Metals in Bone: Proceedings of a EULEP symposium on the deposition, retention and effects of radioactive and stable metals in bone and bone marrow tissues, October 11th – 13th 1984, Angers, France

445 Pages·1985·11.77 MB·English

by  J. T. Triffitt (auth.)

Metals in Bone
This symposium was organised by the Internal Emitters Committee of the Euro
pean Late Effects Project Group (EULEP).lt was co-sponsored by the Commission
of the European Communities, Directorate-General for Research, Science and
Education, Biology, Radiological Protection and Medical Research, Brussels,
a
Belgium and by the Commissariat I' Energie Atomique, Institut de Protection et
de Surete Nucleaire, Bruyeres-Ie-Chatel, France.
COMMISSION OF THE EUROPEAN COMMUNITIES
Radiation Protection
METALS IN
BONE
Proceedings of a EULEP symposium on the deposition, retention and
effects of radioactive and stable metals in bone and bone marrow tissues,
October 11th - 13th 1984, Angers, France.
Editor
Nicholas D. Priest
MTP PRESS LIMITED
~ ~.
~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP ,_
. LANCASTER / BOSTON / THE HAGUE / DORDRECHT 1IIIIIIII-
for the Commission of the European Communities
Published in the UK and Europe by
MTP Press limited
Falcon House
Lancaster, England
British library Cataloguing in Publication Data
Metals in bone: radiation protection: proceedings of a EULEP symposium on the deposition, retention
and effects of radioactive and stable metals in bone and marrow tissues: EULEP Symposium
October 11th - 13th 1984, Angers, France.
1. Bones 2. Metals
I. Priest, Nicholas D. II. EULEP
III. Commission of the European Communities
612'.75 QP88.2
Published in the USA by
MTP Press
A division of Kluwer Boston Inc
190 Old Derby Street
Hingham, MA 02043, USA
library of Congress Cataloging in Publication Data
EULEP Symposium (1984: Angers, France)
Metals in bone.
At head of title: Commission of the European Communities.
At head of title: Radiation protection.
Includes bibliographies and index.
1. Bones - Congresses. 2. Metals in the body - Congresses. 3. Metals - Metabolism - Congresses. 4.
Radioisotopes in the body - Congresses. I. Priest, Nicholas D. II. Commission of the European
Communities. [DNLM: 1. Bone and Bones - metabolism - congresses. 2. Bone Marrow - metabolism
- congresses. 3. Metals - adverse effects - congresses. 4. Metals - metabolism - congresses. 5.
Radioisotopes - adverse effects - congresses. 6. Radioisotopes - metabolism - congresses. WE 200
E88m 1984]
QP88.2.E751984 599'.01852 85-5244
ISBN-13: 978-94-010-8680-6 e-ISBN-13: 978-94-009-4920-1
001: 10.1007/978-94-009-4920-1
© ECSC, EEC, EAEC, Brussels and Luxembourg, 1985
EUR 9250 EN
Softcover reprint of the hardcover 1s t edition 1985
Legal Notice
Neither the Commission of the European Communities nor any person acting on behalf of the
Commission is responsible for the use which might be made of the following information.
Publication arranged by
Commission of the European Communities
Directorate-General Information Market and Innovation
Scientific and Technical Communication
Brussels and Luxembourg.
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or
transmitted in any form or by any means, electronic, mechanical, photocopying, recording or
otherwise, without prior permission from the publishers.
Contents
Introduction xi
List of Contributors xiii
PART 1 BONE MINERALIZATION AND TURNOVER
1 Receptor Molecules, Coprecipitation and Ion Exchange Processes in
the Deposition of Metal Ions in Bone
J. T. Triffitt 3
2 Localization of Technetium-99m in Bone
T. J. F. Savelkoul, W. J. Visser, S. J. Oldenburg and S. A. Duursma 21
3 The Pattern of Calcium Deposition in Rat Bone as Demonstrated by
Calcein Labeling
W. Sontag 29
PART 2 METALS AND THE BONE MARROW
4 Iron Metabolism in the Bone Marrow
A. Jacobs 41
5 The Study of Damage to Bone Marrow Cells as a Biological Dosimeter
after Contamination with Osteotropic a Emitters
C. Schoeters, R. Van Den Heuvel and o. Vanderborght 51
6 Functional Damage to Bone Marrow Fibroblasts after Contamination
with Americium-241
R. Van Den Heuvel, C. Schoeters and o. Vanderborght 63
v
VI CONTENTS
7 The Release of Transportable Plutonium from Macrophages: The
Effects of Dietary Iron
J. W. Haines and N. D. Priest 71
PART 3 ALKALINE EARTH METALS AND BONE
8 Long-term Retention of Radium in Female Former Dial Workers
J. Rundo, A. T. Keane and M. A. Essling 77
9 Strontium-90 Content in Human Bone in West German Residents
R. Dehos and H. Schmier 87
10 Long-term Retention and Turnover Studies with 8SSr
P. N. Sambrook, R. Hesp, J. R. Green, M. Tellez, P. J. Meunier and
J. Reeve 97
11 Dynamics of Lifespan Strontium-90 Distribution in Beagles with
Uniformly Labelled Skeletons Acquired by Radionuclide Ingestion
from In Utero to Adulthood
N. J. Parks 107
12 Effect of Stable Strontium on Bone Metabolism in Rats
P. J. Marie, M. -T. Garba, M. Hott and L. Miravet 117
13 The Distribution of Radium and Plutonium in Human Bone
R. A. Schlenker 127
14 Skeletal Distribution of Stable Strontium and its Incorporation into
Bone Mineral In Vivo
S. Bang, C. A. Baud, H. J. Tochon-Danguy and J. -M. Very 149
15 Convolution Analysis Applied to Skeletal Uptake of 47Ca and 8SSr
Measured by External Counting
V. Jovanovic 151
PART 4 ACTINIDE METALS AND BONE
16 Toxicity of Plutonium and Americium: Relationship of Bone Compos i
tion to Location of 226Ra, 239PU and 241Am-lnduced Bone Sarcomas
W. S. S. Jee, R. B. Dell, N. J. Parks, S. C. Miller and M. E. Wrenn 155
17 Initial Deposition Pattern of Actinides 91 to 96 in the Skeleton of the
Rat
N. D. Priest, G. Howells, D. Green and J. W. Haines 175
CONTENTS vii
18 Pu Microdistribution Study in Cortical Bones of Beagle Dogs
G. Ingrao and W. S. S. lee 199
19 Removal of Plutonium and Americium from Various Parts of Rat
Skeleton by Oral Zn-DTPA
V. Volf 211
20 The Retention of Plutonium in Human Bone: A Reconnaissance
D. M. Taylor 221
21 Distribution of Plutonium-239 and Americium-241 in the Human
Skeleton
l. F. Mcinroy and M. l. Swint 229
22 Uranium, Thorium and Plutonium in Bones from the General Popula-
tion of the United States
N. P. Singh, L. L. Lewis and M. E. Wrenn 231
23 Metabolic Behaviour of Plutonium in Mice
U. Andreozzi, L. Addis and S. Quaggia 243
PART 5 MICRODOSIMETRY OF RADIONUCLIDES IN BONE
24 Microdosimetry of Bone: Implications in Radiological Protection
M. C. Thorne 249
25 Localized Alpha-Dosimetry for Cancer Induction Studies
E. Polig 269
26 The Dosimetry of Pluton ium-23 9 in Bones ofthe Female Mouse and its
Relationship to Observed Effects
D. Green and G. R. Howells 285
27 A New Dosimetric Model for Bone Surface Seeking Radionuclides in
the Skeleton
N. D. Priest and A. Birchall 295
28 Variation of Radiation Exposure Due to the Administration of Iron-59
in Patients with Different Diseases
E. Werner, P. Roth, U. Bohnert, U. Elsasser, K. Henrichs, l. Dietrich and
A. Kaul 297
viii CONTENTS
PART 6 PATHOLOGY OF METALS IN BONE
29 Pathogenesis of Radionuclide-Induced Bone Tumors
W. Gassner 303
30 Effects of Iron Overload on Bone Remodelling in Pigs
M. C. de Vernejoul, A. Pointillart, C. Cywiner Go/enzer, C. Morieux,
J. Bielakoff, D. Modrowski and L. Miravet 321
31 Skeletal lesions from Inhaled Plutonium in Beagles
G. E. Dagle, J. F. Park, R. E. Weller, H. A. Ragan, B. J. McClanahan and
D. R. Fisher 333
32 The Induction, by 239PU, of Myeloid leukaemia and Osteosarcoma in
Female CBA Mice (Interim Results)
E. R. Humphreys, J. F. Loutit and V. A. Stones 343
33 The Effect of Manganese Ingestion, Phosphate Depletion and Starva
tion on the Epiphyseal Growth Plate
B. Engfeldt, A. Hjerpe, F. Reinholt, O. Svensson and B. Wikstrom 353
34 Influence of External Irradiation on Sr Deposit in Bone
P. Gerasimo, R. Ducousso and H. Metivier 357
PART 7 TRACE METALS IN BONE
35 The Variation with Flow-Rate of the Extraction of Bone-Seeking
Tracers in Recirculation Experiments
P. TothW C. Hooper, I. D. McCarthy and S. P. F. Hughes 363
36 Chromium Exchange in the Rat Skeleton
S. Wallach and R. L. Verch 373
37 Historical Changes of Trace Metals in Human Bones from France
Z. Jaworowski, F. Barbalat, C. Blain and E. Peyre 383
38 Some Aspects of lead Uptake by the Bones
C. A. Baud, S. BanK C. Kramar, D. Lacotte, H. J. Tochon-Danguyand
J. -M. Very 395
39 lead Accumulation in Rat's Bone in Relation to Age
M. Blanllsa, OJ. Bre5ki and M. Ciganovic 397
40 The Autoradiographic Method for lead-210 Quantitative
Determination
}. Doniec 401
CONTENTS ix
41 Microdistribution of Lead-210 in the Rabbit's Osseous Tissue
J. Doniec and M. Trzcinka-Ochocka 403
42 Lead in Human Bones and Teeth at the Part-Per-Million Level
M. V. Stack 405
43 Comparative Study of the Chemical Behaviour of Trace Elements in
Dental Enamel
V. Vernois, N. Deschamps, A. Boulay and M. Goldberg 407
PART 8 METABOLISM AND EFFECTS OF STABLE ELEMENTS
44 Ultrastructural Study of Bone and Small Intestine Cells in Lead
Intoxicated Rats
G. Silvestrini and E. Bonucci 419
45 Aluminium Fluoride Inter-Relationships in Renal Failure
M. Gibson, I. M. House, B. Kelly, J. Kwan and V. Parsons 427
46 Evaluation of Different Techniques Used to Determine Aluminium in
Patients with Chronic Renal Failure
W. ]. Visser, F. L. Van de Vyver, A. H. Verbueken, P. 0' Haese, A. B.
Bekaert, R. E. Van Grieken, S. A. Duursma and M. E. De Broe 433
47 Evaluation of the Role of Aluminium on the Bone Histomorphometry
of Uremic Patients
J. L. Sebert, A. Fournier, P. Leflon, M. A. Herve, A. Marie, J. Gueris and
M. Garabedian 443
48 In Vitro Modellingofthe Role of Aluminium in Inducing Osteomalacia
in Dialysis Patients
N. C. Blumenthal, A. L. Boskey and A. S. Posner 451
49 Is Osteomalacia of Renal Osteodystrophy Due to AI Intoxication? An
Experimental Study in the Rat
P. Mocetti, P. Ballanti, C. Della Rocca, S. Costantini, R. Giordano, A.
loppolo, A. Mantovani, O. Stasolla and E. Bonucci 459
Index 461
Introduction
In 1980 the Internal Emitters Committee of EULEP organised a symposium in
Rotterdam on Bone and Bone Seeking Radionu cI ides: Their Physiology,
Dosimetry and Effects. The speakers for this meeting, mostly from EULEP associ
ated laboratories, were chosen to review this field of scientific research mostly for
the benefit of interested scientists who were not actively researching with bone
seeking radionuclides. This meeting was a success and its proceedings were
subsequently published in the form of a book by the Commission of the European
Communities, reflecting the great importance that both EULEP and the Radiologi
cal Protection Programme of the Commission of the European Communities
attaches to the study of radionuclides that deposit in bone.
The Metals in Bone symposium in Angers was intended to serve a different
function from that of the meeting held in Rotterdam in that, while these proceed
ings will certainly be of interest to non-involved scientists, the meeting was
intended to be of most benefit to those actively researching the metabolism and
effects of bone-seeking metals. Moreover, in an attempt to increase the value of its
discussions and the number of interested and participating scientists, the remit of
the meeting was broader and set to include papers on stable as well as radioactive
metals. It is hoped that in this form the meeting provided a forum for discussion
and the exchange of ideas between groups of scientists and clinicians who
normally never meet, but all of whom share a common interest in the distribution
and effects of metals in skeletal tissues. It was intended that the symposium wou Id,
in line with the aims of EULEP, foster inter-laboratory cooperation and communi
cation as well as the occasional exchange of personnel, all of which are now
necessary for the continuation of effective research in the face of dwindling
resources.
The organisers are grateful for the help and encouragement given by many
individuals and organisations during the preparations for the symposium. In
particular we are grateful for that given by Dr. Henri Mehvier and Mrs. Gill
Wilkinson, the Commissariat a l'Energie Atomique (France) and by the National
Radiological Protection Board (UK) and the European Calcified Tissue Society.
N. D. Priest (Editor)
V. Volf (Chairman Internal Emitters Committee, EULEP)
xi