nijhoff Publishers in 1980 Softcover reprint ofthe hardcover lst edition 1980 Ali rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher: Springer-Science+Business Media, B. V. DEVELOPMENTS IN ONCOLOGY VOLUME 4 Previously published in this series: 1. F.J. Cleton and J.W.I.M. Simons, eds., Genetic Origins of Tumor Cells ISBN 90-247-2272-1 2. J. Aisner and P. Chang, eds., Cancer Treatment Research ISBN 90-247-2358-2 3. B.W. Ongerboer de Visser, D.A. Bosch and W.M.H. van Woerkom-Eykenboom, eds., Neuro-Oncology: Clinical and Experimental Aspects ISBN 90-247-2421-X Series ISBN: 90-247-2338-8 METASTASIS PREFACE The Metastasis Group of the European Organization for Research on Treatment of Cancer (EORTC) held an International Meeting at the Royal Institution in London on April 2lst-23rd, 1980. The subject was "Clinical and Experimental Aspects of Metastasis" and these Proceedings are the record of that Meeting. Almost all of those who presented a paper or a poster have written up their contributions as chapters of the Proceedings and we have made no distinction here between posters and oral communications. The Organizers and Editors owe a considerable debt of gratitude to all the contributors who without exception presented the results of their work in a clear and concise manner that did much to reveal the essence of the complex problems central to current thinking on met astasis. Moreover most manuscripts arrived well within the deadline - a circumstance which in our experience is unusual. Of the large audience who attended the Meeting many had come from the far distant corners of the World and to them as well as to the presenters of papers the Organizers wish to express their deep appreciation. The Organizers would also like to express their indebted ness to the organizations whose financial contribution made this EORTC Metastasis Group Meeting possible and a list of them follows. VI The keen interest which was shown in the Meeting has led many to ask about future meetings and these it is hoped can be arranged before long, though the framework within which this will take place remains to be settled. for the EORTC Metastasis Group K. Hellmann, Chairman P. Hilgard, co-Chairman S. Eccles VII ACKNOWLEDGEMENTS The Organizing Committee, which consisted of: J. Castro, London S. Eccles, Sutton K. Hellmann, London P. Hilgard, Brussels F. Spreafico, Milano thanks the following for their generous support of the EORTC Metastasis Conference Abbott Laboratories Ltd. Bayer Pharma-Forschungszentrum Boehringer Ingelheim Ltd. Boots Co. Ltd. Bristol-Myers International Cancer Research Campaign Dome Laboratories Eli Lilly & Co. Ltd. Glaxo Holdings Imperial Cancer Research Fund I.C.I. Ltd. Lederle Laboratories Ltd. Monsanto Company Montedison Pharmaceuticals Ltd. Roche Products Ltd. Wellcome Foundation Ltd. They would also like to thank all the staff of the Cancer Chemotherapy Department, Imperial Cancer Research Fund who helped at the Meeting and whose unstinting efforts made this occasion run as smoothly as it did. They would particularly like to thank Mrs. Jean Hartley who not only organized the secretariat, but who also collated all the papers of the Proceedings and retyped many of them. Thanks are also due to Ms. Stephanie Jibson whose valiant efforts resulted in the exhaustive Index of this book. CONTENTS The Significance of Metastases to the Surgeon • • . . • 1 H. Ellis The Spread of Rectal Cancer into Veins and the Mechanism of Distant Embolism • . . . • 3 I.C. Talbot Squamous Carcinomas of the Head & Neck: Patterns and Mechanisms of Local Invasion and Metastasis 9 R.L. Carter The Relationship between Malignant Melanoma Morphology, Metastases and Patient Survival 13 B. Boeryd, J. Eldh and L.-E. Peterson Animal Tumour Models: The Intrusion of Artefacts 18 H.B. Hewitt Models of Prostate, Breast, Lung and Intestinal Carcinomas which Metastasize in Rats • . 23 M. Pollard A New In-Vitro Model to Study Tumour Cell Invasion 28 R. Tchao, A.B. Schleich, M. Frick and A. Mayer Invasiveness and the "Metastatic Potential" of Tumour Cells • . . • • . • • . • 33 C. Meyvisch, P. Van Hoorde and M. Mareel A Possibility of Predicting the Metastatic Potential of Tumours by Implantation into Chick Embryo Blastoderms • . . • • • 38 G.V. Sherbet and M.S. Lakshmi An Experimental Study on the Barrier Function of Lymph Nodes to Tumor Cells • • • • • 45 K. Kohno, T. Yamaguchi and T. Takahashi X CONTENTS Metastases from DMBA-Induced Carcinomas in Hamster Cheek Pouch .•...••. 50 G.T.Craig Quantitation and Cellular Growth of Occult Metastases of a Rat Mammary Carcinoma 55 H. Speakman and B. Dixon Comparison of Natural and Artificial Lung Metastases from a Murine Tumour of Spontaneous Origin 60 A.C. Begg and K.A. Smith Growth Inhibition of Simulated Metastases by a Large Primary Tumor • • • • . 65 s. Ohl, F. Schuning and e.G. Schmidt Quantitative Studies on Metastasis using Yoshida Rat Ascites Hepatomas, with Special Reference to the Biological Characteristics in Metastasizability and Drug Sensitivity • 69 H. Sate, M. Suzuki and H. Satoh Canine Osteosarcoma and Canine Mammary Carcinoma . . 75 L.N. Owen Selection of a Human Malignant Melanoma X Hamster Hybrid Cell Line by Metastasis 80 J.F. Watkins Morphological Aspects of the Interaction of Blood Coagulation and Tumour Dissemination. 85 K.P. Dingemans Cancer Cell Procoagulant Activity, Warfarin and Experimental Metastases . • . • . • • . • 90 M. Colucci, F. Delaini, G.de Bellis Vitti, D. Locati, A. Poggi, N. Semeraro and M.B. Donati XI CONTENTS Molecular Mechanism of Fibrinolysis and its Potential Role in Metastasis •••. 95 S.A. Cederholm-Williams Fibrinolysis and Anticoagulation in Colo-Rectal Cancer The Way Ahead • • • . . 100 H. White, J. Griffiths and A. Salsbury Studies on Factors Influencing the Lodgement of Circulating Tumour Cells . • • • 105 G. Skolnik, M. Alpsten and L. Ivarsson Critical Analysis of Experimental Models for the Antimetastatic Effects of Anticoagulants 109 B. Moat and P. Hilgard Effect of Fibrinolysis Inhibition on the Growth and Hematogenous Dissemination of Cancer. 116 K. Tanaka, M. Kinjo, A. Iwakawa, H. Ogawa and N. Tanaka Mechanisms Behind the Inhibiting Effect of Tranexamic Acid on Tumour Growth and Spread • . . • • • • • • . ..•• 122 H.-I. Peterson and A. Sundbeck The Inhibitory Effect of Sulfated Polysaccharides, Ancrod or Tranexamic Acid on Pulmonary Metastases in Animals • • • • • • • • • • • 127 T. Yamashita, Y. Higuchi and E. Tsubura Prostacyclin as a Marker for Diagnosing and Staging Carcinoma of the Prostate • • 132 0. Khan, C.N. Hensby, H.D. Mitcheson and G. Williams Prostaglandins and Metastasis 136 M.J. Tisdale The Application of a Defibrinogenating Snake Venom Enzyme in Experimental Tumor Metastasis . • • • • • 142 F.S. Markland, K.M. Hwang, S.S. Bajwa and G.B. Patkos

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